96 Matching Annotations
  1. Oct 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hypoxia Induces Immunosuppression by Silencing STING in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12498107/
  3. Sep 2025
  4. www.nature.com www.nature.com
    A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
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    nature.com/articles/s41587-025-02793-8
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12374242/
  6. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Prognostic and Monitoring Utility of Serum CEA in Lung Adenocarcinoma: Differential Roles in EGFR-TKI and Chemotherapy Treatments
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    onlinelibrary.wiley.com/doi/10.1002/cam4.71170
  7. Aug 2025
  8. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202510197
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    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70238
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    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    sciencedirect.com/science/article/pii/S153458072500471X
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    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    nature.com/articles/s41586-025-09299-y
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
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    Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures
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    sciencedirect.com/science/article/pii/S1535610825003174
  14. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.70018
  15. Jul 2025
  16. translational-medicine.biomedcentral.com translational-medicine.biomedcentral.com
    MCAM interacts with integrin β1 to promote EGFR-TKI resistance in lung adenocarcinoma through the JAK3 signalling pathway
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    translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06874-9
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    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70096
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12261347/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12257754/
  20. Jun 2025
  21. www.sciencedirect.com www.sciencedirect.com
    EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC
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    sciencedirect.com/science/article/pii/S2666379125002721
  22. journals.sagepub.com journals.sagepub.com
    Neuregulin 4: A Key Regulator in Suppressing Lung Adenocarcinoma Progression
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    journals.sagepub.com/doi/full/10.1177/15330338251344424
  23. www.sciencedirect.com www.sciencedirect.com
    Targeting IDH2 promotes antitumor immunity through epigenetic activation of cGAS-STING pathway
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    sciencedirect.com/science/article/pii/S0169500225005033
  24. May 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-mediated suppression of ANGPT2-Tie2 in endothelial cells facilitates tumor vascular normalization during immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075545/
  26. www.sciencedirect.com www.sciencedirect.com
    MYC plus class IIa HDAC inhibition drives mitochondrial dysfunction in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S2211124725004930
  27. Apr 2025
  28. link.springer.com link.springer.com
    Cytokine and epigenetic regulation of CEACAM6 mediates EGFR-driven signaling and drug response in lung adenocarcinoma
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    link.springer.com/article/10.1038/s41698-025-00910-z
  29. Mar 2025
  30. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  31. Feb 2025
  32. aacrjournals.org aacrjournals.org
    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
  33. Jan 2025
  34. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13970
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NRP1 overexpression potentially enhances osimertinib resistance in NSCLC via activation of the PI3K/AKT signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11711526/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668523/
  37. Dec 2024
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Methylation-modulated PFTK1 regulates gefitinib resistance via Wnt/β-catenin signaling in EGFR mutant non-small-cell lung cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11659392/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PFKFB3-dependent redox homeostasis and DNA repair support cell survival under EGFR-TKIs in non-small cell lung carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11658331/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11633494/
  41. www.sciencedirect.com www.sciencedirect.com
    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724013779
  42. Nov 2024
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11487346/
  44. Oct 2024
  45. www.sciencedirect.com www.sciencedirect.com
    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
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    sciencedirect.com/science/article/pii/S2451945624003969
  46. Sep 2024
  47. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    nature.com/articles/s41467-024-51831-7
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting AKR1B10 by drug repurposing with epalrestat overcomes chemoresistance in non-small cell lung cancer patient-derived tumor organoids
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369614/
  50. Jul 2024
  51. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16489
  52. www.sciencedirect.com www.sciencedirect.com
    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0304389424016844
  53. Jun 2024
  54. www.sciencedirect.com www.sciencedirect.com
    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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    sciencedirect.com/science/article/pii/S2211124724006417
  55. May 2024
  56. www.sciencedirect.com www.sciencedirect.com
    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    sciencedirect.com/science/article/pii/S1097276524003241
  57. Apr 2024
  58. aacrjournals.org aacrjournals.org
    EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
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    aacrjournals.org/cancerdiscovery/article/14/3/524/734906/EGFR-Driven-Lung-Adenocarcinomas-Co-opt-Alveolar
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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    ncbi.nlm.nih.gov/pmc/articles/PMC11002505/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Omics Analysis Identifies CCR6 as a Therapeutic Target to Overcome Cancer Resistance to EGFR Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10972824/
  61. Mar 2024
  62. www.nature.com www.nature.com
    Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation
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    nature.com/articles/s41598-024-56920-7
  63. www.sciencedirect.com www.sciencedirect.com
    Low expression of lysosome-related genes KCNE1, NPC2, and SFTPD promote cancer cell proliferation and tumor associated M2 macrophage polarization in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2405844024036065
  64. Feb 2024
  65. www.sciencedirect.com www.sciencedirect.com
    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0304383524001551
  66. aacrjournals.org aacrjournals.org
    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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    aacrjournals.org/clincancerres/article/30/3/506/733551/First-in-Human-Study-with-Preclinical-Data-of-BCL
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    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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    sciencedirect.com/science/article/pii/S1534580724000303
