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    Optimized reporters for multiplexed detection of transcription factor activity
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    1. scibot 10 Dec 2024
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    sciencedirect.com/science/article/pii/S2405471224003120
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors
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    KPNA3 regulates histone locus body formation by modulating condensation and nuclear import of NPAT
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    rupress.org/jcb/article/224/1/e202401036/277130/KPNA3-regulates-histone-locus-body-formation-by
  6. Dec 2024
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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  8. Nov 2024
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson’s model
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    MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
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    ESR1 fusion proteins invoke breast cancer subtype-dependent enrichment of ligand independent pro-oncogenic signatures and phenotypes
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    C19MC Drives Nucleolar Invasion of Mitochondria and Meiotic Nuclear Division in Human Cancers
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    Correlative light and soft X-ray tomography of in situ mesoscale heterochromatin structure in intact cells
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    CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity
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    sciencedirect.com/science/article/pii/S1934590924003692
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Influence of Physical Training on Breast Cancer: The Role of Exercise-Induced Myokines in Regulating Breast Cancer Cell Growth and Survival
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    Combinatorial effects of cannabinoid receptor 1 and 2 agonists on characteristics and proteomic alteration in MDA-MB-231 breast cancer cells
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    Aberrant expression of CD14 in breast tumor cells is associated with poor outcome
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    Biases in the Parsortix® system observed with pancreatic cancer cell lines
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  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    Activation of estrogen-related receptor γ by calcium and cadmium
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    Breast cancer cells utilize T3 to trigger proliferation through cellular Ca2+ modulation
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    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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  26. Oct 2024
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    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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    Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer
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    Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer
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    ERK1/2 mitogen-activated protein kinase dimerization is essential for the regulation of cell motility
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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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  32. Sep 2024
  33. www.biorxiv.org www.biorxiv.org
    WEE1 inhibition delays resistance to CDK4/6 inhibitor and antiestrogen treatment in estrogen receptor-positive breast cancer
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    Dynamic methylation and expression of alternative promoters for oestrogen receptor alpha in cell line models of fulvestrant resistance
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    UA influences the progression of breast cancer via the AhR/p27Kip1/cyclin E pathway
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model
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    Protocol to identify receptors of secreted proteins through CRISPR-Cas9 whole-genome screening technology
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    Computational pipeline predicting cell death suppressors as targets for cancer therapy
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    ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384147/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Siglec‐7 and Siglec‐9 expression in primary triple negative and oestrogen receptor positive breast cancer and in vitro signalling
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  41. Aug 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ceas: an R package for Seahorse data analysis and visualization
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      DOI: 10.1093/bioinformatics/btae503

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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTORC1-driven protein translation correlates with clinical benefit of capivasertib within a genetically preselected cohort of PIK3CA-altered tumours
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells
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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    YTHDC1 m6A-dependent and m6A-independent functions converge to preserve the DNA damage response
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  46. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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      DOI: 10.1016/j.cell.2020.02.019

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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipocytes promote metastasis of breast cancer by attenuating the FOXO1 effects and regulating copper homeostasis
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    A targeting nanoplatform for chemo-photothermal synergistic therapy of small-cell lung cancer
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  49. www.sciencedirect.com www.sciencedirect.com
    Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exosomal Thomsen–Friedenreich Glycoantigen: A New Liquid Biopsy Biomarker for Lung and Breast Cancer Diagnoses
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    The FXR1 network acts as a signaling scaffold for actomyosin remodeling
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    Quantifying genome-wide transcription factor binding affinities for chromatin using BANC-seq
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  53. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enhanced expression of galectin-9 in triple negative breast cancer cells following radiotherapy: Implications for targeted therapy
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTS384 NCI60: The Next Phase of the NCI60 Screen
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    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Engineered Drug 3′UTRMYC1-18 Degrades the c-MYC-STAT5A/B-PD-L1 Complex In Vivo to Inhibit Metastatic Triple-Negative Breast Cancer
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer
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  58. www.cell.com www.cell.com
    ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines
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  59. breast-cancer-research.biomedcentral.com breast-cancer-research.biomedcentral.com
    Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance
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  60. www.nature.com www.nature.com
    TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
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  61. 52.53.155.43 52.53.155.43
    A novel label-free, pre-equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells
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  62. 52.53.155.43 52.53.155.43
    Cadherin-11 increases tumor cell proliferation and metastatic potential via Wnt pathway activation
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  63. aacrjournals.org aacrjournals.org
    Targeted MDM2 degradation reveals a new vulnerability for p53 inactivated triple negative breast cancer
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  64. www.nature.com www.nature.com
    ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model
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  65. www.mdpi.com www.mdpi.com
    Cancer-Associated Fibroblasts Regulate the Plasticity of Breast Cancer Stemness through the Production of Leukemia Inhibitory Factor
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    Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile
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      ATCC® HTB-22

