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Tolerance to extracellular acidic pH facilitates tumor plasticity

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1. scibot 17 Apr 2026
  
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  Plasmid_90294
  
  DOI: 10.1016/j.celrep.2026.117226
  
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sciencedirect.com/science/article/pii/S2211124726003049
Apr 2026
www.biorxiv.org www.biorxiv.org

Phosphorylation-driven Targeted Protein Degradation of Oncogenic β-catenin

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1. scibot 02 Apr 2026
  
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  90294
  
  DOI: 10.64898/2026.03.16.712096
  
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biorxiv.org/content/10.64898/2026.03.16.712096v1
Nov 2025
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FGD3 mediates lytic cell death, enhancing efficacy and immunogenicity of chemotherapy agents in breast cancer

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1. scibot 24 Nov 2025
  
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  90294
  
  DOI: 10.1186/s13046-025-03559-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12613929/
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The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions

1
1. scibot 24 Nov 2025
  
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  90294
  
  DOI: 10.1038/s41420-025-02817-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12638847/
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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

1
1. scibot 06 Nov 2025
  
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  Addgene_90294
  
  DOI: 10.1016/j.celrep.2025.116495
  
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sciencedirect.com/science/article/pii/S2211124725012665
Oct 2025
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Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas

1
1. scibot 23 Oct 2025
  
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  Addgene, #90294
  
  DOI: 10.1101/2025.10.13.681937
  
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biorxiv.org/content/10.1101/2025.10.13.681937v2
Sep 2025
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LTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells

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1. scibot 27 Sep 2025
  
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  Addgene_90294
  
  DOI: 10.1136/jitc-2025-011893
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12458808/
Jul 2025
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CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

1
1. scibot 20 Jul 2025
  
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  90294
  
  DOI: 10.1016/j.molcel.2025.04.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
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Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens

1
1. scibot 11 Jul 2025
  
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  Addgene_90294
  
  DOI: 10.1101/2025.06.30.662330
  
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biorxiv.org/content/10.1101/2025.06.30.662330v1
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Integrated genetic screening reveals FEN1 as a driver of stemness and temozolomide resistance in glioblastoma

1
1. scibot 01 Jul 2025
  
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  Addgene no. 90294
  
  DOI: 10.1101/2025.06.18.660339
  
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biorxiv.org/content/10.1101/2025.06.18.660339v1
Jun 2025
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Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity

1
1. scibot 28 Jun 2025
  
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  Addgene_90294
  
  DOI: 10.1016/j.celrep.2025.115921
  
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sciencedirect.com/science/article/pii/S2211124725006928
May 2025
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Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

1
1. scibot 16 May 2025
  
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  Addgene_90294
  
  DOI: 10.1016/j.celrep.2025.115657
  
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sciencedirect.com/science/article/pii/S2211124725004280
Mar 2025
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A genome-wide atlas of human cell morphology

1
1. scibot 23 Mar 2025
  
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  90294
  
  DOI: 10.1038/s41592-024-02537-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11903339/
Feb 2025
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The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2

1
1. scibot 18 Feb 2025
  
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  Addgene_90294
  
  DOI: 10.7554/eLife.97577
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11793871/
Jan 2025
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The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells

2
1. scibot 07 Jan 2025
  
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  Addgene plasmid library, Cat# 90294
  
  DOI: 10.1016/j.chembiol.2024.11.009
  
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2. scibot 07 Jan 2025
  
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  Addgene_90294
  
  DOI: 10.1016/j.chembiol.2024.11.009
  
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sciencedirect.com/science/article/pii/S2451945624004896
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-Wide CRISPR Screen Identifies KEAP1 Perturbation as a Vulnerability of ARID1A-Deficient Cells

1
1. scibot 25 Sep 2024
  
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  90294
  
  DOI: 10.3390/cancers16172949
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11394604/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

1
1. scibot 20 Jul 2024
  
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  Addgene_90294
  
  DOI: 10.7554/eLife.91766
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257678/
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The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation

1
1. scibot 17 Jul 2024
  
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  Addgene_90294
  
  DOI: 10.1016/j.celrep.2024.114417
  
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sciencedirect.com/science/article/pii/S2211124724007460
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter

1
1. scibot 12 May 2024
  
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  90294
  
  DOI: 10.1093/nar/gkae240
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11077057/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2

