87 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interplay between malic enzyme 2, de novo serine synthesis, and the malate-aspartate shuttle drives metabolic adaptation in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12523003/
  3. Sep 2025
  4. www.sciencedirect.com www.sciencedirect.com
    HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S1550413125003821
  5. Aug 2025
  6. www.biorxiv.org www.biorxiv.org
    Breast cancer cell migration is potentiated by associated fibroblasts through a laminin-511-Integrin α6β1-transduced Arp2/3 localization
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    biorxiv.org/content/10.1101/2025.08.10.669320v1
  7. 52.53.155.43 52.53.155.43
    2025.08.06.668996v1.full-html.html
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    52.53.155.43/9762f0542a12c1b879bb3817e6abf20525e5b06e/2025.08.06.668996v1.full-html.html
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    ZYS-1 is not an ADAR1 inhibitor
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    biorxiv.org/content/10.1101/2025.08.08.669362v2
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
  10. Jul 2025
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    Dual Regulation of FZD1/7 by IGF2BP3 Enhances Stem-like Properties and Carboplatin Resistance in Triple-Negative Breast Cancer
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    sciencedirect.com/science/article/pii/S0304383525005130
  12. pubs.acs.org pubs.acs.org
    Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer
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    pubs.acs.org/doi/full/10.1021/acs.jmedchem.5c00492
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Potent Inhibitor of Caspase-8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12371506/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Novel B7-H4xCD3 Bispecific T-cell Engager (PF-07260437) Synergizes with Breast Cancer Standard of Care and Immune Checkpoint Therapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214883/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214879/
  16. Jun 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281382/
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    Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer
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    sciencedirect.com/science/article/pii/S2451945625001655
  19. May 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TOP1 Mutations and Cross-Resistance to Antibody–Drug Conjugates in Patients with Metastatic Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079096/
  21. Apr 2025
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    CD36-mediated endocytosis of proteolysis-targeting chimeras
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    sciencedirect.com/science/article/pii/S0092867425003861
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  24. Feb 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics
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    pmc.ncbi.nlm.nih.gov/articles/PMC11842356/
  26. aacrjournals.org aacrjournals.org
    Arginine methylation of DDX3 by PRMT1 mediates mitochondrial homeostasis to promote breast cancer metastasis
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    aacrjournals.org/cancerres/article/84/18/3023/747792/Arginine-Methylation-of-DDX3-by-PRMT1-Mediates
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    Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures
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    sciencedirect.com/science/article/pii/S2666979X25000205
  28. Jan 2025
  29. 52.53.155.43 52.53.155.43
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  30. Dec 2024
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    Discovery, Validation and Mechanistic Study of XPO1 Inhibition in the Treatment of Triple-Negative Breast Cancer
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    mdpi.com/2072-6694/16/23/3980
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    Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates
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    sciencedirect.com/science/article/pii/S2451945624004586
  33. Nov 2024
  34. www.biorxiv.org www.biorxiv.org
    Aberrant expression of CD14 in breast tumor cells is associated with poor outcome
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    biorxiv.org/content/10.1101/2024.11.07.622456v1
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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  36. Sep 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic effects of PARP inhibition and cholesterol biosynthesis pathway modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11403291/
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    Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2211124724011021
  39. Aug 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306513/
  41. www.embopress.org www.embopress.org
    Unexpected PD‐L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies
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    embopress.org/doi/full/10.15252/emmm.202012716
  42. May 2024
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11063688/
  44. link.springer.com link.springer.com
    A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer
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    link.springer.com/article/10.1038/s41419-024-06675-w
  45. Apr 2024
  46. www.sciencedirect.com www.sciencedirect.com
    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    sciencedirect.com/science/article/pii/S2211124724004443
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993856/
  48. Mar 2024
  49. www.sciencedirect.com www.sciencedirect.com
    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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    sciencedirect.com/science/article/pii/S2451945624000874
  50. Feb 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein Kinase D drives the secretion of invasion mediators in triple-negative breast cancer cell lines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10844833/
  52. Jan 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10187264/
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    sciencedirect.com/science/article/pii/S1097276523010225
  55. Dec 2023
  56. www.sciencedirect.com www.sciencedirect.com
    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
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    sciencedirect.com/science/article/pii/S2666379123005438
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2211124723015760
  58. Nov 2023
  59. 52.53.155.43 52.53.155.43
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    Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins
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    sciencedirect.com/science/article/pii/S2666379123004329
  61. Oct 2023
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC
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    ncbi.nlm.nih.gov/pmc/articles/PMC10589312/
  63. www.mdpi.com www.mdpi.com
    ETHE1 Accelerates Triple-Negative Breast Cancer Metastasis by Activating GCN2/eIF2α/ATF4 Signaling
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    mdpi.com/1422-0067/24/19/14566
  64. dx.doi.org dx.doi.org
    Chromatin accessibility landscape of human triple-negative breast cancer cell lines reveals variation by patient donor ancestry
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    dx.doi.org/10.1158/2767-9764.CRC-23-0236
  65. Jul 2023
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Improved approaches to channel capacity estimation discover compromised GPCR signaling in diverse cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10368911/
  67. Jun 2023
  68. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    nature.com/articles/s41467-023-39241-7
  69. Mar 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC10035383/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10002699/
