86 Matching Annotations
  1. Nov 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MEK5/ERK5 inhibition sensitizes NRAS-mutant melanoma to MAPK-targeted therapy by preventing Cyclin D/CDK4-mediated G1/S progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501213/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500911/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12491593/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12540771/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering acquired resistance mechanisms to sustained auxin-inducible protein degradation in cells and mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485725/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623503/
  8. Sep 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HIF2-driven PTHrP Causes Cachexia and Hypercalcemia in Kidney Cancer: Treatment with HIF2 Inhibitors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12439952/
  10. www.biorxiv.org www.biorxiv.org
    Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
    1
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    biorxiv.org/content/10.1101/2025.09.04.673818v1
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12409284/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The aflatoxin B1-induced formamidopyrimidine adduct is repaired by transcription-coupled nucleotide excision repair in human cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12409410/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer | EMBO reports
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373837/
  14. Aug 2025
  15. www.sciencedirect.com www.sciencedirect.com
    Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer
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    sciencedirect.com/science/article/pii/S153458072500499X
  16. www.sciencedirect.com www.sciencedirect.com
    SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia
    1
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    sciencedirect.com/science/article/pii/S2211124725009180
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316910/
  18. Jul 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219648/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD81 is a receptor for equine arteritis virus (family: Arteriviridae)
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12239600/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The use of sialic acids as attachment factors is a common feature of Enterovirus-D species
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172487/
  22. www.embopress.org www.embopress.org
    Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer
    1
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    embopress.org/doi/10.1038/s44319-025-00515-4
  23. Jun 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12146761/
  25. May 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070678/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997074/
  28. Apr 2025
  29. www.sciencedirect.com www.sciencedirect.com
    Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation
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    sciencedirect.com/science/article/pii/S153561082500128X
  30. www.nature.com www.nature.com
    Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling
    2
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    nature.com/articles/s41594-025-01522-8
  31. Mar 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11885535/
  33. Feb 2025
  34. www.nature.com www.nature.com
    Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen
    1
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    nature.com/articles/s41467-025-56547-w
  35. Jan 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11704341/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11718230/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11702929/
  39. Sep 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387198/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11398557/
  42. Aug 2024
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306234/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310444/
  45. www.sciencedirect.com www.sciencedirect.com
    Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types
    1
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    sciencedirect.com/science/article/pii/S1873506124002216
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness
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    ncbi.nlm.nih.gov/pmc/articles/PMC11194086/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A tangible method to assess native ferroptosis suppressor activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10985226/
  48. Jul 2024
  49. www.cell.com www.cell.com
    SART3 reads methylarginine-marked glycine- and arginine-rich motifs
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    cell.com/cell-reports/abstract/S2211-1247(24)00788-5
  50. www.cell.com www.cell.com
    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
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    cell.com/cell/fulltext/S0092-8674(24)00693-7
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11217295/
  52. Jun 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Necroptosis stimulates interferon-mediated protective anti-tumor immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11164861/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11138051/
  55. May 2024
  56. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
    1
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    science.org/doi/10.1126/scisignal.adh4475
  57. Apr 2024
  58. www.sciencedirect.com www.sciencedirect.com
    Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
    2
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    sciencedirect.com/science/article/pii/S0092867424003131
  59. rupress.org rupress.org
    Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
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    rupress.org/jcb/article/223/4/e202307026/276570/Tunable-DNMT1-degradation-reveals-DNMT1-DNMT3B
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Scribble/SGEF/Dlg1 complex regulates the stability of apical junctions in epithelial cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996629/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation by the RNA-binding protein Unkempt at its effector interface
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    ncbi.nlm.nih.gov/pmc/articles/PMC11009413/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global and single-nucleotide resolution detection of 7-methylguanosine in RNA
