285 Matching Annotations
  1. Aug 2025
  2. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
  3. www.nature.com www.nature.com
    Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
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    nature.com/articles/s41467-025-62486-3
  4. www.sciencedirect.com www.sciencedirect.com
    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    sciencedirect.com/science/article/pii/S107476132500322X
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    53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway
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    sciencedirect.com/science/article/pii/S2211124725009234
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    Building simplified cancer subtyping and prediction models with glycan gene signatures
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    sciencedirect.com/science/article/pii/S2667237525001766
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-dependent mechanosensing by cells derived from human tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328224/
  8. www.biorxiv.org www.biorxiv.org
    Distinct 2-phenyl-imidazo[1, 2α] pyridine derivatives drive ER degradation and selectively impair proliferation of ER+ breast cancer cells via the aryl hydrocarbon receptor
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    biorxiv.org/content/10.1101/2025.07.28.666967v1
  9. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70089
  10. Jul 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12248657/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12232590/
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    Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer
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    sciencedirect.com/science/article/pii/S2666379125002915
  14. Jun 2025
  15. www.tandfonline.com www.tandfonline.com
    Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination
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    tandfonline.com/doi/full/10.1080/10717544.2025.2512950
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    Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A’s impact on ERα-mediated transcriptional bursting
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    sciencedirect.com/science/article/pii/S2589004225011253
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    A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancer
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    sciencedirect.com/science/article/pii/S2352396425002725
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    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70077
  19. www.nature.com www.nature.com
    PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
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    nature.com/articles/s41388-025-03468-z
  20. breast-cancer-research.biomedcentral.com breast-cancer-research.biomedcentral.com
    Discovery and validation of cell-free DNA methylation markers for specific diagnosis, differentiation from benign tumors, and prognosis of breast cancer
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    breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-025-02066-x
  21. 52.53.155.43 52.53.155.43
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    52.53.155.43/fedd6ccff8c0b6494dbe8595a0c800e33e0860f7/PDF-html.html
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    Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer
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    sciencedirect.com/science/article/pii/S2451945625001655
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12128487/
  24. May 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12122001/
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    Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer
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    sciencedirect.com/science/article/pii/S0304383525003908
  27. link.springer.com link.springer.com
    Microtubule associated serine/threonine kinase-3 inhibits the malignant phenotype of breast cancer by promoting phosphorylation-mediated ubiquitination degradation of yes-associated protein
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    link.springer.com/article/10.1186/s13058-025-02028-3
  28. www.sciencedirect.com www.sciencedirect.com
    Protrusion force and cell-cell adhesion-induced polarity alignment govern collective migration modes
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    sciencedirect.com/science/article/pii/S0006349525002371
  29. Apr 2025
  30. www.sciencedirect.com www.sciencedirect.com
    CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
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    sciencedirect.com/science/article/pii/S2451945625000960
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Potent estrogen receptor β agonists with inhibitory activity in vitro, fail to suppress xenografts of endocrine-resistant cyclin-dependent kinase 4/6 inhibitor-resistant breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11979155/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks
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    pmc.ncbi.nlm.nih.gov/articles/PMC11980100/
  33. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis
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    sciencedirect.com/science/article/pii/S1097276525002023
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951697/
  35. Mar 2025
  36. 52.53.155.43 52.53.155.43
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    52.53.155.43/098761c36b4439bcc578d63b667c303f01bb0050/PDF-html.html
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The transcription factor RIP140 regulates interferon γ signaling in breast cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35405
  38. www.sciencedirect.com www.sciencedirect.com
    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    sciencedirect.com/science/article/pii/S2211124725001743
  39. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70030
  40. www.sciencedirect.com www.sciencedirect.com
    Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids
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    sciencedirect.com/science/article/pii/S2472555225000152
  41. Feb 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11831106/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic Profiling of Breast Cancer Cell Lines: Unique and Shared Metabolites
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    pmc.ncbi.nlm.nih.gov/articles/PMC11816582/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11808005/
  46. www.nature.com www.nature.com
    Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients
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    nature.com/articles/s41598-025-87122-4
  47. Jan 2025
  48. elifesciences.org elifesciences.org
    A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms
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    elifesciences.org/articles/93183
  49. www.sciencedirect.com www.sciencedirect.com
    Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1
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    sciencedirect.com/science/article/pii/S1535610824004434
  50. www.nature.com www.nature.com
    The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer
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    nature.com/articles/s41523-024-00709-4
