Hypothesis

24 Matching Annotations

Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers

1
1. scibot 18 Mar 2026
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1126/scisignal.adx5186
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12983336/
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations

1
1. scibot 22 Jan 2026
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1016/j.celrep.2025.116882
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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pmc.ncbi.nlm.nih.gov/articles/PMC13019158/
www.biorxiv.org www.biorxiv.org

A Pan-Cancer Single-Cell Compendium of Intratumoural Heterogeneity

1
1. scibot 15 Jan 2026
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.64898/2026.01.06.693992
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

biorxiv.org/content/10.64898/2026.01.06.693992v1
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases

1
1. scibot 11 Dec 2025
  
  in Public
  
  RRID: CVCL-1465
  
  DOI: 10.1016/j.jncc.2025.11.003
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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scibot

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sciencedirect.com:5037/science/article/pii/S266700542500122X
Nov 2025
www.sciencedirect.com www.sciencedirect.com

Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells

1
1. scibot 13 Nov 2025
  
  in Public
  
  ATCCCat# CRL-5866
  
  DOI: 10.1016/j.xcrm.2025.102446
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

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sciencedirect.com/science/article/pii/S2666379125005191
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties

1
1. scibot 15 Oct 2025
  
  in Public
  
  ATCCCRL-5866
  
  DOI: 10.1016/j.xcrm.2025.102411
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125004847
Aug 2025
www.nature.com www.nature.com

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers

1
1. scibot 13 Aug 2025
  
  in Public
  
  CRL-5866
  
  DOI: 10.1038/s41586-025-09299-y
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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scibot

URL

nature.com/articles/s41586-025-09299-y
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

1
1. scibot 04 Jul 2025
  
  in Public
  
  CVCL_1465
  
  DOI: 10.1158/0008-5472.CAN-23-3256
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @sonofthor
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312

1
1. scibot 21 May 2025
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1158/2767-9764.CRC-25-0001
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting AKR1B10 by drug repurposing with epalrestat overcomes chemoresistance in non-small cell lung cancer patient-derived tumor organoids

1
1. scibot 05 Sep 2024
  
  in Public
  
  RRID: CVCL_1465
  
  DOI: 10.1158/1078-0432.CCR-23-3980
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @vtello
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11369614/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies

2
1. scibot 18 Jan 2024
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1016/j.isci.2023.108711
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1465
  
  What is this?
  
  RRID:CVCL_1465
2. scibot 18 Jan 2024
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1016/j.isci.2023.108711
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10788224/
Nov 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment

1
1. scibot 12 Nov 2023
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1002/ijc.34783
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/ijc.34783
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

1
1. scibot 06 Sep 2023
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1158/2767-9764.CRC-23-0304
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10473160/
Jun 2023
www.nature.com www.nature.com

Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

1
1. scibot 24 Jun 2023
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1038/s41467-023-39241-7
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

nature.com/articles/s41467-023-39241-7
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes

1
1. scibot 14 Apr 2022
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1016/j.celrep.2022.110636
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1465
  
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  RRID:CVCL_1465
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RRID:CVCL_1465

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722003886
Aug 2021
www.sciencedirect.com www.sciencedirect.com

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

1
1. scibot 01 Aug 2021
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1016/j.chembiol.2019.12.005
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1465
  
  What is this?
  
  RRID:CVCL_1465 RRIDCUR:Validated
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RRID:CVCL_1465

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619304015
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

1
1. scibot 30 Jul 2021
  
  in Public
  
  H1373
  
  DOI: 10.1016/j.ccell.2019.07.002
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1465
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1465
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RRID:CVCL_1465

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1535610819303290
www.sciencedirect.com www.sciencedirect.com

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

1
1. scibot 23 Jul 2021
  
  in Public
  
  CRL-5866
  
  DOI: 10.1016/j.ccell.2021.06.018
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1465
  
  What is this?
  
  RRID:CVCL_1465 RRIDCUR:Missing
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RRID:CVCL_1465

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1535610821003408
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

1
1. scibot 27 Oct 2020
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.7554/eLife.58108
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1465
  
  What is this?
  
  RRID:CVCL_1465 RRIDCUR:Validated
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RRID:CVCL_1465

RRIDCUR:Validated

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7556868/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

1
1. scibot 23 Sep 2020
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1016/j.celrep.2020.107840
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1465
  
  What is this?
  
  RRID:CVCL_1465 RRIDCUR:Validated
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RRID:CVCL_1465

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720308214
www.sciencedirect.com www.sciencedirect.com

A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:CVCL_1465
  
  DOI: 10.1016/j.ccell.2020.03.004
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1465
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1465
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RRID:CVCL_1465

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1535610820301057
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 03 Sep 2020
  
  in Public
  
  CVCL_1465
  
  DOI: 10.1002/1878-0261.12600
  
  Resource: (KCLB Cat# 91373, RRID:CVCL_1465)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1465
  
  What is this?
  
  RRID:CVCL_1465 RRIDCUR:Missing
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RRID:CVCL_1465

RRIDCUR:Missing

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scibot

URL

febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12600
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL-5866
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-5866, RRID:CVCL_1465)
  
  SciCrunch record: RRID:CVCL_1465
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1465 RRIDCUR:Missing
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RRID:CVCL_1465

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S0092867418300412