Hypothesis

26 Matching Annotations

Oct 2025
www.biorxiv.org www.biorxiv.org

Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer

1
1. scibot 23 Oct 2025
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1101/2025.10.09.681343
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

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biorxiv.org/content/10.1101/2025.10.09.681343v1
www.sciencedirect.com www.sciencedirect.com

Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors

1
1. scibot 01 Oct 2025
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.chembiol.2025.09.003
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

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sciencedirect.com/science/article/pii/S2451945625002685
Apr 2025
www.sciencedirect.com www.sciencedirect.com

CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers

1
1. scibot 19 Apr 2025
  
  in Public
  
  ATCCCat# CRL-2330
  
  DOI: 10.1016/j.chembiol.2025.03.006
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S2451945625000960
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Non-invasive multi-cancer detection using DNA hypomethylation of LINE-1 retrotransposons

1
1. scibot 04 Apr 2025
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1158/1078-0432.CCR-24-2669
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC11959274/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pre-Clinical Rationale for Amcenestrant Combinations in HER2+/ER+ Breast Cancer

1
1. scibot 30 Jan 2025
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.3390/ijms26020460
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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pmc.ncbi.nlm.nih.gov/articles/PMC11765389/
Dec 2024
www.sciencedirect.com www.sciencedirect.com

ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis

1
1. scibot 02 Dec 2024
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.celrep.2024.114988
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @vtello
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S2211124724013391
Aug 2024
www.cell.com www.cell.com

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

1
1. scibot 22 Aug 2024
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.cell.2020.02.019
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

URL

cell.com/cell/fulltext/S0092-8674(20)30163-X
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Heterogeneity and transcriptional drivers of triple-negative breast cancer

1
1. scibot 16 Dec 2023
  
  in Public
  
  ATCCCRL-2330
  
  DOI: 10.1016/j.celrep.2023.113564
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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URL

sciencedirect.com/science/article/pii/S2211124723015760
Nov 2023
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

1
1. scibot 03 Nov 2023
  
  in Public
  
  RRID: CVCL_1255
  
  DOI: 10.1158/1078-0432.CCR-23-0103
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1255
  
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  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

URL

pubmed.ncbi.nlm.nih.gov/37279095/
Oct 2023
52.53.155.43 52.53.155.43

ccr-23-0103-html.html

1
1. scibot 07 Oct 2023
  
  in Public
  
  RRID: CVCL_1255
  
  DOI: 10.1158/1078-0432.ccr-23-0103
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @jmitrevska
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

URL

52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
Feb 2022
www.sciencedirect.com www.sciencedirect.com

Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling

1
1. scibot 02 Feb 2022
  
  in Public
  
  ATCC CRL-2330
  
  DOI: 10.1016/j.celrep.2021.110285
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721018003
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness

1
1. scibot 05 Jan 2022
  
  in Public
  
  CRL-2330
  
  DOI: 10.1016/j.cmet.2021.12.001
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1255
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RRIDCUR:Missing

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S1550413121006203
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

1
1. scibot 01 Aug 2021
  
  in Public
  
  CVCL_1255
  
  DOI: 10.1016/j.cels.2019.11.001
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S2405471219303874
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

1
1. scibot 31 Jul 2021
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.cmet.2019.01.020
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119300208
www.sciencedirect.com www.sciencedirect.com

Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

1
1. scibot 01 Jul 2021
  
  in Public
  
  HCC1569
  
  DOI: 10.1016/j.biocel.2021.106028
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1255
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RRIDCUR:Missing

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S1357272521001060
May 2021
www.sciencedirect.com www.sciencedirect.com

Deciphering the signaling network of breast cancer improves drug sensitivity prediction

1
1. scibot 01 May 2021
  
  in Public
  
  CRL-2330
  
  DOI: 10.1016/j.cels.2021.04.002
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S2405471221001113
Nov 2020
www.sciencedirect.com www.sciencedirect.com

G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

1
1. scibot 12 Nov 2020
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.celrep.2020.108341
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1255
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720313309
Oct 2020
www.cell.com www.cell.com

Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing

1
1. scibot 18 Oct 2020
  
  in Public
  
  CVCL_1255
  
  DOI: 10.1016/j.chembiol.2020.07.011
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

cell.com/cell-chemical-biology/abstract/S2451-9456(20)30284-1
mcr.aacrjournals.org mcr.aacrjournals.org

Elevated V-ATPase activity following PTEN loss is required for enhanced oncogenic signaling in breast cancer

1
1. scibot 16 Oct 2020
  
  in Public
  
  RRID: CVCL_1255
  
  DOI: 10.1158/1541-7786.MCR-20-0088
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255
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RRID:CVCL_1255

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scibot

URL

mcr.aacrjournals.org/content/18/10/1477
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

1
1. scibot 26 Sep 2020
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.7554/eLife.51605
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1255
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6961979/
www.sciencedirect.com www.sciencedirect.com

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.cell.2020.05.053
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1255
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S0092867420306863
www.cell.com www.cell.com

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

1
1. scibot 05 Sep 2020
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.cell.2020.02.019
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1255
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

cell.com/cell/fulltext/S0092-8674(20)30163-X
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.cmet.2019.09.009
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119305121
www.sciencedirect.com www.sciencedirect.com

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_1255
  
  DOI: 10.1016/j.cmet.2019.01.020
  
  Resource: (KCLB Cat# 9S1569, RRID:CVCL_1255)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1255
  
  What is this?
  
  RRID:CVCL_1255 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119300208
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL2330
  
  Curator: @Jmenke
  
  Resource used:
  
  (KCLB Cat# 71569, RRID:CVCL_1255)
  
  SciCrunch record: RRID:CVCL_1255
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1255 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S0092867418303088
www.sciencedirect.com www.sciencedirect.com

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:CVCL_1255
  
  Curator: @evieth
  
  Resource used:
  
  (KCLB Cat# 71569, RRID:CVCL_1255)
  
  SciCrunch record: RRID:CVCL_1255
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1255 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_1255

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scibot

URL

sciencedirect.com/science/article/pii/S2405471218300541