87 Matching Annotations
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  2. dx.doi.org dx.doi.org
    Development of a matrix-supported 2.5-dimensional co-culture model: an in vitro platform for studying liver cell interaction and disease mechanisms
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    dx.doi.org/10.1039/d6ra05249e
  3. Aug 2026
  4. dx.doi.org dx.doi.org
    Development of a matrix-supported 2.5-dimensional co-culture model: an in vitro platform for studying liver cell interaction and disease mechanisms
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    dx.doi.org/10.1039/d6ra05249e
  5. link.springer.com link.springer.com
    Human placenta extract declines fat deposition in an in vitro novel 3D MASLD model
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    link.springer.com/article/10.1007/s44164-026-00142-w
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    A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms
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    sciencedirect.com/science/article/pii/S2589004226024156
  7. Jul 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GDF15 Reprograms the Microenvironment to Drive Liver Metastasis of Uveal Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13343499/
  9. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting p21-High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
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  10. Jun 2026
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    Serum SOS1 as a prognostic biomarker and therapeutic target for progressive liver disease
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    sciencedirect.com/science/article/pii/S2589004226018055
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    Sex Hormone-Binding Globulin Prevents Carbon Tetrachloride-Induced Liver Fibrosis Development
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    pmc.ncbi.nlm.nih.gov/articles/PMC13256505/
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    Rosavin mitigates hepatic fibrosis via KLF14-mediated suppression of P2X7 receptor-dependent inflammatory signaling cascades
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    sciencedirect.com/science/article/pii/S0378874126008032
  14. May 2026
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    Hepatic stellate cell-specific METTL3 deficiency promotes hepatocellular carcinoma progression via BMP10-SMAD1/5/8 signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13168861/
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    Curcumin Targets Crispld2 to Suppress Hepatic Stellate Cell Activation via PI3K/AKT Pathway Inhibition in Hepatic Fibrosis
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    onlinelibrary.wiley.com/doi/10.1111/liv.70696
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70499
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    AI-driven network pharmacology and multi-omics validation identify KCNH2 as a prognostic biomarker and candidate therapeutic vulnerability of Acorus tatarinowii in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13149083/
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    Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling
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    nature.com/articles/s41401-026-01807-8
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    Asarinin alleviates hepatic fibrosis through TRα-STAT3 pathway: A new strategy by regulating liver microenvironment
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    sciencedirect.com/science/article/pii/S0378874126006112
  21. Apr 2026
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Potent Anticancer, Antimicrobial, and Anti‐Inflammatory Activities of Boswellia sacra Extracted Oil Nanoemulgel
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    UPLC-MS/MS-Network Pharmacology and Experimental Validation Reveal Active Components of Ficus tikoua for Ameliorating Liver Fibrosis
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    onlinelibrary.wiley.com/doi/10.1002/cbdv.71191
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    Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202521098
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    Deubiquitinase USP2 promotes hepatic stellate cell activation via p300 stabilization
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  26. Mar 2026
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    ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516557
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    Global molecular landscape of early MASLD progression in human obesity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13008360/
  29. Feb 2026
  30. www.sciencedirect.com www.sciencedirect.com
    Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis
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    Inhibitory effect of Anwulignan on the IL-36R/TLR9 signaling pathway: potential therapeutic role in hepatic fibrosis
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  32. Jan 2026
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination
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    Genetic Insights into the Economic Toll of Cell Line Misidentification: A Comprehensive Review
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  35. Dec 2025
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    CADD-engineered peptide protacs efficiently target PCSK9 for hypercholesterolemia in vivo
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    Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD
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  38. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    TFEB-driven autophagy enhancement via a ROS-triggered NIR-II nanoplatform for targeted non-alcoholic fatty liver disease therapy
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  39. Oct 2025
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    Syringin attenuates fibrogenesis and inflammation through SIRT3-regulated P2X7 receptor signaling pathway in hepatic fibrosis
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    sciencedirect.com/science/article/pii/S0944711325010980
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Liver-Targeted Scutellarin Nanoemulsion Alleviates Fibrosis with Ancillary Modulation of the Gut–Liver Microbiota
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    pmc.ncbi.nlm.nih.gov/articles/PMC12524853/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet‐Dependent Thrombin Formation and Release of Profibrotic TGF‐β
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    Bio-fabrication of fibrotic liver microtissues as a scalable and drug-responsive in vitro model
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    sciencedirect.com/science/article/pii/S0378517325010798
  44. Sep 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive Genetic and Molecular Characterization Confirms Hepatic Stellate Cell Origin of the Immortal Col-GFP HSC Line
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  46. Jun 2025
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    Calycosin limits hepatic fibrogenesis via KLF15 dependent repression of P2X7R in thioacetamide-induced hepatic fibrosis
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    sciencedirect.com/science/article/pii/S0378874125008839
  48. May 2025
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    Engineering a three-dimensional liver steatosis model
