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Dissecting cellular ecosystem with single-cell CRISPR screens

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1. scibot 26 Jan 2026
  
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  Addgene_86708
  
  DOI: 10.1097/BS9.0000000000000266
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12680425/
Nov 2025
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SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer

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1. scibot 23 Nov 2025
  
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  86708
  
  DOI: 10.1172/JCI186467
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12483608/
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Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing

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1. scibot 23 Nov 2025
  
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  86708
  
  DOI: 10.1038/s41592-025-02805-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12510883/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Systematic discovery of CRISPR-boosted CAR T cell immunotherapies

1
1. scibot 23 Nov 2025
  
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  86708
  
  DOI: 10.1038/s41586-025-09507-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12545207/
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PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

1
1. scibot 23 Nov 2025
  
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  DOI: 10.1038/s41586-025-09486-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12571902/
Jul 2025
www.science.org www.science.org

High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer

1
1. scibot 25 Jul 2025
  
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  plasmid_86708
  
  DOI: 10.1126/science.adx3800
  
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science.org/doi/10.1126/science.adx3800
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication

1
1. scibot 17 May 2025
  
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  86,708
  
  DOI: 10.1186/s13024-025-00840-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12049787/
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Perturb-tracing enables high-content screening of multi-scale 3D genome regulators

1
1. scibot 17 May 2025
  
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  86708
  
  DOI: 10.1038/s41592-025-02652-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12074983/
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Protecting centrosomes from fracturing enables efficient cell navigation

1
1. scibot 16 May 2025
  
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  86708
  
  DOI: 10.1126/sciadv.adx4047
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12024656/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses

1
1. scibot 24 Apr 2025
  
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  Addgene 86708
  
  DOI: 10.1016/j.molcel.2025.04.002
  
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sciencedirect.com/science/article/pii/S1097276525003053
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Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue

1
1. scibot 07 Apr 2025
  
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  86708
  
  DOI: 10.1101/2025.03.06.641951
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11952344/
Mar 2025
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A genome-wide atlas of human cell morphology

1
1. scibot 23 Mar 2025
  
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  86708
  
  DOI: 10.1038/s41592-024-02537-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11903339/
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Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway

1
1. scibot 11 Mar 2025
  
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  86708
  
  DOI: 10.1101/2025.02.15.638448
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11844499/
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SpaceBar enables clone tracing in spatial transcriptomic data

1
1. scibot 11 Mar 2025
  
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  86708
  
  DOI: 10.1101/2025.02.10.637514
  
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  RRID:Addgene_86708 DOI:10.1101/2025.02.10.637514
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pmc.ncbi.nlm.nih.gov/articles/PMC11844362/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells

1
1. scibot 11 Mar 2025
  
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  86708
  
  DOI: 10.1101/2025.01.30.635675
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838257/
Jan 2025
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Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

1
1. scibot 27 Jan 2025
  
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  86708
  
  DOI: 10.1186/s13059-025-03474-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11740497/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication

1
1. scibot 29 Sep 2024
  
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  86708
  
  DOI: 10.1101/2024.08.14.24312009
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11343251/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ICAM1 (CD54) Contributes to the Metastatic Capacity of Gastric Cancer Stem Cells

1
1. scibot 29 Sep 2024
  
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  86708
  
  DOI: 10.3390/ijms25168865
  
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  DOI:10.3390/ijms25168865 RRID:Addgene_86708
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DOI:10.3390/ijms25168865

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ncbi.nlm.nih.gov/pmc/articles/PMC11354656/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Systematic identification of post-transcriptional regulatory modules

1
1. scibot 28 Sep 2024
  
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  Addgene_86708
  
  DOI: 10.1038/s41467-024-52215-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11385195/
www.sciencedirect.com www.sciencedirect.com

Pooled endogenous protein tagging and recruitment for systematic profiling of protein function

1
1. scibot 10 Sep 2024
  
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  Addgene 86708
  
  DOI: 10.1016/j.xgen.2024.100651
  
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sciencedirect.com/science/article/pii/S2666979X24002623
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution

