118 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of payload sensitivity and other mechanisms of resistance to T-DXd in HER2-mutant NSCLC: implications for subsequent responsiveness to HER2 TKIs
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    pmc.ncbi.nlm.nih.gov/articles/PMC13169646/
  3. May 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JIN-A02, a Mutant-Selective Fourth-Generation EGFR inhibitor, Overcomes C797S-Mediated Resistance and Demonstrates Intracranial Activity in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133602/
  5. Apr 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Moderate-Affinity Antibody–Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13118972/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13055635/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039860/
  9. aacrjournals.org aacrjournals.org
    DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity
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    aacrjournals.org/mct/article/25/1/7/771286/DS-3939a-A-TA-MUC1-Directed-Antibody-Drug
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of miR-29a/b1 cluster reprograms the tumor microenvironment and contributes to immunosuppression in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13034170/
  11. Mar 2026
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    C1RL-AS1/microRNA-424-5p/adrenoceptor β2 axis: A novel regulatory mechanism in lung adenocarcinoma associated with immune infiltration and prognosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12978463/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The STAT3–ZEB1 axis contributes to CCL2-mediated resistance to osimertinib in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12962936/
  14. Feb 2026
  15. www.sciencedirect.com www.sciencedirect.com
    Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS
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    sciencedirect.com/science/article/pii/S2451945626000279
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    Isoalantolactone induces apoptosis of non-small cell lung cancer cells by targeting EGFR and MET kinases and ROS generation
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    sciencedirect.com/science/article/pii/S2405844026000538
  17. Jan 2026
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Profiling of Extracellular Vesicles of Non‐Small Cell Lung Cancer Reveals Proteins Associated With Osimertinib Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12832073/
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    Unveiling poliumoside: A herbal-derived FAK kinase inhibitor with anti-proliferative and anti-metastatic efficacy
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    sciencedirect.com/science/article/pii/S0944711325013819
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    Mitigating tumor heterogeneity in lung Cancer: A dual-targeted NIR-II imaging strategy for accurate tumor localization and intraoperative navigation
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    sciencedirect.com/science/article/pii/S0304383526000042
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    ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer
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    sciencedirect.com/science/article/pii/S002192582502962X
  22. Dec 2025
  23. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer
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    sciencedirect.com:5037/science/article/pii/S109727652500975X
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    Lung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapy
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    sciencedirect.com:5037/science/article/pii/S2666379125005865
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    AMT inhibits the progression of non-small cell lung cancer by suppressing the PI3K/AKT/GSK-3β/β-catenin pathway via H3K27me3 regulation
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    sciencedirect.com:5037/science/article/pii/S0014299925012142
  26. Nov 2025
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    Lysine methylation-mediated SMYD2 degradation by casticin sensitizes non-small-cell lung cancer cells to osimertinib therapy
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    sciencedirect.com:5037/science/article/pii/S0006295225008275
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    Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12638015/
  29. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510733
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    Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
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    sciencedirect.com/science/article/pii/S193459092500373X
  31. Oct 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hypoxia Induces Immunosuppression by Silencing STING in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12498107/
  33. Sep 2025
  34. www.nature.com www.nature.com
    A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
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    nature.com/articles/s41587-025-02793-8
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12374242/
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    Prognostic and Monitoring Utility of Serum CEA in Lung Adenocarcinoma: Differential Roles in EGFR-TKI and Chemotherapy Treatments
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    onlinelibrary.wiley.com/doi/10.1002/cam4.71170
  37. Aug 2025
  38. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202510197
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70238
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    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    sciencedirect.com/science/article/pii/S153458072500471X
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    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    nature.com/articles/s41586-025-09299-y
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
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    Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures
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    sciencedirect.com/science/article/pii/S1535610825003174
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    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.70018
  45. Jul 2025
  46. translational-medicine.biomedcentral.com translational-medicine.biomedcentral.com
    MCAM interacts with integrin β1 to promote EGFR-TKI resistance in lung adenocarcinoma through the JAK3 signalling pathway
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    translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06874-9
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70096
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12261347/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12257754/
  50. Jun 2025
  51. www.sciencedirect.com www.sciencedirect.com
    EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC
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    sciencedirect.com/science/article/pii/S2666379125002721
