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A pooled CRISPR-based neuronal activity screen links TMEM50A-dependent MVB function to synaptic integrity and remote memory

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1. scibot 30 Jul 2026
  
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  Addgene_84832
  
  DOI: 10.1016/j.celrep.2026.117756
  
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sciencedirect.com/science/article/pii/S221112472600834X
Jun 2026
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Structural evolution of the MTCH family of mitochondrial insertases

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1. scibot 06 Jun 2026
  
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  84832
  
  DOI: 10.64898/2026.02.17.705849
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12934571/
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In vivo CRISPR-mediated activation of cardiogenic genes to reprogram cardiac fibroblasts

1
1. scibot 06 Jun 2026
  
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  Addgene_84832
  
  DOI: 10.3389/fcell.2026.1812941
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13143979/
Apr 2026
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Elucidating genes sufficient for viral entry into cells through sequential genome-wide CRISPR activation screens

1
1. scibot 08 Apr 2026
  
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  DOI: 10.64898/2026.03.06.710083
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13001310/
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IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors

1
1. scibot 08 Apr 2026
  
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  84832
  
  DOI: 10.1172/JCI195652
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12948414/
Feb 2026
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ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia

1
1. scibot 20 Feb 2026
  
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  Addgene_84832
  
  DOI: 10.1016/j.celrep.2026.117010
  
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sciencedirect.com/science/article/pii/S2211124726000884
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Mapping cis- and trans-regulatory target genes of human-specific deletions

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1. scibot 01 Feb 2026
  
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  DOI: 10.1038/s41467-025-67424-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12727812/
Jan 2026
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CRISPR activation screens map the genomic landscape of cancer glycome remodeling

1
1. scibot 29 Jan 2026
  
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  Addgene84832
  
  DOI: 10.1016/j.xgen.2026.101139
  
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sciencedirect.com/science/article/pii/S2666979X26000017
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EMT activates ER-to-Golgi trafficking through upregulation of REEP2 to promote lung cancer progression

1
1. scibot 26 Jan 2026
  
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  84832
  
  DOI: 10.1101/2025.11.12.688098
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12642484/
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Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia

1
1. scibot 23 Jan 2026
  
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  plasmid_84832
  
  DOI: 10.1016/j.celrep.2025.116875
  
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sciencedirect.com/science/article/pii/S221112472501647X
Nov 2025
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Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer

1
1. scibot 24 Nov 2025
  
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  RRID:Addgene_84832
  
  DOI: 10.1038/s41598-025-23137-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12603150/
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Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia

1
1. scibot 24 Nov 2025
  
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  addgene_84832
  
  DOI: 10.1038/s41420-025-02810-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12537973/
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Tumor heterogeneity underlies clinical outcome and MEK inhibitor response in somatic NF1-mutant glioblastoma

1
1. scibot 23 Nov 2025
  
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  84832
  
  DOI: 10.1172/jci.insight.192658
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12487855/
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Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer

1
1. scibot 23 Nov 2025
  
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  Addgene_84832
  
  DOI: 10.1038/s41467-025-62710-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12423289/
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FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry

1
1. scibot 15 Nov 2025
  
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  AddgeneCat# 84832
  
  DOI: 10.1016/j.immuni.2025.10.020
  
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sciencedirect.com/science/article/pii/S1074761325004741
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Protocol for simplified parallel perturbations using an abridged long non-coding RNA CRISPR library

1
1. scibot 10 Nov 2025
  
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  Plasmid_84832
  
  DOI: 10.1016/j.xpro.2025.104110
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12509891/
Oct 2025
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Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiation Therapy

1
1. scibot 03 Oct 2025
  
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  RRID:Addgene_84832
  
  DOI: 10.1158/0008-5472.CAN-24-3894
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12442109/
Sep 2025
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EGFR-induced lncRNA TRIDENT promotes drug resistance in non–small cell lung cancer via phospho-TRIM28-mediated DNA damage repair

1
1. scibot 06 Sep 2025
  
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  Addgene_84832
  
  DOI: 10.1073/pnas.2415389122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11912419/
Aug 2025
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The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers

1
1. scibot 11 Aug 2025
  
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  Addgene_84832
  
  DOI: 10.1038/s41418-025-01479-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12284170/
Jul 2025
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A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system

1
1. scibot 20 Jul 2025
  
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  84832
  
  DOI: 10.1073/pnas.2506823122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12260521/
Jun 2025
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PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome

