73 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquisition of resistance to RAS inhibition is associated with the upregulation of macropinocytosis through both PI3K-dependent and -independent signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13410306/
  3. Jul 2026
  4. www.sciencedirect.com www.sciencedirect.com
    HDAC5 depletion promotes hyper-acetylation of FOXA1 and potentiates HIF1α transcriptional activation in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1097276526004119
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13324344/
  6. Jun 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic vulnerabilities exposed by the 9p21 loss identified through multiparametric drug screening inform rational combination strategies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13276166/
  8. aacrjournals.org aacrjournals.org
    Overcoming adaptive resistance to KRASG12D blockade in pancreatic cancer through vertical pathway inhibition
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    aacrjournals.org/clincancerres/article/32/11/2279/785357/Overcoming-Adaptive-Resistance-to-KRASG12D
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A malignant subpopulation of H2AFZ+ cells interacts with myeloid cells to promote an anti-inflammatory microenvironment and drive hepatic metastasis, revealing an immunotherapeutic strategy for pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266339/
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    Mapping cell type-resolved transcriptomic profiles to patient survival in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610826002576
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    SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124726004651
  12. May 2026
  13. www.sciencedirect.com www.sciencedirect.com
    Targeting ADAR1 p150 triggers tumor inhibition and antitumor immunity to overcome immunotherapy resistance
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    sciencedirect.com/science/article/pii/S2589004226013532
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    Integrative multi-omics analysis identifies ATAD1 as a potential regulator of metastasis in pancreatic cancer
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    nature.com/articles/s41598-026-52051-3
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM15-Mediated m6A Modification Regulates Proliferation and Migration of Pancreatic Cancer Cells via the lncRNA LINC01320/miR-1287-5p/FBXO11 Axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13149094/
  16. Apr 2026
  17. www.sciencedirect.com www.sciencedirect.com
    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S221112472600392X
  18. 54.241.53.176 54.241.53.176
    cd-25-1346-html.html
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  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080325/
  20. www.biorxiv.org www.biorxiv.org
    Oncogenic RAS-driven α2 integrin induction under nutrient stress promotes cancer cell motility
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    biorxiv.org/lookup/doi/10.64898/2026.04.02.716145
  21. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202503162RR
  22. Mar 2026
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13003987/
  24. www.sciencedirect.com www.sciencedirect.com
    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
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    Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000777
  26. Feb 2026
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    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    sciencedirect.com/science/article/pii/S0092867425015028
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    USP20–RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake
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    sciencedirect.com/science/article/pii/S0304383526000625
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859075/
  30. Jan 2026
  31. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
  32. Dec 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  35. Nov 2025
  36. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  37. Oct 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  39. Sep 2025
  40. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511726
  41. Aug 2025
  42. www.sciencedirect.com www.sciencedirect.com
    A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2666379125003659
  43. Jul 2025
  44. www.sciencedirect.com www.sciencedirect.com
    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124725007818
  45. May 2025
  46. www.nature.com www.nature.com
    HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
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    nature.com/articles/s41467-025-60129-1
  47. Apr 2025
  48. www.sciencedirect.com www.sciencedirect.com
    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0304383525002794
  49. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  50. Dec 2024
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    B7-H3–Targeted CAR-Vδ1T Cells Exhibit Potent Broad-Spectrum Activity against Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11609632/
  52. Oct 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11448066/
  54. Aug 2024
  55. www.sciencedirect.com www.sciencedirect.com
    A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124724009835
  56. transmedcomms.biomedcentral.com transmedcomms.biomedcentral.com
    iMN041 is an immunotherapeutic and an effective treatment in mouse xenograft models of pancreatic cancer, renal cancer and triple negative breast cancer
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    transmedcomms.biomedcentral.com/articles/10.1186/s41231-024-00161-3
  57. aacrjournals.org aacrjournals.org
    MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
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    aacrjournals.org/mcr/article/21/5/444/726027/MYC-Glutamine-Dependency-Is-a-Therapeutic
  58. Jul 2024
  59. 52.53.155.43 52.53.155.43
    Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway
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    52.53.155.43/3dc7aeecc5cd1b453f882be50c33db8a703a1bae/1-s2.0-S2589004224018236-main-html.html
  60. www.cell.com www.cell.com
    Pan-cancer proteogenomics expands the landscape of therapeutic targets
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    cell.com/cell/fulltext/S0092-8674(24)00583-X
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11238362/
  62. Apr 2024
  63. jhoonline.biomedcentral.com jhoonline.biomedcentral.com
    Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
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    jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01538-5
  64. Feb 2024
  65. 52.53.155.43 52.53.155.43
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  66. aacrjournals.org aacrjournals.org
    Mitochondrial translocase TOMM22 is overexpressed in pancreatic cancer and promotes aggressive growth by modulating mitochondrial protein import and function
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    aacrjournals.org/mcr/article/22/2/197/733695/Mitochondrial-Translocase-TOMM22-Is-Overexpressed
  67. www.sciencedirect.com www.sciencedirect.com
    Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy
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    sciencedirect.com/science/article/abs/pii/S0304383524000892
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nudt21-mediated alternative polyadenylation of MZT1 3’UTR contributes to pancreatic cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831950/
  69. Jan 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vitamin B6 competition in the tumor microenvironment hampers antitumor functions of NK cells.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784745/
  71. Dec 2023
  72. 52.53.155.43 52.53.155.43
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  73. Nov 2023
  74. www.sciencedirect.com www.sciencedirect.com
    In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin
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    sciencedirect.com/science/article/pii/S2451945623003252
  75. www.embopress.org www.embopress.org
    MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
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    embopress.org/doi/full/10.15252/embj.2023114558
  76. Sep 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/abs/pii/S0304383523003622
  78. Jun 2023
  79. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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    aacrjournals.org/cancerres/article/83/5/735/716680/Enhanced-Glutaminolysis-Drives-Hypoxia-Induced
  80. May 2023
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
  82. Dec 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Cell Derived Exosomal GOT1 Suppresses Tumor Cell Ferroptosis to Accelerate Pancreatic Cancer Progression by Activating Nrf2/HO-1 Axis via Upregulating CCR2 Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9735520/
  84. Jun 2022
  85. www.sciencedirect.com www.sciencedirect.com
    GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1424390322001983
  86. Mar 2022
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
  88. cmbl.biomedcentral.com cmbl.biomedcentral.com
    TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis
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    cmbl.biomedcentral.com/articles/10.1186/s11658-022-00321-z
  89. Dec 2021
  90. www.sciencedirect.com www.sciencedirect.com
    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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    sciencedirect.com/science/article/pii/S2211124721015461
  91. Aug 2021
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Role of Long Noncoding RNA AL161431.1 in the Development and Progression of Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8363261/
  93. Jul 2021
  94. www.sciencedirect.com www.sciencedirect.com
    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    sciencedirect.com/science/article/pii/S153458071930485X
  95. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    sciencedirect.com/science/article/pii/S1535610818304677
  96. Jun 2021
  97. www.sciencedirect.com www.sciencedirect.com
    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    sciencedirect.com/science/article/pii/S2211124721006628
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA ELFN1-AS1 in the pathogenesis of pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8184490/
  99. May 2021
  100. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15435
  101. www.sciencedirect.com www.sciencedirect.com
    SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
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    sciencedirect.com/science/article/pii/S1097276521002690
  102. www.sciencedirect.com www.sciencedirect.com
    Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis
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    sciencedirect.com/science/article/pii/S1550413121001108
  103. Apr 2021
  104. www.sciencedirect.com www.sciencedirect.com
    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0092867420313222
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA PART1 predicts a poor prognosis and promotes the malignant progression of pancreatic cancer by sponging miR-122
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    ncbi.nlm.nih.gov/pmc/articles/PMC8053290/
  106. Nov 2020
  107. www.authorea.com www.authorea.com
    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    authorea.com/users/368637/articles/487712-natural-product-trienomycin-a-is-a-stat3-pathway-inhibitor-that-exhibits-potent-in-vitro-and-in-vivo-efficacy-against-pancreatic-cancer
  108. Sep 2020
  109. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    sciencedirect.com/science/article/pii/S2211124720307440
  110. Nov 2018
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of RBF1 changes glutamine catabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC3566311/