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  67. pubs.acs.org pubs.acs.org
    Integrated Compound Profiling Screens Identify the Mitochondrial Electron Transport Chain as the Molecular Target of the Natural Products Manassantin, Sesquicillin, and Arctigenin - ACS Chemical Biology (ACS Publications)
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  68. Jul 2024
  69. www.biorxiv.org www.biorxiv.org
    The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
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    NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers
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    Loss of ZNF408 attenuates STING-mediated immune surveillance in breast carcinogenesis
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    ‘Radical’ differences between two FLIM microscopes affect interpretation of cell signaling dynamics
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    Affimer reagents enable targeted delivery of therapeutic agents and RNA via Virus-Like Particles
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
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    RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release
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    Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1
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  78. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  79. www.biorxiv.org www.biorxiv.org
    Osmotic Stress Influences Microtubule Drug Response Via WNK1 Kinase Signaling
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    A vitamin D-based strategy overcomes chemoresistance in prostate cancer
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity
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  82. link.springer.com link.springer.com
    Cellular Traction Force Holds the Potential as a Drug Testing Readout for In Vitro Cancer Metastasis
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      DOI: 10.1007/s12195-024-00811-4

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    HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice
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    NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: IFNγ mediates the resistance of tumor cells to distinct NK cell subsets
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      DOI: 10.1136/jitc-2024-009410

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  87. Jun 2024
  88. link.springer.com link.springer.com
    Nail fold capillaroscopy as a potential tool to evaluate breast tumor
    1
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      DOI: 10.1186/s40543-024-00449-x

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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An electro-optical platform for the ultrasensitive detection of small extracellular vesicle sub-types and their protein epitope counts
    1
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      DOI: 10.1016/j.isci.2024.109866

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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
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      DOI: 10.1158/1078-0432.CCR-23-3839

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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming
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      DOI: 10.7554/eLife.92511

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  92. May 2024
  93. www.sciencedirect.com www.sciencedirect.com
    Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite
    2
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  94. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
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  95. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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      DOI: 10.1111/febs.17158

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  96. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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  97. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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      DOI: 10.1126/scisignal.adh4475

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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM7A-DT induces genotoxic stress, tumorigenesis, and progression of p53 missense mutation-associated invasive breast cancer
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  99. www.biorxiv.org www.biorxiv.org
    Activation of PKR by a short-hairpin RNA
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  100. www.sciencedirect.com www.sciencedirect.com
    Protocol for mapping physiological DSBs using in-suspension break labeling in situ and sequencing
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy
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  102. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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  103. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma
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  105. www.sciencedirect.com www.sciencedirect.com
    Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma
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      DOI: 10.1016/j.ejps.2024.106789

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  106. www.sciencedirect.com www.sciencedirect.com
    Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer
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      HTB-22

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  107. link.springer.com link.springer.com
    A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer
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  109. Apr 2024
  110. www.sciencedirect.com www.sciencedirect.com
    O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability
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      DOI: 10.1016/j.celrep.2024.114163

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  111. link.springer.com link.springer.com
    Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines
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      DOI: 10.1186/s12885-024-12214-9

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  112. www.embopress.org www.embopress.org
    Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
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      DOI: 10.1038/s44318-024-00065-w

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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
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      DOI: 10.1016/j.ebiom.2024.105129

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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression
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  116. www.sciencedirect.com www.sciencedirect.com
    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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      Cat#HTB-22

      DOI: 10.1016/j.celrep.2024.114111

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  117. link.springer.com link.springer.com
    Functionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies
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      DOI: 10.1007/s00210-024-03068-w

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  118. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel diarylated tacrine derivatives: Synthesis, characterization, anticancer, antiepileptic, antibacterial, and antifungal activities
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
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      DOI: 10.1158/2767-9764.CRC-23-0488

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  120. www.sciencedirect.com www.sciencedirect.com
    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abemaciclib is effective in palbociclib-resistant hormone receptor-positive metastatic breast cancers
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      DOI: 10.1158/0008-5472.CAN-23-0705

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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response
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      DOI: 10.1038/s41467-024-46666-1

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  123. Mar 2024
  124. www.nature.com www.nature.com
    Light-mediated intracellular polymerization
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      DOI: 10.1038/s41596-024-00970-8

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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Eukaryotic release factor 1 from Euplotes promotes frameshifting at premature stop codons in human cells
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      CRL-12584

      DOI: 10.1016/j.isci.2024.109413

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  126. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes
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      HTB-22

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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF217 Gene Copy Number as a Marker of Response to Standard Therapy Drugs According to ERα Status in Breast Cancer
    1
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      DOI: 10.2147/BCTT.S445753

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  128. www.biorxiv.org www.biorxiv.org
    PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
    1
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      DOI: 10.1101/2024.03.03.583221

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  129. www.sciencedirect.com www.sciencedirect.com
    MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
    1
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      DOI: 10.1016/j.heliyon.2024.e28172

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      Curator: @scibot

      SciCrunch record: RRID:CVCL_0031

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      RRID:CVCL_0031
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    sciencedirect.com/science/article/pii/S2405844024042038
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    De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis
    1
    1. scibot 19 Mar 2024
      Cat# HTB-22

      DOI: 10.1016/j.celrep.2024.113936

      Resource: (NCI-DTP Cat# MCF7, RRID:CVCL_0031)

      Curator: @abever99

      SciCrunch record: RRID:CVCL_0031

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      RRID:CVCL_0031
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    sciencedirect.com/science/article/pii/S221112472400264X
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    A gut-derived hormone regulates cholesterol metabolism