96 Matching Annotations
  1. Oct 2025
  2. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
  3. Sep 2025
  4. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.70173
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402299/
  6. Aug 2025
  7. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
  8. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    EGFR-STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1-positive prostate cancer
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70069
  9. www.biorxiv.org www.biorxiv.org
    Exploration of oncogenic cooperation between germline variation and somatic mutation in prostate cancer progression
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    biorxiv.org/content/10.1101/2025.08.05.668679v1
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anticancer activity of triterpene glycosides from the sea star Solaster pacificus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322260/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Androgen receptor–mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12315708/
  12. Jul 2025
  13. www.science.org www.science.org
    Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer
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    science.org/doi/10.1126/sciadv.adu0847
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Clinical Context Shapes the Relationship between Genomic Alterations and Response to AR Inhibitors and Chemotherapy in Metastatic Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12209829/
  15. Jun 2025
  16. www.sciencedirect.com www.sciencedirect.com
    Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer
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    sciencedirect.com/science/article/pii/S1097276525005040
  17. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70049
  18. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/fedd6ccff8c0b6494dbe8595a0c800e33e0860f7/PDF-html.html
  19. www.sciencedirect.com www.sciencedirect.com
    An integrated proteomic portrait of prostate cancer progression
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    sciencedirect.com/science/article/pii/S2211124725005996
  20. www.cell.com www.cell.com
    BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways
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    cell.com/cell-reports/fulltext/S2211-1247(25)00550-9
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC12129099/
  22. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70073
  23. www.sciencedirect.com www.sciencedirect.com
    Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer
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    sciencedirect.com/science/article/pii/S2211124725005637
  24. May 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12017310/
  26. Apr 2025
  27. www.sciencedirect.com www.sciencedirect.com
    Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation
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    sciencedirect.com/science/article/pii/S153561082500128X
  28. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/41777a3551af228340faf9dcf16196ed568ad0b2/PDF-html.html
  29. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70040
  30. Mar 2025
  31. www.cell.com www.cell.com
    Small-molecule RNA therapeutics to target prostate cancer
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    cell.com/cancer-cell/abstract/S1535-6108(25)00079-0
  32. Jan 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor
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    pmc.ncbi.nlm.nih.gov/articles/PMC11774231/
  34. www.sciencedirect.com www.sciencedirect.com
    Amorphous calcium phosphate-coated surfaces as a model for bone microenvironment in prostate cancer
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    sciencedirect.com/science/article/pii/S2405844025003093
  35. Dec 2024
  36. www.sciencedirect.com www.sciencedirect.com
    Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer
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    sciencedirect.com/science/article/pii/S2211124724014402
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11612623/
  38. Oct 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    sciencedirect.com/science/article/pii/S2666379124004828
  40. Sep 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting the cancer cells and cancer‐associated fibroblasts with next‐generation FGFR inhibitors in prostate cancer co‐culture models
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    ncbi.nlm.nih.gov/pmc/articles/PMC11413502/
  42. www.sciencedirect.com www.sciencedirect.com
    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610824003179
  43. Aug 2024
  44. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Assessments of prostate cancer cell functions highlight differences between a pan-PI3K/mTOR inhibitor, gedatolisib, and single-node inhibitors of the PI3K/AKT/mTOR pathway
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13703
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306513/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel potent anti-STEAP1 bispecific antibody to redirect T cells for cancer immunotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC8438958/
  47. Jul 2024
  48. www.biorxiv.org www.biorxiv.org
    Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer
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    biorxiv.org/content/10.1101/2024.07.09.602803v1
  49. Jun 2024
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11187106/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The androgen receptor does not directly regulate the transcription of DNA damage response genes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11022999/
  52. www.mdpi.com www.mdpi.com