  51. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FGFR2-RUNX2 activation: An unexplored therapeutic pathway in luminal breast cancer related to tumor progression
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35302
  52. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13762
  53. www.sciencedirect.com www.sciencedirect.com
    Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma
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    sciencedirect.com/science/article/pii/S2589004224028165
  54. Dec 2024
  55. www.nature.com www.nature.com
    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
  56. 52.53.155.43 52.53.155.43
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  57. Nov 2024
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584840/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    C19MC Drives Nucleolar Invasion of Mitochondria and Meiotic Nuclear Division in Human Cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11575172/
  60. www.biorxiv.org www.biorxiv.org
    Aberrant expression of CD14 in breast tumor cells is associated with poor outcome
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    biorxiv.org/content/10.1101/2024.11.07.622456v1
  61. www.sciencedirect.com www.sciencedirect.com
    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004434
  62. Oct 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  64. Sep 2024
  65. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Dynamic methylation and expression of alternative promoters for oestrogen receptor alpha in cell line models of fulvestrant resistance
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13713
  66. www.biorxiv.org www.biorxiv.org
    Protrusion force and cell-cell adhesion play a critical role in collective tumor cluster migration
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    biorxiv.org/content/10.1101/2024.09.18.613706v1
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic effects of PARP inhibition and cholesterol biosynthesis pathway modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11403291/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model
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    ncbi.nlm.nih.gov/pmc/articles/PMC11404160/
  69. www.sciencedirect.com www.sciencedirect.com
    Computational pipeline predicting cell death suppressors as targets for cancer therapy
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    sciencedirect.com/science/article/pii/S2589004224020844
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384147/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Siglec‐7 and Siglec‐9 expression in primary triple negative and oestrogen receptor positive breast cancer and in vitro signalling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11378723/
  72. Aug 2024
  73. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Engineered Drug 3′UTRMYC1-18 Degrades the c-MYC-STAT5A/B-PD-L1 Complex In Vivo to Inhibit Metastatic Triple-Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11311709/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306513/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTS384 NCI60: The Next Phase of the NCI60 Screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292194/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR T cell activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292204/
  78. www.cell.com www.cell.com
    ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines
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    cell.com/cell-reports/fulltext/S2211-1247(24)00762-9
  79. breast-cancer-research.biomedcentral.com breast-cancer-research.biomedcentral.com
    Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance
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    breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-024-01790-0
  80. genomebiology.biomedcentral.com genomebiology.biomedcentral.com
    The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer
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    genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03161-y
  81. www.nature.com www.nature.com
    TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
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    nature.com/articles/s41417-023-00696-x
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative promoters and splicing create multiple functionally distinct isoforms of oestrogen receptor alpha in breast cancer and healthy tissues
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    ncbi.nlm.nih.gov/pmc/articles/PMC10557849/
  83. Jul 2024
  84. www.biorxiv.org www.biorxiv.org
    The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
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    biorxiv.org/content/10.1101/2024.07.22.604482v1
  85. www.sciencedirect.com www.sciencedirect.com
    Loss of ZNF408 attenuates STING-mediated immune surveillance in breast carcinogenesis
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    sciencedirect.com/science/article/pii/S2589004224015013
  86. www.sciencedirect.com www.sciencedirect.com
    Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
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    sciencedirect.com/science/article/pii/S0092867424006524
  87. www.sciencedirect.com www.sciencedirect.com
    Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
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    sciencedirect.com/science/article/pii/S2211124724008398
  88. www.biorxiv.org www.biorxiv.org
    EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer
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    biorxiv.org/content/10.1101/2024.06.28.601163v1
  89. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16489
  90. www.mdpi.com www.mdpi.com
    HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice
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    mdpi.com/1422-0067/25/13/7475
  91. May 2024
  92. www.sciencedirect.com www.sciencedirect.com
    Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite
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    sciencedirect.com/science/article/pii/S1535610824001697
  93. link.springer.com link.springer.com
    Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
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    link.springer.com/article/10.1186/s13024-024-00725-9
  94. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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    science.org/doi/10.1126/scisignal.adh4475
  95. www.biorxiv.org www.biorxiv.org
    Intracellular Retention of Estradiol is Augmented by GRAM Domain Containing Protein ASTER-B in Breast Cancer Cells
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    biorxiv.org/content/10.1101/2024.05.16.594581v1
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM7A-DT induces genotoxic stress, tumorigenesis, and progression of p53 missense mutation-associated invasive breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11097164/
  97. www.sciencedirect.com www.sciencedirect.com
    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    sciencedirect.com/science/article/pii/S1097276524003241
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11063688/
  99. www.sciencedirect.com www.sciencedirect.com
    Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer
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