203 Matching Annotations
  1. Aug 2025
  2. www.nature.com www.nature.com
    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    nature.com/articles/s41586-025-09299-y
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of Pvt1b isoform contributes to local Pvt1 abundance to repress Myc during stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12312954/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12321584/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defective Olfactomedin-2 connects adipocyte dysfunction to obesity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322249/
  6. 52.53.155.43 52.53.155.43
    pnas.2310221120.sapp (3)-html.html
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    52.53.155.43/49469851344434d5746bce62f9be3ffe361b2410/pnas.2310221120.sapp (3)-html.html
  7. Jul 2025
  8. www.sciencedirect.com www.sciencedirect.com
    Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat
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    sciencedirect.com/science/article/pii/S1934590925002619
  9. www.nature.com www.nature.com
    NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity
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    nature.com/articles/s41586-025-09303-5
  10. www.biorxiv.org www.biorxiv.org
    SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.07.18.664790v1
  11. www.sciencedirect.com www.sciencedirect.com
    HIF-independent oxygen sensing via KDM6A regulates ferroptosis
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    sciencedirect.com/science/article/pii/S1097276525005805
  12. 52.53.155.43 52.53.155.43
    pnas.2310221120.sapp-html.html
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    52.53.155.43/dc9316df8bc7b6c7a2d7fa3e970b3d3ca5c7ea55/pnas.2310221120.sapp-html.html
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of CD38 by 78c Enhanced NAD+, Alleviated Inflammation, and Decreased Oxidative Stress in Old Murine Macrophages Induced by Oral Pathogens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12250114/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TIAM1 drives prostatic branching phenotype and is a potential therapeutic target for benign prostatic hyperplasia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220968/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLIMP1 negatively regulates IL-2 signaling in T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273773/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cryo-EM of wild-type and mutant PMEL amyloid cores reveals structural mechanism of pigment dispersion syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219675/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223245/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endogenous SNAP-Tagging of Munc13‑1 for Monitoring Synapse Nanoarchitecture
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    pmc.ncbi.nlm.nih.gov/articles/PMC12188394/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPβ/GADD45γ
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12264431/
  20. www.sciencedirect.com www.sciencedirect.com
    Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness
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    sciencedirect.com/science/article/pii/S221112472500720X
  21. www.sciencedirect.com www.sciencedirect.com
    Subclonal immune evasion in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S1535610825002624
  22. Jun 2025
  23. www.sciencedirect.com www.sciencedirect.com
    An integrated proteomic portrait of prostate cancer progression
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    sciencedirect.com/science/article/pii/S2211124725005996
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RABEP1 amplifies front signaling in neutrophil migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132377/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neddylation as a target in PIK3CA-mutated head and neck cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12036330/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3
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    pmc.ncbi.nlm.nih.gov/articles/PMC12145718/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    P4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids
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    pmc.ncbi.nlm.nih.gov/articles/PMC12123483/
  28. May 2025
  29. www.sciencedirect.com www.sciencedirect.com
    Two waves of adipogenesis in developing avian skin and dermal plasticity
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    sciencedirect.com/science/article/pii/S0012160625001423
  30. www.sciencedirect.com www.sciencedirect.com
    Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages
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    sciencedirect.com/science/article/pii/S1534580725002874
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A hierarchical pathway for assembly of the distal appendages that organize primary cilia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11984956/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages
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    pmc.ncbi.nlm.nih.gov/articles/PMC11984960/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nidogen-1, a Player in KMT2A-Rearranged Pediatric Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11988693/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer Cell-Intrinsic Type I Interferon Signaling Promotes Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12025670/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogene-induced senescence mitochondrial metabolism and bioenergetics drive the secretory phenotype: further characterization and comparison with other senescence-inducing stimuli
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997345/
  36. Apr 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PAR2 Serves an Indispensable Role in Controlling PAR4 Oncogenicity: The β-Catenin–p53 Axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11942634/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11931939/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11949126/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11937418/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A High-Throughput, Three-Dimensional Multiple Myeloma Model Recapitulating Tumor-Stroma Interactions for CAR-Immune Cell-Mediated Cytotoxicity Assay
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    pmc.ncbi.nlm.nih.gov/articles/PMC11967349/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962599/
  43. Mar 2025
  44. 52.53.155.43 52.53.155.43
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    52.53.155.43/6ffb1e8f8e61cda81dc9b10ac8db2b4f9e212959/PDF-html.html
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generation of antigen-specific paired chain antibody sequences using large language models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870394/
  46. www.sciencedirect.com www.sciencedirect.com
    m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice
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    sciencedirect.com/science/article/pii/S1934590925000797
  47. www.sciencedirect.com www.sciencedirect.com
    Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs
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    sciencedirect.com/science/article/pii/S0092867425001990
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11844498/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839035/
  50. Feb 2025
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11799392/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combinatorial In Vivo Genome Editing Identifies Widespread Epistasis and an Accessible Fitness Landscape During Lung Tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11824425/
  53. aacrjournals.org aacrjournals.org
    PARP7 Inhibitors and AHR Agonists Act Synergistically Across a Wide-Range of Cancer Models
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    aacrjournals.org/mct/article/24/1/56/750662/PARP7-Inhibitors-and-AHR-Agonists-Act
  54. Jan 2025
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD4+ T helper 2 cell–macrophage crosstalk induces IL-24–mediated breast cancer suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11721301/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695814/
  57. www.sciencedirect.com www.sciencedirect.com
    Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding
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    sciencedirect.com/science/article/pii/S1535610824004811
  58. Dec 2024
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD38 Inhibitor 78c Attenuates Pro-Inflammatory Cytokine Expression and Osteoclastogenesis in Macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC11640151/
