185 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124725012045
  4. Oct 2025
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12515478/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12511632/
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1368764625001153
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  9. Sep 2025
  10. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202511726
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    Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12427560/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12415682/
  13. link.springer.com link.springer.com
    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
  14. Aug 2025
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    Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer
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    sciencedirect.com/science/article/pii/S266637912500374X
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
  17. pubs.acs.org pubs.acs.org
    Development and Preclinical Evaluation of CDH17-Specific ImmunoPET Imaging in Colorectal Cancers
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    pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c00525
  18. www.biorxiv.org www.biorxiv.org
    Engineering a Juxtamembrane-Targeting CAR T-Cell Against Mesothelin: A Novel Binder Resilient to Shed Antigen in Ovarian and Pancreatic Cancer
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    biorxiv.org/content/10.1101/2025.08.02.668276v1
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322234/
  21. Jul 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12306140/
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    Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
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    sciencedirect.com/science/article/pii/S266637912500326X
  24. 52.53.155.43 52.53.155.43
    2025.07.14.664742v1.full-html.html
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  25. www.science.org www.science.org
    Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
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    science.org/doi/10.1126/science.adq8331
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124725007818
  27. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508431
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    The transcriptomic fingerprint of cancer response to Tumor Treating Fields (TTFields)
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    nature.com/articles/s41420-025-02615-5
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    Uncertainty-aware quantitative analysis of high-throughput live cell migration data
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    biorxiv.org/content/10.1101/2025.06.12.659342v1
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    CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts
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    nature.com/articles/s41598-025-09411-2
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    Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor
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  32. Jun 2025
  33. 52.53.155.43 52.53.155.43
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    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
  36. 52.53.155.43 52.53.155.43
    Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma
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  37. May 2025
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70062
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    HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
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    nature.com/articles/s41467-025-60129-1
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12071589/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bispecific c-Met/PD-1 CAR-T Cells Have Enhanced Therapeutic Effects on Solid Tumor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12035267/
  43. Apr 2025
  44. www.sciencedirect.com www.sciencedirect.com
    The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy
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    sciencedirect.com/science/article/pii/S2211124725003766
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    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0304383525002794
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    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  47. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  48. Feb 2025
  49. www.sciencedirect.com www.sciencedirect.com
    SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer
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    CV1-secreting sCAR-T cells potentiate the abscopal effect of microwave ablation in heterogeneous tumors
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    sciencedirect.com/science/article/pii/S2666379125000382
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    sciencedirect.com/science/article/pii/S2666379124006980
  53. Jan 2025
  54. www.sciencedirect.com www.sciencedirect.com
    Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
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    sciencedirect.com/science/article/pii/S2666379125000011
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  56. Dec 2024
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11609629/
  58. Nov 2024
  59. www.sciencedirect.com www.sciencedirect.com
    Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2211124724013238
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mesothelin CAR T-cells secreting anti-FAP/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11062832/
  61. Oct 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11448066/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blocking M2-Like Macrophage Polarization Using Decoy Oligodeoxynucleotide-Based Gene Therapy Prevents Immune Evasion for Pancreatic Cancer Treatment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443249/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11437985/
  65. Sep 2024
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    Protocol for establishing and evaluating a cancer cachexia mouse model
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    sciencedirect.com/science/article/pii/S2666166724004465
  68. Aug 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11347226/
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    The role of DPYD and the effects of DPYD suppressor luteolin combined with 5‐FU in pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11331593/
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    A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124724009835
  72. jhoonline.biomedcentral.com jhoonline.biomedcentral.com
    Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
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    jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01538-5
  73. aacrjournals.org aacrjournals.org
    MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
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    aacrjournals.org/mcr/article/21/5/444/726027/MYC-Glutamine-Dependency-Is-a-Therapeutic
  74. Jul 2024
  75. www.sciencedirect.com www.sciencedirect.com
    Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon CYP3A5-targeted inhibition
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    sciencedirect.com/science/article/pii/S2589004224015141
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    Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures
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    thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00254-8/abstract
  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pantoprazole and riluzole target H+/K+-ATPases and pH-sensitive K+ channels in pancreatic cancer cells
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35076
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    The YY1-CPT1C signaling axis modulates the proliferation and metabolism of pancreatic tumor cells under hypoxia
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  79. May 2024
  80. www.biorxiv.org www.biorxiv.org
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    biorxiv.org/content/10.1101/2024.03.12.584316v1
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16397
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    PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124724005047
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  86. Apr 2024
  87. www.sciencedirect.com www.sciencedirect.com
    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells
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  89. rupress.org rupress.org
    WW domains form a folded type of nuclear localization signal to guide YAP1 nuclear import
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    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34960
  91. www.sciencedirect.com www.sciencedirect.com
    The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia
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    sciencedirect.com/science/article/pii/S1535610824000941
  92. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13609
  93. Mar 2024
  94. academic.oup.com academic.oup.com
    LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism
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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgae011/7608949
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10924943/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
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  97. Feb 2024
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  99. aacrjournals.org aacrjournals.org
    Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma
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    aacrjournals.org/clincancerres/article/29/24/5183/731660/Nuclear-GRP78-Promotes-Metabolic-Reprogramming-and
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    Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S0944711324000576
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nudt21-mediated alternative polyadenylation of MZT1 3’UTR contributes to pancreatic cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831950/
  102. Jan 2024
  103. www.mdpi.com www.mdpi.com
    Multi-Algorithm Analysis Reveals Pyroptosis-Linked Genes as Pancreatic Cancer Biomarkers
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  209. Nov 2020
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  212. Sep 2020
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  217. www.nature.com www.nature.com
    Development and application of two novel monoclonal antibodies against overexpressed CD26 and integrin α3 in human pancreatic cancer
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    nature.com/articles/s41598-019-57287-w
  218. Jan 2020
  219. www.sciencedirect.com www.sciencedirect.com
    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    sciencedirect.com/science/article/pii/S2451945619304015
  220. Nov 2018
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    LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia
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  222. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  223. www.sciencedirect.com www.sciencedirect.com
    Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1535610818300655
  224. Nov 2017
  225. elifesciences.org elifesciences.org
    Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
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    elifesciences.org/articles/27713
  226. www.sciencedirect.com www.sciencedirect.com
    Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport
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    sciencedirect.com/science/article/pii/S1097276517305087
  227. www.sciencedirect.com www.sciencedirect.com
    MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1535610817302544
  228. www.sciencedirect.com www.sciencedirect.com
    Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo
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    Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules
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