115 Matching Annotations
  1. Sep 2026
  2. www.sciencedirect.com www.sciencedirect.com
    Lack of tumor-derived LCN2 sensitizes pancreatic cancer cells to ferroptosis induction
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    sciencedirect.com/science/article/pii/S0304383526005872
  3. Jun 2026
  4. www.sciencedirect.com www.sciencedirect.com
    The CD49b (ITGA2) collagen receptor excludes CD8+ T cell infiltration in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2589004226018754
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting HAS2 to enhance anti-tumor immunity in pancreatic cancer via PD-L1 regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13237160/
  6. May 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136880/
  8. Apr 2026
  9. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70455
  10. www.biorxiv.org www.biorxiv.org
    Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.04.13.717530v1
  11. aacrjournals.org aacrjournals.org
    DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity
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    aacrjournals.org/mct/article/25/1/7/771286/DS-3939a-A-TA-MUC1-Directed-Antibody-Drug
  12. Mar 2026
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TIPE2 knockdown enhances the anti-tumor efficacy of NKG2D CAR-T cells against pancreatic cancer via activating NF-κb signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13011749/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13003987/
  15. www.sciencedirect.com www.sciencedirect.com
    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sym024 interacts with a unique epitope on the CD73 homodimer, favoring effective bivalent binding to improve anti-PD1 therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12950896/
  17. Feb 2026
  18. www.sciencedirect.com www.sciencedirect.com
    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    sciencedirect.com/science/article/pii/S0092867425015028
  19. Jan 2026
  20. www.sciencedirect.com www.sciencedirect.com
    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
  22. link.springer.com link.springer.com
    Comparative theranostic efficacy of 177Lu- and 161Tb-labeled A1K2 SdAb in mesothelin-positive tumors
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    link.springer.com/article/10.1007/s00259-025-07723-z
  23. Nov 2025
  24. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  25. Oct 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  27. Sep 2025
  28. link.springer.com link.springer.com
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
  29. Aug 2025
  30. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
  31. pubs.acs.org pubs.acs.org
    A Nucleoside Analogue Featuring a C3′-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of KRAS-Mutated Pancreatic Cancer Cells
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    pubs.acs.org/doi/10.1021/acsmedchemlett.5c00378
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
  33. www.sciencedirect.com www.sciencedirect.com
    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  34. www.degruyterbrill.com www.degruyterbrill.com
    KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells
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    degruyterbrill.com/document/doi/10.1515/oncologie-2025-0171/html
  35. Jul 2025
  36. www.sciencedirect.com www.sciencedirect.com
    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124725007818
  37. Jun 2025
  38. www.sciencedirect.com www.sciencedirect.com
    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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    sciencedirect.com/science/article/pii/S1535610825002259
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stromal Hedgehog Signaling Is Associated with Favorable Outcomes in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12154493/
  40. link.springer.com link.springer.com
    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
  41. May 2025
  42. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70062
  43. www.nature.com www.nature.com
    HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
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    nature.com/articles/s41467-025-60129-1
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12071589/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
  46. Apr 2025
  47. www.sciencedirect.com www.sciencedirect.com
    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0304383525002794
  48. www.sciencedirect.com www.sciencedirect.com
    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124725003122
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962393/
  50. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  51. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  52. Feb 2025
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel B7-H3 CAR T cells show potent antitumor effects in glioblastoma: a preclinical study
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    pmc.ncbi.nlm.nih.gov/articles/PMC11784176/
  54. www.sciencedirect.com www.sciencedirect.com
    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    sciencedirect.com/science/article/pii/S2666379124006980
  55. Jan 2025
  56. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225001026-main-html.html
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    52.53.155.43/9cdc52fc0b70ce3d9f24b335db5892b38840adb3/1-s2.0-S2589004225001026-main-html.html
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11704331/
  58. Dec 2024
  59. 52.53.155.43 52.53.155.43
    mct-24-0266-html.html
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    52.53.155.43/e3c3817ac819dde6c15544fa19222c2e3fb37801/mct-24-0266-html.html
  60. Nov 2024
  61. www.sciencedirect.com www.sciencedirect.com
    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004434
  62. www.sciencedirect.com www.sciencedirect.com
    Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2211124724013238
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mesothelin CAR T-cells secreting anti-FAP/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11062832/
  64. Oct 2024
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDB2 expression lights the way for precision radiotherapy response in PDAC cells, with or without olaparib
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    ncbi.nlm.nih.gov/pmc/articles/PMC11436999/
  66. Sep 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365971/
  68. Aug 2024
  69. cmbl.biomedcentral.com cmbl.biomedcentral.com
    TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis
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    cmbl.biomedcentral.com/articles/10.1186/s11658-022-00321-z
