27 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 Overexpression Abrogates ST6GAL1 Mediated Rectal Cancer Chemoradiation Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC13321710/
  3. Jun 2026
  4. pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com
    Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights
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    pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.70087
  5. www.sciencedirect.com www.sciencedirect.com
    Distinct ERK and PI3K dependencies mediate a heterogeneous response to RAS(ON) inhibition in KRAS-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726006376
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WEE1 kinase inhibition to overcome acquired resistance to targeted therapies in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13269805/
  7. May 2026
  8. aacrjournals.org aacrjournals.org
    Constitutive EGFR activation induced by PTPRR downregulation confers resistance to KRAS inhibitors
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    aacrjournals.org/cancerrescommun/article/6/4/728/781786/Constitutive-EGFR-Activation-Induced-by-PTPRR
  9. www.sciencedirect.com www.sciencedirect.com
    Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis
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    sciencedirect.com/science/article/pii/S221112472600416X
  10. Apr 2026
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13060645/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13042376/
  13. Dec 2025
  14. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases
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    sciencedirect.com:5037/science/article/pii/S266700542500122X
  15. www.nature.com www.nature.com
    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
  16. Nov 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit
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    pmc.ncbi.nlm.nih.gov/articles/PMC12827889/
  18. Sep 2025
  19. www.sciencedirect.com www.sciencedirect.com
    Chemotherapy modulation by a cancer-associated microbiota metabolite
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    sciencedirect.com/science/article/pii/S2405471225002303
  20. Jul 2025
  21. www.sciencedirect.com www.sciencedirect.com
    Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
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    sciencedirect.com/science/article/pii/S266637912500326X
  22. May 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
  24. Feb 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11795354/
  26. Aug 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310748/
  28. Jan 2024
  29. www.sciencedirect.com www.sciencedirect.com
    A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
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    sciencedirect.com/science/article/pii/S1535610823004440
  30. Sep 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AMT-562, a novel HER3-targeting antibody drug conjugate, demonstrates a potential to broaden therapeutic opportunities for HER3-expressing tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10477830/
  32. Jul 2023
  33. 52.53.155.43 52.53.155.43
    mct-23-0198-html.html
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    52.53.155.43/8898fbf5a65a5137143414e835a98a5ee1580728/mct-23-0198-html.html
  34. Jun 2023
  35. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S030438352300215X
  36. www.science.org www.science.org
    Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis
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    science.org/doi/10.1126/sciimmunol.adg3196
  37. Dec 2021
  38. www.sciencedirect.com www.sciencedirect.com
    Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach
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    sciencedirect.com/science/article/pii/S2211124721015904
  39. Apr 2021
  40. www.sciencedirect.com www.sciencedirect.com
    A selective p53 activator and anticancer agent to improve colorectal cancer therapy
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    sciencedirect.com/science/article/pii/S2211124721002965
  41. Sep 2020
  42. cancerres.aacrjournals.org cancerres.aacrjournals.org
    CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer
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    cancerres.aacrjournals.org/content/80/2/334
  43. Nov 2018
  44. www.sciencedirect.com www.sciencedirect.com
    Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
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    sciencedirect.com/science/article/pii/S0092867418300412
  45. Nov 2017
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
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    ncbi.nlm.nih.gov/pmc/articles/PMC5224920/