Hypothesis

16 Matching Annotations

Aug 2025
www.sciencedirect.com www.sciencedirect.com

A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers

1
1. scibot 08 Aug 2025
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1016/j.ccell.2025.07.006
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
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  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

sciencedirect.com/science/article/pii/S1535610825003101
Jul 2025
www.sciencedirect.com www.sciencedirect.com

KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

1
1. scibot 17 Jul 2025
  
  in Public
  
  ATCCCRL-2170
  
  DOI: 10.1016/j.ccell.2025.06.011
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

sciencedirect.com/science/article/pii/S1535610825002612
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312

1
1. scibot 21 May 2025
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1158/2767-9764.CRC-25-0001
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models

1
1. scibot 07 Feb 2025
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1158/2767-9764.CRC-24-0411
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11795354/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

1
1. scibot 04 Jan 2025
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.7554/eLife.89638
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11668523/
May 2024
www.sciencedirect.com www.sciencedirect.com

Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

1
1. scibot 23 May 2024
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1016/j.xcrm.2024.101578
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

sciencedirect.com/science/article/pii/S2666379124002702
Jan 2024
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FBXL16 promotes cell growth and drug resistance in lung adenocarcinomas with KRAS mutation by stabilizing IRS1 and upregulating IRS1/AKT signaling

1
1. scibot 25 Jan 2024
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1002/1878-0261.13554
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13554
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies

1
1. scibot 19 Jan 2024
  
  in Public
  
  CVCL_1720
  
  DOI: 10.1038/s41698-023-00423-7
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10421872/
Oct 2022
www.sciencedirect.com www.sciencedirect.com

Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer

1
1. scibot 05 Oct 2022
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1016/j.celrep.2022.111443
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722012840
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

1
1. scibot 23 Aug 2022
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1016/j.molcel.2022.07.014
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

sciencedirect.com/science/article/pii/S1097276522007109
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Oncogene-dependent sloppiness in mRNA translation

1
1. scibot 25 Sep 2021
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1016/j.molcel.2021.09.002
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

sciencedirect.com/science/article/pii/S109727652100736X
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

1
1. scibot 30 Jul 2021
  
  in Public
  
  SW1573
  
  DOI: 10.1016/j.ccell.2019.07.002
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1720

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610819303290
www.sciencedirect.com www.sciencedirect.com

Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

1
1. scibot 22 Jul 2021
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.1016/j.ccell.2021.06.016
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720
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RRID:CVCL_1720

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scibot

URL

sciencedirect.com/science/article/pii/S153561082100338X
Sep 2020
elifesciences.org elifesciences.org

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

1
1. scibot 25 Sep 2020
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.7554/eLife.53618
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1720
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RRID:CVCL_1720

RRIDCUR:Validated

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scibot

URL

elifesciences.org/articles/53618
elifesciences.org elifesciences.org

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

1
1. scibot 14 Sep 2020
  
  in Public
  
  RRID:CVCL_1720
  
  DOI: 10.7554/eLife.53367
  
  Resource: (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1720
  
  What is this?
  
  RRID:CVCL_1720 RRIDCUR:Validated
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RRID:CVCL_1720

RRIDCUR:Validated

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scibot

URL

elifesciences.org/articles/53367
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

1
1. scibot 05 Nov 2018
  
  in Public
  
  CRL-2170
  
  Curator: @Jmenke
  
  Resource used:
  
  (ATCC Cat# CRL-2170, RRID:CVCL_1720)
  
  SciCrunch record: RRID:CVCL_1720
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1720 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1720

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0092867418300412