309 Matching Annotations
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    Interplay of host and viral genetic variations in modulating antibody responses to genotype 3a hepatitis C virus: Implications for vaccine design
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    sciencedirect.com/science/article/pii/S2211124725011891
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    The upregulation of GDF15 is controlled epigenetically by oncogenic TCF19 signaling in human hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S258900422501764X
  4. Oct 2025
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    Bio-fabrication of fibrotic liver microtissues as a scalable and drug-responsive in vitro model
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    sciencedirect.com/science/article/pii/S0378517325010798
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    A Galactose-Engineered Dual-Responsive Nanocarrier for ASO/CRISPR-Cas9 Delivery to Inhibit HBV Replication
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/adhm.202502835
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    Tumor-derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485388/
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    Nitroxoline mitigates hepatic steatosis by enhancing cholesterol efflux and promoting bile acid synthesis through LRH-1 signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12482622/
  9. Sep 2025
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    miR-199a-5p/GPR89A axis modulates sorafenib resistance in hepatocellular carcinoma through glutamate metabolic reprogramming
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    pmc.ncbi.nlm.nih.gov/articles/PMC12457768/
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    Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells
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    Phosphatidylserine-positive extracellular vesicles for detecting multiple operable cancers
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    sciencedirect.com/science/article/pii/S2211124725010307
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    CD24 recruits tumor-associated neutrophils to promote the progression of hepatocellular carcinoma
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    DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site
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    DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis
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  16. Aug 2025
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    HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma
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    Nitroxoline upregulates low-density lipoprotein receptors expression, enhances lipid metabolism, and reduces hepatic steatosis and atherosclerosis in Apoe−/− mice
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    Preclinical Evaluation of DB-1419, a Novel Bifunctional and Bispecific Anti–B7-H3 × PD-L1 Antibody–Drug Conjugate
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    CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription
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    53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations
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    ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma
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  25. Jul 2025
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    MICA+ Tumor Cells Modulate Macrophage Phenotype and Function via PPAR/EHHADH-Mediated Fatty Acid Metabolism in Hepatocellular Carcinoma (HCC)
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    STAT1-mediated interferon signaling in the hematopoietic system is essential for restricting Usutu virus infection in vivo
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    Thyroid hormone suppresses cell growth by regulating CDK2 and cyclin E1 expression via Hepsin
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    Chalcone derivative 1m mitigates hepatic fibrosis and inflammation, enhances cholesterol efflux and reduces atherosclerosis
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    Frontiers | TREM1 is essential for maintaining stemness of liver cancer stem-like cells in hepatocellular carcinoma
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    The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway
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  35. Jun 2025
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    The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway
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    SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes
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    Exosomal encapsulation of a steviol derivative SD9 to overcome TRAIL resistance as a highly effective therapy against lung cancer
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    Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma
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    The solute carrier superfamily interactome
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    Metabolic mapping of the human solute carrier superfamily
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    LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma
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  45. May 2025
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    Dimethyl fumarate abrogates hepatocellular carcinoma growth by inhibiting Nrf2/Bcl-xL axis and enhances sorafenib’s efficacy
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  47. Apr 2025
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    PDZK1 inhibits MRP2-mediated oxaliplatin chemosensitivity in hepatocellular carcinoma
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    Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma
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    Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm
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  51. Mar 2025
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    ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma
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    Antiviral alkaloids from Crinum jagus: Extraction, synergistic effects, and activity against dengue virus and human coronavirus OC43
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  55. Feb 2025
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    Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D
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    The IGF2BP1 oncogene is a druggable m6A-dependent enhancer of YAP1-driven gene expression in ovarian cancer
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    Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism
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    Lactate drives senescence-resistant lineages in hepatocellular carcinoma via histone H2B lactylation of NDRG1
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    Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor
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    Dual Roles of Canagliflozin on Cholangiocarcinoma Cell Growth and Enhanced Growth Suppression in Combination with FK866
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  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming
