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Isorhamnetin Exhibits Hypoglycemic Activity and Targets PI3K/AKT and COX-2 Pathways in Type 1 Diabetes

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1. scibot 23 Oct 2025
  
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  DOI: 10.3390/nu17203201
  
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mdpi.com/2072-6643/17/20/3201
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Expression, localization and regulation of NADPH oxidases in pancreatic beta cells

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1. scibot 17 Oct 2025
  
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  DOI: 10.1080/13510002.2025.2568300
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12507117/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Spatiotemporal Analysis of Glucagon Secretory Granule Dynamics

1
1. scibot 27 Sep 2025
  
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  RRID:CVCL_0351
  
  DOI: 10.1111/tra.70019
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12457985/
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Disruption of mitochondria-associated membranes contributes to the dysregulation of insulin secretion in undernutrition, obesity, and double burden of malnutrition

1
1. scibot 16 Sep 2025
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.metabol.2025.156393
  
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sciencedirect.com/science/article/pii/S0026049525002628
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In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion.

1
1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.jbc.2025.110661
  
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sciencedirect.com/science/article/pii/S002192582502513X
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Secretory stimuli distinctly regulate insulin secretory granule maturation through structural remodeling

1
1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.str.2025.07.022
  
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sciencedirect.com/science/article/pii/S0969212625002710
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Insulator-based dielectrophoresis-assisted separation of insulin secretory vesicles

1
1. scibot 29 Aug 2024
  
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  RRID:CVCL_0351
  
  DOI: 10.7554/eLife.74989
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11349295/
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Mitochondria to plasma membrane redox signaling is essential for fatty acid β-oxidation-driven insulin secretion

1
1. scibot 23 Aug 2024
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.redox.2024.103283
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11332078/
academic.oup.com academic.oup.com

Endothelial cell-derived triosephosphate isomerase attenuates insulin secretion from pancreatic beta cells of male rats

1
1. scibot 02 Aug 2024
  
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  RRID:CVCL_0351
  
  DOI: 10.1210/endocr/bqaa234
  
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academic.oup.com/endo/article-abstract/162/3/bqaa234/6042346
Dec 2023
52.53.155.43 52.53.155.43

Lysophosphotidylinositols (LysoPIs) are upregulated following human ß-cell loss and act to potentiate insulin release.

1
1. scibot 01 Dec 2023
  
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  RRID:CVCL_0351
  
  DOI: 10.2337/db23-0205
  
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52.53.155.43/cd72489e1556c808acbc0cfde44ddd59335197ad/db230205-html.html
Nov 2023
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Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate

1
1. scibot 18 Nov 2023
  
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  RRID:CVCL_0351
  
  DOI: 10.3390/nu15224791
  
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mdpi.com/2072-6643/15/22/4791
Oct 2023
www.nature.com www.nature.com

Warburg-associated acidification represses lactic fermentation independently of lactate, contribution from real-time NMR on cell-free systems

1
1. scibot 20 Oct 2023
  
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  RRID:CVCL_0351
  
  DOI: 10.1038/s41598-023-44783-3
  
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nature.com/articles/s41598-023-44783-3
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway

1
1. scibot 14 Oct 2023
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.isci.2023.107956
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10562789/
Apr 2023
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FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

1
1. scibot 19 Apr 2023
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.cmet.2023.03.018
  
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sciencedirect.com/science/article/pii/S1550413123001237
Mar 2023
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BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis

1
1. scibot 24 Mar 2023
  
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  RRID:CVCL_0351
  
  DOI: 10.3390/ijms24065657
  
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mdpi.com/1422-0067/24/6/5657
Dec 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting Apollo-NADP+ to Image NADPH Generation in Pancreatic Beta-Cell Organelles

1
1. scibot 02 Dec 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1021/acssensors.2c01174
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9706804/
Aug 2022
www.nature.com www.nature.com

Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity

1
1. scibot 16 Aug 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1038/s41598-022-17845-1
  
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nature.com/articles/s41598-022-17845-1
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Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

1
1. scibot 12 Aug 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.isci.2022.104771
  
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sciencedirect.com/science/article/pii/S2589004222010434
Jul 2022
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The alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells

1
1. scibot 02 Jul 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.fct.2022.113266
  
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sciencedirect.com/science/article/pii/S0278691522004641
May 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model

1
1. scibot 18 May 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.3390/ijms23095040
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9102687/
Apr 2022
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G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERα and ERβ in pancreatic beta cells

1
1. scibot 20 Apr 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.envint.2022.107250
  
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sciencedirect.com/science/article/pii/S0160412022001763
Feb 2022
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Soft X-ray tomography to map and quantify organelle interactions at the mesoscale

2
1. scibot 11 Feb 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.str.2022.01.006
  
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2. scibot 11 Feb 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.str.2022.01.006
  
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sciencedirect.com/science/article/pii/S0969212622000065
Jan 2022
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Divergent effects of HIV reverse transcriptase inhibitors on pancreatic beta-cell function and survival: Potential role of oxidative stress and mitochondrial dysfunction

1
1. scibot 29 Jan 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.lfs.2022.120329
  