  72. Nov 2022
  73. www.nature.com www.nature.com
    Carboxyl-terminal modulator protein facilitates tumor metastasis in triple-negative breast cancer
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    nature.com/articles/s41417-022-00559-x
  74. Oct 2022
  75. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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    sciencedirect.com/science/article/pii/S1550413122004119
  76. Sep 2022
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decellularization of xenografted tumors provides cell-specific in vitro 3D environment
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    ncbi.nlm.nih.gov/pmc/articles/PMC9434107/
  78. Aug 2022
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytotoxicity and molecular-docking approach of a new rosane-type diterpenoid from the roots of Euphorbia nematocypha
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    ncbi.nlm.nih.gov/pmc/articles/PMC9393309/
  80. Jun 2022
  81. aacrjournals.org aacrjournals.org
    Rab13 sustains breast cancer stem cells by supporting tumor-stroma crosstalk
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    aacrjournals.org/cancerres/article/82/11/2124/699097/Rab13-Sustains-Breast-Cancer-Stem-Cells-by
  82. May 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    8-azaadenosine and 8-chloroadenosine are not selective inhibitors of ADAR
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    ncbi.nlm.nih.gov/pmc/articles/PMC9113518/
  84. Mar 2022
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
  86. www.sciencedirect.com www.sciencedirect.com
    CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities
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    sciencedirect.com/science/article/pii/S2211124722001759
  87. Feb 2022
  88. www.sciencedirect.com www.sciencedirect.com
    Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
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    sciencedirect.com/science/article/pii/S2211124722000316
  89. Nov 2021
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    The allergy mediator histamine confers resistanceto immunotherapy in cancer patients via activationof the macrophage histamine receptor H1
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    sciencedirect.com/science/article/pii/S1535610821006024
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    A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors
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  92. Sep 2021
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    Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2451945621004001
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    Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
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    sciencedirect.com/science/article/pii/S1535610821004499
  95. Aug 2021
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5726799/
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    cell.com/developmental-cell/abstract/S1534-5807(17)30871-7
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    The GEF‐H1/PKD3 signaling pathway promotes the maintenance of triple negative breast cancer stem cells
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32798
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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    sciencedirect.com/science/article/pii/S2405471219303874
  100. Jul 2021
  101. www.sciencedirect.com www.sciencedirect.com
    Development and Characterization of a Wee1 Kinase Degrader
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    sciencedirect.com/science/article/pii/S2451945619303587
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    Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization
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    Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases
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    sciencedirect.com/science/article/pii/S2405471218301923
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    Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
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    sciencedirect.com/science/article/pii/S2451945619301746
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    Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer
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  106. www.nature.com www.nature.com
    A chemical toolbox for the study of bromodomains and epigenetic signaling
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    nature.com/articles/s41467-019-09672-2
  107. www.sciencedirect.com www.sciencedirect.com
    Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity
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    sciencedirect.com/science/article/pii/S221112471930974X
  108. May 2021
  109. www.sciencedirect.com www.sciencedirect.com
    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    sciencedirect.com/science/article/pii/S1097276520305815
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    Deciphering the signaling network of breast cancer improves drug sensitivity prediction
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    sciencedirect.com/science/article/pii/S2405471221001113
  111. Apr 2021
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    Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets
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    sciencedirect.com/science/article/pii/S1550413120305453
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8384339/
  114. Feb 2021
  115. cancerres.aacrjournals.org cancerres.aacrjournals.org
    3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
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    cancerres.aacrjournals.org/content/81/4/847
  116. Oct 2020
  117. www.cell.com www.cell.com
    Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing
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    cell.com/cell-chemical-biology/abstract/S2451-9456(20)30284-1
  118. Sep 2020
  119. www.sciencedirect.com www.sciencedirect.com
    Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression
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    sciencedirect.com/science/article/pii/S1534580720300575
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    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    sciencedirect.com/science/article/pii/S2211124720308214
  121. link.springer.com link.springer.com
    A Modified Lentivirus-Based Reporter for Magnetic Separation of Cancer Stem Cells
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    link.springer.com/article/10.1134/S0026893319040046
  122. Aug 2020
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    Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
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  124. Jan 2020
  125. www.cell.com www.cell.com
    miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
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    cell.com/cell-reports/fulltext/S2211-1247(19)31576-1
  126. www.sciencedirect.com www.sciencedirect.com
    Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
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    sciencedirect.com/science/article/pii/S1550413119300208
  127. Nov 2018
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    Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling
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    sciencedirect.com/science/article/pii/S1550413118303887
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    Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer
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    sciencedirect.com/science/article/pii/S0092867418303088
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    Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer
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    sciencedirect.com/science/article/pii/S1534580717308717