153 Matching Annotations
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    Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer
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    aacrjournals.org/mct/article/25/4/599/776467/Mosperafenib-a-Novel-Paradox-Breaker-BRAF
  3. Apr 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AURKA-mediated destabilization of SAPS3 drives ferroptosis evasion via 7-dehydrocholesterol biosynthesis in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039981/
  5. Mar 2026
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    ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment
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    Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion
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    sciencedirect.com/science/article/pii/S2666379126001217
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    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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  9. Feb 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity
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    Mechanosensation promotes broad-spectrum antiviral defense through membrane remodeling
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    A nuclear isoform of hydroxyacyl-COA dehydrogenase inhibits tumor progression in colorectal cancer
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    The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model
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  15. Jan 2026
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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    Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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  21. Dec 2025
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    KRT81 promotes metastasis of colorectal cancer by acting as a protein scaffold for ezrin
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    Nuclear translocation of Cx43 promotes to CRC progression and associates with β-catenin accumulation
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    Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R-Loop Accumulation and DNA Repair Deficiencies
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  25. Nov 2025
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    Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53
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    Fosl1 is a transcriptional effector of BRAFV600E-driven intestinal tumorigenesis
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    BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer
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  30. Oct 2025
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    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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  32. Sep 2025
  33. www.biorxiv.org www.biorxiv.org
    Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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  40. Aug 2025
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    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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  46. Jul 2025
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    The XPO1 inhibitor Eltanexor modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis
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    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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  51. Jun 2025
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    Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin
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  54. May 2025
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    OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression
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  57. Apr 2025
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    A new EGFR and c-Met bispecific NIR-II fluorescent probe for visualising colorectal cancer and metastatic lymph nodes
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    Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage
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  62. Mar 2025
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    Antitumor effects of immunotherapy combined with BRAF and MEK inhibitors in BRAF V600E metastatic colorectal cancer
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  64. Feb 2025
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    Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated colorectal cancer
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  68. Dec 2024
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    Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine
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    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    RPF2 and CARM1 cooperate to enhance colorectal cancer metastasis via the AKT/GSK-3β signaling pathway.
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    Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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  76. Nov 2024
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    Degradome analysis to identify direct protein substrates of small-molecule degraders
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    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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    biorxiv.org/content/10.1101/2024.11.08.622636v2
  80. Oct 2024
  81. aacrjournals.org aacrjournals.org
    2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis
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    aacrjournals.org/cancerres/article/81/2/289/649623/2-Hydroxylation-of-Fatty-Acids-Represses
  82. Sep 2024
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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  84. Aug 2024
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    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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    MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
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  87. Jul 2024
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types
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  89. May 2024
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    Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers
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    Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
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    Multiple ubiquitin ligases protect human genome integrity by targeting cancer-associated APOBEC3 deaminases for degradation
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    biorxiv.org/content/10.1101/2024.04.23.590688v1
  93. Apr 2024
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11043890/
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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  96. Feb 2024
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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  99. www.biorxiv.org www.biorxiv.org
    A common druggable signature of oncogenic CMYC, mutant KRAS and mutant p53 reveals functional redundancy and competition of the oncogenes in cancer
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    biorxiv.org/content/10.1101/2023.12.20.572548v1
  100. Jan 2024
  101. www.sciencedirect.com www.sciencedirect.com
    Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3
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    A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
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  103. Dec 2023
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    A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival
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    Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies
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    RPF2 mediates the CARM1‑MYCN axis to promote chemotherapy resistance in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10696550/
  107. Nov 2023
  108. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
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