81 Matching Annotations
  1. Jun 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DDR1 Promotes Immune Evasion in Colorectal Cancer by Orchestrating IL33-Mediated M2-like Polarization of Tumor-Associated Macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC13227095/
  3. May 2026
  4. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Molecular Mechanism of NSUN6-Mediated Epigenetic Modifications in the Malignant Progression of Colorectal Cancer Cells
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202600351R
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136880/
  6. Apr 2026
  7. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cholesterol Reprograms Oxysterol Metabolism via the LOX1/CH25H/CYP7B1 Signaling Axis to Drive Multidrug Resistance in Colorectal Cancer
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    onlinelibrary.wiley.com/doi/10.1155/humu/3675889
  8. aacrjournals.org aacrjournals.org
    The allogeneic FAP-CAR-IL15 iNKT therapy MiNK-215 remodels the tumor stroma to enhance antitumor immunity
    1
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    aacrjournals.org/cancerimmunolres/article/14/2/243/771961/The-Allogeneic-FAP-CAR-IL15-iNKT-Therapy-MiNK-215
  9. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70256
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080315/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Efficacy of an XPO1 inhibitor in combination with irinotecan in a preclinical colorectal cancer model
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13076135/
  12. aacrjournals.org aacrjournals.org
    DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity
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    aacrjournals.org/mct/article/25/1/7/771286/DS-3939a-A-TA-MUC1-Directed-Antibody-Drug
  13. Mar 2026
  14. www.sciencedirect.com www.sciencedirect.com
    Receptor-ubiquitination-targeting antibody-drug conjugates for enhanced endocytosis and lysosomal delivery
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    sciencedirect.com/science/article/pii/S245194562600070X
  15. Feb 2026
  16. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Single-Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513341
  17. Jan 2026
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12848756/
  19. www.sciencedirect.com www.sciencedirect.com
    MYLK4 promotes colorectal cancer progression by regulating lipid metabolism reprogramming via targeting ferroptosis
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    sciencedirect.com/science/article/pii/S1476558625001496
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12816352/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The dysadherin/carbonic anhydrase 9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12804794/
  22. link.springer.com link.springer.com
    Afatinib exerts an inhibitory effect on T cell-mediated cytotoxicity
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    link.springer.com/article/10.1007/s00262-025-04279-7
  23. www.sciencedirect.com www.sciencedirect.com
    Targeted nanoparticle delivery of irinotecan enhances tumor response to PD-L1 blockade in colorectal cancer
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    sciencedirect.com/science/article/pii/S0168365926000106
  24. www.sciencedirect.com www.sciencedirect.com
    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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    sciencedirect.com/science/article/pii/S266637912500607X
  25. Dec 2025
  26. www.nature.com www.nature.com
    KRT81 promotes metastasis of colorectal cancer by acting as a protein scaffold for ezrin
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    nature.com/articles/s41388-025-03665-w
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  28. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R-Loop Accumulation and DNA Repair Deficiencies
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202512074
  29. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225025647-main-html.html
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  30. Nov 2025
  31. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53
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    sciencedirect.com:5037/science/article/pii/S2211124725013956
  32. Sep 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological Folate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12427396/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
  35. Jul 2025
  36. www.oaepublish.com www.oaepublish.com
    CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axis
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    oaepublish.com/articles/cdr.2025.76
  37. www.sciencedirect.com www.sciencedirect.com
    BDH2 promotes GLIPR1 promoter methylation and thus increases 5-FU sensitivity in colorectal cancer
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    sciencedirect.com/science/article/pii/S0006295225004186
  38. May 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metformin reverses 5-FU resistance induced by radiotherapy through mediating folate metabolism in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12093704/
  40. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202504704
  41. Apr 2025
  42. 52.53.155.43 52.53.155.43
    618530-html.html
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    52.53.155.43/416789ac7df726491b564812e1d36841853b9ba2/Maunscript_BJP_20230110-html.html
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer stem cells develop NK cell resistance via homotypic cell-in-cell structures suppressed by Stathmin1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11984389/
  44. www.sciencedirect.com www.sciencedirect.com
    Pentagalloyl Glucose Targets the JAK1/JAK3-STAT3 Pathway to Inhibit Cancer Stem Cells and Epithelial–Mesenchymal Transition in 5-Fluorouracil-Resistant Colorectal Cancer
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    sciencedirect.com/science/article/pii/S094471132500412X
  45. Mar 2025
  46. www.sciencedirect.com www.sciencedirect.com
    SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response
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    sciencedirect.com/science/article/pii/S2211124725002050
  47. www.sciencedirect.com www.sciencedirect.com
    FSTL3 promotes colorectal cancer by activating the HIF1 pathway
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    sciencedirect.com/science/article/pii/S0378111925002239
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11932694/
  49. Feb 2025
  50. 52.53.155.43 52.53.155.43
    618530-html.html
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    52.53.155.43/416789ac7df726491b564812e1d36841853b9ba2/Maunscript_BJP_20230110-html.html
  51. www.sciencedirect.com www.sciencedirect.com
    Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer
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    sciencedirect.com/science/article/pii/S2211124725000981
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11831107/
  53. Jan 2025
  54. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17374
  55. www.sciencedirect.com www.sciencedirect.com
    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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    sciencedirect.com/science/article/pii/S1074761324005685
  56. Dec 2024
