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Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems

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1. scibot 03 Sep 2025
  
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  RRID:Addgene_89308
  
  DOI: 10.1038/s41467-025-63570-4
  
  Resource: RRID:Addgene_89308
  
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nature.com/articles/s41467-025-63570-4
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Zika virus non-structural protein NS2A mediated endoplasmic reticulum stress through interacting with Sarco/endoplasmic reticulum Ca2+-ATPase 2

1
1. scibot 11 Aug 2025
  
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  LentiMPH v2-hygro
  
  DOI: 10.1128/jvi.00405-25
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12282174/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity

1
1. scibot 20 Jul 2025
  
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  89308
  
  DOI: 10.1038/s41467-025-60389-x
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12215363/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells

1
1. scibot 20 Jul 2025
  
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  89308
  
  DOI: 10.1016/j.stemcr.2025.102499
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12181958/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CDX2 loss in colorectal cancer cells is associated with invasive properties and tumor budding

1
1. scibot 20 Jul 2025
  
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  plasmid_89
  
  DOI: 10.1038/s41598-025-07278-x
  
  Resource: None
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRIDCUR:Unresolved RRID:Addgene_89308 RRIDCUR:Incorrect
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pmc.ncbi.nlm.nih.gov/articles/PMC12230109/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modified screening of MYC promotor region elements using the CRISPR library in ovarian cancer

1
1. scibot 05 Apr 2025
  
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  89,308
  
  DOI: 10.1186/s13048-025-01644-z
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11963443/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells

1
1. scibot 23 Mar 2025
  
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  89308
  
  DOI: 10.1038/s41698-025-00860-6
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11906894/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PRDM16 controls smooth muscle cell fate in atherosclerosis

1
1. scibot 11 Mar 2025
  
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  89308
  
  DOI: 10.1101/2025.02.19.639186
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870537/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression

1
1. scibot 27 Dec 2024
  
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  89308
  
  DOI: 10.1016/j.omtn.2024.102390
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11666955/
Nov 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

PPM1G Inhibits Epithelial–Mesenchymal Transition in Cholangiocarcinoma by Catalyzing TET1 Dephosphorylation for Destabilization to Impair Its Targeted Demethylation of the CLDN3 Promoter

1
1. scibot 07 Nov 2024
  
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  RRID:Addgene_89308
  
  DOI: 10.1002/advs.202407323
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202407323
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The disruption of NEAT1-miR-125b-5p-SLC1A5 cascade defines the oncogenicity and differential immune profile in head and neck squamous cell carcinoma

1
1. scibot 29 Sep 2024
  
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  89308
  
  DOI: 10.1038/s41420-024-02158-1
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_89308
  
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  DOI:10.1038/s41420-024-02158-1 RRID:Addgene_89308
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DOI:10.1038/s41420-024-02158-1

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ncbi.nlm.nih.gov/pmc/articles/PMC11369192/
www.biorxiv.org www.biorxiv.org

Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems

1
1. scibot 27 Sep 2024
  
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  RRID:Addgene_89308
  
  DOI: 10.1101/2024.09.23.614524
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
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biorxiv.org/content/10.1101/2024.09.23.614524v1
Mar 2024
www.sciencedirect.com www.sciencedirect.com

The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA

2
1. scibot 14 Mar 2024
  
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  plasmid_89308
  
  DOI: 10.1016/j.devcel.2024.02.008
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
2. scibot 14 Mar 2024
  
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  plasmid_89308
  
  DOI: 10.1016/j.devcel.2024.02.008
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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sciencedirect.com/science/article/pii/S1534580724001072
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib

1
1. scibot 28 Feb 2024
  
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  plasmid_89
  
  DOI: 10.1186/s12935-024-03233-4
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308 RRIDCUR:Unresolved
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RRID:Addgene_89308

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ncbi.nlm.nih.gov/pmc/articles/PMC10893712/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy

1
1. scibot 13 Feb 2024
  
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  89308
  
  DOI: 10.1038/s41467-023-44393-7
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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ncbi.nlm.nih.gov/pmc/articles/PMC10761979/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Tracing back primed resistance in cancer via sister cells

1
1. scibot 13 Feb 2024
  
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  plasmid_89308
  
  DOI: 10.1038/s41467-024-45478-7
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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ncbi.nlm.nih.gov/pmc/articles/PMC10850087/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide