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  63. Jan 2025
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    OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth
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    SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling
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    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    Re-evaluation of the relationship between PrPc expression and patient prognosis in primary esophageal squamous cell carcinoma and primary hepatocellular carcinoma
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  71. Dec 2024
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    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer
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    Host specific sphingomyelin is critical for replication of diverse RNA viruses
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    Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson’s disease
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    Enhancing Immune Response and Survival in Hepatocellular Carcinoma with Novel Oncolytic Jurona Virus and Immune Checkpoint Blockade
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
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  81. Nov 2024
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    Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis
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    Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
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  84. Oct 2024
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma
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  86. www.biorxiv.org www.biorxiv.org
    Metabolic mapping of the human solute carrier superfamily
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    Upregulated PrPC by HBx enhances NF-κB signal via liquid–liquid phase separation to advance liver cancer
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  88. Sep 2024
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    Hypoxic tumour-derived exosomal miR-1290 exacerbates the suppression of CD8+ T cells by promoting M2 macrophage polarization
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    Invention of circRNA promoting RNA to specifically promote circRNA production
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    Sorafenib and SIAIS361034, a novel PROTAC degrader of BCL-xL, display synergistic antitumor effects on hepatocellular carcinoma with minimal hepatotoxicity
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  92. Aug 2024
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    Harnessing Porphyrin Accumulation in Liver Cancer: Combining Genomic Data and Drug Targeting
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    YTHDF3-mediated m6A modification of NKD1 regulates hepatocellular carcinoma invasion and metastasis by activating the WNT/β-catenin signaling axis
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    GNA14’s interaction with RACK1 inhibits Hepatocellular Carcinoma progression through reducing MAPK/JNK and PI3K/AKT signaling pathway
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  96. Jul 2024
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    ASGR1 Is a Promising Target for Lipid Reduction in Pigs with PON2 As Its Inhibitor
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    TGF-β1-Induced LINC01094 promotes epithelial-mesenchymal transition in hepatocellular carcinoma through the miR-122-5p/TGFBR2–SAMD2–SMAD3 Axis
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    The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant
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  206. Nov 2022
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    Cobalt-conjugated carbon quantum dots for in vivo monitoring of the pyruvate dehydrogenase kinase inhibitor drug dichloroacetic acid
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    GALNT14-mediated O-glycosylation on PHB2 serine-161 enhances cell growth, migration and drug resistance by activating IGF1R cascade in hepatoma cells
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  211. Oct 2022
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    Sorbitol dehydrogenase induction of cancer cell necroptosis and macrophage polarization in the HCC microenvironment suppresses tumor progression
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  213. Sep 2022
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    A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants
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  216. Aug 2022
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    Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization
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    Drug transporters are implicated in the diffusion of tacrolimus into the T lymphocyte in kidney and liver transplant recipients: Genetic, mRNA, protein expression, and functionality
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    Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis
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  220. Jul 2022
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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  223. Jun 2022
  224. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Integrin alpha 6 (ITGA6) is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex
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  225. www.nature.com www.nature.com
    Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus
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    An antibacterial compound pyrimidomycin produced by Streptomyces sp. PSAA01 isolated from soil of Eastern Himalayan foothill
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  227. May 2022
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    CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway
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    SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies
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  230. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chimeric HDAC and the cytoskeleton inhibitor broxbam as a novel therapeutic strategy for liver cancer
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  231. Apr 2022
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    Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage
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    SARS-CoV-2 variants C.1.2 and B.1.621 (Mu) partially evade neutralization by antibodies elicited upon infection or vaccination
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  234. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one with Lipid Lowering Effects in Hepatocytes
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    In vitro and in vivo assay of the ER lipid scramblase TMEM41B
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    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    The calcium channel inhibitor lacidipine inhibits Zika virus replication in neural progenitor cells
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    Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
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  240. Mar 2022
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    A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer
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