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Forced Overexpression and Knockout Analysis of SLC30A and SLC39A Family Genes Suggests Their Involvement in Establishing Resistance to Cisplatin in Human Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11594112/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    B7-H3–Targeted CAR-Vδ1T Cells Exhibit Potent Broad-Spectrum Activity against Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11609632/
  60. www.sciencedirect.com www.sciencedirect.com
    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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    sciencedirect.com/science/article/pii/S1097276524009146
  61. www.nature.com www.nature.com
    The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression
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    nature.com/articles/s41467-024-54920-9
  62. Oct 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443317/
  64. Sep 2024
  65. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    CT45A1-mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell-in-cell structure, potentiating the progression of microsatellite instability-high colorectal cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13736
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11424096/
  67. Aug 2024
  68. www.sciencedirect.com www.sciencedirect.com
    Spatial characterization and stratification of colorectal adenomas by deep visual proteomics
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    sciencedirect.com/science/article/pii/S2589004224018455
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTS384 NCI60: The Next Phase of the NCI60 Screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292194/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306514/
  71. 52.53.155.43 52.53.155.43
    The Natural Alkaloid (-)- N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex
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    52.53.155.43/8d57977b9b9f6e94560266e27b39ad1669186ba3/acs.jnatprod.3c00125 (1)-html.html
  72. bmccancer.biomedcentral.com bmccancer.biomedcentral.com
    Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer
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    bmccancer.biomedcentral.com/article/10.1186/s12885-021-07900-x
  73. Mar 2024
  74. 52.53.155.43 52.53.155.43
    Eosinophils exhibit a unique transcriptional signature and increased sensitivity to IL-3-induced activation in response to colorectal cancer cells
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    52.53.155.43/7241ac452b455844d7e12ac1740a76e49c0fc746/qiae063-html.html
  75. Nov 2023
  76. link.springer.com link.springer.com
    TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
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    link.springer.com/article/10.1007/s12032-023-02218-z
  77. www.sciencedirect.com www.sciencedirect.com
    Inhibitory effects of lidocaine on colon carcinoma progression in a rat model: a pilot study
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    sciencedirect.com/science/article/pii/S0007091223004403
  78. Sep 2023
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AMT-562, a novel HER3-targeting antibody drug conjugate, demonstrates a potential to broaden therapeutic opportunities for HER3-expressing tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10477830/
  80. Jul 2023
  81. 52.53.155.43 52.53.155.43
    mct-23-0198-html.html
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    52.53.155.43/8898fbf5a65a5137143414e835a98a5ee1580728/mct-23-0198-html.html
  82. www.sciencedirect.com www.sciencedirect.com
    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    sciencedirect.com/science/article/pii/S2211124723007751
  83. 52.53.155.43 52.53.155.43
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    52.53.155.43/416789ac7df726491b564812e1d36841853b9ba2/Maunscript_BJP_20230110-html.html
  84. Jun 2023
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
  86. Apr 2023
  87. www.sciencedirect.com www.sciencedirect.com
    Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex
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    sciencedirect.com/science/article/pii/S2589004223006405
  88. onlinelibrary.wiley.com onlinelibrary.wiley.com
    An integrated multi-omics analysis of rectal cancer patients identified POU2F3 as a putative druggable target and entinostat as a cytotoxic enhancer of 5-Fluorouracil
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34478
  89. Oct 2022
  90. www.sciencedirect.com www.sciencedirect.com
    Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA
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    sciencedirect.com/science/article/pii/S2211124722013353
  91. www.nature.com www.nature.com
    A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
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    nature.com/articles/s41467-022-33430-6
  92. Jun 2022
  93. www.sciencedirect.com www.sciencedirect.com
    Supramolecular assembly of GSK3α as a cellular response to amino acid starvation
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    sciencedirect.com/science/article/pii/S1097276522004920
  94. www.sciencedirect.com www.sciencedirect.com
    Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124722006246
  95. May 2022
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FILIP1L loss is a driver of aggressive mucinous colorectal adenocarcinoma and mediates cytokinesis defects through PFDN1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8563430/
  97. Feb 2022
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8845119/
  99. Jul 2021
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC5655689/
  101. Jun 2021
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition
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    ncbi.nlm.nih.gov/pmc/articles/PMC8195604/
  103. Apr 2021
  104. www.sciencedirect.com www.sciencedirect.com
    Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
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    sciencedirect.com/science/article/pii/S2451945621000490
  105. Jan 2021
  106. jeccr.biomedcentral.com jeccr.biomedcentral.com
    Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer
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    jeccr.biomedcentral.com/articles/10.1186/s13046-020-01811-8
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Polyphenolic Fraction Obtained From Thalassia testudinum Marine Plant and Thalassiolin B Exert Cytotoxic Effects in Colorectal Cancer Cells and Arrest Tumor Progression in a Xenograft Mouse Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC7774314/
  108. Sep 2020
  109. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14981
  110. www.nature.com www.nature.com
    Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer
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    nature.com/articles/s41388-020-01416-7
  111. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A mutant KRAS‐induced factor REG4 Promotes Cancer Stem Cell Properties via Wnt/β‐catenin Signaling
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32728
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7062870/
  113. Jan 2020
  114. www.sciencedirect.com www.sciencedirect.com
    VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells
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