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993922/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10987646/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10997609/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11001640/
  66. Mar 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920751/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein supersaturation powers innate immune signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10055258/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC10907621/
  70. Feb 2024
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10878100/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue-location-specific transcription programs drive tumor dependencies in colon cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10869357/
  73. www.biorxiv.org www.biorxiv.org
    Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications
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    biorxiv.org/content/10.1101/2023.12.16.571619v1
  74. www.sciencedirect.com www.sciencedirect.com
    Machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing
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    sciencedirect.com/science/article/pii/S2211124724000937
  75. www.sciencedirect.com www.sciencedirect.com
    Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
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    sciencedirect.com/science/article/pii/S240547122400022X
  76. Dec 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Synonymous codon usage regulates translation initiation
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    sciencedirect.com/science/article/pii/S2211124723014250
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10695362/
  79. Nov 2023
  80. www.sciencedirect.com www.sciencedirect.com
    A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
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    sciencedirect.com/science/article/pii/S1534580723005518
  81. Oct 2023
  82. www.cell.com www.cell.com
    CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
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    cell.com/cell-metabolism/fulltext/S1550-4131(23)00368-6
  83. www.cell.com www.cell.com
    MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis
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    cell.com/cell-reports/abstract/S2211-1247(23)01034-3
  84. May 2023
  85. www.biorxiv.org www.biorxiv.org
    Copyback viral genomes trigger stress granule formation independent of the antiviral response to interfere with viral translation in acute and persistent infections
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    biorxiv.org/content/10.1101/2023.05.17.541157v1
  86. Mar 2023
  87. www.sciencedirect.com www.sciencedirect.com
    Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124723002231
  88. Feb 2023
  89. www.sciencedirect.com www.sciencedirect.com
    An adverse tumor-protective effect of IDO1 inhibition
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    sciencedirect.com/science/article/pii/S2666379123000332
  90. Dec 2022
  91. www.sciencedirect.com www.sciencedirect.com
    Generation of human induced pluripotent stem cell lines with HMOX1 promoter polymorphism and CRISPR/Cas9-mediated deletion of exon 50 of DMD gene
    1
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    sciencedirect.com/science/article/pii/S1873506122003531
  92. Jun 2022
  93. www.sciencedirect.com www.sciencedirect.com
    RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
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    sciencedirect.com/science/article/pii/S2666379122001872
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SETDB1–TRIM28 complex suppresses antitumor immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8647838/
  95. May 2022
  96. www.sciencedirect.com www.sciencedirect.com
    The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
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    sciencedirect.com/science/article/pii/S1074761322001777
  97. Apr 2022
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC9037950/
  99. Mar 2022
  100. elifesciences.org elifesciences.org
    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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    elifesciences.org/articles/73150
  101. Feb 2022
  102. www.sciencedirect.com www.sciencedirect.com
    Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy
    2
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    sciencedirect.com/science/article/pii/S2666979X2200012X
  103. www.sciencedirect.com www.sciencedirect.com
    Sparse dictionary learning recovers pleiotropy from human cell fitness screens
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    sciencedirect.com/science/article/pii/S2405471221004889
  104. Sep 2021
  105. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target
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    sciencedirect.com/science/article/pii/S0092867421010539
  106. www.sciencedirect.com www.sciencedirect.com
    Title: Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1)
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    sciencedirect.com/science/article/pii/S1873506121003767
  107. Aug 2021
  108. elifesciences.org elifesciences.org
    GIPC proteins negatively modulate Plexind1 signaling during vascular development
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    elifesciences.org/articles/30454
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6499541/
  110. May 2021
  111. www.sciencedirect.com www.sciencedirect.com
    A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation
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    sciencedirect.com/science/article/pii/S1550413121000139
  112. Nov 2020
  113. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Activation of Clustered IFNγ Target Genes Drives Cohesin-Controlled Transcriptional Memory
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    pubmed.ncbi.nlm.nih.gov/33108759/
  114. Jan 2020
  115. www.sciencedirect.com www.sciencedirect.com
    Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing
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    sciencedirect.com/science/article/pii/S2211124719311088
  116. www.sciencedirect.com www.sciencedirect.com
    Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold
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    sciencedirect.com/science/article/pii/S0092867419306774