1
1. scibot 14 Jun 2025
  
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  Addgene_84832
  
  DOI: 10.1016/j.jbc.2025.108467
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12147174/
May 2025
onlinelibrary.wiley.com onlinelibrary.wiley.com

Identification of a Distal Enhancer That Regulates TGF-β–Induced SNAI1 Expression

2
1. scibot 20 May 2025
  
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  plasmid_84832
  
  DOI: 10.1111/cas.70091
  
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  RRID: Addgene_84,832
  
  DOI: 10.1111/cas.70091
  
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onlinelibrary.wiley.com/doi/10.1111/cas.70091
Mar 2025
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SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation

1
1. scibot 11 Mar 2025
  
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  DOI: 10.1038/s41467-025-56130-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11760969/
Jan 2025
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Involvement of RBP-J interacting and tubulin-associated protein in the distribution of protein regulator of cytokinesis 1 in mitotic spindles

1
1. scibot 27 Jan 2025
  
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  pCRISPRia-V2
  
  DOI: 10.3389/fcell.2024.1472340
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11747798/
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Claudin-4 stabilizes the genome via nuclear and cell cycle remodeling to support ovarian cancer cell survival

1
1. scibot 15 Jan 2025
  
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  RRID:Addgene_84832
  
  DOI: 10.1158/2767-9764.CRC-24-0558
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11705808/
Dec 2024
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PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome

1
1. scibot 27 Dec 2024
  
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  Addgene_84832
  
  DOI: 10.1101/2024.12.10.627778
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11661142/
52.53.155.43 52.53.155.43

crc-24-0558-html.html

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1. scibot 24 Dec 2024
  
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  RRID:Addgene_84832
  
  DOI: 10.1158/2767-9764.crc-24-0558
  
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52.53.155.43/84b181f6e67618dcb22aba5ea65de17db9b57a38/crc-24-0558-html.html
52.53.155.43 52.53.155.43

can-24-0456-html.html

1
1. scibot 13 Dec 2024
  
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  RRID:Addgene_84832
  
  DOI: 10.1158/0008-5472.can-24-0456
  
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52.53.155.43/e3985cf6f143830bda4dc2c0ff3a15e131833b3e/can-24-0456-html.html
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer

1
1. scibot 29 Sep 2024
  
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  84832
  
  DOI: 10.1126/sciadv.ado1218
  
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ncbi.nlm.nih.gov/pmc/articles/PMC466953/
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Systematic identification of post-transcriptional regulatory modules

1
1. scibot 28 Sep 2024
  
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  Addgene_84832
  
  DOI: 10.1038/s41467-024-52215-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11385195/
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Deciphering regulation of FOXP3 expression in human conventional T cells

1
1. scibot 25 Sep 2024
  
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  84832
  
  DOI: 10.1101/2024.08.30.610436
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398386/
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A systematic search for RNA structural switches across the human transcriptome

1
1. scibot 25 Sep 2024
  
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  84832
  
  DOI: 10.1038/s41592-024-02335-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11399106/
Aug 2024
www.sciencedirect.com www.sciencedirect.com

Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS

1
1. scibot 27 Aug 2024
  
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  plasmid_84832
  
  DOI: 10.1016/j.neuron.2024.07.025
  
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sciencedirect.com/science/article/pii/S0896627324005701
www.nature.com www.nature.com

Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells

1
1. scibot 13 Aug 2024
  
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  84832
  
  DOI: 10.1038/s41588-024-01743-5
  
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nature.com/articles/s41588-024-01743-5
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ribosome rescue factor PELOTA modulates translation start site choice for C/EBPα protein isoforms

1
1. scibot 13 Aug 2024
  
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  84832
  
  DOI: 10.26508/lsa.202302501
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11109482/
Jul 2024
www.cell.com www.cell.com

A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence

1
1. scibot 11 Jul 2024
  
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  RRID:Addgene_84832
  
  DOI: 10.1016/j.cell.2024.06.019
  
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cell.com/cell/fulltext/S0092-8674(24)00693-7
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Revealing the grammar of small RNA secretion using interpretable machine learning

2
1. scibot 23 Apr 2024
  
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  84832
  
  DOI: 10.1016/j.xgen.2024.100522
  
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2. scibot 23 Apr 2024
  
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  Addgene_84832
  
  DOI: 10.1016/j.xgen.2024.100522
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11019361/
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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

