Hypothesis

33 Matching Annotations

Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy

1
1. scibot 11 Jun 2025
  
  in Public
  
  RRID: CVCL_1531
  
  DOI: 10.1158/0008-5472.CAN-24-2054
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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pmc.ncbi.nlm.nih.gov/articles/PMC12127800/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation

1
1. scibot 17 Apr 2025
  
  in Public
  
  CVCL_1531
  
  DOI: 10.1016/j.bbadis.2025.167859
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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sciencedirect.com/science/article/pii/S0925443925002042
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models

1
1. scibot 07 Feb 2025
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1158/2767-9764.CRC-24-0411
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11795354/
Dec 2024
www.sciencedirect.com www.sciencedirect.com

RNA sensing induced by chromosome missegregation augments anti-tumor immunity

1
1. scibot 21 Dec 2024
  
  in Public
  
  ATCCCRL-5985
  
  DOI: 10.1016/j.molcel.2024.11.025
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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scibot

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sciencedirect.com/science/article/pii/S109727652400950X
Oct 2024
www.sciencedirect.com www.sciencedirect.com

Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer

1
1. scibot 09 Oct 2024
  
  in Public
  
  Cat# CRL-5985
  
  DOI: 10.1016/j.chembiol.2024.09.004
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @vtello
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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scibot

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sciencedirect.com/science/article/pii/S2451945624003969
aacrjournals.org aacrjournals.org

ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

1
1. scibot 02 Oct 2024
  
  in Public
  
  RRID: CVCL_1531
  
  DOI: 10.1158/1535-7163.MCT-20-0909
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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scibot

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aacrjournals.org/mct/article/20/10/1757/665735/ASTX029-a-Novel-Dual-mechanism-ERK-Inhibitor
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors

1
1. scibot 21 Aug 2024
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1158/1078-0432.CCR-24-0096
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11325149/
May 2024
www.sciencedirect.com www.sciencedirect.com

Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

1
1. scibot 23 May 2024
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.xcrm.2024.101578
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S2666379124002702
Mar 2024
www.sciencedirect.com www.sciencedirect.com

FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis

1
1. scibot 22 Mar 2024
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.molcel.2024.02.037
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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URL

sciencedirect.com/science/article/pii/S1097276524001801
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

1
1. scibot 03 Feb 2024
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.isci.2024.108858
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC10830871/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies

1
1. scibot 19 Jan 2024
  
  in Public
  
  CVCL_1531
  
  DOI: 10.1038/s41698-023-00423-7
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @anisehay
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC10421872/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Phosphoprotein dynamics of interacting T cells and tumor cells by HySic

2
1. scibot 29 Dec 2023
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.celrep.2023.113598
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531
2. scibot 29 Dec 2023
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.celrep.2023.113598
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S2211124723016108
Nov 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment

1
1. scibot 12 Nov 2023
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1002/ijc.34783
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/ijc.34783
Apr 2023
www.mdpi.com www.mdpi.com

TEAD Inhibitors Sensitize KRASG12C Inhibitors via Dual Cell Cycle Arrest in KRASG12C-Mutant NSCLC

1
1. scibot 20 Apr 2023
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.3390/ph16040553
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

mdpi.com/1424-8247/16/4/553
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AZD4625 is a Potent and Selective Inhibitor of KRASG12C

1
1. scibot 12 Jan 2023
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1158/1535-7163.MCT-22-0241
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9538594/
Sep 2022
www.sciencedirect.com www.sciencedirect.com

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

1
1. scibot 24 Sep 2022
  
  in Public
  
  CRL-5985
  
  DOI: 10.1016/j.ccell.2022.08.015
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S1535610822003798
Jul 2022
www.sciencedirect.com www.sciencedirect.com

FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma

1
1. scibot 15 Jul 2022
  
  in Public
  
  ATCCCat#CRL-5985
  
  DOI: 10.1016/j.devcel.2022.06.017
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S1534580722004580
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes

1
1. scibot 14 Apr 2022
  
  in Public
  
  CVCL_1531
  
  DOI: 10.1016/j.celrep.2022.110636
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722003886
Mar 2022
www.sciencedirect.com www.sciencedirect.com

AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

1
1. scibot 18 Mar 2022
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.xcrm.2022.100554
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S266637912200060X
Jul 2021
www.sciencedirect.com www.sciencedirect.com

ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors

1
1. scibot 22 Jul 2021
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.xcrm.2021.100350
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S2666379121001993
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells

1
1. scibot 01 Jul 2021
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.18632/oncotarget.27989
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8238250/
May 2021
www.sciencedirect.com www.sciencedirect.com

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

1
1. scibot 07 May 2021
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.molcel.2020.10.010
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
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  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S1097276520306936
www.sciencedirect.com www.sciencedirect.com

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

1
1. scibot 01 May 2021
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1016/j.cmet.2021.02.001
  
  Resource: (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

sciencedirect.com/science/article/pii/S1550413121000577
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

1
1. scibot 27 Oct 2020
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.7554/eLife.58108
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531 RRIDCUR:Validated
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RRID:CVCL_1531

RRIDCUR:Validated

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7556868/
Sep 2020
elifesciences.org elifesciences.org

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

1
1. scibot 15 Sep 2020
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.7554/eLife.53367
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531 RRIDCUR:Validated
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RRID:CVCL_1531

RRIDCUR:Validated

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scibot

URL

elifesciences.org/articles/53367
Aug 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Novel engineered TRAIL‐based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance

1
1. scibot 17 Aug 2020
  
  in Public
  
  RRID:CVCL_1531
  
  DOI: 10.1002/ijc.32845
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1531
  
  Curator comments: NCI-H2122 cell line ATCC Cat# CRL-5985
  
  What is this?
  
  RRID:CVCL_1531
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RRID:CVCL_1531

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/ijc.32845
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

1
1. scibot 13 Jan 2020
  
  in Public
  
  CVCL_1531
  
  DOI: 10.1016/j.cmet.2019.11.012
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @ethanbadger
  
  SciCrunch record: CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531 RRIDCUR:Validated
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RRID:CVCL_1531

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119306199
www.sciencedirect.com www.sciencedirect.com

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

1
1. scibot 13 Jan 2020
  
  in Public
  
  CVCL_1531
  
  DOI: 10.1016/j.cmet.2019.01.020
  
  Resource: (KCLB Cat# 92122, RRID:CVCL_1531)
  
  Curator: @ethanbadger
  
  SciCrunch record: CVCL_1531
  
  What is this?
  
  RRID:CVCL_1531 RRIDCUR:Validated
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RRID:CVCL_1531

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119300208
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL-5985
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  SciCrunch record: RRID:CVCL_1531
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1531 RRIDCUR:Missing
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RRID:CVCL_1531

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1535610818303696
www.sciencedirect.com www.sciencedirect.com

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL-5985
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  SciCrunch record: RRID:CVCL_1531
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1531 RRIDCUR:Missing
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RRID:CVCL_1531

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S0092867418300412
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

1
1. scibot 08 Nov 2017
  
  in Public
  
  CRL-5985
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  SciCrunch record: RRID:CVCL_1531
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1531 RRIDCUR:Missing
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RRID:CVCL_1531

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S0092867417310474
www.sciencedirect.com www.sciencedirect.com

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

1
1. scibot 08 Nov 2017
  
  in Public
  
  NCI-H2122ATCCCat#CRL-5985
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-5985, RRID:CVCL_1531)
  
  SciCrunch record: RRID:CVCL_1531
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1531 RRIDCUR:Missing
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RRID:CVCL_1531

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1097276517304069