  70. May 2024
  71. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13658
  72. www.biorxiv.org www.biorxiv.org
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    biorxiv.org/content/10.1101/2024.03.12.584316v1
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
  74. Apr 2024
  75. www.sciencedirect.com www.sciencedirect.com
    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    sciencedirect.com/science/article/pii/S2666379124001927
  76. jhoonline.biomedcentral.com jhoonline.biomedcentral.com
    Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
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    jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01538-5
  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34960
  78. Mar 2024
  79. academic.oup.com academic.oup.com
    LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgae011/7608949
  80. www.sciencedirect.com www.sciencedirect.com
    A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice
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    sciencedirect.com/science/article/pii/S1097276524001382
  81. Feb 2024
  82. 52.53.155.43 52.53.155.43
    176-html.html
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    52.53.155.43/2ec0d88e67b798a89b6c5516dbe547b3b2c5ce80/176-html.html
  83. aacrjournals.org aacrjournals.org
    Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma
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    aacrjournals.org/clincancerres/article/29/24/5183/731660/Nuclear-GRP78-Promotes-Metabolic-Reprogramming-and
  84. www.sciencedirect.com www.sciencedirect.com
    Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S0944711324000576
  85. www.biorxiv.org www.biorxiv.org
    A common druggable signature of oncogenic CMYC, mutant KRAS and mutant p53 reveals functional redundancy and competition of the oncogenes in cancer
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    biorxiv.org/content/10.1101/2023.12.20.572548v1
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nudt21-mediated alternative polyadenylation of MZT1 3’UTR contributes to pancreatic cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831950/
  87. Jan 2024
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vitamin B6 competition in the tumor microenvironment hampers antitumor functions of NK cells.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784745/
  89. Dec 2023
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10690095/
  91. 52.53.155.43 52.53.155.43
    ccr-23-1143-html.html
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    52.53.155.43/aa509a782208f9df8c6754b69c5c07021388a9c4/ccr-23-1143-html.html
  92. Nov 2023
  93. www.sciencedirect.com www.sciencedirect.com
    SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124723014468
  94. www.biorxiv.org www.biorxiv.org
    LMO3 is a suppressor of the basal-like/squamous PDAC subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
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    biorxiv.org/content/10.1101/2023.11.01.564448v1
  95. link.springer.com link.springer.com
    CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines
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    link.springer.com/article/10.1038/s41598-023-45964-w
  96. Oct 2023
  97. 52.53.155.43 52.53.155.43
    ccr-23-1182-html.html
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    52.53.155.43/65c36a5cdd4f77902b5a0c626487c84333ec98dd/ccr-23-1182-html.html
  98. Sep 2023
  99. www.biorxiv.org www.biorxiv.org
    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
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    biorxiv.org/content/10.1101/2023.09.23.558894v1
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10502454/
  101. Aug 2023
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Palbociclib suppresses the cancer stem cell properties and cell proliferation through increased levels of miR-506 or miR-150 in Panc-1 and MiaPaCa-2 cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10387936/
  103. Jun 2023
  104. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    nature.com/articles/s41467-023-39241-7
  105. aacrjournals.org aacrjournals.org
    MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
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    aacrjournals.org/mcr/article/21/5/444/726027/MYC-Glutamine-Dependency-Is-a-Therapeutic
  106. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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    aacrjournals.org/cancerres/article/83/5/735/716680/Enhanced-Glutaminolysis-Drives-Hypoxia-Induced
  107. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124723005922
  108. Apr 2023
  109. link.springer.com link.springer.com
    Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
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    link.springer.com/article/10.1007/s10620-023-07931-3
  110. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  111. Feb 2023
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  113. Dec 2022
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC9773984/
  115. Oct 2022
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XDec-CHI reveals immunosuppressive interactions in pancreatic ductal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9579012/
  117. Sep 2022
  118. www.sciencedirect.com www.sciencedirect.com
    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    sciencedirect.com/science/article/pii/S2211124722012694
  119. Aug 2022
  120. insight.jci.org insight.jci.org
    Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer
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  121. Jul 2022
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  126. Feb 2022
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  128. Jan 2022
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  131. Dec 2021
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  134. Nov 2021
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  136. Oct 2021
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  138. Jul 2021
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  141. May 2021
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  144. Apr 2021
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  147. Nov 2020
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  150. Sep 2020
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  154. www.nature.com www.nature.com
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  155. Jan 2020
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  157. Nov 2018
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  162. Nov 2017
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