78 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatic stellate cell-specific METTL3 deficiency promotes hepatocellular carcinoma progression via BMP10-SMAD1/5/8 signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13168861/
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    Curcumin Targets Crispld2 to Suppress Hepatic Stellate Cell Activation via PI3K/AKT Pathway Inhibition in Hepatic Fibrosis
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    onlinelibrary.wiley.com/doi/10.1111/liv.70696
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70499
  5. May 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AI-driven network pharmacology and multi-omics validation identify KCNH2 as a prognostic biomarker and candidate therapeutic vulnerability of Acorus tatarinowii in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13149083/
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    Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling
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    nature.com/articles/s41401-026-01807-8
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    Asarinin alleviates hepatic fibrosis through TRα-STAT3 pathway: A new strategy by regulating liver microenvironment
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    sciencedirect.com/science/article/pii/S0378874126006112
  9. Apr 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Potent Anticancer, Antimicrobial, and Anti‐Inflammatory Activities of Boswellia sacra Extracted Oil Nanoemulgel
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    pmc.ncbi.nlm.nih.gov/articles/PMC13108431/
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    UPLC-MS/MS-Network Pharmacology and Experimental Validation Reveal Active Components of Ficus tikoua for Ameliorating Liver Fibrosis
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    onlinelibrary.wiley.com/doi/10.1002/cbdv.71191
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    Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202521098
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    Deubiquitinase USP2 promotes hepatic stellate cell activation via p300 stabilization
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70301
  14. Mar 2026
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    ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516557
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    Global molecular landscape of early MASLD progression in human obesity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13008360/
  17. Feb 2026
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    Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis
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    sciencedirect.com/science/article/pii/S1550413126000161
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    Inhibitory effect of Anwulignan on the IL-36R/TLR9 signaling pathway: potential therapeutic role in hepatic fibrosis
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    sciencedirect.com/science/article/pii/S0944711326001704
  20. Jan 2026
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination
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    pmc.ncbi.nlm.nih.gov/articles/PMC12839083/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic Insights into the Economic Toll of Cell Line Misidentification: A Comprehensive Review
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    pmc.ncbi.nlm.nih.gov/articles/PMC12821653/
  23. Dec 2025
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    CADD-engineered peptide protacs efficiently target PCSK9 for hypercholesterolemia in vivo
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    sciencedirect.com/science/article/pii/S0026049525003555
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    Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD
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    sciencedirect.com/science/article/pii/S2352396425005481
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    TFEB-driven autophagy enhancement via a ROS-triggered NIR-II nanoplatform for targeted non-alcoholic fatty liver disease therapy
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    sciencedirect.com:5037/science/article/pii/S1385894725128295
  27. Oct 2025
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    Syringin attenuates fibrogenesis and inflammation through SIRT3-regulated P2X7 receptor signaling pathway in hepatic fibrosis
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    sciencedirect.com/science/article/pii/S0944711325010980
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    Liver-Targeted Scutellarin Nanoemulsion Alleviates Fibrosis with Ancillary Modulation of the Gut–Liver Microbiota
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    pmc.ncbi.nlm.nih.gov/articles/PMC12524853/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet‐Dependent Thrombin Formation and Release of Profibrotic TGF‐β
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    pmc.ncbi.nlm.nih.gov/articles/PMC12521956/
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    Bio-fabrication of fibrotic liver microtissues as a scalable and drug-responsive in vitro model
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    sciencedirect.com/science/article/pii/S0378517325010798
  32. Sep 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive Genetic and Molecular Characterization Confirms Hepatic Stellate Cell Origin of the Immortal Col-GFP HSC Line
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    pmc.ncbi.nlm.nih.gov/articles/PMC12386721/
  34. Jun 2025
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    Calycosin limits hepatic fibrogenesis via KLF15 dependent repression of P2X7R in thioacetamide-induced hepatic fibrosis
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    sciencedirect.com/science/article/pii/S0378874125008839
  36. May 2025
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    Engineering a three-dimensional liver steatosis model
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    sciencedirect.com/science/article/pii/S0925443925002364
  38. Apr 2025
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    A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1-Induced LX-2 Human Hepatic Stellate Cells
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  40. Jan 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy in mice
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  42. Nov 2024
  43. pubs.acs.org pubs.acs.org
    Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling
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    pubs.acs.org/doi/10.1021/acs.jafc.4c03286
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    Eriocitrin ameliorates hepatic fibrosis and inflammation: The involvement of PPARα-mediated NLRP1/NLRC4 inflammasome signaling cascades
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    sciencedirect.com/science/article/pii/S0378874124014181
  45. Aug 2024
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    GSK805 inhibits alpha-smooth muscle expression and modulates liver inflammation without impairing the well-being of mice
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202400733R
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    Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling
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  48. Jul 2024
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    Identification and characterization of TM4SF1+ tumor self-seeded cells
