334 Matching Annotations
  1. Last 7 days
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    Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70169
  3. Nov 2025
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    UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
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    sciencedirect.com/science/article/pii/S1097276525008913
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    An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma
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    link.springer.com/article/10.1186/s13046-025-03566-6
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    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
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    Cortical organoid-derived models of the melanoma brain metastatic niche enable prioritization of cancer-targeting drugs
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    sciencedirect.com/science/article/pii/S2667237525002723
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    Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells
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    2025.11.06.686987v1.full-html.html
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    CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability
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    sciencedirect.com/science/article/pii/S2211124725012665
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    The lipid droplet protein DHRS3 is a regulator of melanoma cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC12244328/
  12. Oct 2025
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    High-throughput combination screening of Pidnarulex and other G-quadruplex ligands in multi-cell type tumor spheroids
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    sciencedirect.com/science/article/pii/S2472555225000772
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    Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3
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    Cannabidivarin directly targets the immunosuppressive activity of regulatory myeloid cells in tumors
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    Systematic design of DMBT1-derived peptides correlating physicochemical properties and sequence motifs with siRNA delivery and efficacy in cancer therapy
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases
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    Inhibiting Cyclin-Dependent Kinase 13-Mediated Nuclear Ubiquitous Casein Kinase and Cyclin-Dependent Kinase Substrate 1 Phosphorylation Facilitates Oxidative Stress-Induced Apoptosis in Melanoma
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    Laeverin is Cell-Surface Target for Liquid-Phase Metastasizing Cancer Cells
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    CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma
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    USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
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    Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis
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  24. Sep 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RHOJ enhances adhesion and proliferation capabilities and suppresses apoptosis of melanoma cells by activating the Rap1 signaling pathway
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    Phase Ib Study of Pembrolizumab in Combination with Intratumoral Injection of Clostridium novyi-NT in Patients with Advanced Solid Tumors
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    mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport
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    RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity
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    PKN2 is a dependency of the mesenchymal-like cancer cell state
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  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
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    Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response
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    Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems
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  33. Aug 2025
  34. www.biorxiv.org www.biorxiv.org
    DFFB suppresses interferon to enable cancer persister cell regrowth
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    biorxiv.org/content/10.1101/2025.08.15.670603v1
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    Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection
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  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of DB-1419, a Novel Bifunctional and Bispecific Anti–B7-H3 × PD-L1 Antibody–Drug Conjugate
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    A Nanovial-Based Platform for Functional Discovery of Antigen-Reactive TCRs from Unconventional T Cells
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    biorxiv.org/content/10.1101/2025.08.06.668816v2
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    Tissue-dependent mechanosensing by cells derived from human tumors
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    Investigating the relationship Between AMBRA1 and Cell Proliferation in Melanoma
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  43. Jul 2025
  44. www.nature.com www.nature.com
    Secretogranin 2 binds LILRB4 resulting in immunosuppression
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    nature.com/articles/s41590-025-02233-4
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    Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion
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    nature.com/articles/s41419-025-07863-y
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12243136/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
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    CDC42-effector interaction inhibitors alter patterns of vessel arborization in skin and tumors in vivo
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    Salmonella hijacks a host glucose transporter for intravacuolar proliferation
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    biorxiv.org/content/10.1101/2025.06.10.658782v1
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    A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer
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    Identification of UBE3C as an E3 ubiquitin ligase for mutant BRAF
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  52. Jun 2025
  53. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22
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    sciencedirect.com/science/article/pii/S2451945625001734
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour‐Derived Extracellular Vesicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12173530/
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    A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome
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    nature.com/articles/s41467-024-44905-z
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas
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  58. 52.53.155.43 52.53.155.43
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    Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket
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    EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
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  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Potentiating T cell tumor targeting using a combination of TCR with a Siglec-7 based CSR
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  65. www.cell.com www.cell.com
    Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming
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    cell.com/cell-metabolism/abstract/S1550-4131(25)00265-7
  66. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Dose-dependent induction of epithelial-mesenchymal transition in 3D melanoma models by non-thermal plasma treatment
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  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human CSPG4-targeting CAR-macrophages inhibit melanoma growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12122381/
  68. May 2025
  69. www.sciencedirect.com www.sciencedirect.com
    Machine-learning-assisted universal protein activation in living mice
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    Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Small Molecule Functional Converter of B-Cell Lymphoma-2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis
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    Generation of T cell responses against broad KRAS hotspot neoantigens for cell therapy or TCR discovery
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    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
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    Stromal lipid species dictate melanoma metastasis and tropism
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  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Liposome-Polymer Nanoparticles Loaded with Copper Diethyldithiocarbamate and 6-Bromo-Indirubin-3′-Oxime Enable the Treatment of Refractive Melanoma
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    onlinelibrary.wiley.com/doi/10.1002/smll.202409012
  78. Apr 2025
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172627/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing the Efficacy of CAR-T Cell Production Using BX795 and Rosuvastatin in a Serum-Free Medium
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  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol to profile tumor and microenvironment from ovarian cancer patient samples and evaluate cell-based therapy using in vitro killing assays
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    pmc.ncbi.nlm.nih.gov/articles/PMC12002649/
  82. aacrjournals.org aacrjournals.org
    SEMA3G-NRP1 Signaling Functions as an Immune Checkpoint that Enables Tumor Immune Evasion by Impairing T Cell Cytotoxicity
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    aacrjournals.org/cancerres/article/85/5/912/751997/SEMA3G-NRP1-Signaling-Functions-as-an-Immune
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    Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence
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  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962400/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-KRAS Inhibitors BI-2493 and BI-2865 Display Potent Antitumor Activity in Tumors with KRAS Wild-type Allele Amplification
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962398/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Augmenting CAR T Cell Functions with LIGHT
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    Homeostatic regulation of nucleoporins is a central driver of nuclear pore biogenesis
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    sciencedirect.com/science/article/pii/S2211124725002396
  88. Mar 2025
  89. www.sciencedirect.com www.sciencedirect.com
    Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma
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    sciencedirect.com/science/article/pii/S1534580725001212
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    Antagonistic roles for MITF and TFE3 in melanoma plasticity
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    Translation dysregulation in cancer as a source for targetable antigens
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    Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells
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    biorxiv.org/content/10.1101/2025.03.18.643973v1
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    Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits
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  95. www.sciencedirect.com www.sciencedirect.com
    Overexpression of LMOD1 induces oxidative stress and enhances cell apoptosis of melanoma through the RIG-I like receptor pathway
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    sciencedirect.com/science/article/pii/S0925443925001073
  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recognition of MR1-antigen complexes by TCR Vγ9Vδ2
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    Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression
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  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade
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  203. May 2023
  204. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Relationship between Maturity Stage, Triterpenoid Content and Cytotoxicity of Sorbus intermedia (EHRH.) PERS. Fruits – A Chemometric Approach
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  205. Apr 2023
  206. aacrjournals.org aacrjournals.org
    Discovery of a novel ATP-competitive MEK inhibitor DS03090629 that overcomes resistance conferred by BRAF overexpression in BRAF-mutated melanoma
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    aacrjournals.org/mct/article/22/3/317/718402/Discovery-of-a-Novel-ATP-Competitive-MEK-Inhibitor
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    Targeting ULK1 decreases interferon-γ-mediated resistance to immune checkpoint inhibitors
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  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950
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  209. Mar 2023
  210. link.springer.com link.springer.com
    Repurposing fluphenazine to suppress melanoma brain, lung and bone metastasis by inducing G0/G1 cell cycle arrest and apoptosis and disrupting autophagic flux
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    Multifunctional bismuth oxide (Bi2O3) particles: Evidence for selective melanoma therapy
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer
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  213. Feb 2023
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    An adverse tumor-protective effect of IDO1 inhibition
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  215. Jan 2023
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    S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas
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    A dynamic DNA tetrahedron framework for active targeting
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  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy
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  219. Dec 2022
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    Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells
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    Table 2 Tumor cell lines used to set up less-common subcutaneous mouse tumor models
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  222. Nov 2022
  223. aacrjournals.org aacrjournals.org
    Potent and selective PTDSS1 inhibitors induce collateral lethality in cancers with PTDSS2 deletion
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    PARP10 Mediates Mono-ADP-Ribosylation of Aurora-A Regulating G2/M Transition of the Cell Cycle
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    Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation
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    Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma
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    Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964
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