60 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080325/
  3. Apr 2026
  4. www.biorxiv.org www.biorxiv.org
    Oncogenic RAS-driven α2 integrin induction under nutrient stress promotes cancer cell motility
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    biorxiv.org/content/10.64898/2026.04.02.716145v1
  5. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202503162RR
  6. Mar 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13003987/
  8. www.sciencedirect.com www.sciencedirect.com
    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
  9. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000777
  10. Feb 2026
  11. www.sciencedirect.com www.sciencedirect.com
    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    sciencedirect.com/science/article/pii/S0092867425015028
  12. www.sciencedirect.com www.sciencedirect.com
    USP20–RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake
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    sciencedirect.com/science/article/pii/S0304383526000625
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859075/
  14. Jan 2026
  15. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
  16. Dec 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  19. Nov 2025
  20. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  21. Oct 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  23. Sep 2025
  24. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511726
  25. Aug 2025
  26. www.sciencedirect.com www.sciencedirect.com
    A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2666379125003659
  27. Jul 2025
  28. www.sciencedirect.com www.sciencedirect.com
    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124725007818
  29. May 2025
  30. www.nature.com www.nature.com
    HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
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    nature.com/articles/s41467-025-60129-1
  31. Apr 2025
  32. www.sciencedirect.com www.sciencedirect.com
    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0304383525002794
  33. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  34. Dec 2024
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    B7-H3–Targeted CAR-Vδ1T Cells Exhibit Potent Broad-Spectrum Activity against Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11609632/
  36. Oct 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11448066/
  38. Aug 2024
  39. www.sciencedirect.com www.sciencedirect.com
    A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124724009835
  40. transmedcomms.biomedcentral.com transmedcomms.biomedcentral.com
    iMN041 is an immunotherapeutic and an effective treatment in mouse xenograft models of pancreatic cancer, renal cancer and triple negative breast cancer
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    transmedcomms.biomedcentral.com/articles/10.1186/s41231-024-00161-3
  41. aacrjournals.org aacrjournals.org
    MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
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    aacrjournals.org/mcr/article/21/5/444/726027/MYC-Glutamine-Dependency-Is-a-Therapeutic
  42. Jul 2024
  43. 52.53.155.43 52.53.155.43
    Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway
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    52.53.155.43/3dc7aeecc5cd1b453f882be50c33db8a703a1bae/1-s2.0-S2589004224018236-main-html.html
  44. www.cell.com www.cell.com
    Pan-cancer proteogenomics expands the landscape of therapeutic targets
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    cell.com/cell/fulltext/S0092-8674(24)00583-X
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11238362/
  46. Apr 2024
  47. jhoonline.biomedcentral.com jhoonline.biomedcentral.com
    Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
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    jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01538-5
  48. Feb 2024
  49. 52.53.155.43 52.53.155.43
    176-html.html
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    52.53.155.43/2ec0d88e67b798a89b6c5516dbe547b3b2c5ce80/176-html.html
  50. aacrjournals.org aacrjournals.org
    Mitochondrial translocase TOMM22 is overexpressed in pancreatic cancer and promotes aggressive growth by modulating mitochondrial protein import and function
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    aacrjournals.org/mcr/article/22/2/197/733695/Mitochondrial-Translocase-TOMM22-Is-Overexpressed
  51. www.sciencedirect.com www.sciencedirect.com
    Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy
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    sciencedirect.com/science/article/abs/pii/S0304383524000892
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nudt21-mediated alternative polyadenylation of MZT1 3’UTR contributes to pancreatic cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831950/
  53. Jan 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vitamin B6 competition in the tumor microenvironment hampers antitumor functions of NK cells.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784745/
  55. Dec 2023
  56. 52.53.155.43 52.53.155.43
    mcr-23-0138-html.html
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    52.53.155.43/35aec9dc6d388b7cf372e8caf56749d4ccbc7935/mcr-23-0138-html.html
  57. Nov 2023
  58. www.sciencedirect.com www.sciencedirect.com
    In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin
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    sciencedirect.com/science/article/pii/S2451945623003252
  59. www.embopress.org www.embopress.org
    MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
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    embopress.org/doi/full/10.15252/embj.2023114558
  60. Sep 2023
  61. www.sciencedirect.com www.sciencedirect.com
    Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/abs/pii/S0304383523003622
  62. Jun 2023
  63. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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    aacrjournals.org/cancerres/article/83/5/735/716680/Enhanced-Glutaminolysis-Drives-Hypoxia-Induced
  64. May 2023
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
  66. Dec 2022
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Cell Derived Exosomal GOT1 Suppresses Tumor Cell Ferroptosis to Accelerate Pancreatic Cancer Progression by Activating Nrf2/HO-1 Axis via Upregulating CCR2 Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9735520/
  68. Jun 2022
  69. www.sciencedirect.com www.sciencedirect.com
    GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1424390322001983
  70. Mar 2022
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
  72. cmbl.biomedcentral.com cmbl.biomedcentral.com
    TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis
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    cmbl.biomedcentral.com/articles/10.1186/s11658-022-00321-z
  73. Dec 2021
  74. www.sciencedirect.com www.sciencedirect.com
    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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    sciencedirect.com/science/article/pii/S2211124721015461
  75. Aug 2021
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Role of Long Noncoding RNA AL161431.1 in the Development and Progression of Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8363261/
  77. Jul 2021
  78. www.sciencedirect.com www.sciencedirect.com
    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    sciencedirect.com/science/article/pii/S153458071930485X
  79. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    sciencedirect.com/science/article/pii/S1535610818304677
  80. Jun 2021
  81. www.sciencedirect.com www.sciencedirect.com
    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    sciencedirect.com/science/article/pii/S2211124721006628
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA ELFN1-AS1 in the pathogenesis of pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8184490/
  83. May 2021
  84. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15435
  85. www.sciencedirect.com www.sciencedirect.com
    SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
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    sciencedirect.com/science/article/pii/S1097276521002690
  86. www.sciencedirect.com www.sciencedirect.com
    Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis
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    sciencedirect.com/science/article/pii/S1550413121001108
  87. Apr 2021
  88. www.sciencedirect.com www.sciencedirect.com
    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0092867420313222
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA PART1 predicts a poor prognosis and promotes the malignant progression of pancreatic cancer by sponging miR-122
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    ncbi.nlm.nih.gov/pmc/articles/PMC8053290/
  90. Nov 2020
  91. www.authorea.com www.authorea.com
    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    authorea.com/users/368637/articles/487712-natural-product-trienomycin-a-is-a-stat3-pathway-inhibitor-that-exhibits-potent-in-vitro-and-in-vivo-efficacy-against-pancreatic-cancer
  92. Sep 2020
  93. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    sciencedirect.com/science/article/pii/S2211124720307440
  94. Nov 2018
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of RBF1 changes glutamine catabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC3566311/