69 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13411104/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquisition of resistance to RAS inhibition is associated with the upregulation of macropinocytosis through both PI3K-dependent and -independent signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13410306/
  4. Jul 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13343314/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13324344/
  7. www.biorxiv.org www.biorxiv.org
    Vertical inhibition of the autophagy pathway impairs growth and enhances sensitivity to mTORC1 inhibition in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.06.28.734981v1
  8. Jun 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13243779/
  10. May 2026
  11. www.sciencedirect.com www.sciencedirect.com
    ALDH1A3 promotes the lung metastatic organotropism of pancreatic ductal adenocarcinoma through semaphorin signaling
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    sciencedirect.com/science/article/pii/S2589004226013258
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Characterization and Clinical Activity of RNK08954, a Highly Selective and Orally Bioavailable KRAS G12D Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133609/
  13. Apr 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13198247/
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    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S221112472600392X
  16. 54.241.53.176 54.241.53.176
    cd-25-1346-html.html
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  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080315/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080325/
  19. aacrjournals.org aacrjournals.org
    DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity
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    aacrjournals.org/mct/article/25/1/7/771286/DS-3939a-A-TA-MUC1-Directed-Antibody-Drug
  20. Mar 2026
  21. www.sciencedirect.com www.sciencedirect.com
    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    sciencedirect.com/science/article/pii/S0092867426002692
  22. www.sciencedirect.com www.sciencedirect.com
    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
  23. Jan 2026
  24. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
  25. Dec 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12717533/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
  29. Oct 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
  31. www.science.org www.science.org
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
  32. Sep 2025
  33. link.springer.com link.springer.com
    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
  34. Aug 2025
  35. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
  36. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70080
  37. Jul 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time
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    pmc.ncbi.nlm.nih.gov/articles/PMC12288891/
  39. Jun 2025
  40. link.springer.com link.springer.com
    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
  41. Apr 2025
  42. www.sciencedirect.com www.sciencedirect.com
    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124725003122
  43. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  44. Feb 2025
  45. www.sciencedirect.com www.sciencedirect.com
    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    sciencedirect.com/science/article/pii/S2666379124006980
  46. Oct 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11448066/
  48. Aug 2024
  49. www.researchsquare.com www.researchsquare.com
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  50. Jul 2024
  51. www.thelancet.com www.thelancet.com
    Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures
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    thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00254-8/abstract
  52. Dec 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
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    sciencedirect.com/science/article/pii/S2211124723015152
  54. Oct 2023
  55. 52.53.155.43 52.53.155.43
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    52.53.155.43/7b3101f3d01462bbcf14399b3becbcb8b341bb38/Molecular Oncology - 2023 - Hsieh - Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer-html.html
  56. Jun 2023
  57. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124723005922
  58. May 2023
  59. www.sciencedirect.com www.sciencedirect.com
    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1535610823001629
  60. Apr 2023
  61. link.springer.com link.springer.com
    Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
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    link.springer.com/article/10.1007/s10620-023-07931-3
  62. Mar 2023
  63. www.nature.com www.nature.com
    Non-canonical functions of SNAIL drive context-specific cancer progression
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    nature.com/articles/s41467-023-36505-0
  64. Feb 2023
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9929516/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  67. Jan 2023
  68. www.biorxiv.org www.biorxiv.org
    The regulatory role of the CD2AP/TKS4 interaction in EMT and its potential as a biomarker for colon cancer
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    biorxiv.org/content/10.1101/2023.01.13.523903v1
  69. Dec 2022
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional noninvasive detection of glycolytic pancreatic ductal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9737747/
  71. Aug 2022
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Concurrent inhibition of IGF1R and ERK increases pancreatic cancer sensitivity to autophagy inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8886214/
  73. Mar 2022
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
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    ncbi.nlm.nih.gov/pmc/articles/PMC8901637/
  75. Jan 2022
  76. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyaluronic acid fuels pancreatic cancer cell growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC8730721/
  78. Dec 2021
  79. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutamine deprivation triggers NAGK-dependent hexosamine salvage
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    ncbi.nlm.nih.gov/pmc/articles/PMC8631944/
  81. www.sciencedirect.com www.sciencedirect.com
    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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    sciencedirect.com/science/article/pii/S2211124721015461
  82. Nov 2021
  83. www.sciencedirect.com www.sciencedirect.com
    A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer
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    sciencedirect.com/science/article/pii/S004520682100883X
  84. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  85. Aug 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Muscle-Derived Cytokines Reduce Growth, Viability and Migratory Activity of Pancreatic Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8345221/
  87. Jul 2021
  88. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    sciencedirect.com/science/article/pii/S1535610818304677
  89. Jun 2021
  90. www.sciencedirect.com www.sciencedirect.com
    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    sciencedirect.com/science/article/pii/S2211124721006628
  91. May 2021
  92. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15435
  93. Apr 2021
  94. www.sciencedirect.com www.sciencedirect.com
    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0092867420313222
  95. Nov 2020
  96. www.authorea.com www.authorea.com
    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    authorea.com/users/368637/articles/487712-natural-product-trienomycin-a-is-a-stat3-pathway-inhibitor-that-exhibits-potent-in-vitro-and-in-vivo-efficacy-against-pancreatic-cancer
  97. Oct 2020
  98. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer
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    pubmed.ncbi.nlm.nih.gov/33027658/
  99. Sep 2020
  100. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    sciencedirect.com/science/article/pii/S2211124720307440
  101. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel engineered TRAIL‐based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32845
  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33137
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS
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    ncbi.nlm.nih.gov/pmc/articles/PMC6952431/
  104. Jan 2020
  105. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A Chirality‐Dependent Action of Vitamin C in Suppressing KRAS Mutant Tumor Growth by the Oxidative Combination: Rationale for Cancer Therapeutics
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32658
  106. Nov 2018
  107. www.sciencedirect.com www.sciencedirect.com
    Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1535610818300655