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De novo design of potent CRISPR–Cas13 inhibitors

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1. scibot 08 Aug 2026
  
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  98293
  
  DOI: 10.1038/s41589-025-02136-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13423800/
Aug 2026
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Genotoxic antibody-drug conjugates combined with BCL-XL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer

1
1. scibot 05 Aug 2026
  
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  RRID:Addgene_98293
  
  DOI: 10.1172/JCI200438
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13430021/
Jun 2026
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SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma

1
1. scibot 10 Jun 2026
  
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  RRID:Addgene_98293
  
  DOI: 10.1158/0008-5472.CAN-25-3195
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13244386/
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Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus

1
1. scibot 06 Jun 2026
  
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  98293
  
  DOI: 10.7554/eLife.105105
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13221179/
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A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer

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1. scibot 06 Jun 2026
  
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  addgene_98293
  
  DOI: 10.1016/j.xcrm.2026.102776
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13198260/
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nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability

1
1. scibot 05 Jun 2026
  
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  plasmid_98293
  
  DOI: 10.1016/j.celrep.2026.117495
  
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sciencedirect.com/science/article/pii/S2211124726005735
Apr 2026
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MYC-ATF4-ASS1 axis governs intracellular arginine synthesis and dictates the immune microenvironment in melanoma

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1. scibot 08 Apr 2026
  
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  98293
  
  DOI: 10.64898/2026.02.27.707779
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13001425/
Mar 2026
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Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling

1
1. scibot 18 Mar 2026
  
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  Addgene_98293
  
  DOI: 10.64898/2026.02.17.706344
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12934820/
Nov 2025
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UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN

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1. scibot 21 Nov 2025
  
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  98293
  
  DOI: 10.1038/s41467-025-64977-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12627610/
Oct 2025
www.biorxiv.org www.biorxiv.org

Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer

1
1. scibot 14 Oct 2025
  
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  RRID:Addgene_98293
  
  DOI: 10.1101/2025.09.05.674562
  
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biorxiv.org/content/10.1101/2025.09.05.674562v1
Sep 2025
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CLDN4 regulates cell proliferation in small cell lung cancer cells via SAA1 inhibition

1
1. scibot 27 Sep 2025
  
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  RRID:Addgene_98293
  
  DOI: 10.1016/j.bbrc.2025.152710
  
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sciencedirect.com/science/article/pii/S0006291X25014263
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Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer

1
1. scibot 22 Sep 2025
  
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  RRID:Addgene_98293
  
  DOI: 10.1101/2025.09.05.674562
  
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biorxiv.org/content/10.1101/2025.09.05.674562v1
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ACTL6A depletion induces KLF4-mediated anti-tumorigenic effects in colorectal cancer

1
1. scibot 06 Sep 2025
  
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  98293
  
  DOI: 10.1038/s41419-025-07946-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12394641/
Aug 2025
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ADAM17 is an HIV-1 Restriction Factor Antagonized by Nef

1
1. scibot 11 Aug 2025
  
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  RRID:Addgene_98293
  
  DOI: 10.21203/rs.3.rs-6923186/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12270201/
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Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new inhibitors

1
1. scibot 11 Aug 2025
  
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  plasmid_98293
  
  DOI: 10.1016/j.redox.2025.103789
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314328/
Jul 2025
journals.plos.org journals.plos.org

Functional characterization of DPP4 and FcRn as receptor and coreceptor for classical human astroviruses in Caco-2 cells

1
1. scibot 22 Jul 2025
  
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  RRID:Addgene_98293
  
  DOI: 10.1371/journal.ppat.1013316
  
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journals.plos.org/plospathogens/article
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Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically

1
1. scibot 20 Jul 2025
  
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  98293
  
  DOI: 10.1371/journal.ppat.1013281
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12204619/
Jun 2025
www.nature.com www.nature.com

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

1
1. scibot 18 Jun 2025
  
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  Addgene, cat. no. 98293
  
  DOI: 10.1038/s41594-025-01581-x
  
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  Curator: @dhovakimyan1
  
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nature.com/articles/s41594-025-01581-x
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Translation suppresses exogenous target RNA-mediated microRNA decay

1
1. scibot 14 Jun 2025
  
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  98293
  
  DOI: 10.1038/s41467-025-60374-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12144122/
May 2025
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Cooperative nutrient scavenging is an evolutionary advantage in cancer

1
1. scibot 16 May 2025
  
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  98293
  
  DOI: 10.1038/s41586-025-08588-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11981941/
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An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death

1
1. scibot 16 May 2025
  
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  98293
  
  DOI: 10.1038/s41467-025-58619-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11986000/
Mar 2025
www.sciencedirect.com www.sciencedirect.com

Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death

1
1. scibot 14 Mar 2025
  
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  Addgene#98293
  
  DOI: 10.1016/j.devcel.2025.02.012
  
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sciencedirect.com/science/article/pii/S1534580725001170
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

STING-induced noncanonical autophagy regulates endolysosomal homeostasis

1
1. scibot 11 Mar 2025
  
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  98293
  
  DOI: 10.1073/pnas.2415422122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11874320/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation

1
1. scibot 23 Feb 2025
  
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  lentiCRISPRv2-blast
  
  DOI: 10.1038/s41467-025-57099-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11839913/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters

1
1. scibot 27 Jan 2025
  
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  98293
  
  DOI: 10.1038/s41588-024-02015-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735410/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

1
1. scibot 28 Dec 2024
  
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  98293
  
  DOI: 10.1101/2024.12.04.624804
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11642887/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ELM2‐SANT Domain‐Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human‐Induced Pluripotent Stem Cells

1
1. scibot 26 Aug 2024
  
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  Addgene_98293
  
  DOI: 10.1161/JAHA.124.034816
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11255699/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death

1
1. scibot 13 Aug 2024
  
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  98293
  
  DOI: 10.1136/jmg-2023-109779
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11287636/
Jun 2024
www.sciencedirect.com www.sciencedirect.com

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

1
1. scibot 21 Jun 2024
  
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  Addgene_98293
  
  DOI: 10.1016/j.cmet.2024.05.015
  
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sciencedirect.com/science/article/pii/S1550413124001918
Apr 2024
www.sciencedirect.com www.sciencedirect.com

BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response

2
1. scibot 09 Apr 2024
  
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  Addgene98293
  
  DOI: 10.1016/j.molcel.2024.03.011
  
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  Curator: @abever99
  
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  RRID:Addgene_98293
2. scibot 09 Apr 2024
  
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  plasmid_98293
  
  DOI: 10.1016/j.molcel.2024.03.011
  
  Resource: RRID:Addgene_98293
  
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sciencedirect.com/science/article/pii/S1097276524002211
Jun 2023
www.sciencedirect.com www.sciencedirect.com

DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

2
1. scibot 21 Jun 2023
  
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  Addgene_98293
  
  DOI: 10.1016/j.cell.2023.05.028
  
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  RRID:Addgene_98293
2. scibot 21 Jun 2023
  
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  RRID:Addgene_982
  
  DOI: 10.1016/j.cell.2023.05.028
  
  Resource: RRID:Addgene_98293
  
  Curator: @sofiakhan13
  
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  RRID:Addgene_98293 RRIDCUR:Unresolved
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sciencedirect.com/science/article/pii/S0092867423005809
May 2023
www.sciencedirect.com www.sciencedirect.com

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

1
1. scibot 25 May 2023
  
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  RRID:Addgene_98293
  
  DOI: 10.1016/j.celrep.2023.112536
  
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sciencedirect.com/science/article/pii/S2211124723005478
Apr 2023
www.sciencedirect.com www.sciencedirect.com

A tissue injury sensing and repair pathway distinct from host pathogen defense

1
1. scibot 26 Apr 2023
  
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  RRID:Addgene_98293
  
  DOI: 10.1016/j.cell.2023.03.031
  
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sciencedirect.com/science/article/pii/S0092867423003288
Nov 2022
www.sciencedirect.com www.sciencedirect.com

NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma

1
1. scibot 09 Nov 2022
  
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  98293
  
  DOI: 10.1016/j.celrep.2022.111623
  
  Resource: RRID:Addgene_98293
  
  Curator: @a5munoz
  
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sciencedirect.com/science/article/pii/S2211124722014942
Jul 2021
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A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts

1
1. scibot 20 Jul 2021
  
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  RRID:Addgene_98293
  
  DOI: 10.1016/j.biomaterials.2021.121032
  
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sciencedirect.com/science/article/pii/S0142961221003884
Jan 2021
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ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway

1
1. scibot 27 Jan 2021
  
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  Plasmid_98293
  
  DOI: 10.1016/j.celrep.2020.107564
  
  Resource: RRID:Addgene_98293
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_98293
  
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  RRID:Addgene_98293 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_98293

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720305131
Jan 2020
www.sciencedirect.com www.sciencedirect.com

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_98293
  
  DOI: 10.1016/j.cell.2019.06.005
  
  Resource: RRID:Addgene_98293
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_98293
  
  What is this?
  
  RRID:Addgene_98293 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:Addgene_98293

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0092867419306336