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    Growth factors maintain intratumoral heterogeneity and drive therapeutic resistance in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2211124725015980
  3. Nov 2025
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    MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer
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    sciencedirect.com/science/article/pii/S2211124725013762
  5. Oct 2025
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    High-throughput combination screening of Pidnarulex and other G-quadruplex ligands in multi-cell type tumor spheroids
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    sciencedirect.com/science/article/pii/S2472555225000772
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARP inhibitor and PRMT5 inhibitor synergy is independent of BRCA1/2 and MTAP status in breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12540990/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Depleting the Action of EZH2 through PI3K–mTOR Inhibition to Overcome Metastasis and Immunotherapy Resistance in Triple-Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485387/
  9. Jul 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells
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  11. Jun 2025
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  13. May 2025
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    E‐Cadherin Is a Structuring Component of Invadopodia in Pancreatic Cancer
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  15. Nov 2024
  16. pubs.acs.org pubs.acs.org
    Discovery of Pyrazolo[1,5,4-de]quinoxalin-2(3H)-one Derivatives as Highly Potent and Selective PARP1 Inhibitors
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    pubs.acs.org/doi/10.1021/acs.jmedchem.4c02276
  17. Aug 2024
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    Anti-EGFR Antibody–Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292198/
  19. May 2024
  20. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
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    nature.com/articles/s41416-024-02697-5
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    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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    science.org/doi/10.1126/scisignal.adh4475
  22. Apr 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2
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  24. Mar 2024
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    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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  26. Feb 2024
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    SAA1-dependent reprogramming of adipocytes by tumor cells is associated with triple negative breast cancer aggressiveness
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.34859
  28. Jan 2024
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15
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    New submission 26/10/2023, 09:04:32
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    biorxiv.org/content/10.1101/2023.08.03.550647v2
  31. Dec 2023
  32. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10683240/
  34. Sep 2023
  35. dx.doi.org dx.doi.org
    RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
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  36. Jul 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness
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  38. Jun 2023
  39. www.sciencedirect.com www.sciencedirect.com
    An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer
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    Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
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  41. May 2023
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    Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
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    sciencedirect.com/science/article/pii/S2211124723005491
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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  44. Mar 2023
  45. academic.oup.com academic.oup.com
    Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers
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    Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis
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  47. Dec 2022
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
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  49. Nov 2022
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    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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    Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis
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  52. Sep 2022
  53. www.sciencedirect.com www.sciencedirect.com
    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2666379122002907
  54. Sep 2021
  55. www.sciencedirect.com www.sciencedirect.com
    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    sciencedirect.com/science/article/pii/S1097276521007395
  56. www.mdpi.com www.mdpi.com
    Tumor Growth Progression in Ectopic and Orthotopic Xenografts from Inflammatory Breast Cancer Cell Lines
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    mdpi.com/2306-7381/8/9/194
  57. Aug 2021
  58. www.sciencedirect.com www.sciencedirect.com
    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    sciencedirect.com/science/article/pii/S2405471219303874
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    Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity
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  60. Jul 2021
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    Untitled document
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  62. Jun 2021
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    Oncogene-regulated release of extracellular vesicles
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  64. May 2021
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    Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
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  66. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response
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  67. Apr 2021
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    The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development
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  69. Feb 2021
  70. cancerandmetabolism.biomedcentral.com cancerandmetabolism.biomedcentral.com
    The PD-L1 metabolic interactome intersects with choline metabolism and inflammation
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    cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00245-w
  71. Oct 2020
  72. www.cell.com www.cell.com
    Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing
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    cell.com/cell-chemical-biology/abstract/S2451-9456(20)30284-1
  73. Sep 2020
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    sciencedirect.com/science/article/pii/S0092867420306863
  75. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FGF13 promotes metastasis of triple‐negative breast cancer
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  76. Jan 2020
  77. www.cell.com www.cell.com
    miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
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    cell.com/cell-reports/fulltext/S2211-1247(19)31576-1
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    Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC6425951/
  80. Nov 2018
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    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
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    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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    Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality
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