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    sciencedirect.com/science/article/pii/S0925443925002364
  50. Apr 2025
  51. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1-Induced LX-2 Human Hepatic Stellate Cells
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  52. Jan 2025
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy in mice
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  54. Nov 2024
  55. pubs.acs.org pubs.acs.org
    Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling
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    pubs.acs.org/doi/10.1021/acs.jafc.4c03286
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    Eriocitrin ameliorates hepatic fibrosis and inflammation: The involvement of PPARα-mediated NLRP1/NLRC4 inflammasome signaling cascades
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  57. Aug 2024
  58. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    GSK805 inhibits alpha-smooth muscle expression and modulates liver inflammation without impairing the well-being of mice
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202400733R
  59. pubs.acs.org pubs.acs.org
    Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling
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  60. Jul 2024
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    Identification and characterization of TM4SF1+ tumor self-seeded cells
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  62. Jun 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nicotine aggravates liver fibrosis via α7 nicotinic acetylcholine receptor expressed on activated hepatic stellate cells in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11155520/
  65. May 2024
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bioengineering scalable and drug-responsive in vitro human multicellular non-alcoholic fatty liver disease microtissues encapsulated in the liver extracellular matrix-derived hydrogel
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  67. Apr 2024
  68. www.sciencedirect.com www.sciencedirect.com
    Albiflorin ameliorates thioacetamide-induced hepatic fibrosis: The involvement of NURR1-mediated inflammatory signaling cascades in hepatic stellate cells activation
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    The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice
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    Virological response to nucleos(t)ide analogues treatment in chronic hepatitis B patients is associated with Bacteroides-dominant gut microbiome
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  71. Feb 2024
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway
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  73. Jan 2024
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways
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    IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intranasal Delivery of Oncolytic Adenovirus XVir-N-31 via Optimized Shuttle Cells Significantly Extends Survival of Glioblastoma-Bearing Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10605419/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation
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  78. Nov 2023
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Matrix stiffness triggers lipid metabolic crosstalk between tumor and stromal cells to mediate bevacizumab resistance in colorectal cancer liver metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618741/
  80. Oct 2023
  81. www.sciencedirect.com www.sciencedirect.com
    Sesamol as a potential candidate for the treatment of hepatic fibrosis, based on its regulation of FXR/LXR axis-mediated inhibition of autophagy through crosstalk between hepatic cells and macrophage
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    Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis
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  84. Sep 2023
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  86. Jul 2023
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation
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  88. Jan 2023
  89. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15997
  90. Dec 2022
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    Physcion alleviates chronic alcoholic hepatic inflammation and pyroptosis through SIRT1-AMPK activation
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  92. Nov 2022
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    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2 Associated Cell Adhesion
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    ncbi.nlm.nih.gov/pmc/articles/PMC9635595/
  95. Sep 2022
  96. www.sciencedirect.com www.sciencedirect.com
    Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR
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  97. Jul 2022
  98. www.nature.com www.nature.com
    Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis
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    nature.com/articles/s41588-022-01120-0
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiproliferative and Antimicrobial Effects of Rosmarinus officinalis L. Loaded Liposomes
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  100. Jun 2022
  101. 52.53.155.43 52.53.155.43
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  102. Mar 2022
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer
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  104. www.sciencedirect.com www.sciencedirect.com
    The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis
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    sciencedirect.com/science/article/pii/S0045206822001201
  105. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel HSF1 activator ameliorates nonalcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15727
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    Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus
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    sciencedirect.com/science/article/pii/S2352396422000871
  107. Dec 2021
  108. cancerimmunolres.aacrjournals.org cancerimmunolres.aacrjournals.org
    The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells
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    cancerimmunolres.aacrjournals.org/content/9/11/1283
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    Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation
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    sciencedirect.com/science/article/pii/S2589004221014206
  110. Sep 2021
  111. www.mdpi.com www.mdpi.com
    Costunolide Loaded in pH-Responsive Mesoporous Silica Nanoparticles for Increased Stability and an Enhanced Anti-Fibrotic Effect
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    mdpi.com/1424-8247/14/10/951
  112. Aug 2021
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6316133/
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC6896671/
  115. Jul 2021
  116. www.sciencedirect.com www.sciencedirect.com
    Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule
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    sciencedirect.com/science/article/pii/S2211124719314901
  117. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  118. May 2021
  119. www.sciencedirect.com www.sciencedirect.com
    P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells
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  120. Mar 2021
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