88 Matching Annotations
  1. Jun 2026
  2. www.biorxiv.org www.biorxiv.org
    The autophagy core protein Atg18 regulates exosome release and rescues pathogenic dysfunction associated to Parkinson Sac domain mutation in Synaptojanin
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    biorxiv.org/content/10.64898/2026.05.26.727892v1
  3. May 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NLGN3 autism variants have distinct functional impact on synapses and sleep behavior in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC13041802/
  5. Apr 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human FUS is toxic via association with RNA polymerase II in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039543/
  7. Mar 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum
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    pmc.ncbi.nlm.nih.gov/articles/PMC12863683/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12904864/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reduced expression of the electron transport chain component ATPsynβL in glutamate neurons changes Drosophila melanogaster sleep patterns through adulthood
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    pmc.ncbi.nlm.nih.gov/articles/PMC12988437/
  11. Feb 2026
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heterozygous loss of SRRM1 may be associated with neurodevelopmental phenotypes and anomalies in cell growth and neurite morphology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12858978/
  13. Jan 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in Drosophila neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC8384225/
  15. Nov 2025
  16. 54.241.53.176 54.241.53.176
    Aberrant NSUN1 activity connects m5C-RNA modification to TDP-43 neurotoxicity in ALS/FTD
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    54.241.53.176/29266c821148923660676f0aa34275a086b7a924/PMID_41188020-html.html
  17. www.biorxiv.org www.biorxiv.org
    Mitochondrial Complex I and ROS control synapse function through opposing pre- and postsynaptic mechanisms
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    biorxiv.org/content/10.1101/2024.12.30.630694v3
  18. Oct 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The CHD Protein, Kismet, Restricts Synaptic BMP Signaling at Glutamatergic Synapses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12457766/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    New submission 10/11/2023, 08:55:25
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    pmc.ncbi.nlm.nih.gov/articles/PMC10418107/
  21. 54.241.53.176 54.241.53.176
    pbio.3003388.s001-html.html
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    54.241.53.176/c3470113ff9b6414993bffc84a98e3d95c62dca9/pbio.3003388.s001-html.html
  22. 54.241.53.176 54.241.53.176
    Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and responses to hypoxia
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    54.241.53.176/c767fe3e9ecfb942aa2fe96844d7102e16aa3a6e/pnas.1902537116.sapp-html.html
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC7183762/
  24. Sep 2025
  25. 52.53.155.43 52.53.155.43
    JNEUROSCI.0682-25.2025.full-html.html
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    52.53.155.43/1bd4e903078a1c90eb790bb15188c8aeec31880d/JNEUROSCI.0682-25.2025.full-html.html
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS
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    pmc.ncbi.nlm.nih.gov/articles/PMC6557627/
  27. www.sciencedirect.com www.sciencedirect.com
    ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation
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    sciencedirect.com/science/article/pii/S2211124725010010
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Effects of Overexpressing K2p Channels in Various Tissues on Physiology and Behaviors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12386602/
  29. Aug 2025
  30. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225017237-main-html.html
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    52.53.155.43/025998c334a0bd985efa08b3c6e18f2288d45d59/1-s2.0-S2589004225017237-main-html.html
  31. 52.53.155.43 52.53.155.43
    media-2-html.html
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  32. Jul 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The impact of Megf10/Drpr gain-of-function on muscle development in Drosophila
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    pmc.ncbi.nlm.nih.gov/articles/PMC6504253/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential response of neurons to autophagy modulation in Huntington’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12218432/
  35. Jun 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a pathogenic mutation in ATP2A1 via in silico analysis of exome data for cryptic aberrant splice sites
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    pmc.ncbi.nlm.nih.gov/articles/PMC6418371/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neural substrates of cold nociception in Drosophila larva
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    pmc.ncbi.nlm.nih.gov/articles/PMC12165694/
  38. May 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin
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    pmc.ncbi.nlm.nih.gov/articles/PMC11742450/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal effect of 0.3 % DMSO and the synergism between 0.3 % DMSO and loss function of UCH-L1 on Drosophila melanogaster model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11783005/
  41. Apr 2025
  42. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/3e4768a62dd0729fdf0506ba8cb8de888609fe2e/PDF-html.html
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC6077250/
  44. Feb 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson’s Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC5849740/
  46. Jan 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Examining the potential involvement of NONO in TDP‐43 proteinopathy in Drosophila
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11670437/
  48. Dec 2024
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects
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    pmc.ncbi.nlm.nih.gov/articles/PMC6105379/
  50. Aug 2024
  51. www.frontiersin.org www.frontiersin.org
    Glutamatergic Synapse Dysfunction in Drosophila Neuromuscular Junctions Can Be Rescued by Proteostasis Modulation
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    frontiersin.org/articles/10.3389/fnmol.2022.842772
  52. www.tandfonline.com www.tandfonline.com
    Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy
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    tandfonline.com/doi/full/10.1080/15548627.2019.1596477
  53. Jul 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during Drosophila Aging: A Tissue-Specific Pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC10253371/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in Drosophila Models
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    ncbi.nlm.nih.gov/pmc/articles/PMC10045361/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8188407/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin signaling mediates neurodegeneration in glioma
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    ncbi.nlm.nih.gov/pmc/articles/PMC7898663/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder
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    ncbi.nlm.nih.gov/pmc/articles/PMC8206390/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Medium-Chain Fatty Acids Rescue Motor Function and Neuromuscular Junction Degeneration in a Drosophila Model of Amyotrophic Lateral Sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10486503/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Octopamine signaling via OctαR is essential for a well-orchestrated climbing performance of adult Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC9388497/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Botulinum neurotoxin accurately separates tonic vs. phasic transmission and reveals heterosynaptic plasticity rules in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC9439677/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC7568321/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small heat shock proteins determine synapse number and neuronal activity during development