  52. journals.sagepub.com journals.sagepub.com
    Neuregulin 4: A Key Regulator in Suppressing Lung Adenocarcinoma Progression
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    journals.sagepub.com/doi/full/10.1177/15330338251344424
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    Targeting IDH2 promotes antitumor immunity through epigenetic activation of cGAS-STING pathway
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    sciencedirect.com/science/article/pii/S0169500225005033
  54. May 2025
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-mediated suppression of ANGPT2-Tie2 in endothelial cells facilitates tumor vascular normalization during immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075545/
  56. www.sciencedirect.com www.sciencedirect.com
    MYC plus class IIa HDAC inhibition drives mitochondrial dysfunction in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S2211124725004930
  57. Apr 2025
  58. link.springer.com link.springer.com
    Cytokine and epigenetic regulation of CEACAM6 mediates EGFR-driven signaling and drug response in lung adenocarcinoma
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    link.springer.com/article/10.1038/s41698-025-00910-z
  59. Mar 2025
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    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  61. Feb 2025
  62. aacrjournals.org aacrjournals.org
    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
  63. Jan 2025
  64. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13970
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NRP1 overexpression potentially enhances osimertinib resistance in NSCLC via activation of the PI3K/AKT signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11711526/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668523/
  67. Dec 2024
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Methylation-modulated PFTK1 regulates gefitinib resistance via Wnt/β-catenin signaling in EGFR mutant non-small-cell lung cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11659392/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PFKFB3-dependent redox homeostasis and DNA repair support cell survival under EGFR-TKIs in non-small cell lung carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11658331/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11633494/
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724013779
  72. Nov 2024
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11487346/
  74. Oct 2024
  75. www.sciencedirect.com www.sciencedirect.com
    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
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    sciencedirect.com/science/article/pii/S2451945624003969
  76. Sep 2024
  77. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    nature.com/articles/s41467-024-51831-7
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    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting AKR1B10 by drug repurposing with epalrestat overcomes chemoresistance in non-small cell lung cancer patient-derived tumor organoids
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369614/
  80. Jul 2024
  81. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16489
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    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0304389424016844
  83. Jun 2024
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    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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    sciencedirect.com/science/article/pii/S2211124724006417
  85. May 2024
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    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    sciencedirect.com/science/article/pii/S1097276524003241
  87. Apr 2024
  88. aacrjournals.org aacrjournals.org
    EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
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    aacrjournals.org/cancerdiscovery/article/14/3/524/734906/EGFR-Driven-Lung-Adenocarcinomas-Co-opt-Alveolar
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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    ncbi.nlm.nih.gov/pmc/articles/PMC11002505/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Omics Analysis Identifies CCR6 as a Therapeutic Target to Overcome Cancer Resistance to EGFR Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10972824/
  91. Mar 2024
  92. www.nature.com www.nature.com
    Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation
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    nature.com/articles/s41598-024-56920-7
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    Low expression of lysosome-related genes KCNE1, NPC2, and SFTPD promote cancer cell proliferation and tumor associated M2 macrophage polarization in lung adenocarcinoma
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  94. Feb 2024
  95. www.sciencedirect.com www.sciencedirect.com
    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0304383524001551
  96. aacrjournals.org aacrjournals.org
    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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    aacrjournals.org/clincancerres/article/30/3/506/733551/First-in-Human-Study-with-Preclinical-Data-of-BCL
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    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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    sciencedirect.com/science/article/pii/S1534580724000303
  98. Jan 2024
  99. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    Alisertib inhibits migration and invasion of EGFR-TKI resistant cells by partially reversing the epithelial-mesenchymal transition
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    sciencedirect.com/science/article/pii/S0167488921000707
  101. Nov 2023
  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34783
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  104. Aug 2023
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  107. Jun 2023
  108. 52.53.155.43 52.53.155.43
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  109. May 2023
  110. peerj.com peerj.com
    Increased death and exhaustion of CD69high T cells and NK cells are associated with PD-1 antibody application in the in vitro co-culture system
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    peerj.com/articles/15374
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    Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
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    sciencedirect.com/science/article/pii/S2667237522001291
  112. Apr 2023
  113. www.biorxiv.org www.biorxiv.org
    EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
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    biorxiv.org/content/10.1101/2023.04.15.536974v1
  114. Mar 2023
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  139. Jul 2021
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  149. May 2021
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  153. Mar 2021
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