  68. Jan 2024
  69. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13564
  70. www.sciencedirect.com www.sciencedirect.com
    Alisertib inhibits migration and invasion of EGFR-TKI resistant cells by partially reversing the epithelial-mesenchymal transition
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    sciencedirect.com/science/article/pii/S0167488921000707
  71. Nov 2023
  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34783
  73. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13505
  74. Aug 2023
  75. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  76. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  77. Jun 2023
  78. 52.53.155.43 52.53.155.43
    can-22-3009-html.html
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  79. May 2023
  80. peerj.com peerj.com
    Increased death and exhaustion of CD69high T cells and NK cells are associated with PD-1 antibody application in the in vitro co-culture system
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    peerj.com/articles/15374
  81. www.sciencedirect.com www.sciencedirect.com
    Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
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    sciencedirect.com/science/article/pii/S2667237522001291
  82. Apr 2023
  83. www.biorxiv.org www.biorxiv.org
    EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
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    biorxiv.org/content/10.1101/2023.04.15.536974v1
  84. Mar 2023
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10035388/
  86. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Cell-free chromatin immunoprecipitation can determine tumor gene expression in lung cancer patients
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13394
  87. Feb 2023
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9903082/
  89. www.sciencedirect.com www.sciencedirect.com
    Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
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    sciencedirect.com/science/article/pii/S2589004223001578
  90. Dec 2022
  91. www.sciencedirect.com www.sciencedirect.com
    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    sciencedirect.com/science/article/pii/S2211124722017193
  92. Aug 2022
  93. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cancer-associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34127
  94. May 2022
  95. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC9064299/
  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Annexin A2: The Diversity of Pathological Effects in Tumorigenesis and Immune Response
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34048
  98. Apr 2022
  99. www.sciencedirect.com www.sciencedirect.com
    The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
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    sciencedirect.com/science/article/pii/S221112472200482X
  100. aacrjournals.org aacrjournals.org
    Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET
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    aacrjournals.org/cancerres/article/82/8/1534/694341/Loss-of-KMT5C-Promotes-EGFR-Inhibitor-Resistance
  101. Nov 2021
  102. www.sciencedirect.com www.sciencedirect.com
    HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6
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    sciencedirect.com/science/article/pii/S2589004221013146
  103. Sep 2021
  104. www.sciencedirect.com www.sciencedirect.com
    Oncogene-dependent sloppiness in mRNA translation
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    sciencedirect.com/science/article/pii/S109727652100736X
  105. Aug 2021
  106. www.sciencedirect.com www.sciencedirect.com
    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
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    sciencedirect.com/science/article/pii/S1535610821003834
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8337080/
  108. www.sciencedirect.com www.sciencedirect.com
    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    sciencedirect.com/science/article/pii/S2451945619304015
  109. Jul 2021
  110. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Radioresistance of KRAS/TP53‐Mutated Lung Cancer can be overcome by Radiation Dose Escalation or EGFR Tyrosine Kinase Inhibition In Vivo
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32598
  111. www.sciencedirect.com www.sciencedirect.com
    SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization
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    sciencedirect.com/science/article/pii/S1097276518310050
  112. www.sciencedirect.com www.sciencedirect.com
    A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis
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    sciencedirect.com/science/article/pii/S2211124719314895
  113. www.sciencedirect.com www.sciencedirect.com
    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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    sciencedirect.com/science/article/pii/S1535610821003408
  114. mcr.aacrjournals.org mcr.aacrjournals.org
    An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
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    mcr.aacrjournals.org/content/19/7/1234
  115. www.sciencedirect.com www.sciencedirect.com
    Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
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    sciencedirect.com/science/article/pii/S2211124721007622
  116. Jun 2021
  117. www.tandfonline.com www.tandfonline.com
    MicroRNA-320a-containing exosomes from human umbilical cord mesenchymal stem cells curtail proliferation and metastasis in lung cancer by binding to SOX4
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    tandfonline.com/doi/abs/10.1080/10799893.2021.1918166
  118. www.nature.com www.nature.com
    Pericentromeric Satellite III transcripts induce etoposide resistance
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    nature.com/articles/s41419-021-03810-9
  119. May 2021
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    Metronomic Chemotherapy Modulates Clonal Interactions to Prevent Drug Resistance in Non-Small Cell Lung Cancer
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  121. Apr 2021
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    Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
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  123. Mar 2021
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    Alisertib inhibits migration and invasion of EGFR-TKI resistant cells by partially reversing the epithelial-mesenchymal transition
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    Circular RNA hsa_circ_0102231 sponges miR-145 to promote non-small cell lung cancer cell proliferation by up-regulating the expression of RBBP4
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  126. Sep 2020
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    Structure and Function of the Bacterial Protein Toxin Phenomycin
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    Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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  130. Jan 2020
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    Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold
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  132. Nov 2018
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    The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment
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    The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells
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    Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization
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