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    sciencedirect.com/science/article/pii/S2211124724008416
  50. Jun 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11163038/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nicotine aggravates liver fibrosis via α7 nicotinic acetylcholine receptor expressed on activated hepatic stellate cells in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11155520/
  53. May 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bioengineering scalable and drug-responsive in vitro human multicellular non-alcoholic fatty liver disease microtissues encapsulated in the liver extracellular matrix-derived hydrogel
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    ncbi.nlm.nih.gov/pmc/articles/PMC11089098/
  55. Apr 2024
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    Albiflorin ameliorates thioacetamide-induced hepatic fibrosis: The involvement of NURR1-mediated inflammatory signaling cascades in hepatic stellate cells activation
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    The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice
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    sciencedirect.com/science/article/pii/S0006295224001886
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    Virological response to nucleos(t)ide analogues treatment in chronic hepatitis B patients is associated with Bacteroides-dominant gut microbiome
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    sciencedirect.com/science/article/pii/S2352396424001361
  59. Feb 2024
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC10897550/
  61. Jan 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10242051/
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    IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids
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    sciencedirect.com/science/article/pii/S2666379123005694
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intranasal Delivery of Oncolytic Adenovirus XVir-N-31 via Optimized Shuttle Cells Significantly Extends Survival of Glioblastoma-Bearing Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10605419/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation
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    pmc.ncbi.nlm.nih.gov/articles/PMC10367116/
  66. Nov 2023
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Matrix stiffness triggers lipid metabolic crosstalk between tumor and stromal cells to mediate bevacizumab resistance in colorectal cancer liver metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618741/
  68. Oct 2023
  69. www.sciencedirect.com www.sciencedirect.com
    Sesamol as a potential candidate for the treatment of hepatic fibrosis, based on its regulation of FXR/LXR axis-mediated inhibition of autophagy through crosstalk between hepatic cells and macrophage
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    Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis
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  72. Sep 2023
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  74. Jul 2023
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation
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  76. Jan 2023
  77. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  78. Dec 2022
  79. 52.53.155.43 52.53.155.43
    Physcion alleviates chronic alcoholic hepatic inflammation and pyroptosis through SIRT1-AMPK activation
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  80. Nov 2022
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    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2 Associated Cell Adhesion
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    ncbi.nlm.nih.gov/pmc/articles/PMC9635595/
  83. Sep 2022
  84. www.sciencedirect.com www.sciencedirect.com
    Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR
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    sciencedirect.com/science/article/pii/S0944711322005244
  85. Jul 2022
  86. www.nature.com www.nature.com
    Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiproliferative and Antimicrobial Effects of Rosmarinus officinalis L. Loaded Liposomes
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  88. Jun 2022
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  90. Mar 2022
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer
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    The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis
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    sciencedirect.com/science/article/pii/S0045206822001201
  93. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel HSF1 activator ameliorates nonalcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15727
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    Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus
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    sciencedirect.com/science/article/pii/S2352396422000871
  95. Dec 2021
  96. cancerimmunolres.aacrjournals.org cancerimmunolres.aacrjournals.org
    The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells
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    cancerimmunolres.aacrjournals.org/content/9/11/1283
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    Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation
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    sciencedirect.com/science/article/pii/S2589004221014206
  98. Sep 2021
  99. www.mdpi.com www.mdpi.com
    Costunolide Loaded in pH-Responsive Mesoporous Silica Nanoparticles for Increased Stability and an Enhanced Anti-Fibrotic Effect
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    mdpi.com/1424-8247/14/10/951
  100. Aug 2021
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC6896671/
  103. Jul 2021
  104. www.sciencedirect.com www.sciencedirect.com
    Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule
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    sciencedirect.com/science/article/pii/S2211124719314901
  105. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15490
  106. May 2021
  107. www.sciencedirect.com www.sciencedirect.com
    P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells
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    sciencedirect.com/science/article/pii/S0378427420303416
  108. Mar 2021
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and Its Target APOBEC3G and Thereby Pancreatic Cancer Progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC7920255/
  110. Feb 2021
  111. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14873
  112. Jan 2021
  113. www.sciencedirect.com www.sciencedirect.com
    Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia
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    sciencedirect.com/science/article/pii/S0092867420314550
  114. Dec 2020
  115. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Evidence for liver and peripheral immune cells secreting tumor-suppressive extracellular vesicles in melanoma patients
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    pubmed.ncbi.nlm.nih.gov/33242827/
  116. Sep 2020
  117. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  118. Jan 2020
  119. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  121. Nov 2017
  122. www.sciencedirect.com www.sciencedirect.com
    Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes
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    sciencedirect.com/science/article/pii/S2352396417303614