1
1. scibot 22 Aug 2024
  
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  Addgene_86708
  
  DOI: 10.1038/s41586-024-07663-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11306103/
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Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types

1
1. scibot 15 Aug 2024
  
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  Addgene#86708
  
  DOI: 10.1016/j.scr.2024.103523
  
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sciencedirect.com/science/article/pii/S1873506124002216
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Alzheimer’s disease risk allele of PICALM causes detrimental lipid droplets in microglia

1
1. scibot 21 Jun 2024
  
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  Addgene_86708
  
  DOI: 10.21203/rs.3.rs-4407146/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11142308/
May 2024
www.nature.com www.nature.com

Pooled multicolour tagging for visualizing subcellular protein dynamics

1
1. scibot 03 May 2024
  
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  RRID:Addgene_86708
  
  DOI: 10.1038/s41556-024-01407-w
  
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nature.com/articles/s41556-024-01407-w
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma

1
1. scibot 30 Apr 2024
  
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  plasmid_86708
  
  DOI: 10.1093/hmg/ddae003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11031357/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Detecting subtle transcriptomic perturbations induced by lncRNAs knock-down in single-cell CRISPRi screening using a new sparse supervised autoencoder neural network

1
1. scibot 15 Apr 2024
  
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  86,708
  
  DOI: 10.3389/fbinf.2024.1340339
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10945021/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

1
1. scibot 15 Feb 2024
  
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  86708
  
  DOI: 10.1126/sciadv.adj4767
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma

1
1. scibot 08 Feb 2024
  
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  plasmid_86
  
  DOI: 10.1186/s12885-024-11895-6
  
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  RRID:Addgene_86708 RRIDCUR:Incorrect RRIDCUR:Unresolved
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ncbi.nlm.nih.gov/pmc/articles/PMC10840274/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers

1
1. scibot 17 Dec 2023
  
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  RRID:Addgene_86708
  
  DOI: 10.1016/j.immuni.2023.11.008
  
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sciencedirect.com/science/article/pii/S1074761323004909
Aug 2023
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Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons

1
1. scibot 30 Aug 2023
  
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  RRID:Addgene_86708
  
  DOI: 10.1016/j.xgen.2023.100399
  
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sciencedirect.com/science/article/pii/S2666979X23002136
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CHD-associated enhancers shape human cardiomyocyte lineage commitment

1
1. scibot 06 May 2023
  
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  RRID:Addgene_86708
  
  DOI: 10.7554/eLife.86206
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10156167/
Sep 2022
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Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages

1
1. scibot 08 Sep 2022
  
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  Plasmid_86708
  
  DOI: 10.1016/j.celrep.2022.111315
  
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sciencedirect.com/science/article/pii/S2211124722011391
Apr 2021
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Defining the Teratoma as a Model for Multi-lineage Human Development

1
1. scibot 24 Apr 2021
  
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  Addgene_86708
  
  DOI: 10.1016/j.cell.2020.10.018
  
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sciencedirect.com/science/article/pii/S0092867420313817
Feb 2021
www.nature.com www.nature.com

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

1
1. scibot 25 Feb 2021
  
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  RRID:Addgene_86708
  
  DOI: 10.1038/s41467-020-17209-1
  
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nature.com/articles/s41467-020-17209-1
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time

1
1. scibot 12 Dec 2020
  
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  RRID:Addgene_86708
  
  DOI: 10.1101/gr.261503.120
  
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  Curator: @evieth
  
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  RRIDCUR:Validated RRID:Addgene_86708
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RRIDCUR:Validated

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ncbi.nlm.nih.gov/pmc/articles/PMC7706735/
Aug 2020
www.nature.com www.nature.com

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

1
1. scibot 24 Aug 2020
  
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  RRID:Addgene_86708
  
  DOI: 10.1038/s41467-020-17209-1
  
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  Curator: @evieth
  
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nature.com/articles/s41467-020-17209-1
Jan 2020
www.sciencedirect.com www.sciencedirect.com

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_86708
  
  DOI: 10.1016/j.neuron.2019.07.014
  
  Resource: RRID:Addgene_86708
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_86708
  
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  RRID:Addgene_86708 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S0896627319306403