90 Matching Annotations
  1. Last 7 days
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    Reprogramming endocytic trafficking of antibody–drug conjugates to enhance tumor penetration and lysosomal delivery
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    sciencedirect.com/science/article/pii/S0168365926009235
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    Fatty acid-derived dicarboxylic acid modification mitigates human epidermal growth factor receptor 2-targeted antibody–drug conjugate-induced interstitial lung disease
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    sciencedirect.com/science/article/pii/S0168365926009120
  4. Sep 2026
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    Spontaneous lytic reactivation drives a persistent B cell-vector pathway for epithelial dissemination of the Epstein-Barr virus
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    sciencedirect.com/science/article/pii/S221112472601096X
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    Mitigating HER2-targeted antibody‒drug conjugate-induced interstitial lung disease through Fc-region glycosylation engineering
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    sciencedirect.com/science/article/pii/S2211383526005915
  7. Jul 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Yes-Associated Protein Drives Helicobacter pylori–Induced Metaplastic Changes in Gastric Epithelium
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    pmc.ncbi.nlm.nih.gov/articles/PMC13324660/
  9. www.nature.com www.nature.com
    A novel circSLIT2-encoded SLIT2 isoform suppresses neural invasion in gastric cancer
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    nature.com/articles/s41388-026-03873-y
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ubiquitin Specific Peptidase 48 Deubiquitinates METTL3 to Modulate Ferroptosis in Gastric Cancer Cells
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    onlinelibrary.wiley.com/doi/10.1002/mc.70145
  11. Jun 2026
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    Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors
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    sciencedirect.com/science/article/pii/S2666379126003022
  13. aacrjournals.org aacrjournals.org
    UBE2B Drives NF-κB Signaling and Gastric Cancer Progression through BIRC2-Mediated K63-Linked Ubiquitination of TRAF1
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    aacrjournals.org/mcr/article/24/6/487/785398/UBE2B-Drives-NF-B-Signaling-and-Gastric-Cancer
  14. May 2026
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bi-functional anti-LAG-3-IL-2c enhances immune checkpoint inhibitor and CAR T-cell therapy for cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13186045/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GAL3ST1-Mediated Histone Tyrosine Sulfation Induced by Cancer-Associated Fibroblasts Promotes Gastric Cancer Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13176828/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pertuzumab Enhances the Antitumor Activity of T-DXd in HER2-Positive Gastric Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136884/
  18. Apr 2026
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The vesicle transport gene SEC23A is a novel prognostic indicator and therapeutic target in gastric cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13111058/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Moderate-Affinity Antibody–Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13118972/
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    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70248
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Salinomycin as a death switch: how gastric cancer cells choose their demise
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    pmc.ncbi.nlm.nih.gov/articles/PMC13040004/
  23. aacrjournals.org aacrjournals.org
    DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity
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    aacrjournals.org/mct/article/25/1/7/771286/DS-3939a-A-TA-MUC1-Directed-Antibody-Drug
  24. Mar 2026
  25. www.sciencedirect.com www.sciencedirect.com
    Antigen-induced IL-12 potentiates piggyBac-engineered HER2-CAR-T cells against gastric cancer
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    sciencedirect.com/science/article/pii/S1567576926002973
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bioorthogonal catalytic centres engineered for gastrointestinal stabilization provide oral delivery for the treatment of gastric cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12980911/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo Auto-tuning of Antibody-Drug Conjugate Delivery to Maximize Efficacy using High-Avidity, Low-Affinity Antibodies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12964248/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubenimex synergizes with the PD-L1 blockade in gastric cancer by competitively binding LAP3 with UBE3A
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    pmc.ncbi.nlm.nih.gov/articles/PMC12960727/
  29. Feb 2026
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OSMR coordinates a self-perpetuating circuit linking chemoresistance and neutrophil-driven immunosuppression in gastric cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12906089/
  31. Jan 2026
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates
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    pmc.ncbi.nlm.nih.gov/articles/PMC12820277/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer
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  34. Nov 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCL26–CX3CR1 Axis Mediates a Feedback Loop between Cancer Cell and PMN-MDSCs to Promote CD8+ T Cell Exhaustion during Stomach Carcinogenesis
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  36. Sep 2025
