135 Matching Annotations
  1. Aug 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer
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    sciencedirect.com/science/article/pii/S153458072500499X
  3. www.nature.com www.nature.com
    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    nature.com/articles/s41586-025-09299-y
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM5α/Cyclophilin A-Modified MDBK Cells for Lentiviral-Based Gene Editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12298503/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SMARCA5 is required for the development of granule cell neuron precursors and Sonic Hedgehog Medulloblastoma growth
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12274346/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302539/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12332072/
  8. 52.53.155.43 52.53.155.43
    fan-et-al-macrophages-form-dendrite-like-pseudopods-to-enhance-bacterial-ingestion-html.html
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    52.53.155.43/eb9f280da21a8c493f782497490efc75c3d12f84/fan-et-al-macrophages-form-dendrite-like-pseudopods-to-enhance-bacterial-ingestion-html.html
  9. www.sciencedirect.com www.sciencedirect.com
    Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells
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    sciencedirect.com/science/article/pii/S1074761325003176
  10. Jul 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12180443/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12165809/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFITM proteins are key entry factors for porcine epidemic diarrhea coronavirus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172462/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167974/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gasdermin E in glioblastoma –pyroptosis resistance and tumor-promoting functions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12182582/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of serotonin-Htr2b signaling in skeletal muscle mitigates obesity-induced insulin resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227683/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis[image]
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    pmc.ncbi.nlm.nih.gov/articles/PMC12182360/
  18. www.sciencedirect.com www.sciencedirect.com
    A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy
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    sciencedirect.com/science/article/pii/S2667237525001420
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements
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    pmc.ncbi.nlm.nih.gov/articles/PMC12209767/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycosphingolipid synthesis mediates immune evasion in Kras-driven cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11892728/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137
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    pmc.ncbi.nlm.nih.gov/articles/PMC12203918/
  22. Jun 2025
  23. www.sciencedirect.com www.sciencedirect.com
    Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation
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    sciencedirect.com/science/article/pii/S1097276525004721
  24. 52.53.155.43 52.53.155.43
    1-s2.0-S258900422501226X-main-html.html
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    52.53.155.43/d1f78810f1eafd7cac950f9c8a5713f79fe4d700/1-s2.0-S258900422501226X-main-html.html
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12135451/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12086175/
  27. www.sciencedirect.com www.sciencedirect.com
    TAMs-specific ARF1 inhibition reprograms glioma microenvironment and enhances the therapeutic effect of oncolytic adenovirus
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    sciencedirect.com/science/article/pii/S2589004225009575
  28. May 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075365/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070678/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A chimeric viral platform for directed evolution in mammalian cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12059018/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cooperative nutrient scavenging is an evolutionary advantage in cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11981941/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    N‐terminomics and proteomics analysis of Calpain‐2 reveal key proteolytic processing of metabolic and cell adhesion proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12023407/
  34. Apr 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11937597/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting FANCM by antisense oligonucleotides in ALT-positive cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11930073/
  37. Mar 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP
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    pmc.ncbi.nlm.nih.gov/articles/PMC11923992/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC11888413/
  40. www.sciencedirect.com www.sciencedirect.com
    Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
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    sciencedirect.com/science/article/pii/S1097276525001479
  41. www.sciencedirect.com www.sciencedirect.com
    Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death
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    sciencedirect.com/science/article/pii/S1534580725001170
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Isocyanic acid–mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11887815/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STING-induced noncanonical autophagy regulates endolysosomal homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11874320/
  44. www.sciencedirect.com www.sciencedirect.com
    Hypoxia inducible factor-1α drives cancer resistance to cuproptosis
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    sciencedirect.com/science/article/pii/S1535610825000674
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11988688/
  46. Feb 2025
  47. www.sciencedirect.com www.sciencedirect.com
    Potentiating anti-tumor immunity by re-engaging immune synapse molecules
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    sciencedirect.com/science/article/pii/S2666379125000485
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839913/
  49. www.sciencedirect.com www.sciencedirect.com
    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
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    sciencedirect.com/science/article/pii/S1934590925000104
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11814296/
  51. www.sciencedirect.com www.sciencedirect.com
    ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
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    sciencedirect.com/science/article/pii/S0092867425000960
