Hypothesis

24 Matching Annotations

Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer

1
1. scibot 14 Jan 2026
  
  in Public
  
  CVCL_1251
  
  DOI: 10.1158/2159-8290.CD-25-0605
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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pmc.ncbi.nlm.nih.gov/articles/PMC12793832/
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer

1
1. scibot 17 Dec 2025
  
  in Public
  
  ATCC (American Type Culture Collection)CRL-2326
  
  DOI: 10.1016/j.xcrm.2025.102478
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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sciencedirect.com:5037/science/article/pii/S2666379125005518
Oct 2025
www.biorxiv.org www.biorxiv.org

Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer

1
1. scibot 23 Oct 2025
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1101/2025.10.09.681343
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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scibot

URL

biorxiv.org/content/10.1101/2025.10.09.681343v1
www.sciencedirect.com www.sciencedirect.com

Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors

1
1. scibot 01 Oct 2025
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1016/j.chembiol.2025.09.003
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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scibot

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sciencedirect.com/science/article/pii/S2451945625002685
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 24 Mar 2025
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1158/1535-7163.mct-24-0928
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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scibot

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52.53.155.43/098761c36b4439bcc578d63b667c303f01bb0050/PDF-html.html
Dec 2024
www.sciencedirect.com www.sciencedirect.com

ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis

1
1. scibot 02 Dec 2024
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1016/j.celrep.2024.114988
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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URL

sciencedirect.com/science/article/pii/S2211124724013391
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy

1
1. scibot 07 Jun 2024
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1158/1078-0432.CCR-23-3839
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC11145169/
Feb 2024
www.sciencedirect.com www.sciencedirect.com

Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR

1
1. scibot 06 Feb 2024
  
  in Public
  
  ATCCCRL-2326
  
  DOI: 10.1016/j.devcel.2024.01.010
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @abever99
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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scibot

URL

sciencedirect.com/science/article/pii/S1534580724000303
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer

1
1. scibot 15 Sep 2021
  
  in Public
  
  CRL-2326
  
  DOI: 10.1016/j.chembiol.2021.08.011
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRIDCUR:Missing RRID:CVCL_1251
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RRID:CVCL_1251

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2451945621004001
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

1
1. scibot 01 Aug 2021
  
  in Public
  
  CVCL_1251
  
  DOI: 10.1016/j.cels.2019.11.001
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1251
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1251
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RRID:CVCL_1251

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2405471219303874
Jul 2021
www.embopress.org www.embopress.org

CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling

1
1. scibot 30 Jul 2021
  
  in Public
  
  HCC‐1419
  
  DOI: 10.15252/embr.201948058
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251 RRIDCUR:Missing
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RRID:CVCL_1251

RRIDCUR:Missing

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scibot

URL

embopress.org/doi/10.15252/embr.201948058
www.sciencedirect.com www.sciencedirect.com

Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

1
1. scibot 22 Jul 2021
  
  in Public
  
  CVCL_1251
  
  DOI: 10.1016/j.ccell.2021.06.016
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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scibot

URL

sciencedirect.com/science/article/pii/S153561082100338X
May 2021
www.sciencedirect.com www.sciencedirect.com

Deciphering the signaling network of breast cancer improves drug sensitivity prediction

1
1. scibot 01 May 2021
  
  in Public
  
  CRL-2326
  
  DOI: 10.1016/j.cels.2021.04.002
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1251
  
  What is this?
  
  RRID:CVCL_1251 RRIDCUR:Missing
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RRID:CVCL_1251

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2405471221001113
Apr 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

1
1. scibot 11 Apr 2021
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1016/j.molcel.2021.01.033
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1251
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8384339/
Nov 2020
www.sciencedirect.com www.sciencedirect.com

G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

1
1. scibot 12 Nov 2020
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1016/j.celrep.2020.108341
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1251
  
  What is this?
  
  RRID:CVCL_1251 RRIDCUR:Validated
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RRID:CVCL_1251

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720313309
Oct 2020
www.cell.com www.cell.com

Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing

1
1. scibot 18 Oct 2020
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1016/j.chembiol.2020.07.011
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1251
  
  What is this?
  
  RRID:CVCL_1251 RRIDCUR:Validated
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RRID:CVCL_1251

RRIDCUR:Validated

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scibot

URL

cell.com/cell-chemical-biology/abstract/S2451-9456(20)30284-1
Sep 2020
www.mdpi.com www.mdpi.com

Statin Drugs Plus Th1 Cytokines Potentiate Apoptosis and Ras Delocalization in Human Breast Cancer Lines and Combine with Dendritic Cell-Based Immunotherapy to Suppress Tumor Growth in a Mouse Model of HER-2pos Disease

1
1. scibot 25 Sep 2020
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.3390/vaccines8010072
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1251
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1251
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RRID:CVCL_1251

RRIDCUR:Validated

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scibot

URL

mdpi.com/2076-393X/8/1/72
onlinelibrary.wiley.com onlinelibrary.wiley.com

FGF13 promotes metastasis of triple‐negative breast cancer

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1002/ijc.32874
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1251
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1251
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RRID:CVCL_1251

RRIDCUR:Validated

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/ijc.32874
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1016/j.chembiol.2019.05.005
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1251
  
  What is this?
  
  RRID:CVCL_1251 RRIDCUR:Validated
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RRID:CVCL_1251

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619301746
www.sciencedirect.com www.sciencedirect.com

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1251
  
  DOI: 10.1016/j.cmet.2019.01.020
  
  Resource: (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1251
  
  What is this?
  
  RRID:CVCL_1251 RRIDCUR:Validated
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RRID:CVCL_1251

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119300208
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL2326
  
  Curator: @Jmenke
  
  Resource used:
  
  (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  SciCrunch record: RRID:CVCL_1251
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_1251 RRIDCUR:Missing
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RRID:CVCL_1251

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S0092867418303088
elifesciences.org elifesciences.org

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:CVCL_1251
  
  Curator: @evieth
  
  Resource used:
  
  (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  SciCrunch record: RRID:CVCL_1251
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_1251
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RRID:CVCL_1251

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scibot

URL

elifesciences.org/articles/27155
www.sciencedirect.com www.sciencedirect.com

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID: CVCL_1251
  
  Curator: @evieth
  
  Resource used:
  
  (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  SciCrunch record: RRID:CVCL_1251
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1251 RRIDCUR:Missing
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RRID:CVCL_1251

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2405471218300541
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

1
1. scibot 08 Nov 2017
  
  in Public
  
  CRL-2326
  
  Curator: @Jmenke
  
  Resource used:
  
  (KCLB Cat# 9S1419, RRID:CVCL_1251)
  
  SciCrunch record: RRID:CVCL_1251
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1251 RRIDCUR:Missing
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RRID:CVCL_1251

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1097276517304914