1
1. scibot 08 Feb 2024
  
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  lentiMPH v2
  
  DOI: 10.1038/s41419-023-06392-w
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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ncbi.nlm.nih.gov/pmc/articles/PMC10766990/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma

1
1. scibot 08 Feb 2024
  
  in Public
  
  plasmid_89
  
  DOI: 10.1186/s12885-024-11895-6
  
  Resource: RRID:Addgene_89308
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRIDCUR:Incorrect RRIDCUR:Unresolved RRID:Addgene_89308
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RRIDCUR:Unresolved

RRID:Addgene_89308

RRIDCUR:Incorrect

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC10840274/
Jan 2024
www.sciencedirect.com www.sciencedirect.com

PAPAS promotes differentiation of mammary epithelial cells and suppresses breast carcinogenesis

1
1. scibot 11 Jan 2024
  
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  RRID:Addgene_89308
  
  DOI: 10.1016/j.celrep.2023.113644
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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sciencedirect.com/science/article/pii/S2211124723016558
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

1
1. scibot 28 Oct 2023
  
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  RRID:Addgene_89308
  
  DOI: 10.1016/j.stem.2023.09.007
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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scibot

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sciencedirect.com/science/article/pii/S1934590923003284
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

LINE-1 activation in the cerebellum drives ataxia

2
1. scibot 20 Oct 2023
  
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  Addgene #89308
  
  DOI: 10.1016/j.neuron.2022.08.011
  
  Resource: RRID:Addgene_89308
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
2. scibot 20 Oct 2023
  
  in Public
  
  RRID:Addgene_89308
  
  DOI: 10.1016/j.neuron.2022.08.011
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Resurrection of endogenous retroviruses during aging reinforces senescence

1
1. scibot 07 Jan 2023
  
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  plasmid_89308
  
  DOI: 10.1016/j.cell.2022.12.017
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
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  RRID:Addgene_89308
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sciencedirect.com/science/article/pii/S0092867422015306
Nov 2022
www.sciencedirect.com www.sciencedirect.com

Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma

1
1. scibot 04 Nov 2022
  
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  RRID:Addgene_89308
  
  DOI: 10.1016/j.ccell.2022.10.012
  
  Resource: RRID:Addgene_89308
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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scibot

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sciencedirect.com/science/article/pii/S1535610822005037
May 2022
www.nature.com www.nature.com

Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

1
1. scibot 03 May 2022
  
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  RRID:Addgene_89308
  
  DOI: 10.1038/s41467-022-29942-w
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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nature.com/articles/s41467-022-29942-w
Feb 2022
www.sciencedirect.com www.sciencedirect.com

LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland

1
1. scibot 16 Feb 2022
  
  in Public
  
  AddgeneCat#89308
  
  DOI: 10.1016/j.celrep.2022.110375
  
  Resource: RRID:Addgene_89308
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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scibot

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sciencedirect.com/science/article/pii/S2211124722000961
May 2021
www.sciencedirect.com www.sciencedirect.com

Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function

1
1. scibot 09 May 2021
  
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  RRID:Addgene_89308
  
  DOI: 10.1016/j.stem.2020.09.019
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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sciencedirect.com/science/article/pii/S193459092030494X
www.sciencedirect.com www.sciencedirect.com

A Single-Cell Transcriptomic Atlas of Human Skin Aging

1
1. scibot 05 May 2021
  
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  Addgene_89308
  
  DOI: 10.1016/j.devcel.2020.11.002
  
  Resource: RRID:Addgene_89308
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308
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sciencedirect.com/science/article/pii/S1534580720308777
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

1
1. scibot 04 Sep 2020
  
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  RRID:Addgene_89308
  
  DOI: 10.1016/j.cell.2020.03.002
  
  Resource: RRID:Addgene_89308
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRIDCUR:Validated RRID:Addgene_89308
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RRIDCUR:Validated

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scibot

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sciencedirect.com/science/article/pii/S0092867420302646
Jan 2020
www.sciencedirect.com www.sciencedirect.com

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_89308
  
  DOI: 10.1016/j.cell.2019.06.005
  
  Resource: RRID:Addgene_89308
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_89308
  
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  RRID:Addgene_89308 RRIDCUR:Validated
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RRIDCUR:Validated

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scibot

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sciencedirect.com/science/article/pii/S0092867419306336