  52. Jan 2025
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735410/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11746948/
  55. Dec 2024
  56. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/2fb487e0ec740e682ba0aad1a706fe30bd8fc51d/PDF-html.html
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZBTB48 is a priming factor regulating B-cell-specific CIITA expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11649694/
  58. www.sciencedirect.com www.sciencedirect.com
    1-s2.0-S2589004224027718-main-html.html
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    sciencedirect.com/science/article/pii/S2589004224027718
  59. www.sciencedirect.com www.sciencedirect.com
    Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
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    sciencedirect.com/science/article/pii/S2211124724013676
  60. Nov 2024
  61. www.biorxiv.org www.biorxiv.org
    Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth
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    biorxiv.org/content/10.1101/2023.07.15.549147v1
  62. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202404109
  63. Sep 2024
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system
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    ncbi.nlm.nih.gov/pmc/articles/PMC11373621/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10945809/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387198/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
  68. www.sciencedirect.com www.sciencedirect.com
    MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0304383524006153
  69. Aug 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-muscle myosin 2 can incorporate into established filaments in cells without an assembly competence domain
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    ncbi.nlm.nih.gov/pmc/articles/PMC11257479/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CAR T-cells targeting FGFR4 and CD276 simultaneously show potent antitumor effect against childhood rhabdomyosarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11266617/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11304869/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11175508/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10989277/
  75. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/47007dbc2cda4f961c79d2e8158521ca8af7c5b7/Molecular Oncology - 2023 - Bots - Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus -html.html
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche
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    ncbi.nlm.nih.gov/pmc/articles/PMC10844594/
  77. Jul 2024
  78. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
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    sciencedirect.com/science/article/pii/S153561082400237X
  79. Jun 2024
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11196642/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibitors of dermatan sulfate epimerase 1 decreased accumulation of glycosaminoglycans in mucopolysaccharidosis type I fibroblasts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11101759/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC11101626/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11142138/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antipsychotics possess anti-glioblastoma activity by disrupting lysosomal function and inhibiting oncogenic signaling by stabilizing PTEN
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    ncbi.nlm.nih.gov/pmc/articles/PMC11176297/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of the IKK2-NF𝜅B pathway in VSMCs inhibits calcified vascular stiffness in CKD
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    pmc.ncbi.nlm.nih.gov/articles/PMC11128211/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148551/
  87. May 2024
  88. aacrjournals.org aacrjournals.org
    Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma
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    aacrjournals.org/cancerres/article/84/10/1570/745316/Bile-Acid-Metabolism-Mediates-Cholesterol
  89. 52.53.155.43 52.53.155.43
    mct-23-0285-html.html
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    52.53.155.43/c4dad1b9844bc76f61b814848871e558944174e3/mct-23-0285-html.html
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-esterified fatty acid palmitate facilitates oxidative endoplasmic reticulum stress and apoptosis of β-cells by upregulating ERO-1α expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11070623/
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11077976/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RRP8, associated with immune infiltration, is a prospective therapeutic target in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11082032/
  93. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/47007dbc2cda4f961c79d2e8158521ca8af7c5b7/Molecular Oncology - 2023 - Bots - Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus -html.html
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Influenza Virus Reduces Ubiquitin E3 Ligase MARCH10 Expression to Decrease Ciliary Beat Frequency
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    ncbi.nlm.nih.gov/pmc/articles/PMC10151042/
  95. Apr 2024
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies
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    ncbi.nlm.nih.gov/pmc/articles/PMC11053310/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Satellite double-stranded RNA induces mesenchymal transition in pancreatic cancer by regulating alternative splicing
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    ncbi.nlm.nih.gov/pmc/articles/PMC10943486/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GPX4‐mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP‐TEAD signalling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10945084/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer
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  104. Mar 2024
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  106. Feb 2024
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  114. Dec 2023
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  126. Jan 2023
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  133. Jun 2022
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  138. Feb 2022
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  144. Oct 2021
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  157. Apr 2021
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  159. Mar 2021
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  161. Dec 2020
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  163. Oct 2020
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  165. Sep 2020
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  170. Jan 2020
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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