Hypothesis

29 Matching Annotations

Jan 2026
www.sciencedirect.com www.sciencedirect.com

Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

1
1. scibot 09 Jan 2026
  
  in Public
  
  ATC TIB-180
  
  DOI: 10.1016/j.chembiol.2025.12.002
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

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sciencedirect.com/science/article/pii/S2451945625003952
Oct 2025
www.sciencedirect.com www.sciencedirect.com

A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential

1
1. scibot 30 Oct 2025
  
  in Public
  
  ATCCTIB-180
  
  DOI: 10.1016/j.celrep.2025.116496
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

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sciencedirect.com/science/article/pii/S2211124725012677
Jul 2025
www.biorxiv.org www.biorxiv.org

Development of PROTACs for targeted degradation of oncogenic TRK fusions

1
1. scibot 01 Jul 2025
  
  in Public
  
  #TIB-180
  
  DOI: 10.1101/2025.06.18.660465
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

biorxiv.org/content/10.1101/2025.06.18.660465v1
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pre-clinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms (MPN) transformed to AML

1
1. scibot 20 Feb 2025
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1182/blood.2024026388
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11811934/
Dec 2024
www.sciencedirect.com www.sciencedirect.com

The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells

1
1. scibot 19 Dec 2024
  
  in Public
  
  ATCCTIB-180
  
  DOI: 10.1016/j.immuni.2024.11.019
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

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sciencedirect.com/science/article/pii/S107476132400534X
Mar 2024
www.sciencedirect.com www.sciencedirect.com

Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling

1
1. scibot 29 Mar 2024
  
  in Public
  
  Cat#TIB-180
  
  DOI: 10.1016/j.chembiol.2024.02.013
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @abever99
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

sciencedirect.com/science/article/pii/S2451945624000874
Nov 2023
www.sciencedirect.com www.sciencedirect.com

Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

1
1. scibot 28 Nov 2023
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1016/j.ccell.2023.11.001
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

sciencedirect.com/science/article/pii/S1535610823003665
Jun 2023
aacrjournals.org aacrjournals.org

Targeting CHAF1B enhances Interferon activity against Myeloproliferative Neoplasm cells

1
1. scibot 02 Jun 2023
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1158/2767-9764.CRC-23-0010
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

aacrjournals.org/cancerrescommun/article/3/5/943/727012/Targeting-CHAF1B-Enhances-IFN-Activity-against
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Transcriptionally imprinted glycomic signatures of acute myeloid leukemia

1
1. scibot 17 Feb 2023
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1186/s13578-023-00981-0
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9926860/
May 2022
www.sciencedirect.com www.sciencedirect.com

Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation

1
1. scibot 04 May 2022
  
  in Public
  
  ATCCTIB-180
  
  DOI: 10.1016/j.cell.2022.04.005
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

sciencedirect.com/science/article/pii/S0092867422004433
Mar 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Acute inflammation down-regulates alpha-synuclein expression in enteric neurons

1
1. scibot 31 Mar 2022
  
  in Public
  
  CVCL_2481
  
  DOI: 10.1111/jnc.14656
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

onlinelibrary.wiley.com/doi/10.1111/jnc.14656
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Epigenetics-Associated Risk Reduction of Hematologic Neoplasms in a Nationwide Cohort Study: The Chemopreventive and Therapeutic Efficacy of Hydralazine

1
1. scibot 19 Feb 2022
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.3389/fonc.2022.809014
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
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  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8848747/
Jan 2022
link.springer.com link.springer.com

Novel inhibitor of hematopoietic cell kinase as a potential therapeutic agent for acute myeloid leukemia

1
1. scibot 20 Jan 2022
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1007/s00262-021-03111-2
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

link.springer.com/article/10.1007/s00262-021-03111-2
www.sciencedirect.com www.sciencedirect.com

SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

1
1. scibot 12 Jan 2022
  
  in Public
  
  TIB-180
  
  DOI: 10.1016/j.celrep.2021.110233
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721017423
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity

1
1. scibot 12 Aug 2021
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1016/j.cmet.2019.01.011
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119300117
www.sciencedirect.com www.sciencedirect.com

ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

1
1. scibot 07 Aug 2021
  
  in Public
  
  TIB-180
  
  DOI: 10.1016/j.molcel.2021.07.018
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_2481
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RRID:CVCL_2481

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1097276521005876
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity

