73 Matching Annotations
  1. Last 7 days
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    p53 activates chaperone-mediated autophagy to remodel metabolism and suppress tumorigenesis
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    sciencedirect.com/science/article/pii/S1534580726003953
  3. Sep 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting PRMT5 inhibitor-induced adaptation in pancreatic cancer with the RBM39 degrader indisulam
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    pmc.ncbi.nlm.nih.gov/articles/PMC13530115/
  5. Aug 2026
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    STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition
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    sciencedirect.com/science/article/pii/S2589004226025575
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    A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer
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    A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13411104/
  9. Jul 2026
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    Acquisition of resistance to RAS inhibition is associated with the upregulation of macropinocytosis through both PI3K-dependent and -independent signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13410306/
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    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13343314/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13324344/
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    Vertical inhibition of the autophagy pathway impairs growth and enhances sensitivity to mTORC1 inhibition in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.06.28.734981v1
  14. Jun 2026
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma
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  16. May 2026
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    ALDH1A3 promotes the lung metastatic organotropism of pancreatic ductal adenocarcinoma through semaphorin signaling
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    sciencedirect.com/science/article/pii/S2589004226013258
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Characterization and Clinical Activity of RNK08954, a Highly Selective and Orally Bioavailable KRAS G12D Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133609/
  19. Apr 2026
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13198247/
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    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S221112472600392X
  22. 54.241.53.176 54.241.53.176
    cd-25-1346-html.html
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma
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  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080325/
  25. aacrjournals.org aacrjournals.org
    DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity
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  26. Mar 2026
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
  29. Jan 2026
  30. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
  31. Dec 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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  35. Oct 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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  37. www.science.org www.science.org
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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  38. Sep 2025
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    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
  40. Aug 2025
  41. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70080
  43. Jul 2025
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time
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    pmc.ncbi.nlm.nih.gov/articles/PMC12288891/
  45. Jun 2025
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    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
  47. Apr 2025
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    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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  49. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  50. Feb 2025
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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  52. Oct 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
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  54. Aug 2024
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  56. Jul 2024
  57. www.thelancet.com www.thelancet.com
    Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures
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    thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00254-8/abstract
  58. Dec 2023
  59. www.sciencedirect.com www.sciencedirect.com
    Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
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    sciencedirect.com/science/article/pii/S2211124723015152
  60. Oct 2023
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    52.53.155.43/7b3101f3d01462bbcf14399b3becbcb8b341bb38/Molecular Oncology - 2023 - Hsieh - Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer-html.html
  62. Jun 2023
  63. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
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  64. May 2023
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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  66. Apr 2023
  67. link.springer.com link.springer.com
    Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
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    link.springer.com/article/10.1007/s10620-023-07931-3
  68. Mar 2023
  69. www.nature.com www.nature.com
    Non-canonical functions of SNAIL drive context-specific cancer progression
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    nature.com/articles/s41467-023-36505-0
  70. Feb 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9929516/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  73. Jan 2023
  74. www.biorxiv.org www.biorxiv.org
    The regulatory role of the CD2AP/TKS4 interaction in EMT and its potential as a biomarker for colon cancer
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    biorxiv.org/content/10.1101/2023.01.13.523903v1
  75. Dec 2022
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional noninvasive detection of glycolytic pancreatic ductal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9737747/
  77. Aug 2022
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Concurrent inhibition of IGF1R and ERK increases pancreatic cancer sensitivity to autophagy inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8886214/
  79. Mar 2022
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
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    ncbi.nlm.nih.gov/pmc/articles/PMC8901637/
  81. Jan 2022
  82. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hyaluronic acid fuels pancreatic cancer cell growth
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  84. Dec 2021
  85. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutamine deprivation triggers NAGK-dependent hexosamine salvage
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    ncbi.nlm.nih.gov/pmc/articles/PMC8631944/
  87. www.sciencedirect.com www.sciencedirect.com
    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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    sciencedirect.com/science/article/pii/S2211124721015461
  88. Nov 2021
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    A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer
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    sciencedirect.com/science/article/pii/S004520682100883X
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    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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  91. Aug 2021
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Muscle-Derived Cytokines Reduce Growth, Viability and Migratory Activity of Pancreatic Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8345221/
  93. Jul 2021
  94. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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  95. Jun 2021
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    sciencedirect.com/science/article/pii/S2211124721006628
  97. May 2021
  98. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15435
  99. Apr 2021
  100. www.sciencedirect.com www.sciencedirect.com
    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0092867420313222
  101. Nov 2020
  102. www.authorea.com www.authorea.com
    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    authorea.com/users/368637/articles/487712-natural-product-trienomycin-a-is-a-stat3-pathway-inhibitor-that-exhibits-potent-in-vitro-and-in-vivo-efficacy-against-pancreatic-cancer
  103. Oct 2020
  104. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer
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    pubmed.ncbi.nlm.nih.gov/33027658/
  105. Sep 2020
  106. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    sciencedirect.com/science/article/pii/S2211124720307440
  107. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel engineered TRAIL‐based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32845
  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33137
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS
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    ncbi.nlm.nih.gov/pmc/articles/PMC6952431/
  110. Jan 2020
  111. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A Chirality‐Dependent Action of Vitamin C in Suppressing KRAS Mutant Tumor Growth by the Oxidative Combination: Rationale for Cancer Therapeutics
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32658
  112. Nov 2018
  113. www.sciencedirect.com www.sciencedirect.com
    Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1535610818300655