    Genomic Characterization of Preclinical Prostate Cancer Cell Line Models
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    mdpi.com/1422-0067/25/11/6111
  53. May 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD8+ T cell targeting of tumor antigens presented by HLA-E
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    ncbi.nlm.nih.gov/pmc/articles/PMC11086602/
  55. Apr 2024
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11031830/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ERBB3 overexpression is enriched in diverse patient populations with castration-sensitive prostate cancer and is associated with a unique AR activity signature
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    ncbi.nlm.nih.gov/pmc/articles/PMC11016893/
  58. link.springer.com link.springer.com
    EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
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    link.springer.com/article/10.1007/s00018-024-05209-z
  59. Mar 2024
  60. www.sciencedirect.com www.sciencedirect.com
    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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    sciencedirect.com/science/article/pii/S2451945624000874
  61. Feb 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10879682/
  63. www.mdpi.com www.mdpi.com
    Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2
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    mdpi.com/1422-0067/25/4/2222
  64. Jan 2024
  65. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13577
  66. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13572
  67. Dec 2023
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Master transcription factor reprograming unleashes selective translation promoting castration resistance and immune evasion in lethal prostate cancer.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10714140/
  69. 52.53.155.43 52.53.155.43
    cd-23-0306-html.html
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    52.53.155.43/2d1591f4bcff82c10886f9ef5d1f22c1addeb365/cd-23-0306-html.html
  70. Nov 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Concurrent targeting of HDAC and PI3K to overcome phenotypic heterogeneity of castration-resistant and neuroendocrine prostate cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10658857/
  72. Aug 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The long transcript of lncRNA TMPO-AS1 promotes bone metastases of prostate cancer by regulating the CSNK2A1/DDX3X complex in Wnt/β-catenin signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403548/
  74. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/908848ce9212d2a4c8be94b24c71e399d1f50f03/Molecular Oncology - 2023 - Ito-html.html
  75. Jun 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10261916/
  77. www.sciencedirect.com www.sciencedirect.com
    Minor intron splicing is critical for survival of lethal prostate cancer
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    sciencedirect.com/science/article/pii/S1097276523003738
  78. May 2023
  79. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/4e85ba1ed1516c780407b3a64dcb4d2814a68c56/Molecular Oncology - 2023 - Gonthier - Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic mitochondrial tricarboxylic-html.html
  80. www.biorxiv.org www.biorxiv.org
    The androgen receptor does not directly regulate the transcription of DNA damage response genes
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    biorxiv.org/content/10.1101/2023.05.13.540653v1
  81. Apr 2023
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10108886/
  83. Mar 2023
  84. www.sciencedirect.com www.sciencedirect.com
    Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer
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    sciencedirect.com/science/article/pii/S2352396423000658
  85. Feb 2023
  86. www.science.org www.science.org
    PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition
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    science.org/doi/10.1126/sciadv.ade8641
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimization and characterization of a bone culture model to study prostate cancer bone metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357208/
  88. Dec 2022
  89. aacrjournals.org aacrjournals.org
    First-in-Class Small Molecule to Inhibit CYP11A1 And Steroid Hormone Biosynthesis
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    aacrjournals.org/mct/article/21/12/1765/711143/First-in-Class-Small-Molecule-to-Inhibit-CYP11A1
  90. 52.53.155.43 52.53.155.43
    mct-22-0115-html.html
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    52.53.155.43/3a25c128cea05782eba8d0bded9bddafbf0b7017/mct-22-0115-html.html
  91. Aug 2022
  92. 52.53.155.43 52.53.155.43
    1360-html.html
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    52.53.155.43/49d342e1bd5865d528f0b694cb2824f7aad4df9f/1360-html.html
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9378683/
  94. www.nature.com www.nature.com
    Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer
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    nature.com/articles/s41467-022-32530-7
  95. Jul 2022
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9251882/
  97. Apr 2022
  98. www.sciencedirect.com www.sciencedirect.com
    Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer
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    sciencedirect.com/science/article/pii/S2666379122001215
  99. aacrjournals.org aacrjournals.org
    Targeting protein arginine methyltransferase 5 (PRMT5) suppresses radiation-induced neuroendocrine differentiation and sensitizes prostate cancer cells to radiation
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    aacrjournals.org/mct/article/21/3/448/681881/Targeting-Protein-Arginine-Methyltransferase-5