1
1. scibot 28 Jul 2021
  
  in Public
  
  RRID: CVCL_2481
  
  DOI: 10.1016/j.cmet.2019.01.011
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRIDCUR:Unrecognized RRID:CVCL_2481
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RRIDCUR:Unrecognized

RRID:CVCL_2481

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scibot

URL

sciencedirect.com/science/article/pii/S1550413119300117
www.sciencedirect.com www.sciencedirect.com

JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells

1
1. scibot 27 Jul 2021
  
  in Public
  
  TIB-180
  
  DOI: 10.1016/j.ccell.2018.10.008
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @Jmenke
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRIDCUR:Missing RRID:CVCL_2481
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RRID:CVCL_2481

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1535610818304744
Apr 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors

1
1. scibot 10 Apr 2021
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1182/blood.2019002922
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481 RRIDCUR:Validated
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RRID:CVCL_2481

RRIDCUR:Validated

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7146021/
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

1
1. scibot 02 Mar 2021
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.7554/eLife.65905
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7886351/
Feb 2021
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

1
1. scibot 25 Feb 2021
  
  in Public
  
  CVCL_2481
  
  DOI: 10.1158/1078-0432.CCR-19-1900
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

clincancerres.aacrjournals.org/content/26/13/3371
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1016/j.cell.2020.03.051
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481 RRIDCUR:Validated
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RRID:CVCL_2481

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S0092867420303445
www.nature.com www.nature.com

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

1
1. scibot 10 Sep 2020
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1038/s41467-020-17209-1
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481 RRIDCUR:Validated
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RRID:CVCL_2481

RRIDCUR:Validated

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scibot

URL

nature.com/articles/s41467-020-17209-1
Aug 2020
www.nature.com www.nature.com

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

1
1. scibot 23 Aug 2020
  
  in Public
  
  RRID:CVCL_2481
  
  DOI: 10.1038/s41467-020-17209-1
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481
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RRID:CVCL_2481

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scibot

URL

nature.com/articles/s41467-020-17209-1
Jan 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Untitled document

1
1. scibot 12 Jan 2020
  
  in Public
  
  CVCL_2481
  
  DOI: 10.1111/jnc.14656
  
  Resource: (ECACC Cat# 92111706, RRID:CVCL_2481)
  
  Curator: @ethanbadger
  
  SciCrunch record: CVCL_2481
  
  What is this?
  
  RRID:CVCL_2481 RRIDCUR:Validated
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RRID:CVCL_2481

RRIDCUR:Validated

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scibot

URL

onlinelibrary.wiley.com/doi/full/10.1111/jnc.14656
Nov 2018
www.sciencedirect.com www.sciencedirect.com

LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia

1
1. scibot 05 Nov 2018
  
  in Public
  
  TIB-180
  
  Curator: @Jmenke
  
  Resource used:
  
  (CLS Cat# 300462/p465_HEL_9217, RRID:CVCL_2481)
  
  SciCrunch record: RRID:CVCL_2481
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_2481 RRIDCUR:Missing
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RRID:CVCL_2481

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1097276518301096
www.sciencedirect.com www.sciencedirect.com

MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

1
1. scibot 05 Nov 2018
  
  in Public
  
  TIB-180
  
  Curator: @Jmenke
  
  Resource used:
  
  (CLS Cat# 300462/p465_HEL_9217, RRID:CVCL_2481)
  
  SciCrunch record: RRID:CVCL_2481
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_2481 RRIDCUR:Missing
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RRID:CVCL_2481

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1535610818302691
Nov 2017
elifesciences.org elifesciences.org

Erythropoietin signaling regulates heme biosynthesis

1
1. scibot 08 Nov 2017
  
  in Public
  
  CVCL_2481
  
  Curator: @chewbeccax
  
  Resource used:
  
  (CLS Cat# 300462/p465_HEL_9217, RRID:CVCL_2481)
  
  SciCrunch record: RRID:CVCL_2481
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_2481 RRIDCUR:Validated
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RRID:CVCL_2481

RRIDCUR:Validated

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scibot

URL

elifesciences.org/articles/24767
www.sciencedirect.com www.sciencedirect.com

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

1
1. scibot 08 Nov 2017
  
  in Public
  
  CVCL_2481
  
  Curator: @kaitlinsung
  
  Resource used:
  
  (CLS Cat# 300462/p465_HEL_9217, RRID:CVCL_2481)
  
  SciCrunch record: RRID:CVCL_2481
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:CVCL_2481 RRIDCUR:Validated
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RRID:CVCL_2481

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1535610817300624