  60. 52.53.155.43 52.53.155.43
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    52.53.155.43/e965e8c267bcac477ace8b0fa7455c4f20806539/PDF-html.html
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting ketone body metabolism in mitigating gemcitabine resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11665555/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An ADPRS variant disrupts ARH3 stability and subcellular localization in children with neurodegeneration and respiratory failure
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    pmc.ncbi.nlm.nih.gov/articles/PMC11667697/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents
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    pmc.ncbi.nlm.nih.gov/articles/PMC11648251/
  64. Nov 2024
  65. www.sciencedirect.com www.sciencedirect.com
    Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency
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    sciencedirect.com/science/article/pii/S2211124724013366
  66. Oct 2024
  67. aacrjournals.org aacrjournals.org
    RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
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    aacrjournals.org/mcr/article/19/6/1063/672883/RAF-Mutant-Melanomas-Differentially-Depend-on-ERK2
  68. www.biorxiv.org www.biorxiv.org
    Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements
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    biorxiv.org/content/10.1101/2024.09.23.614494v1
  69. Sep 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming
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    ncbi.nlm.nih.gov/pmc/articles/PMC10899090/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ICAM1 (CD54) Contributes to the Metastatic Capacity of Gastric Cancer Stem Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11354656/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Grb2 SH3 Domains with Affimer Proteins Provides Novel Insights into Ras Signalling Modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11352564/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358006/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of GCN2 by mTOR confers adaptation to conditions of hyper-mTOR activation under stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11362803/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating mutations remodel the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A‐rearranged acute leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11426354/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    miR-449a mediated repression of the cell cycle machinery prevents neuronal apoptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11419829/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Comparison of Two Versions of the CRISPR-Sirius System for the Live-Cell Visualization of the Borders of Topologically Associating Domains
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    ncbi.nlm.nih.gov/pmc/articles/PMC11394217/
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11413085/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Jumonji histone demethylases are therapeutic targets in small cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11405284/
  80. www.sciencedirect.com www.sciencedirect.com
    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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    sciencedirect.com/science/article/pii/S2589004224021059
  81. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Enhancing immunotherapy through PD-L1 upregulation: the promising combination of anti-PD-L1 plus mTOR inhibitors
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13699
  82. Aug 2024
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PUS7‐dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11341916/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11329700/
  85. www.sciencedirect.com www.sciencedirect.com
    Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanisms
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    sciencedirect.com/science/article/pii/S153458072400457X
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11286358/
  87. www.cell.com www.cell.com
    Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard
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    cell.com/developmental-cell/fulltext/S1534-5807(24)00386-1
  88. www.science.org www.science.org
    Interpretation of cancer mutations using a multiscale map of protein systems
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    science.org/doi/10.1126/science.abf3067
  89. Jul 2024
  90. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Linoleic acid-derived diol 12,13-DiHOME enhances NLRP3 inflammasome activation in macrophages
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202301640RR
  91. www.sciencedirect.com www.sciencedirect.com
    Identification and characterization of TM4SF1+ tumor self-seeded cells
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    sciencedirect.com/science/article/pii/S2211124724008416
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to study CCT-mediated folding of Gβ5 by single-particle cryo-EM
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    ncbi.nlm.nih.gov/pmc/articles/PMC11215110/
  93. Jun 2024
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11199018/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11178498/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11157841/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC
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    ncbi.nlm.nih.gov/pmc/articles/PMC11102494/
  98. www.sciencedirect.com www.sciencedirect.com
    Lineage specification in glioblastoma is regulated by METTL7B
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    sciencedirect.com/science/article/pii/S2211124724006375
  99. www.biorxiv.org www.biorxiv.org
    Aging represses lung tumorigenesis and alters tumor suppression
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    biorxiv.org/content/10.1101/2024.05.28.596319v1
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  102. May 2024
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  111. Apr 2024
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  118. Mar 2024
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  135. Jan 2024
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  140. Dec 2023
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  145. Oct 2023
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  148. Sep 2023
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  151. Aug 2023
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  156. May 2023
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    ATR protects centromere identity by promoting DAXX association with PML nuclear bodies
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  159. Apr 2023
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  162. Mar 2023
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  164. Jan 2023
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  168. Dec 2022
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  173. Nov 2022
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  176. Oct 2022
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  178. Aug 2022
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    Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells
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  181. Jun 2022
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    Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
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  187. Apr 2022
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    The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes
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    Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies
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  191. Mar 2022
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  195. Jan 2022
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    Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy
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  198. Dec 2021
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  200. Nov 2021
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  206. Sep 2021
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    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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  208. Aug 2021
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    The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base
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  212. Jul 2021
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