Hypothesis

22 Matching Annotations

May 2026
aacrjournals.org aacrjournals.org

Constitutive EGFR activation induced by PTPRR downregulation confers resistance to KRAS inhibitors

1
1. scibot 07 May 2026
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1158/2767-9764.CRC-25-0489
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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aacrjournals.org/cancerrescommun/article/6/4/728/781786/Constitutive-EGFR-Activation-Induced-by-PTPRR
www.sciencedirect.com www.sciencedirect.com

Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis

1
1. scibot 06 May 2026
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1016/j.celrep.2026.117338
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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sciencedirect.com/science/article/pii/S221112472600416X
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

1
1. scibot 11 Apr 2026
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1002/1878-0261.70150
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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RRID:CVCL_1729

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC13060645/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

1
1. scibot 04 Apr 2026
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1002/1878-0261.70152
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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pmc.ncbi.nlm.nih.gov/articles/PMC13042376/
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases

1
1. scibot 11 Dec 2025
  
  in Public
  
  RRID: CDCL-1729
  
  DOI: 10.1016/j.jncc.2025.11.003
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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sciencedirect.com:5037/science/article/pii/S266700542500122X
www.nature.com www.nature.com

RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer

1
1. scibot 06 Dec 2025
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1038/s41556-025-01816-5
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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nature.com/articles/s41556-025-01816-5
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit

1
1. scibot 18 Nov 2025
  
  in Public
  
  RRID: CVCL_1729
  
  DOI: 10.1016/j.apsb.2025.11.015
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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pmc.ncbi.nlm.nih.gov/articles/PMC12827889/
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Chemotherapy modulation by a cancer-associated microbiota metabolite

1
1. scibot 11 Sep 2025
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1016/j.cels.2025.101397
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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sciencedirect.com/science/article/pii/S2405471225002303
Jul 2025
www.sciencedirect.com www.sciencedirect.com

Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

1
1. scibot 29 Jul 2025
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1016/j.xcrm.2025.102253
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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sciencedirect.com/science/article/pii/S266637912500326X
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312

1
1. scibot 16 May 2025
  
  in Public
  
  RRID: CVCL_1729
  
  DOI: 10.1158/2767-9764.CRC-25-0001
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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pmc.ncbi.nlm.nih.gov/articles/PMC12076188/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models

1
1. scibot 07 Feb 2025
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1158/2767-9764.CRC-24-0411
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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URL

pmc.ncbi.nlm.nih.gov/articles/PMC11795354/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy

1
1. scibot 21 Aug 2024
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1158/2767-9764.CRC-24-0077
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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RRID:CVCL_1729

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC11310748/
Jan 2024
www.sciencedirect.com www.sciencedirect.com

A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization

1
1. scibot 18 Jan 2024
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1016/j.ccell.2023.12.016
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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RRID:CVCL_1729

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URL

sciencedirect.com/science/article/pii/S1535610823004440
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AMT-562, a novel HER3-targeting antibody drug conjugate, demonstrates a potential to broaden therapeutic opportunities for HER3-expressing tumors

1
1. scibot 07 Sep 2023
  
  in Public
  
  RRID: CVCL_1729
  
  DOI: 10.1158/1535-7163.MCT-23-0198
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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RRID:CVCL_1729

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC10477830/
Jul 2023
52.53.155.43 52.53.155.43

mct-23-0198-html.html

1
1. scibot 13 Jul 2023
  
  in Public
  
  RRID: CVCL_1729
  
  DOI: 10.1158/1535-7163.mct-23-0198
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @olekpark
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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RRID:CVCL_1729

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scibot

URL

52.53.155.43/8898fbf5a65a5137143414e835a98a5ee1580728/mct-23-0198-html.html
Jun 2023
www.sciencedirect.com www.sciencedirect.com

MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells

1
1. scibot 21 Jun 2023
  
  in Public
  
  RRID: CVCL_1729
  
  DOI: 10.1016/j.canlet.2023.216264
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @sofiakhan13
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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RRID:CVCL_1729

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URL

sciencedirect.com/science/article/pii/S030438352300215X
www.science.org www.science.org

Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis

1
1. scibot 02 Jun 2023
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1126/sciimmunol.adg3196
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_1729
  
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  RRID:CVCL_1729
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RRID:CVCL_1729

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scibot

URL

science.org/doi/10.1126/sciimmunol.adg3196
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach

1
1. scibot 15 Dec 2021
  
  in Public
  
  CCL-235
  
  DOI: 10.1016/j.celrep.2021.110096
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1729
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1729
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RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721015904
Apr 2021
www.sciencedirect.com www.sciencedirect.com

A selective p53 activator and anticancer agent to improve colorectal cancer therapy

1
1. scibot 14 Apr 2021
  
  in Public
  
  CCL-235
  
  DOI: 10.1016/j.celrep.2021.108982
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_1729
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_1729
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RRID:CVCL_1729

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721002965
Sep 2020
cancerres.aacrjournals.org cancerres.aacrjournals.org

CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer

1
1. scibot 08 Sep 2020
  
  in Public
  
  RRID:CVCL_1729
  
  DOI: 10.1158/0008-5472.CAN-19-1161
  
  Resource: (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_1729
  
  What is this?
  
  RRIDCUR:Validated RRID:CVCL_1729
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RRID:CVCL_1729

RRIDCUR:Validated

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scibot

URL

cancerres.aacrjournals.org/content/80/2/334
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

1
1. scibot 05 Nov 2018
  
  in Public
  
  CCL-235
  
  Curator: @Jmenke
  
  Resource used:
  
  (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  SciCrunch record: RRID:CVCL_1729
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1729 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:CVCL_1729

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scibot

URL

sciencedirect.com/science/article/pii/S0092867418300412
Nov 2017
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

1
1. scibot 08 Nov 2017
  
  in Public
  
  CVCL_1729
  
  Curator: @gabimpine
  
  Resource used:
  
  (ICLC Cat# HTL99021, RRID:CVCL_1729)
  
  SciCrunch record: RRID:CVCL_1729
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_1729
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RRID:CVCL_1729

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5224920/