135 Matching Annotations
  1. Last 7 days
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    Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53
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    sciencedirect.com:5037/science/article/pii/S2211124725013956
  3. Nov 2025
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    Fosl1 is a transcriptional effector of BRAFV600E-driven intestinal tumorigenesis
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    sciencedirect.com/science/article/pii/S2589004225021364
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    2025.11.06.687028v2.full-html.html
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  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12591322/
  7. Oct 2025
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    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S0021925825027164
  9. Sep 2025
  10. www.biorxiv.org www.biorxiv.org
    Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1
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    biorxiv.org/content/10.1101/2025.09.16.676613v1
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    sciencedirect.com/science/article/pii/S2666379125004367
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    A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
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    nature.com/articles/s41587-025-02793-8
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    GALNT7 stratifies dMMR/MSI colorectal cancer into distinct molecular subsets associated with prognosis and PD-L1 expression
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    Chemotherapy modulation by a cancer-associated microbiota metabolite
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    Hypoxia-Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis
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  17. Aug 2025
  18. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
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    Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11802306/
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    Trametinib thwarts activation of survival pathways induced by pro-ferroptotic drug conjugate ACXT-3102 resulting in enhanced pancreatic cancer cell death
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  23. Jul 2025
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    The XPO1 inhibitor Eltanexor modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis
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    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    Cancer biomarkers discovered using pan-cancer plasma proteomic profiling
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    link.springer.com/article/10.1038/s41551-025-01448-y
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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  28. Jun 2025
  29. www.cell.com www.cell.com
    BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival
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    Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35504
  31. May 2025
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    Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands
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    OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression
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  34. Apr 2025
  35. 52.53.155.43 52.53.155.43
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    A new EGFR and c-Met bispecific NIR-II fluorescent probe for visualising colorectal cancer and metastatic lymph nodes
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    Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage
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  39. Mar 2025
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    Antitumor effects of immunotherapy combined with BRAF and MEK inhibitors in BRAF V600E metastatic colorectal cancer
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  41. Feb 2025
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  43. aacrjournals.org aacrjournals.org
    Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated colorectal cancer
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    E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence
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  45. Dec 2024
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    Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine
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    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    RPF2 and CARM1 cooperate to enhance colorectal cancer metastasis via the AKT/GSK-3β signaling pathway.
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    Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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  53. Nov 2024
  54. www.sciencedirect.com www.sciencedirect.com
    Degradome analysis to identify direct protein substrates of small-molecule degraders
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  56. www.biorxiv.org www.biorxiv.org
    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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    biorxiv.org/content/10.1101/2024.11.08.622636v2
  57. Oct 2024
  58. aacrjournals.org aacrjournals.org
    2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis
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    aacrjournals.org/cancerres/article/81/2/289/649623/2-Hydroxylation-of-Fatty-Acids-Represses
  59. Sep 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365971/
  61. Aug 2024
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    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MMP‐9‐dependent proteolysis of the histone H3 N‐terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306514/
  64. Jul 2024
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types
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    ncbi.nlm.nih.gov/pmc/articles/PMC11183118/
  66. May 2024
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    Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers
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    Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11059122/
  69. www.biorxiv.org www.biorxiv.org
    Multiple ubiquitin ligases protect human genome integrity by targeting cancer-associated APOBEC3 deaminases for degradation
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    biorxiv.org/content/10.1101/2024.04.23.590688v1
  70. Apr 2024
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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  73. Feb 2024
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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  76. www.biorxiv.org www.biorxiv.org
    A common druggable signature of oncogenic CMYC, mutant KRAS and mutant p53 reveals functional redundancy and competition of the oncogenes in cancer
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    biorxiv.org/content/10.1101/2023.12.20.572548v1
  77. Jan 2024
  78. www.sciencedirect.com www.sciencedirect.com
    Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3
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    A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
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  80. Dec 2023
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    A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival
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    Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies
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    RPF2 mediates the CARM1‑MYCN axis to promote chemotherapy resistance in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10696550/
  84. Nov 2023
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
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    link.springer.com/article/10.1007/s12032-023-02218-z
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    Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development
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    sciencedirect.com/science/article/pii/S0925443923003071
  88. Oct 2023
  89. www.sciencedirect.com www.sciencedirect.com
    BRD4-binding enhancer promotes CRC progression by interacting with YY1 to activate the Wnt pathway through upregulation of TCF7L2
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    52.53.155.43/7b3101f3d01462bbcf14399b3becbcb8b341bb38/Molecular Oncology - 2023 - Hsieh - Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer-html.html
  91. Sep 2023
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    Natural killer cell therapy targeting cancer stem cells: Old wine in a new bottle
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    Epigenomic analysis reveals a unique DNA methylation program of metastasis-competent circulating tumor cells in colorectal cancer
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    Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10475482/
  96. Aug 2023
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids
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    ncbi.nlm.nih.gov/pmc/articles/PMC10411481/
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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    sciencedirect.com/science/article/pii/S2211124723009385
  100. Jul 2023
  101. 52.53.155.43 52.53.155.43
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  102. Jun 2023
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    Microsatellite instability states serve as predictive biomarkers for tumors chemotherapy sensitivity
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    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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    The Natural Alkaloid (-)- N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex
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    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
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    A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
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  108. Feb 2023
  109. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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