  37. www.sciencedirect.com www.sciencedirect.com
    Pan-carcinoma sialyl-Tn-targeting expands CAR therapy to solid tumors
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  38. Aug 2025
  39. www.sciencedirect.com www.sciencedirect.com
    Imaging and targeting S1PR1 in HER2+ tumors
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    sciencedirect.com/science/article/pii/S0969805125000666
  40. Jul 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Histone Deacetylase Inhibitor Entinostat Mediates HER2 Downregulation in Gastric Cancer, Providing the Basis for Its Particular Efficacy in HER2-Amplified Tumors and in Combination Therapies
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  42. aacrjournals.org aacrjournals.org
    Development of a Novel DNA Mono-alkylator Platform for Antibody Drug Conjugates
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    aacrjournals.org/mct/article/23/4/541/741864/Development-of-a-Novel-DNA-Mono-alkylator-Platform
  43. Jun 2025
  44. 52.53.155.43 52.53.155.43
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    Preferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy
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    sciencedirect.com/science/article/pii/S1934590925001870
  47. May 2025
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Assessment of the Effects of Single-Domain Anti-Idiotypic Distribution Enhancers on the Disposition of Trastuzumab and on the Efficacy of a PE24-Trastuzumab Immunotoxin
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2+ gastric cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12081668/
  50. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting PTBP3-Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202415983
  51. Apr 2025
  52. www.sciencedirect.com www.sciencedirect.com
    Expression characteristics and biological functions of CGB5 gene in gastric cancer
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    sciencedirect.com/science/article/pii/S0065128125000261
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962393/
  54. Mar 2025
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  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11906863/
  57. Feb 2025
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11847841/
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  60. Jan 2025
  61. www.sciencedirect.com www.sciencedirect.com
    Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat
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    sciencedirect.com/science/article/pii/S1476558624001623
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    The inhibition of SLC8A1 promotes Ca2+-dependent cell death in Gastric Cancer
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  63. Dec 2024
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  65. Oct 2024
  66. aacrjournals.org aacrjournals.org
    Clinical and Immunologic Responses to a B-Cell Epitope Vaccine in Patients with HER2/neu-Overexpressing Advanced Gastric Cancer—Results from Phase Ib Trial IMU.ACS.001
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  67. Sep 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phase II trial of HER-Vaxx, a B cell peptide-based vaccine, in HER2-overexpressing advanced gastric cancer patients under platinum-based chemotherapy (HERIZON)
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    Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
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  70. Aug 2024
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vorinostat Treatment of Gastric Cancer Cells Leads to ROS-Induced Cell Inhibition and a Complex Pattern of Molecular Alterations in Nrf2-Dependent Genes
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  72. Jul 2024
  73. www.mdpi.com www.mdpi.com
    Define Critical Parameters of Trastuzumab-Mediated ADCC Assays via Assay Optimization Processes, Focusing on the Impact of Cryopreserved Effector Cells on Assay Performance
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  74. May 2024
  75. aacrjournals.org aacrjournals.org
    Spatiotemporal quantification of HER2-targeting antibody-drug conjugate bystander activity and enhancement of solid tumor penetration
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    aacrjournals.org/clincancerres/article/30/5/984/734305/Spatiotemporal-Quantification-of-HER2-targeting
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    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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  78. Apr 2024
  79. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13654
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting the receptor tyrosine kinase MerTK shows therapeutic value in gastric adenocarcinoma
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    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
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  82. Feb 2024
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    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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    aacrjournals.org/clincancerres/article/30/3/506/733551/First-in-Human-Study-with-Preclinical-Data-of-BCL
  85. www.cell.com www.cell.com
    Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice
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    cell.com/cell/fulltext/S0092-8674(24)00006-0
  86. Jan 2024
  87. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2-positive gastric cancer cells to trastuzumab
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17069
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    Therapeutic antibody targeting natriuretic peptide receptor 1 inhibits gastric cancer growth via BCL-2-mediated intrinsic apoptosis
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.34831
  89. Dec 2023
