Hypothesis

22 Matching Annotations

May 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Preclinical Characterization and Clinical Activity of RNK08954, a Highly Selective and Orally Bioavailable KRAS G12D Inhibitor

1
1. scibot 05 May 2026
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1158/2159-8290.CD-25-1346
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
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  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC13133609/
Apr 2026
54.241.53.176 54.241.53.176

cd-25-1346-html.html

1
1. scibot 23 Apr 2026
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1158/2159-8290.CD-25-1346
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

54.241.53.176/86f1cde136cae9cb2b05401d7da6d7a0a1acbc52/cd-25-1346-html.html
Jan 2026
elifesciences.org elifesciences.org

Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

1
1. scibot 08 Jan 2026
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.7554/eLife.108665.1
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

elifesciences.org/reviewed-preprints/108665
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases

1
1. scibot 11 Dec 2025
  
  in Public
  
  RRID:CDCL-1055
  
  DOI: 10.1016/j.jncc.2025.11.003
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRIDCUR:Unresolved RRID:CVCL_1055
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RRIDCUR:Unresolved

RRID:CVCL_1055

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scibot

URL

sciencedirect.com:5037/science/article/pii/S266700542500122X
Nov 2025
www.sciencedirect.com www.sciencedirect.com

Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells

1
1. scibot 13 Nov 2025
  
  in Public
  
  ATCCCat# HTB-53
  
  DOI: 10.1016/j.xcrm.2025.102446
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1055
  
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  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125005191
Aug 2025
www.sciencedirect.com www.sciencedirect.com

A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers

1
1. scibot 08 Aug 2025
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1016/j.ccell.2025.07.006
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S1535610825003101
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Azenosertib Is a Potent and Selective WEE1 Kinase Inhibitor with Broad Antitumor Activity Across a Range of Solid Tumors

1
1. scibot 05 Aug 2025
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1158/1535-7163.MCT-24-1194
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12314526/
Jul 2025
www.sciencedirect.com www.sciencedirect.com

RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations

1
1. scibot 16 Jul 2025
  
  in Public
  
  ATCCCat# HTB-53
  
  DOI: 10.1016/j.xcrm.2025.102235
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125003088
Apr 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 19 Apr 2025
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1158/1535-7163.mct-24-1194
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

52.53.155.43/fb744ae1c201e64705cbba4fb67640ca74ff97a4/PDF-html.html
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Efficacy of CBP/p300 Dual Inhibitors against De-repression of KREMEN2 in cBAF-Deficient Cancers

1
1. scibot 08 Jan 2025
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1158/2767-9764.CRC-24-0484
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11701801/
Nov 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment

1
1. scibot 12 Nov 2023
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1002/ijc.34783
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/ijc.34783
www.sciencedirect.com www.sciencedirect.com

Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers

1
1. scibot 02 Nov 2023
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1016/j.immuni.2023.09.013
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S1074761323004181
Nov 2022
www.sciencedirect.com www.sciencedirect.com

Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

1
1. scibot 03 Nov 2022
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1016/j.chembiol.2022.10.005
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S2451945622003592
Sep 2022
www.sciencedirect.com www.sciencedirect.com

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

1
1. scibot 24 Sep 2022
  
  in Public
  
  HTB-53
  
  DOI: 10.1016/j.ccell.2022.08.015
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S1535610822003798
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases

1
1. scibot 18 Mar 2022
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1016/j.isci.2022.103985
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
Jan 2022
www.sciencedirect.com www.sciencedirect.com

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

1
1. scibot 26 Jan 2022
  
  in Public
  
  CVCL_1055
  
  DOI: 10.1016/j.ccell.2021.12.009
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S1535610821006620
Oct 2021
link.springer.com link.springer.com

EGFR transcriptionally upregulates UTX via STAT3 in non-small cell lung cancer

1
1. scibot 19 Oct 2021
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1007/s00432-021-03800-6
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

link.springer.com/article/10.1007/s00432-021-03800-6
Aug 2021
www.sciencedirect.com www.sciencedirect.com

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

1
1. scibot 01 Aug 2021
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1016/j.chembiol.2019.12.005
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619304015
Sep 2020
www.sciencedirect.com www.sciencedirect.com

The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance

1
1. scibot 10 Sep 2020
  
  in Public
  
  A427
  
  DOI: 10.1016/j.celrep.2020.108102
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1055
  
  Curator comments: A-427 cell line ATCC Cat# HTB-53
  
  What is this?
  
  RRID:CVCL_1055 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720310913
elifesciences.org elifesciences.org

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.7554/eLife.53367
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1055
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RRIDCUR:Validated

RRID:CVCL_1055

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scibot

URL

elifesciences.org/articles/53367
www.sciencedirect.com www.sciencedirect.com

FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

1
1. scibot 03 Sep 2020
  
  in Public
  
  RRID:CVCL_1055
  
  DOI: 10.1016/j.celrep.2019.12.032
  
  Resource: (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1055
  
  What is this?
  
  RRID:CVCL_1055
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RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719316821
Nov 2018
www.sciencedirect.com www.sciencedirect.com

UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F

1
1. scibot 05 Nov 2018
  
  in Public
  
  HTB-53
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-7906, RRID:CVCL_1055)
  
  SciCrunch record: RRID:CVCL_1055
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1055 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1055

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scibot

URL

sciencedirect.com/science/article/pii/S1097276518304441