  100. Mar 2022
  101. www.sciencedirect.com www.sciencedirect.com
    Multi-omics and Pathway Analysis Identify Potential Roles for Tumour N-Acetyl Aspartate Accumulation in Murine Models of Castration Resistant Prostate Cancer
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    sciencedirect.com/science/article/pii/S2589004222003261
  102. Feb 2022
  103. www.sciencedirect.com www.sciencedirect.com
    A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer
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    sciencedirect.com/science/article/pii/S2211124722001413
  104. Jan 2022
  105. www.mdpi.com www.mdpi.com
    Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression
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    mdpi.com/2072-6694/14/2/278/htm
  106. Nov 2021
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8567381/
  108. www.sciencedirect.com www.sciencedirect.com
    Continued Androgen Signalling Inhibition improves Cabazitaxel Efficacy in Prostate Cancer
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    sciencedirect.com/science/article/pii/S2352396421004758
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    circFL-seq reveals full-length circular RNAs with rolling circular reverse transcription and nanopore sequencing
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    ncbi.nlm.nih.gov/pmc/articles/PMC8550772/
  110. Oct 2021
  111. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124721013371
  112. Sep 2021
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC8416027/
  114. Aug 2021
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD9 is a critical regulator of androgen receptor signaling and prostate cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC8026650/
  116. Jul 2021
  117. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The functional inter‐link between AR and MMP9/VEGF signaling axis is mediated through PIP5K1α/pAKT in prostate cancer
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32607
  118. www.sciencedirect.com www.sciencedirect.com
    The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
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    sciencedirect.com/science/article/pii/S1535610819303009
  119. elifesciences.org elifesciences.org
    A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer
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    elifesciences.org/articles/28482
  120. Jun 2021
  121. cancerres.aacrjournals.org cancerres.aacrjournals.org
    Stomatin-Mediated Inhibition of the Akt Signaling Axis Suppresses Tumor Growth
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    cancerres.aacrjournals.org/content/81/9/2318
  122. May 2021
  123. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Iron Induces Cell Death and Strengthens the Efficacy of Antiandrogen Therapy in Prostate Cancer Models
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    clincancerres.aacrjournals.org/content/26/23/6387
  124. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Expression and ERG regulation of PIM kinases in prostate cancer
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    onlinelibrary.wiley.com/doi/10.1002/cam4.3893
  125. Apr 2021
  126. www.sciencedirect.com www.sciencedirect.com
    Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
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    sciencedirect.com/science/article/pii/S0092867420308746
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8024724/
  128. Mar 2021
  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC7916378/
  130. Feb 2021
  131. www.sciencedirect.com www.sciencedirect.com
    Apocryphal FADS2 activity promotes fatty acid diversification in cancer
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    sciencedirect.com/science/article/pii/S2211124721000516
  132. Nov 2020
  133. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Thyroid and androgen receptor signaling are antagonized by CRYM in prostate cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33332
  134. Oct 2020
  135. www.sciencedirect.com www.sciencedirect.com
    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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    sciencedirect.com/science/article/pii/S2451945620303809
  136. Sep 2020
  137. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase
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    pubmed.ncbi.nlm.nih.gov/32971916/
  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC7386908/
  139. www.sciencedirect.com www.sciencedirect.com
    Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
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    sciencedirect.com/science/article/pii/S1535610820303093
  140. Nov 2018
  141. www.sciencedirect.com www.sciencedirect.com
    ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer
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    sciencedirect.com/science/article/pii/S1097276518306890
  142. www.sciencedirect.com www.sciencedirect.com
    Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus
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    sciencedirect.com/science/article/pii/S0092867418307281
  143. Nov 2017
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    Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9
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  145. www.sciencedirect.com www.sciencedirect.com
    ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer
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  146. www.sciencedirect.com www.sciencedirect.com
    Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer
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    sciencedirect.com/science/article/pii/S1535610817300600