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel HER2-targeted therapy to overcome trastuzumab resistance in HER2-amplified gastric cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10730520/
  91. Sep 2023
  92. www.sciencedirect.com www.sciencedirect.com
    Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1
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    sciencedirect.com/science/article/pii/S0014482723002628
  93. Aug 2023
  94. 52.53.155.43 52.53.155.43
    Intl Journal of Cancer - 2023 - Cao-html.html
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  95. Jul 2023
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis
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  97. Apr 2023
  98. aacrjournals.org aacrjournals.org
    Payload-binding Fab fragments increase the therapeutic index of MMAE antibody-drug conjugates
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950
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  100. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Ebselen oxide and derivatives are new allosteric HER2 inhibitors for HER2-positive cancers
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13419
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody
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    ncbi.nlm.nih.gov/pmc/articles/PMC10069597/
  102. Feb 2023
  103. www.sciencedirect.com www.sciencedirect.com
    VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer
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    sciencedirect.com/science/article/pii/S2352396423000166
  104. Dec 2022
  105. www.mdpi.com www.mdpi.com
    Alteration of Cellular Energy Metabolism through LPAR2-Axin2 Axis in Gastric Cancer
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    mdpi.com/2218-273X/12/12/1805
  106. Oct 2022
  107. www.nature.com www.nature.com
    Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies
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    nature.com/articles/s41467-022-33282-0
  108. Jul 2022
  109. www.medrxiv.org www.medrxiv.org
    Transcriptomic Profiling on Localized Gastric Cancer Identified CPLX1 as a Gene Promoting Malignant Phenotype of Gastric Cancer and a Predictor of Recurrence after Surgery and Subsequent Chemotherapy
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    medrxiv.org/content/10.1101/2021.03.25.21254204v1
  110. Jun 2022
  111. link.springer.com link.springer.com
    Transcriptomic profiling on localized gastric cancer identified CPLX1 as a gene promoting malignant phenotype of gastric cancer and a predictor of recurrence after surgery and subsequent chemotherapy
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    link.springer.com/article/10.1007/s00535-022-01884-6
  112. Mar 2022
  113. link.springer.com link.springer.com
    Lysosomal-associated membrane protein family member 5 promotes the metastatic potential of gastric cancer cells
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    link.springer.com/article/10.1007/s10120-022-01284-y
  114. Jan 2022
  115. www.dovepress.com www.dovepress.com
    <p>Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells</p>
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    dovepress.com/dynamics-of-endocytosis-and-degradation-of-antibody-drug-conjugate-t-d-peer-reviewed-fulltext-article-DDDT
  116. Jul 2021
  117. mcr.aacrjournals.org mcr.aacrjournals.org
    KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
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    mcr.aacrjournals.org/content/17/9/1945
  118. Local file Local file
    CCR-20-3742 3649..3660
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  119. Jun 2021
  120. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer
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    onlinelibrary.wiley.com/doi/10.1002/ctm2.454
  121. May 2021
  122. www.sciencedirect.com www.sciencedirect.com
    NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells
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    sciencedirect.com/science/article/pii/S2666379121001075
  123. www.mdpi.com www.mdpi.com
    Genetic and Epigenetic Alterations of CDH1 Regulatory Regions in Hereditary and Sporadic Gastric Cancer
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    mdpi.com/1424-8247/14/5/457
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC8079403/
  125. Apr 2021
  126. www.sciencedirect.com www.sciencedirect.com
    Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy
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    sciencedirect.com/science/article/pii/S2451945620302312
  127. Sep 2020
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel HER2-targeting antibody 5G9 identified by large-scale trastuzumab-based screening exhibits potent synergistic antitumor activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC7501074/
  129. mct.aacrjournals.org mct.aacrjournals.org
    ARX788, a Site-specific anti-HER2 Antibody Drug Conjugate, Demonstrates Potent and Selective Activity in HER2 Low and T-DM1 Resistant Breast and Gastric Cancers
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    mct.aacrjournals.org/content/19/9/1833
  130. www.sciencedirect.com www.sciencedirect.com
    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    sciencedirect.com/science/article/pii/S2211124720308214
  131. Jan 2020
  132. onlinelibrary.wiley.com onlinelibrary.wiley.com
    EphA2‐to‐YAP Pathway Drives Gastric Cancer Growth and Therapy Resistance
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32609
  133. Nov 2018
  134. www.sciencedirect.com www.sciencedirect.com
    Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery
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    sciencedirect.com/science/article/pii/S1931312817303931
  135. www.sciencedirect.com www.sciencedirect.com
    Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
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    sciencedirect.com/science/article/pii/S1535610818301740