313 Matching Annotations
  1. Last 7 days
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    PARP inhibitor combined with platinum activates the cGAS-STING pathway to enhance anti-PD-L1 immunotherapy in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1567576926001694
  3. Jan 2026
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    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility
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    pmc.ncbi.nlm.nih.gov/articles/PMC12850047/
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    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
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    SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity
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    sciencedirect.com/science/article/pii/S2211124725016687
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70209
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    p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer
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    DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12806248/
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    Tumor-associated macrophages educated by IGSF9 exhibit a senescence-associated secretory phenotype to promote tumor immune escape
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    pmc.ncbi.nlm.nih.gov/articles/PMC12815053/
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    Distinct Regulation of the ARF and TAp73 Tumor Suppressor Genes by the Transcription Factor E2F1 Enables Discrimination of Cancer Cells from Normal Growing Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12785935/
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    Spatiotemporal regulation of MKK4 dictates switch-like JNK activation and binary cell-fate decisions
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    nature.com/articles/s41467-025-67943-7
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    IRF3 attenuates hypoxia signaling by retaining HIF-α in the cytoplasm
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    ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer
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    Anti-tumor effects and mechanism of the histone demethylase inhibitor GSK-J4 in non-small cell lung cancer cells
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    link.springer.com/article/10.1007/s12032-025-03185-3
  17. Dec 2025
  18. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer
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    sciencedirect.com:5037/science/article/pii/S109727652500975X
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    Sappanchalcone Suppresses NSCLC by Oxidative Stress-Driven DNA Damage and ER Stress Activation through PIEZO1 Modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12702247/
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    A novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression
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    Nanoreactor-enabled PANoptosis via ZBP1 activation potentiates immunotherapy in non-small cell lung cancer
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    AMT inhibits the progression of non-small cell lung cancer by suppressing the PI3K/AKT/GSK-3β/β-catenin pathway via H3K27me3 regulation
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    TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12669767/
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    A Machine Learning-Derived Taurine Metabolism Signature Predicts Prognosis and Immune Landscape in Lung Adenocarcinoma via Integrative Single-Cell Analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12672081/
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    Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12666321/
  26. Nov 2025
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    Multimodal cell death induced by indirubin-3′-oxime through inhibition of Akt/mTOR axis in lung cancer cells
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    Lysine methylation-mediated SMYD2 degradation by casticin sensitizes non-small-cell lung cancer cells to osimertinib therapy
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    PROTAC-mediated structure–function disruption of CD26: a therapeutic strategy for driver-negative non-small cell lung cancer
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    Down-regulation of MFNG promotes the metastatic potential of lung adenocarcinoma by regulating TGF-β/Smad signaling
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    Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy
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    The α5-nAChR/GINS4 axis contributed to nicotine-promoted lung adenocarcinoma progression
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  37. Oct 2025
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    Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    Targeted citrullination enables p53 binding to non-canonical sites
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    A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases
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  42. Sep 2025
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    RAD21-mediated epigenetic regulation promotes lung adenocarcinoma progression and sensitizes cancer cells to ERK-targeted therapy
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    Notch3 mediated TGF-β1 activation enhances epithelial-mesenchymal transition and cancer stemness in non-small lung cancer
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    Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response
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    Host cell entry efficiency and neutralization sensitivity of the SARS-CoV-2 MC.10.1 variant
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  48. Aug 2025
  49. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    DACT3-DVL1 Interaction-Mediated Canonical WNT Signaling Regulates Non-Small Cell Lung Cancer Progression and Cisplatin Resistance
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    APOA1 as a Potential Therapeutic Target and Novel Biomarker in Lung Adenocarcinoma
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    53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.70018
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    Dominant-Negative Effects of p53 R337 Variants in Li–Fraumeni Syndrome: Impact on Tetramer Formation and Transcriptional Activity
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  55. Jul 2025
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    LINE1 insertion into the NACC2 locus disrupts the HDM2 axis and activates lung oncogenic signaling
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    High PER1 expression is associated with STK11 mutation and clinical biomarkers of immunotherapy resistance in lung adenocarcinoma
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    Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
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    elifesciences.org/articles/106469
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    Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
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    m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy
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    KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
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    Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration
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    Rbpms2 prevents major cardiac defects in cardiomyocyte-specific Rbpms-deficient mice
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  64. Jun 2025
  65. www.authorea.com www.authorea.com
    Harmine inhibits non-small cell lung cancer growth by targeting PDE4D and inducing ferroptosis
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    An engineered glutamic acid tRNA for efficient suppression of pathogenic nonsense mutations
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    The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein
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    link.springer.com/article/10.1007/s00018-025-05763-0
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    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma
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    link.springer.com/article/10.1007/s10142-025-01629-7
  70. May 2025
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    NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors
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    link.springer.com/article/10.1007/s00262-025-04079-z
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    MYC plus class IIa HDAC inhibition drives mitochondrial dysfunction in non-small cell lung cancer
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    FAT1 Enhances the Sensitivity of Non-Small Cell Lung Cancer to VCP Inhibitors by Regulating the Activation of the Endoplasmic Reticulum Stress Pathway
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500097RR
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    Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8+ T cells infiltration in non-small cell lung cancer
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    link.springer.com/article/10.1038/s42003-025-08108-6
  76. Apr 2025
  77. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Aberrant expression of nuclear prothymosin α contributes to epithelial-mesenchymal transition in lung cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70035
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    EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11996642/
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    Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation
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    Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies
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    Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage
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    nature.com/articles/s41420-025-02441-9
  83. Mar 2025
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    A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancer
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    Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth
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    cell.com/cell-reports/fulltext/S2211-1247(25)00212-8
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    SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
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    Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC11861669/
  88. Feb 2025
  89. translational-medicine.biomedcentral.com translational-medicine.biomedcentral.com
    JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14/m6A/SLC3A2 axis mediated cell ferroptosis
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    translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06241-8
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    Targeting Tumor-Associated Sialic Acids using Chimeric Switch Receptors based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells
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    aacrjournals.org/cancerimmunolres/article/12/10/1380/748721/Targeting-Tumor-Associated-Sialic-Acids-Using
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    Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism
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    Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy
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    Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability
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  94. Jan 2025
  95. www.nature.com www.nature.com
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  197. Mar 2023
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  200. Jan 2023
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  203. Dec 2022
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  205. Oct 2022
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  207. Sep 2022
  208. www.jci.org www.jci.org
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  211. Aug 2022
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  218. Jun 2022
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  222. May 2022
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  225. Apr 2022
  226. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  232. Mar 2022
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