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Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci

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  DOI: 10.1016/j.xgen.2025.100982
  
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cell.com/cell-genomics/abstract/S2666-979X(25)00238-1
Aug 2025
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Kinome reprogramming of G2/M kinases and repression of MYCN contribute to superior efficacy of lorlatinib in ALK-driven neuroblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12322148/
Jul 2025
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CRISPRware: a software package for contextual gRNA library design

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pmc.ncbi.nlm.nih.gov/articles/PMC12210694/
Jun 2025
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CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation

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link.springer.com/article/10.1186/s12943-025-02361-3
May 2025
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CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression

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pmc.ncbi.nlm.nih.gov/articles/PMC11534545/
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Human long noncoding RNA VILMIR is induced by major respiratory viral infections and modulates the host interferon response

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1. scibot 16 May 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11998520/
Apr 2025
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Requirements for the neurodevelopmental disorder-associated gene ZNF292 in human cortical interneuron development and function

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115597
  
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sciencedirect.com/science/article/pii/S2211124725003687
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SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity

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cell.com/cell-reports/fulltext/S2211-1247(25)00247-5
Mar 2025
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Comparative characterization of human accelerated regions in neurons

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nature.com/articles/s41586-025-08622-x
Feb 2025
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Massively parallel assessment of gene regulatory activity at human cortical structure associated variants

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pmc.ncbi.nlm.nih.gov/articles/PMC11839127/
Jan 2025
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Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

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1. scibot 27 Jan 2025
  
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  DOI: 10.1186/s13059-025-03474-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11740497/
Dec 2024
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3D chromatin hubs as regulatory units of identity and survival in human acute leukemia

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1. scibot 24 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.040
  
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sciencedirect.com/science/article/pii/S109727652400995X
Sep 2024
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Atrial fibrillation variant-to-gene prioritization through cross-ancestry eQTL and single-nucleus multiomic analyses

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ncbi.nlm.nih.gov/pmc/articles/PMC11388022/
Jun 2024
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An enhancer RNA recruits KMT2A to regulate transcription of Myb

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1. scibot 21 Jun 2024
  
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  plasmid_89567
  
  DOI: 10.1016/j.celrep.2024.114378
  
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sciencedirect.com/science/article/pii/S221112472400706X
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Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer

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ncbi.nlm.nih.gov/pmc/articles/PMC11162492/
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CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling

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1. scibot 06 Jun 2024
  
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  DOI: 10.1073/pnas.2322524121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11145268/
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Defining cis-regulatory elements and transcription factors that control human cortical interneuron development

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  DOI: 10.1016/j.isci.2024.109967
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11140214/
Apr 2024
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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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1. scibot 15 Apr 2024
  
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  DOI: 10.1038/s41467-024-46602-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10944492/
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Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/β-catenin addiction in cancer

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1. scibot 14 Apr 2024
  
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  DOI: 10.1126/sciadv.adk1031
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10990278/
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Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response

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1. scibot 13 Apr 2024
  
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  DOI: 10.1101/2024.03.25.586578
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996554/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells

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  DOI: 10.1101/2024.02.15.580539
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10896345/
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Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma

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  DOI: 10.1158/1541-7786.MCR-22-0916
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10542885/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription

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  DOI: 10.21203/rs.3.rs-3854707/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10862967/
Sep 2023
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Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression

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1. scibot 19 Sep 2023
  
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  RRID:Addgene_89567
  
  DOI: 10.1016/j.ajhg.2023.07.003
  
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sciencedirect.com/science/article/pii/S0002929723002434
Aug 2023
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Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons

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1. scibot 30 Aug 2023
  
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  DOI: 10.1016/j.xgen.2023.100399
  
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sciencedirect.com/science/article/pii/S2666979X23002136
52.53.155.43 52.53.155.43

mcr-22-0916-html.html

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  RRID:Addgene_89567
  
  DOI: 10.1158/1541-7786.mcr-22-0916
  
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52.53.155.43/ee24162242ef05486fd8a6e1481e2011af4e24fe/mcr-22-0916-html.html
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi’s sarcoma-associated herpesvirus

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  DOI: 10.1101/2023.07.08.548212
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10350069/
May 2023
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

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  DOI: 10.1016/j.celrep.2023.112484
  
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  RRID:Addgene_89567
  
  DOI: 10.1016/j.celrep.2023.112484
  
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sciencedirect.com/science/article/pii/S2211124723004953
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CHD-associated enhancers shape human cardiomyocyte lineage commitment

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  DOI: 10.7554/eLife.86206
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10156167/
Feb 2022
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HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization

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  DOI: 10.1016/j.molcel.2022.01.023
  
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sciencedirect.com/science/article/pii/S1097276522000983
Nov 2021
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A multi-omic single-cell landscape of human gynecologic malignancies

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  DOI: 10.1016/j.molcel.2021.10.013
  
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sciencedirect.com/science/article/pii/S109727652100842X
Jul 2021
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Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression

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sciencedirect.com/science/article/pii/S1873506121003202
Apr 2021
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Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.06.037
  
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sciencedirect.com/science/article/pii/S009286742030814X
Sep 2020
cancerres.aacrjournals.org cancerres.aacrjournals.org

Proteomic profiling of the ECM of xenograft breast cancer metastases in different organs reveals distinct metastatic niches

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1. scibot 13 Sep 2020
  
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  RRID:Addgene_89567
  
  DOI: 10.1158/0008-5472.CAN-19-2961
  
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cancerres.aacrjournals.org/content/80/7/1475
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Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells

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  DOI: 10.1016/j.celrep.2020.107532
  
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sciencedirect.com/science/article/pii/S2211124720304320
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Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

1
1. scibot 04 Sep 2020
  
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  addgene_89567
  
  DOI: 10.7554/eLife.53381
  
  Resource: RRID:Addgene_89567
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_89567
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_89567
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Tags

RRID:Addgene_89567

RRIDCUR:Validated

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7200154/