1
1. scibot 15 Apr 2024
  
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  84832
  
  DOI: 10.1038/s41467-024-46602-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10944492/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

1
1. scibot 14 Apr 2024
  
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  Addgene_84832
  
  DOI: 10.21203/rs.3.rs-3979098/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10984014/
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The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P

1
1. scibot 13 Apr 2024
  
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  84832
  
  DOI: 10.1126/scisignal.ade3643
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11003704/
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KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury

1
1. scibot 05 Apr 2024
  
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  Addgene_84832
  
  DOI: 10.1016/j.stem.2024.03.004
  
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sciencedirect.com/science/article/pii/S1934590924000857
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Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

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1. scibot 02 Apr 2024
  
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  AddgeneCat# 84832
  
  DOI: 10.1016/j.cub.2024.03.010
  
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sciencedirect.com/science/article/pii/S0960982224003075
Mar 2024
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Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6’s role in hematopoietic differentiation and leukemia

1
1. scibot 01 Mar 2024
  
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  plasmid_84832
  
  DOI: 10.1186/s12929-024-01015-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10900714/
Feb 2024
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The HRI branch of the integrated stress response selectively triggers mitophagy

2
1. scibot 14 Feb 2024
  
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  RRID:Addgene_84832
  
  DOI: 10.1016/j.molcel.2024.01.016
  
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2. scibot 14 Feb 2024
  
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  RRID:Addgene_84832
  
  DOI: 10.1016/j.molcel.2024.01.016
  
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sciencedirect.com/science/article/pii/S1097276524000522
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Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance

1
1. scibot 05 Feb 2024
  
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  84832
  
  DOI: 10.1038/s41467-024-44755-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10786885/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Large tandem duplications in cancer result from transcription and DNA replication collisions

1
1. scibot 30 Jan 2024
  
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  plasmid_84832
  
  DOI: 10.1101/2023.05.17.23290140
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10802642/
Aug 2023
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Loss of the Novel Myelin Protein CMTM5 in Multiple Sclerosis Lesions and Its Involvement in Oligodendroglial Stress Responses

1
1. scibot 29 Aug 2023
  
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  plasmid_84832
  
  DOI: 10.3390/cells12162085
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10453064/
Jun 2023
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Comparative landscape of genetic dependencies in human and chimpanzee stem cells

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1. scibot 21 Jun 2023
  
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  Addgene_84832
  
  DOI: 10.1016/j.cell.2023.05.043
  
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sciencedirect.com/science/article/pii/S0092867423005950
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Coupled protein quality control during nonsense-mediated mRNA decay

1
1. scibot 03 Jun 2023
  
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  Addgene_84832
  
  DOI: 10.1242/jcs.261216
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10234110/
May 2023
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

1
1. scibot 10 May 2023
  
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  RRID:Addgene_84832
  
  DOI: 10.1016/j.celrep.2023.112484
  
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sciencedirect.com/science/article/pii/S2211124723004953
www.biorxiv.org www.biorxiv.org

Comparative landscape of genetic dependencies in human and chimpanzee stem cells

1
1. scibot 04 May 2023
  
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  Addgene_84832
  
  DOI: 10.1101/2023.03.19.533346
  
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biorxiv.org/content/10.1101/2023.03.19.533346v1
Jan 2023
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

1
1. scibot 11 Jan 2023
  
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  Addgene_84832
  
  DOI: 10.7554/eLife.81856
  
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pubmed.ncbi.nlm.nih.gov/36576240/
Jul 2022
www.nature.com www.nature.com

Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice

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1. scibot 27 Jul 2022
  
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  Addgene_84832
  
  DOI: 10.1038/s41587-022-01386-z
  
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nature.com/articles/s41587-022-01386-z
May 2021
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GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control

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1. scibot 07 May 2021
  
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  Addgene_84832
  
  DOI: 10.1016/j.molcel.2020.07.007
  
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sciencedirect.com/science/article/pii/S1097276520304731
Sep 2020
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The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells

1
1. scibot 17 Sep 2020
  
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  Plasmid_84832
  
  DOI: 10.1016/j.molcel.2020.06.014
  
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  RRID:Addgene_84832 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276520303993
Jan 2020
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CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_84832
  
  DOI: 10.1016/j.neuron.2019.07.014
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S0896627319306403