1
1. scibot 14 Apr 2024
  
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  Addgene_90294
  
  DOI: 10.1101/2024.03.18.585604
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983909/
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DePARylation is critical for S phase progression and cell survival

1
1. scibot 13 Apr 2024
  
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  90294
  
  DOI: 10.7554/eLife.89303
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10997334/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Optimized protocol for CRISPR knockout of human iPSC-derived macrophages

1
1. scibot 17 Mar 2024
  
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  90294
  
  DOI: 10.1016/j.xpro.2024.102903
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10904194/
Feb 2024
www.biorxiv.org www.biorxiv.org

New submission 27/09/2023, 09:17:54

1
1. scibot 21 Feb 2024
  
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  90294
  
  DOI: 10.1101/2023.07.31.551317
  
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biorxiv.org/content/10.1101/2023.07.31.551317v1
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe

1
1. scibot 23 Dec 2023
  
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  Addgene_90294
  
  DOI: 10.1158/2767-9764.CRC-23-0306
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10734389/
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

1
1. scibot 31 Oct 2023
  
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  Addgene_90294
  
  DOI: 10.1038/s41467-023-42342-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10611716/
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors

1
1. scibot 06 Jan 2023
  
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  Addgene_90294
  
  DOI: 10.1016/j.heliyon.2022.e12744
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9800021/
Nov 2022
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POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

1
1. scibot 18 Nov 2022
  
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  Plasmid_90294
  
  DOI: 10.1016/j.celrep.2022.111716
  
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sciencedirect.com/science/article/pii/S2211124722015947
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Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

1
1. scibot 11 Nov 2022
  
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  RRID:Addgene_90294
  
  DOI: 10.1016/j.ccell.2022.10.009
  
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sciencedirect.com/science/article/pii/S1535610822005001
Feb 2022
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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

2
1. scibot 11 Feb 2022
  
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  Addgene_90294
  
  DOI: 10.1016/j.celrep.2022.110343
  
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  RRID:Addgene_90294
2. scibot 09 Feb 2022
  
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  Addgene_90294
  
  DOI: 10.1016/j.celrep.2022.110343
  
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sciencedirect.com/science/article/pii/S2211124722000596
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identifying chemogenetic interactions from CRISPR screens with drugZ

1
1. scibot 14 Aug 2021
  
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  Addgene_90294
  
  DOI: 10.1186/s13073-019-0665-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6706933/
Jul 2021
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Untitled document

1
1. scibot 29 Jul 2021
  
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  Addgene_90294
  
  DOI: 10.1016/j.celrep.2019.03.047
  
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sciencedirect.com/science/article/pii/S2211124719303638
May 2021
www.embopress.org www.embopress.org

A method for benchmarking genetic screens reveals a predominant mitochondrial bias

1
1. scibot 22 May 2021
  
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  Addgene_90294
  
  DOI: 10.15252/msb.202010013
  
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embopress.org/doi/full/10.15252/msb.202010013
Apr 2021
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Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

1
1. scibot 23 Apr 2021
  
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  Addgene_90294
  
  DOI: 10.1016/j.cell.2020.04.047
  
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sciencedirect.com/science/article/pii/S0092867420305535
Feb 2021
www.nature.com www.nature.com

Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages

1
1. scibot 25 Feb 2021
  
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  Addgene_90294
  
  DOI: 10.1038/s41598-021-82137-z
  
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  RRIDCUR:Validated RRID:Addgene_90294
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nature.com/articles/s41598-021-82137-z
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

1
1. scibot 09 Dec 2020
  
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  Addgene_90294
  
  DOI: 10.1038/s42255-020-0211-z
  
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  RRID:Addgene_90294 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7566881/
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

1
1. scibot 15 Sep 2020
  
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  Addgene_90294
  
  DOI: 10.1016/j.molcel.2020.07.009
  
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  SciCrunch record: RRID:Addgene_90294
  
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  RRIDCUR:Validated RRID:Addgene_90294
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pubmed.ncbi.nlm.nih.gov/32738194/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins

1
1. scibot 03 Sep 2020
  
  in Public
  
  Addgene plasmid 90294
  
  DOI: 10.1016/j.cell.2020.06.005
  
  Resource: RRID:Addgene_90294
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_90294
  
  Curator comments: Toronto KnockOut version 3 library (TKOv3)
  
  What is this?
  
  RRID:Addgene_90294 RRIDCUR:Missing
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Tags

RRIDCUR:Missing

RRID:Addgene_90294

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7316060/