56 Matching Annotations
  1. Jun 2026
  2. www.sciencedirect.com www.sciencedirect.com
    Autoinhibition of the mechanosensitive lipid scramblase TMEM63B by its C-terminal tail
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    sciencedirect.com/science/article/pii/S0021925826020958
  3. May 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Characterization and Clinical Activity of RNK08954, a Highly Selective and Orally Bioavailable KRAS G12D Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133609/
  5. Apr 2026
  6. 54.241.53.176 54.241.53.176
    cd-25-1346-html.html
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    54.241.53.176/86f1cde136cae9cb2b05401d7da6d7a0a1acbc52/cd-25-1346-html.html
  7. 54.241.53.176 54.241.53.176
    advs74452-sup-0002-supplementarytable.xlsx - Table 3-html.html
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    54.241.53.176/9b856d86ecf8a852db3b0ae8ed2942e0e1621583/advs74452-sup-0002-supplementarytable.xlsx - Table 3-html.html
  8. Jan 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12793832/
  10. Dec 2025
  11. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70249
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-cancer analysis of oncogenic MET fusions reveals distinct pathogenomic subsets with differential sensitivity to MET-targeted therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12133426/
  13. Nov 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12630735/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients
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    pmc.ncbi.nlm.nih.gov/articles/PMC12591307/
  16. Oct 2025
  17. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511573
  18. Aug 2025
  19. journals.sagepub.com journals.sagepub.com
    Protein kinase B inhibitors enhance the sensitivity of translocated promoter region–fibroblast growth factor receptor 1 cells to fibroblast growth factor receptor 1 inhibitor-induced apoptosis
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    journals.sagepub.com/doi/full/10.1177/03000605251362968
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A long-lasting prolactin stimulates galactopoiesis in mice.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12337787/
  21. Jul 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20–Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260510/
  23. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225013732-main-html.html
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  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Zidesamtinib Selective Targeting of Diverse ROS1 Drug-Resistant Mutations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214885/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12193305/
  26. Jun 2025
  27. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/3e81ed4154fee0b68ed39cd7c108fb3e26bd25fc/PDF-html.html
  28. May 2025
  29. pubs.acs.org pubs.acs.org
    Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity
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    pubs.acs.org/doi/10.1021/acs.jmedchem.5c00264
  30. Mar 2025
  31. www.sciencedirect.com www.sciencedirect.com
    TTC7A-ALK, a novel ALK fusion variant identified in a patient with metastatic lung adenocarcinoma, exhibits excellent response to crizotinib
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    sciencedirect.com/science/article/pii/S1936523325000762
  32. Feb 2025
  33. www.sciencedirect.com www.sciencedirect.com
    Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation
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    sciencedirect.com/science/article/pii/S193459092500013X
  34. Jan 2025
  35. www.sciencedirect.com www.sciencedirect.com
    The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC
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    sciencedirect.com/science/article/pii/S2666379125000023
  36. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.15084
  37. Oct 2024
  38. aacrjournals.org aacrjournals.org
    Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
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    aacrjournals.org/mct/article/20/3/564/92877/Identification-of-Predictive-ERBB-Mutations-by
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11405138/
  40. Aug 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    µPhos: a scalable and sensitive platform for high-dimensional phosphoproteomics
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    ncbi.nlm.nih.gov/pmc/articles/PMC11297287/
  42. Jul 2024
  43. www.embopress.org www.embopress.org
    µPhos: a scalable and sensitive platform for high-dimensional phosphoproteomics
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    embopress.org/doi/10.1038/s44320-024-00050-9
  44. May 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integration of genomic sequencing drives therapeutic targeting of PDGFRA in T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10872648/
  46. Mar 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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    ncbi.nlm.nih.gov/pmc/articles/PMC10940854/
  48. Feb 2024
  49. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    A newly identified 45‐kDa JAK2 variant with an altered kinase domain structure represents a novel mode of JAK2 kinase inhibitor resistance
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13566
  50. Aug 2023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
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    ncbi.nlm.nih.gov/pmc/articles/PMC10430783/
  52. 52.53.155.43 52.53.155.43
    crc-22-0293-html.html
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  53. Jun 2023
  54. 52.53.155.43 52.53.155.43
    Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
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    52.53.155.43/26aa5ba62138ec506c6f952066d20d6f92d1221c/acs.jmedchem.3c00150-html.html
  55. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    sciencedirect.com/science/article/pii/S2451945623001502
  56. May 2023
  57. aacrjournals.org aacrjournals.org
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
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    aacrjournals.org/clincancerres/article/28/14/3091/706867/RASGRF1-Fusions-Activate-Oncogenic-RAS-Signaling
  58. Oct 2022
  59. www.sciencedirect.com www.sciencedirect.com
    Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID
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    sciencedirect.com/science/article/pii/S2451945622003555
  60. Sep 2022
  61. www.sciencedirect.com www.sciencedirect.com
    Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo
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    sciencedirect.com/science/article/pii/S2211124722011925
  62. Aug 2022
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combination of type I and type II MET tyrosine kinase inhibitors as therapeutic approach to prevent resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC8828669/
  64. Jul 2022
  65. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13264
  66. Mar 2022
  67. www.sciencedirect.com www.sciencedirect.com
    Epitope length variants balance protective immune responses and viral escape in HIV-1 infection
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    sciencedirect.com/science/article/pii/S2211124722001760
  68. www.sciencedirect.com www.sciencedirect.com
    The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia
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    sciencedirect.com/science/article/pii/S2589004222001511
  69. Nov 2021
  70. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13115
  71. Sep 2021
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A method for overcoming plasma protein inhibition of tyrosine kinase inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8478262/
  73. Aug 2021
  74. www.sciencedirect.com www.sciencedirect.com
    Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells
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    sciencedirect.com/science/article/pii/S2211124721009372
  75. Jul 2021
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC7611204/
  77. May 2021
  78. www.sciencedirect.com www.sciencedirect.com
    SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts
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    sciencedirect.com/science/article/pii/S1097276520303129
  79. Sep 2020
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter
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    ncbi.nlm.nih.gov/pmc/articles/PMC7418154/
  81. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14809
  82. Jan 2020
  83. www.sciencedirect.com www.sciencedirect.com
    Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome
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    sciencedirect.com/science/article/pii/S1535610819302983
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Critical individual roles of the BCR and FGFR1 kinase domains in BCR‐FGFR1‐driven stem cell leukemia/lymphoma syndrome
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32665
  85. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Colorectal adenocarcinoma‐derived EGFR mutants are oncogenic and sensitive to EGFR‐targeted monoclonal antibodies, cetuximab and panitumumab
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32499
  86. Nov 2018
  87. www.sciencedirect.com www.sciencedirect.com
    Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice
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    sciencedirect.com/science/article/pii/S2211124718314207
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC5814751/