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Scaling and self-similarity in the formation of the embryonic epigenome

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1. scibot 08 May 2026
  
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  DOI: 10.1038/s41567-026-03263-x
  
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nature.com/articles/s41567-026-03263-x
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of SPECC1L in cranial neural crest cells results in increased hedgehog signaling and frontonasal dysplasia

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1. scibot 07 Feb 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12873473/
Dec 2024
www.biorxiv.org www.biorxiv.org

Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human

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1. scibot 27 Dec 2024
  
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  DOI: 10.1101/2024.12.21.629881
  
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biorxiv.org/content/10.1101/2024.12.21.629881v2
Sep 2024
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mTOR activity paces human blastocyst stage developmental progression

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1. scibot 27 Sep 2024
  
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sciencedirect.com/science/article/pii/S0092867424009772
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Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice

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1. scibot 17 Sep 2024
  
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sciencedirect.com/science/article/pii/S221112472401101X
Aug 2024
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The fork protection complex promotes parental histone recycling and epigenetic memory

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1. scibot 18 Aug 2024
  
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sciencedirect.com/science/article/pii/S0092867424007773
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths

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1. scibot 06 Sep 2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10475046/
Jul 2023
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Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1

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1. scibot 06 Jul 2023
  
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sciencedirect.com/science/article/pii/S1097276523004306
Mar 2023
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DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network

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1. scibot 03 Mar 2023
  
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sciencedirect.com/science/article/pii/S1097276523001077
Feb 2023
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Recycling of modified H2A-H2B provides short-term memory of chromatin states

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1. scibot 09 Feb 2023
  
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sciencedirect.com/science/article/pii/S0092867423000077
Jan 2023
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Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation

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1. scibot 02 Jan 2023
  
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  DOI: 10.1016/j.celrep.2022.111865
  
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sciencedirect.com/science/article/pii/S2211124722017612
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mcm2 promotes stem cell differentiation via its ability to bind H3-H4

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1. scibot 30 Nov 2022
  
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  DOI: 10.7554/eLife.80917
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9681210/
Aug 2022
www.embopress.org www.embopress.org

E-cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities

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1. scibot 23 Aug 2022
  
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  DOI: 10.15252/embj.2022111021
  
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embopress.org/doi/10.15252/embj.2022111021
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Efficient and strand-specific profiling of replicating chromatin with enrichment and sequencing of protein-associated nascent DNA in mammalian cells

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1. scibot 09 Jul 2022
  
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  DOI: 10.1038/s41596-021-00520-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9261918/
Jun 2022
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JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation

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1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110889
  
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sciencedirect.com/science/article/pii/S2211124722006647
May 2022
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DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism

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1. scibot 25 May 2022
  
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  DOI: 10.1016/j.devcel.2022.04.020
  
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sciencedirect.com/science/article/pii/S1534580722003069
Jan 2022
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Multi-CUT&Tag to simultaneously profile multiple chromatin factors

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1. scibot 21 Jan 2022
  
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  DOI: 10.1016/j.xpro.2021.101100
  
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sciencedirect.com/science/article/pii/S2666166721008066
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Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

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1. scibot 13 Jan 2022
  
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  DOI: 10.1038/s42255-021-00422-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7611553/
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface

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1. scibot 21 Dec 2021
  
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  DOI: 10.7554/eLife.73348
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8673838/
Nov 2021
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CUT&Tag-BS for simultaneous profiling of histone modification and DNA methylation with high efficiency and low cost

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1. scibot 16 Nov 2021
  
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  DOI: 10.1016/j.crmeth.2021.100118
  
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sciencedirect.com/science/article/pii/S266723752100182X
Oct 2021
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Simultaneous profiling of multiple chromatin proteins in the same cells

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1. scibot 12 Oct 2021
  
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  DOI: 10.1016/j.molcel.2021.09.019
  
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sciencedirect.com/science/article/pii/S109727652100753X
Aug 2021
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Low-input ATAC&mRNA-seq protocol for simultaneous profiling of chromatin accessibility and gene expression

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1. scibot 28 Aug 2021
  
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sciencedirect.com/science/article/pii/S2666166721004706
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Genome-wide and sister chromatid-resolved profiling of protein occupancy in replicated chromatin with ChOR-seq and SCAR-seq

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1. scibot 16 Aug 2021
  
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  DOI: 10.1038/s41596-021-00585-3
  
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nature.com/articles/s41596-021-00585-3
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Untitled document

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1. scibot 09 Aug 2021
  
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  DOI: 10.1016/j.stem.2018.10.017
  
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sciencedirect.com/science/article/pii/S1934590918304983
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Untitled document

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1. scibot 07 Aug 2021
  
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  DOI: 10.7554/eLife.23468
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5562443/
Jul 2021
www.biorxiv.org www.biorxiv.org

A lncRNA/Lin28/Mirlet7 axis coupled to DNA methylation fine tunes the dynamics of a cell state transition

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1. scibot 30 Jul 2021
  
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  DOI: 10.1101/131110
  
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biorxiv.org/content/10.1101/131110v1
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A simple and robust method for simultaneous dual-omics profiling with limited numbers of cells

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1. scibot 01 Jul 2021
  
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  DOI: 10.1016/j.crmeth.2021.100041
  
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sciencedirect.com/science/article/pii/S2667237521000862
Jun 2021
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Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin

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1. scibot 24 Jun 2021
  
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sciencedirect.com/science/article/pii/S109727652100410X
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Generation of locus-specific degradable tag knock-ins in mouse and human cell lines

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1. scibot 04 Jun 2021
  
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sciencedirect.com/science/article/pii/S2666166721002823
Apr 2021
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Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

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1. scibot 19 Apr 2021
  
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sciencedirect.com/science/article/pii/S1097276521000988
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Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells

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1. scibot 10 Apr 2021
  
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  DOI: 10.1016/j.xpro.2021.100426
  
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sciencedirect.com/science/article/pii/S2666166721001337
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

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1. scibot 26 Feb 2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7380943/
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

F1000Research Article: Inducible TDG knockout models to study epigenetic regulation.

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1. scibot 26 Sep 2020
  
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  DOI: 10.12688/f1000research.25637.1
  
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pubmed.ncbi.nlm.nih.gov/33082936/
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A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program

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1. scibot 17 Sep 2020
  
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  DOI: 10.1016/j.cels.2020.06.004
  
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sciencedirect.com/science/article/pii/S2405471220302015
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Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome

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1. scibot 05 Sep 2020
  
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sciencedirect.com/science/article/pii/S2211124720308779
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.41769
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6534382/
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1038/s41467-018-08006-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6318327/
currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com

High‐Resolution Chromatin Profiling Using CUT&RUN

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  DOI: 10.1002/cpmb.85
  
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Untitled document

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  DOI: 10.1016/j.molcel.2019.04.033
  
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Untitled document

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  DOI: 10.1038/s41467-018-08006-y
  
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nature.com/articles/s41467-018-08006-y
Nov 2018
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Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal

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Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

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Untitled document

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Mapping the Mouse Cell Atlas by Microwell-Seq

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A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3α and GSK3β in Regulating Embryonic Stem Cell Fate.

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Untitled document

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Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

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Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells

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A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

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DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells

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