152 Matching Annotations
  1. Last 7 days
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    Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors
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    sciencedirect.com/science/article/pii/S1074761326002578
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exosome-like biogenesis from the Golgi releases extracellular vesicles lacking conventional tetraspanins that mediate immune evasion in cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13192941/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131474/
  6. May 2026
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    Constitutive EGFR activation induced by PTPRR downregulation confers resistance to KRAS inhibitors
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    aacrjournals.org/cancerrescommun/article/6/4/728/781786/Constitutive-EGFR-Activation-Induced-by-PTPRR
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    Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis
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    sciencedirect.com/science/article/pii/S221112472600416X
  9. Apr 2026
  10. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A covalent molecular glue hijacks the E3 ligase MKRN2 to degrade the ribosomal protein RPS7 and induce synthetic lethality in p53-deficient NSCLC cells
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70434
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    mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway
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    sciencedirect.com/science/article/pii/S1097276526001954
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    Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs
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    pmc.ncbi.nlm.nih.gov/articles/PMC13055633/
  13. Mar 2026
  14. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    E2A selectively regulates TGF-β–induced apoptosis in KRAS-mutant non-small cell lung cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70236
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    UFMylation-dependent inhibition of AKT signaling by PHLDA3 in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124726002329
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    Identification and characterization of BRAF⇔TP53 interactions in melanoma
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    sciencedirect.com/science/article/pii/S2211124726001567
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    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12983336/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wildtype RAS Activation in Non-Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12962340/
  20. Feb 2026
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    High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay
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    Covalent modification of a glutamic acid inspired by HaloTag technology
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  23. Jan 2026
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    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
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    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
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    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
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    Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan-cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70205
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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  29. www.biorxiv.org www.biorxiv.org
    A Pan-Cancer Single-Cell Compendium of Intratumoural Heterogeneity
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    biorxiv.org/content/10.64898/2026.01.06.693992v1
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer
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  32. Dec 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SMURF2 facilitates GAP17 Isoform 1 membrane displacement to promote mutant p53-KRAS oncogenic synergy
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  34. Nov 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors
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    Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells
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    FOSL2-induced transcriptional activation of L1CAM promotes progression of lung adenocarcinoma via the PI3K/AKT/mTOR signaling pathway
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    Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma
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  39. Oct 2025
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    Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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  42. Sep 2025
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    RAD21-mediated epigenetic regulation promotes lung adenocarcinoma progression and sensitizes cancer cells to ERK-targeted therapy
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  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In situ RAS:RAF binding correlates with response to KRASG12C inhibitors in KRASG12C-mutant non–small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11924342/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKN2 is a dependency of the mesenchymal-like cancer cell state
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  46. Aug 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Smoking carcinogen induced inflammation promotes lung carcinogenesis via IRAK4 activation
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of DB-1419, a Novel Bifunctional and Bispecific Anti–B7-H3 × PD-L1 Antibody–Drug Conjugate
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    Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617988/
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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  51. Jul 2025
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
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    RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations
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    KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
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    Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
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    science.org/doi/10.1126/sciimmunol.adr1105
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
  57. Jun 2025
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    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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  60. May 2025
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  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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  63. Apr 2025
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    Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation
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  66. Mar 2025
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    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
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    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape
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  70. Feb 2025
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic mutant KRAS inhibition through oxidation at cysteine 118
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  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
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  74. Jan 2025
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C–MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies
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  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Efficacy of CBP/p300 Dual Inhibitors against De-repression of KREMEN2 in cBAF-Deficient Cancers
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    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2
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  78. Dec 2024
  79. www.nature.com www.nature.com
    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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  81. Oct 2024
  82. www.sciencedirect.com www.sciencedirect.com
    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
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    sciencedirect.com/science/article/pii/S2451945624003969
  83. Aug 2024
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    Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic alterations predict poor efficacy, outcomes and resistance to second-line osimertinib treatment in non-small cell lung cancer
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  86. May 2024
  87. www.sciencedirect.com www.sciencedirect.com
    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergy of EGFR and AURKA Inhibitors in KRAS-mutated Non–small Cell Lung Cancers
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  89. Apr 2024
  90. aacrjournals.org aacrjournals.org
    The immune suppressor IGSF1 as a potential target for cancer immunotherapy
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    aacrjournals.org/cancerimmunolres/article/12/4/491/741941/The-Immune-Suppressor-IGSF1-as-a-Potential-Target
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    A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8
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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983104/
  93. Mar 2024
  94. www.sciencedirect.com www.sciencedirect.com
    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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  95. Feb 2024
  96. aacrjournals.org aacrjournals.org
    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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    aacrjournals.org/clincancerres/article/30/3/506/733551/First-in-Human-Study-with-Preclinical-Data-of-BCL
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    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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  99. Jan 2024
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Griseofulvin Radiosensitizes Non-Small Cell Lung Cancer Cells and Activates cGAS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10073282/
  101. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FBXL16 promotes cell growth and drug resistance in lung adenocarcinomas with KRAS mutation by stabilizing IRS1 and upregulating IRS1/AKT signaling
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13554
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    UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10790128/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies
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  105. www.mdpi.com www.mdpi.com
    β-Caryophyllene Inhibits Endothelial Tube Formation by Modulating the Secretome of Hypoxic Lung Cancer Cells—Possible Role of VEGF Downregulation
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    mdpi.com/1422-0067/25/2/810
  106. Dec 2023
  107. www.sciencedirect.com www.sciencedirect.com
    Phosphoprotein dynamics of interacting T cells and tumor cells by HySic
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  108. Nov 2023
  109. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  110. Oct 2023
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