Hypothesis

28 Matching Annotations

Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

1
1. scibot 26 Jan 2026
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.7554/eLife.104545
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
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  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12747521/
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer

1
1. scibot 17 Dec 2025
  
  in Public
  
  ATCC (American Type Culture Collection)HTB-21
  
  DOI: 10.1016/j.xcrm.2025.102478
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1115
  
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  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

sciencedirect.com:5037/science/article/pii/S2666379125005518
www.sciencedirect.com:5037 www.sciencedirect.com:5037

CDK4/6 inhibition reprograms the breast cancer immunopeptidome via Rb-dependent chromatin and transcriptomic remodeling

1
1. scibot 16 Dec 2025
  
  in Public
  
  RRID: CVCL_1115
  
  DOI: 10.1016/j.celrep.2025.116676
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1115
  
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  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

sciencedirect.com:5037/science/article/pii/S2211124725014482
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding

1
1. scibot 23 Nov 2025
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1158/2159-8290.CD-25-0647
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
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  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12631751/
www.sciencedirect.com www.sciencedirect.com

System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells

1
1. scibot 22 Nov 2025
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1016/j.xcrm.2025.102425
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
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  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125004987
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Retinoic acid-induced 2 deficiency impairs genomic stability in breast cancer

1
1. scibot 25 Jul 2025
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1186/s13058-025-02085-8
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
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  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12285165/
Mar 2025
www.sciencedirect.com www.sciencedirect.com

CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

1
1. scibot 11 Mar 2025
  
  in Public
  
  ATCCHTB-21
  
  DOI: 10.1016/j.ccell.2025.02.006
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1115
  
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  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
www.nature.com www.nature.com

Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients

1
1. scibot 01 Feb 2025
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1038/s41598-025-87122-4
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
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  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

nature.com/articles/s41598-025-87122-4
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Patient-derived response estimates from zero-passage organoids of luminal breast cancer

1
1. scibot 04 Jan 2025
  
  in Public
  
  ATCC, #HTB-21
  
  DOI: 10.1186/s13058-024-01931-5
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11687200/
Nov 2024
www.biorxiv.org www.biorxiv.org

Aberrant expression of CD14 in breast tumor cells is associated with poor outcome

1
1. scibot 14 Nov 2024
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1101/2024.11.07.622456
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

biorxiv.org/content/10.1101/2024.11.07.622456v1
Sep 2024
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

Dynamic methylation and expression of alternative promoters for oestrogen receptor alpha in cell line models of fulvestrant resistance

1
1. scibot 27 Sep 2024
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1002/1878-0261.13713
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13713
Jul 2024
www.sciencedirect.com www.sciencedirect.com

Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance

1
1. scibot 18 Jul 2024
  
  in Public
  
  HTB-21
  
  DOI: 10.1016/j.cell.2024.06.012
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @vtello
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

sciencedirect.com/science/article/pii/S0092867424006524
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer

1
1. scibot 07 Sep 2023
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1158/1535-7163.MCT-22-0786
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10477829/
Jul 2023
52.53.155.43 52.53.155.43

mct-22-0786-html.html

1
1. scibot 08 Jul 2023
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1158/1535-7163.mct-22-0786
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

52.53.155.43/7c2ea74aab93db45711a21ec870d80353fa447be/mct-22-0786-html.html
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition

1
1. scibot 29 Mar 2023
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1158/2767-9764.CRC-22-0119
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10035383/
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mediator of DNA damage checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive lobular carcinoma of the breast

1
1. scibot 02 Feb 2022
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1158/1541-7786.MCR-21-0025
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8349796/
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

1
1. scibot 01 Aug 2021
  
  in Public
  
  CVCL_1115
  
  DOI: 10.1016/j.cels.2019.11.001
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1115
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RRID:CVCL_1115

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2405471219303874
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity

1
1. scibot 28 Jul 2021
  
  in Public
  
  RRID: CVCL_1115
  
  DOI: 10.1016/j.chembiol.2019.05.005
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619301746
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

1
1. scibot 27 Jul 2021
  
  in Public
  
  CAMA-1
  
  DOI: 10.1186/s13058-017-0890-x
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @mpairish
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1115
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RRID:CVCL_1115

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5562991/
www.sciencedirect.com www.sciencedirect.com

Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

1
1. scibot 01 Jul 2021
  
  in Public
  
  CAMA-1
  
  DOI: 10.1016/j.biocel.2021.106028
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1115
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RRID:CVCL_1115

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1357272521001060
May 2021
www.sciencedirect.com www.sciencedirect.com

Deciphering the signaling network of breast cancer improves drug sensitivity prediction

1
1. scibot 01 May 2021
  
  in Public
  
  HTB-21
  
  DOI: 10.1016/j.cels.2021.04.002
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115 RRIDCUR:Missing
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RRID:CVCL_1115

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2405471221001113
Feb 2021
www.sciencedirect.com www.sciencedirect.com

Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1

1
1. scibot 24 Feb 2021
  
  in Public
  
  CAMA-1
  
  DOI: 10.1016/j.celrep.2021.108749
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1115
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RRID:CVCL_1115

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124721000620
Oct 2020
www.cell.com www.cell.com

Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing

1
1. scibot 18 Oct 2020
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1016/j.chembiol.2020.07.011
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115 RRIDCUR:Validated
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RRID:CVCL_1115

RRIDCUR:Validated

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scibot

URL

cell.com/cell-chemical-biology/abstract/S2451-9456(20)30284-1
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

1
1. scibot 26 Sep 2020
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1016/j.cell.2020.05.053
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115 RRIDCUR:Validated
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RRID:CVCL_1115

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0092867420306863
elifesciences.org elifesciences.org

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

1
1. scibot 23 Sep 2020
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.7554/eLife.44525
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115 RRIDCUR:Validated
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RRID:CVCL_1115

RRIDCUR:Validated

Annotators

scibot

URL

elifesciences.org/articles/44525
onlinelibrary.wiley.com onlinelibrary.wiley.com

FGF13 promotes metastasis of triple‐negative breast cancer

1
1. scibot 03 Sep 2020
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1002/ijc.32874
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1115
  
  Curator comments: CAMA-1 cell line ATCC Cat# HTB-21
  
  What is this?
  
  RRID:CVCL_1115
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RRID:CVCL_1115

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/ijc.32874
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility

1
1. scibot 13 Jan 2020
  
  in Public
  
  CVCL_1115
  
  DOI: 10.1016/j.cell.2019.06.026
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @ethanbadger
  
  SciCrunch record: CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115 RRIDCUR:Validated
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RRID:CVCL_1115

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S0092867419306890
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1115
  
  DOI: 10.1016/j.molcel.2019.01.004
  
  Resource: (ATCC Cat# HTB-21, RRID:CVCL_1115)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1115
  
  What is this?
  
  RRID:CVCL_1115 RRIDCUR:Validated
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RRID:CVCL_1115

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1097276519300048