Hypothesis

25 Matching Annotations

Jun 2025
link.springer.com link.springer.com

Application of CRISPR-Based Epigenome Editing Tools for Engineering Programmable Embryo Models

1
1. scibot 15 Jun 2025
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1007/7651_2025_637
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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scibot

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link.springer.com/protocol/10.1007/7651_2025_637
Mar 2025
www.cell.com www.cell.com

Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming

1
1. scibot 23 Mar 2025
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1016/j.stem.2025.02.015
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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scibot

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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00083-9
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The FIRE biosensor illuminates iron regulatory protein activity and cellular iron homeostasis

1
1. scibot 23 Feb 2025
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1016/j.crmeth.2024.100960
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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RRID:CVCL_C865

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC11840943/
Aug 2023
www.nature.com www.nature.com

Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression

1
1. scibot 24 Aug 2023
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1038/s41596-023-00863-2
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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URL

nature.com/articles/s41596-023-00863-2
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Histone exchange sensors reveal variant specific dynamics in mouse embryonic stem cells

1
1. scibot 30 Jun 2023
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1038/s41467-023-39477-3
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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URL

ncbi.nlm.nih.gov/pmc/articles/PMC10293259/
www.embopress.org www.embopress.org

DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres

1
1. scibot 22 Jun 2023
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.15252/embr.202256492
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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embopress.org/doi/10.15252/embr.202256492
Dec 2022
link.springer.com link.springer.com

LINE-1 Retrotransposition Assays in Embryonic Stem Cells

1
1. scibot 06 Dec 2022
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1007/978-1-0716-2883-6_13
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @sofiakhan13
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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link.springer.com/protocol/10.1007/978-1-0716-2883-6_13
Nov 2022
www.sciencedirect.com www.sciencedirect.com

Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

1
1. scibot 24 Nov 2022
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1016/j.molcel.2022.11.002
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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URL

sciencedirect.com/science/article/abs/pii/S1097276522010644
www.sciencedirect.com www.sciencedirect.com

Transcription factor antagonism regulates heterogeneity in embryonic stem cell states

1
1. scibot 10 Nov 2022
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1016/j.molcel.2022.10.022
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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sciencedirect.com/science/article/pii/S109727652201022X
Aug 2022
www.nature.com www.nature.com

Balanced gene dosage control rather than parental origin underpins genomic imprinting

1
1. scibot 02 Aug 2022
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1038/s41467-022-32144-z
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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nature.com/articles/s41467-022-32144-z
www.sciencedirect.com www.sciencedirect.com

The intrinsic and extrinsic effects of TET proteins during gastrulation

1
1. scibot 02 Aug 2022
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1016/j.cell.2022.06.049
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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sciencedirect.com/science/article/pii/S009286742200842X
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Manipulation of TAD reorganization by chemical-dependent genome linking

1
1. scibot 09 Sep 2021
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1016/j.xpro.2021.100799
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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URL

sciencedirect.com/science/article/pii/S2666166721005050
Aug 2021
www.biorxiv.org www.biorxiv.org

A lncRNA/Lin28/Mirlet7 axis coupled to DNA methylation fine tunes the dynamics of a cell state transition

1
1. scibot 14 Aug 2021
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1101/131110
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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RRID:CVCL_C865

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URL

biorxiv.org/content/10.1101/131110v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 07 Aug 2021
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.7554/eLife.23468
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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RRID:CVCL_C865

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC5562443/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 03 Aug 2021
  
  in Public
  
  CVCL_C865
  
  DOI: 10.1186/s13072-016-0100-6
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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URL

ncbi.nlm.nih.gov/pmc/articles/PMC5097419/
May 2021
www.sciencedirect.com www.sciencedirect.com

Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions

1
1. scibot 26 May 2021
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1016/j.stem.2021.04.023
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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URL

sciencedirect.com/science/article/pii/S1934590921001818
www.sciencedirect.com www.sciencedirect.com

A single-embryo, single-cell time-resolved model for mouse gastrulation

1
1. scibot 01 May 2021
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.1016/j.cell.2021.04.004
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @scibot
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865
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RRID:CVCL_C865

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URL

sciencedirect.com/science/article/pii/S0092867421004396
Sep 2020
elifesciences.org elifesciences.org

Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice

1
1. scibot 04 Sep 2020
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.7554/eLife.43738
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_C865

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scibot

URL

elifesciences.org/articles/43738
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:CVCL_C865
  
  DOI: 10.7554/eLife.43738
  
  Resource: (RRID:CVCL_C865)
  
  Curator: @evieth
  
  SciCrunch record: RRID:CVCL_C865
  
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  RRID:CVCL_C865 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_C865

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6392498/
Nov 2017
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors

1
1. scibot 08 Nov 2017
  
  in Public
  
  RRID:CVCL_C865
  
  Resource used:
  
  RRID:CVCL_C865
  
  SciCrunch record: RRID:CVCL_C865
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_C865
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RRID:CVCL_C865

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5648527/
elifesciences.org elifesciences.org

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

1
1. scibot 08 Nov 2017
  
  in Public
  
  RRID:CVCL_C865
  
  Curator: @kaitlinsung
  
  Resource used:
  
  RRID:CVCL_C865
  
  SciCrunch record: RRID:CVCL_C865
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_C865 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_C865

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scibot

URL

elifesciences.org/articles/23468
elifesciences.org elifesciences.org

Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states

1
1. scibot 08 Nov 2017
  
  in Public
  
  RRID:CVCL_C865
  
  Curator: @chewbeccax
  
  Resource used:
  
  RRID:CVCL_C865
  
  SciCrunch record: RRID:CVCL_C865
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_C865 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:CVCL_C865

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scibot

URL

elifesciences.org/articles/20487
www.sciencedirect.com www.sciencedirect.com

Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency

1
1. scibot 08 Nov 2017
  
  in Public
  
  CVCL_C865
  
  Curator: @gabimpine
  
  Resource used:
  
  RRID:CVCL_C865
  
  SciCrunch record: RRID:CVCL_C865
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_C865 RRIDCUR:Validated
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RRID:CVCL_C865

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scibot

URL

sciencedirect.com/science/article/pii/S155041311730222X
www.sciencedirect.com www.sciencedirect.com

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

1
1. scibot 08 Nov 2017
  
  in Public
  
  V6.5 mouse embryonic stem cells
  
  Curator: @kaitlinsung
  
  Resource used:
  
  RRID:CVCL_C865
  
  SciCrunch record: RRID:CVCL_C865
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_C865 RRIDCUR:Missing
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RRID:CVCL_C865

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scibot

URL

sciencedirect.com/science/article/pii/S1097276517300394
www.sciencedirect.com www.sciencedirect.com

Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction

1
1. scibot 08 Nov 2017
  
  in Public
  
  Immunoblot analysis revealed that the expression levels of Ezrin were similar in V6.5 ES cells, ES–TS and TS cells.
  
  Curator: @gabimpine
  
  Resource used:
  
  RRID:CVCL_C865
  
  SciCrunch record: RRID:CVCL_C865
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:CVCL_C865
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RRID:CVCL_C865

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scibot

URL

sciencedirect.com/science/article/pii/S0012160613000079