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    ncbi.nlm.nih.gov/pmc/articles/PMC7241713/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function
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    ncbi.nlm.nih.gov/pmc/articles/PMC8358705/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATP-citrate lyase promotes axonal transport across species
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    ncbi.nlm.nih.gov/pmc/articles/PMC8497606/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function
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    ncbi.nlm.nih.gov/pmc/articles/PMC7080231/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNAi of Complex I and V of the electron transport chain in glutamate neurons extends life span, increases sleep, and decreases locomotor activity in Drosophila melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC10270625/
  68. 52.53.155.43 52.53.155.43
    Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate
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    52.53.155.43/8367afa0072963dd46d57c10d39ab722075d61c7/JCB_201904148_sm-html.html
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding
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    ncbi.nlm.nih.gov/pmc/articles/PMC7021487/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel in‐frame deletion in KIF5C gene causes infantile onset epilepsy and psychomotor retardation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10960728/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC6917273/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction
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    ncbi.nlm.nih.gov/pmc/articles/PMC10931923/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport
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    ncbi.nlm.nih.gov/pmc/articles/PMC10873455/
  74. May 2024
  75. academic.oup.com academic.oup.com
    Humanized Drosophila Model of the Meier-Gorlin Syndrome Reveals Conserved and Divergent Features of the Orc6 Protein
    2
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    academic.oup.com/genetics/article/216/4/995/6065819
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simplified homology-assisted CRISPR for gene editing in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC10849607/
  77. Mar 2024
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CHD family chromatin remodeling enzyme, Kismet, promotes both clathrin-mediated and activity-dependent bulk endocytosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10956772/
  79. Feb 2024
  80. www.science.org www.science.org
    ATAT1-enriched vesicles promote microtubule acetylation via axonal transport
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    science.org/doi/10.1126/sciadv.aax2705
  81. www.nature.com www.nature.com
    CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum
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    nature.com/articles/s41436-019-0585-z
  82. journals.plos.org journals.plos.org
    Hyperpolarization by activation of halorhodopsin results in enhanced synaptic transmission: Neuromuscular junction and CNS circuit
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    journals.plos.org/plosone/article
  83. www.biorxiv.org www.biorxiv.org
    Examining the potential involvement of NONO in TDP-43 proteinopathy in Drosophila
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    biorxiv.org/content/10.1101/2023.12.13.571416v1
  84. Jan 2024
  85. www.sciencedirect.com www.sciencedirect.com
    Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster
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    sciencedirect.com/science/article/abs/pii/S0304394018308553
  86. journals.plos.org journals.plos.org
    A comparison of three different methods of eliciting rapid activity-dependent synaptic plasticity at the Drosophila NMJ
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    journals.plos.org/plosone/article
  87. Oct 2023
  88. www.science.org www.science.org
    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import
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    science.org/doi/10.1126/sciadv.adi5548
  89. Jul 2023
  90. link.springer.com link.springer.com
    A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy
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    link.springer.com/article/10.1007/s13311-023-01406-z
  91. Nov 2022
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC9672966/
  93. Mar 2022
  94. www.sciencedirect.com www.sciencedirect.com
    Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models
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    sciencedirect.com/science/article/pii/S1534580722001241
  95. Dec 2021
  96. www.sciencedirect.com www.sciencedirect.com
    Distinct molecular pathways govern presynaptic homeostatic plasticity
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    sciencedirect.com/science/article/pii/S2211124721015990
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macros to Quantify Exosome Release and Autophagy at the Neuromuscular Junction of Drosophila Melanogaster
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    ncbi.nlm.nih.gov/pmc/articles/PMC8634598/
  98. Aug 2021
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5760215/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8353793/
  101. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ethanol stimulates the in vivo axonal movement of neuropeptide dense‐core vesicles in Drosophila motor neurons
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14230
  102. Jul 2021
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14230/full
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in Drosophila Glutamatergic Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC6705968/
  105. www.sciencedirect.com www.sciencedirect.com
    Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT
    2
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    sciencedirect.com/science/article/pii/S0896627317306864
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNAi-Mediated Reverse Genetic Screen Identified Drosophila Chaperones Regulating Eye and Neuromuscular Junction Morphology
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    ncbi.nlm.nih.gov/pmc/articles/PMC5499113/
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin
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    ncbi.nlm.nih.gov/pmc/articles/PMC5438252/
  108. May 2021
  109. www.sciencedirect.com www.sciencedirect.com
    Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
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    sciencedirect.com/science/article/pii/S1097276520304214
  110. Feb 2021
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of FoxP circuits involved in locomotion and object fixation in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC7776582/
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3
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    ncbi.nlm.nih.gov/pmc/articles/PMC7748415/
  113. Sep 2020
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding
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    ncbi.nlm.nih.gov/pmc/articles/PMC7021487/
  115. Nov 2018
  116. www.jneurosci.org www.jneurosci.org
    Untitled document
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    Hsp90 Mediates Membrane Deformation and Exosome Release
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    sciencedirect.com/science/article/pii/S1097276518305859
  118. Nov 2017
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    Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration
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    The Spacing Effect for Structural Synaptic Plasticity Provides Specificity and Precision in Plastic Changes
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    jneurosci.org/content/37/19/4992
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    Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material
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    sciencedirect.com/science/article/pii/S089662731631042X