Hypothesis

29 Matching Annotations

Last 7 days
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection

1
1. scibot 07 Sep 2025
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1158/2767-9764.CRC-25-0144
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12392265/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

1
1. scibot 07 Sep 2025
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1158/0008-5472.CAN-24-0798
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11875910/
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex

1
1. scibot 06 Aug 2025
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1016/j.molcel.2025.07.007
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1097276525006082
Jul 2025
www.sciencedirect.com www.sciencedirect.com

Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance

1
1. scibot 03 Jul 2025
  
  in Public
  
  ATCCCat#CCL-220
  
  DOI: 10.1016/j.molcel.2025.06.013
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1097276525005428
www.biorxiv.org www.biorxiv.org

Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models

1
1. scibot 01 Jul 2025
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1101/2025.06.18.660406
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

biorxiv.org/content/10.1101/2025.06.18.660406v1
May 2025
www.sciencedirect.com www.sciencedirect.com

Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors

1
1. scibot 16 May 2025
  
  in Public
  
  CVCL_0219
  
  DOI: 10.1016/j.cell.2025.04.012
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0092867425004143
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

1
1. scibot 16 May 2025
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1002/advs.202504704
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202504704
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Unraveling the mechanism of microRNA-134 in colon cancer progression: targeting KRAS and PIK3CA for cell cycle control and histone deacetylase regulation.

1
1. scibot 03 Jan 2025
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1016/j.yexcr.2024.114385
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0014482724004762
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

1
1. scibot 21 Dec 2024
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1101/2024.02.20.581056
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reduced chemokine C‐C motif ligand 1 expression may negatively regulate colorectal cancer progression at liver metastatic sites

1
1. scibot 22 Mar 2024
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1111/jcmm.18193
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10952021/
Sep 2023
52.53.155.43 52.53.155.43

British J Pharmacology - 2023 - Kleszcz-html.html

1
1. scibot 07 Sep 2023
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1111/bph.16224
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

52.53.155.43/bda5ca2ff5fc6352261b5aa6b5327e2f6367b095/British J Pharmacology - 2023 - Kleszcz-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AMT-562, a novel HER3-targeting antibody drug conjugate, demonstrates a potential to broaden therapeutic opportunities for HER3-expressing tumors

1
1. scibot 07 Sep 2023
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1158/1535-7163.MCT-23-0198
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10477830/
Jul 2023
52.53.155.43 52.53.155.43

mct-23-0198-html.html

1
1. scibot 13 Jul 2023
  
  in Public
  
  RRID: CVCL_0219
  
  DOI: 10.1158/1535-7163.mct-23-0198
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @olekpark
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

52.53.155.43/8898fbf5a65a5137143414e835a98a5ee1580728/mct-23-0198-html.html
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer

1
1. scibot 08 Jun 2023
  
  in Public
  
  RRID: CVCL_0219
  
  DOI: 10.1158/2767-9764.CRC-22-0469
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10241187/
Apr 2023
www.science.org www.science.org

Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis

1
1. scibot 20 Apr 2023
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1126/sciadv.ade3422
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @jmitrevska
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

science.org/doi/10.1126/sciadv.ade3422
Dec 2022
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 23 Dec 2022
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1111/bph.15988
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15988
www.sciencedirect.com www.sciencedirect.com

Cancer cell-derived type I interferons instruct tumor monocyte polarization

1
1. scibot 08 Dec 2022
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1016/j.celrep.2022.111769
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124722016527
May 2022
www.sciencedirect.com www.sciencedirect.com

CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells

1
1. scibot 13 May 2022
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1016/j.isci.2022.104314
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2589004222005855
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair

1
1. scibot 05 May 2022
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1096/fj.202200154R
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9044500/
Apr 2022
aacrjournals.org aacrjournals.org

Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models

1
1. scibot 27 Apr 2022
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1158/2767-9764.CRC-22-0027
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

aacrjournals.org/cancerrescommun/article/2/4/233/694510/The-Tankyrase-Inhibitor-OM-153-Demonstrates
Mar 2022
www.sciencedirect.com www.sciencedirect.com

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

1
1. scibot 09 Mar 2022
  
  in Public
  
  Walter Bodmer's laboratory, University of OxfordCCL-220
  
  DOI: 10.1016/j.celrep.2022.110493
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124722002261
Jan 2022
www.sciencedirect.com www.sciencedirect.com

YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

1
1. scibot 06 Jan 2022
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1016/j.devcel.2021.12.006
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1534580721009953
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

1
1. scibot 15 Aug 2021
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1016/j.isci.2021.102807
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 05 Aug 2021
  
  in Public
  
  CVCL_0219
  
  DOI: 10.1016/j.celrep.2017.10.103
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5710012/
Jul 2021
academic.oup.com academic.oup.com

Untitled document

1
1. scibot 31 Jul 2021
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1210/en.2018-00920
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:CVCL_0219

Annotators

scibot

URL

academic.oup.com/endo/article/160/2/276/5231486
onlinelibrary.wiley.com onlinelibrary.wiley.com

Double‐strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation

1
1. scibot 30 Jul 2021
  
  in Public
  
  COLO 320DM
  
  DOI: 10.1002/gcc.22810
  
  Resource: (JCRB Cat# JCRB0225, RRID:CVCL_0219)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_0219
Visit annotations in context

Tags

RRID:CVCL_0219

RRIDCUR:Missing

Annotators

scibot

URL

onlinelibrary.wiley.com/doi/10.1002/gcc.22810
Sep 2020
link.springer.com link.springer.com

A preliminary assessment of oral monepantel’s tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

1
1. scibot 23 Sep 2020
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1007/s00280-020-04146-5
  
  Resource: (CLS Cat# 300153/p521_Colo-320_DM, RRID:CVCL_0219)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_0219
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:CVCL_0219

Annotators

scibot

URL

link.springer.com/article/10.1007/s00280-020-04146-5
Jan 2020
academic.oup.com academic.oup.com

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1210/en.2018-00920
  
  Resource: (CLS Cat# 300153/p521_Colo-320_DM, RRID:CVCL_0219)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:CVCL_0219

Annotators

scibot

URL

academic.oup.com/endo/article/160/2/276/5231486
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_0219
  
  DOI: 10.1016/j.chembiol.2019.02.009
  
  Resource: (CLS Cat# 300153/p521_Colo-320_DM, RRID:CVCL_0219)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_0219
  
  What is this?
  
  RRID:CVCL_0219 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:CVCL_0219

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2451945619300443