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sciencedirect.com/science/article/pii/S0024320522000297
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Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells

1
1. scibot 13 Jan 2022
  
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  RRID:CVCL_0351
  
  DOI: 10.1007/s00125-021-05633-x
  
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link.springer.com/article/10.1007/s00125-021-05633-x
Sep 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Genetically Encoded Protein Thermometer Enables Precise Electrothermal Control of Transgene Expression

1
1. scibot 10 Sep 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1002/advs.202101813
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202101813
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Role of Alpha Cells in the Self-Assembly of Bioengineered Islets

1
1. scibot 04 Sep 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1089/ten.tea.2020.0080
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8392094/
Aug 2021
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The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death

1
1. scibot 17 Aug 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.mce.2021.111424
  
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sciencedirect.com/science/article/pii/S0303720721002689
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Untitled document

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1. scibot 10 Aug 2021
  
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  CVCL_0351
  
  DOI: 10.1007/s00125-018-4782-0
  
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link.springer.com/article/10.1007/s00125-018-4782-0
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Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

1
1. scibot 04 Aug 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.celrep.2021.109490
  
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sciencedirect.com/science/article/pii/S2211124721009177
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Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling

1
1. scibot 01 Aug 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.bbamcr.2019.118619
  
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sciencedirect.com/science/article/pii/S0167488919302277
Jul 2021
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Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets

1
1. scibot 31 Jul 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.cmet.2019.02.012
  
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sciencedirect.com/science/article/pii/S1550413119300762
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Conditioned media from contracting skeletal muscle potentiates insulin secretion and enhances mitochondrial energy metabolism of pancreatic beta-cells

1
1. scibot 30 Jul 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.metabol.2018.11.004
  
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sciencedirect.com/science/article/pii/S002604951830235X
Jun 2021
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MCPIP1 is a novel link between diabetogenic conditions and impaired insulin secretory capacity

1
1. scibot 23 Jun 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.bbadis.2021.166199
  
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sciencedirect.com/science/article/pii/S0925443921001320
May 2021
academic.oup.com academic.oup.com

Endothelial cell-derived triosephosphate isomerase attenuates insulin secretion from pancreatic beta cells of male rats

1
1. scibot 11 May 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1210/endocr/bqaa234
  
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academic.oup.com/endo/article-abstract/162/3/bqaa234/6042346
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Amino acid restriction alters survival mechanisms in pancreatic beta cells: possible role of the PI3K/Akt pathway

1
1. scibot 01 May 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1007/s00394-021-02568-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8081284/
Apr 2021
www.sciencedirect.com www.sciencedirect.com

AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells

1
1. scibot 02 Apr 2021
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.redox.2021.101962
  
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sciencedirect.com/science/article/pii/S2213231721001105
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography

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1. scibot 19 Dec 2020
  
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  CVCL_0351
  
  DOI: 10.1126/sciadv.abc8262
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7725475/
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Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

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1. scibot 07 Dec 2020
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.celrep.2020.108466
  
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sciencedirect.com/science/article/pii/S2211124720314558
Jan 2020
diabetes.diabetesjournals.org diabetes.diabetesjournals.org

Differential effect of glucose on ER-mitochondria Ca2+ exchange participates to insulin secretion and to glucotoxicity-mediated dysfunction of β cells.

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1. scibot 13 Jan 2020
  
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  RRID:CVCL_0351
  
  DOI: 10.2337/db18-1112
  
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diabetes.diabetesjournals.org/content/68/9/1778
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 13 Jan 2020
  
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  CVCL_0351
  
  DOI: 10.1111/bph.14757
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14757
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Conditioned media from contracting skeletal muscle potentiates insulin secretion and enhances mitochondrial energy metabolism of pancreatic beta-cells

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1. scibot 13 Jan 2020
  
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  RRID:CVCL_0351
  
  DOI: 10.1016/j.metabol.2018.11.004
  
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sciencedirect.com/science/article/pii/S002604951830235X
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Amino acid restriction increases β‐cell death under challenging conditions

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1. scibot 12 Jan 2020
  
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  RRID:CVCL_0351
  
  DOI: 10.1002/jcp.28389
  
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onlinelibrary.wiley.com/doi/full/10.1002/jcp.28389
Nov 2018
link.springer.com link.springer.com

Untitled document

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1. scibot 05 Nov 2018
  
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  RRID:CVCL_0351
  
  Curator: @evieth
  
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link.springer.com/article/10.1007/s00424-018-2215-z
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Untitled document

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1. scibot 05 Nov 2018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6023166/
Nov 2017
academic.oup.com academic.oup.com

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis

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1. scibot 08 Nov 2017
  
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  CVCL_0351
  
  Curator: @kaitlinsung
  
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academic.oup.com/endo/article/158/8/2503/3861370/Protective-Role-of-Complement-C3-Against-Cytokine
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Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis

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1. scibot 08 Nov 2017
  
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  CVCL_0351
  
  Curator: @bandrow
  
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academic.oup.com/endo/article/158/6/1659/3058741/Guanabenz-Sensitizes-Pancreatic-Cells-to-Lipotoxic