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Integrative proteomics defines FANCA as a multifunctional hub linking DNA repair to translation

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1. scibot 11 Sep 2026
  
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  DOI: 10.1016/j.isci.2026.117461
  
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sciencedirect.com/science/article/pii/S2589004226028397
Sep 2026
www.biorxiv.org www.biorxiv.org

Cell-state–dependent responses to PLK1 inhibition reveal a non-canonical microtubule-endolysosomal vulnerability in quiescent leukemia stem cells

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1. scibot 03 Sep 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.64898/2026.08.25.746864
  
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biorxiv.org/content/10.64898/2026.08.25.746864v1
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species

1
1. scibot 01 Sep 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1113/EP093939
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/EP093939
Aug 2026
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An inherited hypomorphic variant in PIEZO2 reveals structural features of mechanotransduction

1
1. scibot 27 Aug 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.neuron.2026.07.030
  
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sciencedirect.com/science/article/pii/S0896627326005854
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Translational reading frame predicts the pathogenicity of C-terminal frameshift deletions in MeCP2

1
1. scibot 14 Aug 2026
  
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  DOI: 10.7554/eLife.109170
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13456685/
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

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1. scibot 11 Aug 2026
  
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  DOI: 10.1002/1873-3468.70428
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70428
Jul 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Dynamic regulation of origin firing factors links CDK activity to dormant origin activation

1
1. scibot 23 Jul 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1038/s41467-026-73333-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13381859/
elifesciences.org elifesciences.org

Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

1
1. scibot 22 Jul 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.7554/eLife.109170.2
  
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elifesciences.org/reviewed-preprints/109170
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Functional validation of a novel PBX1 missense variant in a 46,XY girl

1
1. scibot 03 Apr 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1159/000550575
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13043130/
Mar 2026
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RNA binding as an emerging regulatory dimension in the type I IFN response

1
1. scibot 31 Mar 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.celrep.2026.117174
  
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sciencedirect.com/science/article/pii/S2211124726002524
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing

1
1. scibot 25 Mar 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.7554/eLife.103167
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13004596/
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CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1

1
1. scibot 24 Mar 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.str.2026.02.015
  
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sciencedirect.com/science/article/pii/S0969212626000560
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ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA

1
1. scibot 20 Mar 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.molcel.2026.02.015
  
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sciencedirect.com/science/article/pii/S1097276526001292
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SMG1:SMG8:SMG9-complex integrity supports efficient execution of nonsense-mediated mRNA decay

1
1. scibot 17 Mar 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1093/nar/gkag193
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12988323/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells

1
1. scibot 06 Mar 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1038/s44318-025-00690-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12953764/
Feb 2026
www.nature.com www.nature.com

Composite SMG5-SMG6 PIN domain formation is essential for NMD

1
1. scibot 24 Feb 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1038/s41467-026-69819-w
  
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nature.com/articles/s41467-026-69819-w
Jan 2026
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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

1
1. scibot 23 Jan 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.cell.2025.12.012
  
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sciencedirect.com/science/article/pii/S0092867425014254
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Protocol to identify mechanosensitive nuclear proteins using tunable actomyosin contractility and proximity biotinylation in mammalian cells

1
1. scibot 08 Jan 2026
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.xpro.2025.104288
  
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sciencedirect.com/science/article/pii/S266616672500694X
Oct 2025
rupress.org rupress.org

PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy

1
1. scibot 23 Oct 2025
  
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  CVCL_U427
  
  DOI: 10.1083/jcb.202411184
  
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rupress.org/jcb/article/224/11/e202411184/278363/PEX14-acts-as-a-molecular-link-between-optineurin
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain

1
1. scibot 17 Oct 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1038/s41419-025-08030-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12501252/
Sep 2025
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Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome

1
1. scibot 11 Sep 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.molcel.2025.08.015
  
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sciencedirect.com/science/article/pii/S1097276525007002
Aug 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225016700-main-html.html

1
1. scibot 26 Aug 2025
  
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  CVCL_U427
  
  DOI: 10.1016/j.isci.2025.113409
  
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52.53.155.43/4372abf4b2014350098304e34a7dd181ed1c457c/1-s2.0-S2589004225016700-main-html.html
Jul 2025
journals.plos.org journals.plos.org

Legionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins

1
1. scibot 30 Jul 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1371/journal.pbio.3003261
  
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journals.plos.org/plosbiology/article
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

1
1. scibot 25 Jun 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.7554/eLife.103403
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12185105/
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Machine-guided dual-objective protein engineering for deimmunization and therapeutic functions

1
1. scibot 04 Jun 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.cels.2025.101299
  
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sciencedirect.com/science/article/pii/S2405471225001322
May 2025
onlinelibrary.wiley.com onlinelibrary.wiley.com

Proteomics Analysis of the TDP-43 Interactome in Cellular Models of ALS Pathogenesis

1
1. scibot 20 May 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1111/jnc.70079
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70079
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Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism

1
1. scibot 17 May 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.chembiol.2025.04.006
  
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sciencedirect.com/science/article/pii/S2451945625001291
Apr 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225005346-main-html.html

2
1. scibot 05 Apr 2025
  
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  RRID: CVCL_U427
  
  DOI: 10.1016/j.isci.2025.112273
  
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  Curator: @areedewitt04
  
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  DOI: 10.1016/j.isci.2025.112273
  
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52.53.155.43/ffc1abcd89845af00863627f973ae3032304893a/1-s2.0-S2589004225005346-main-html.html
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase

1
1. scibot 28 Mar 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.molpha.2024.100008
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11934283/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges

1
1. scibot 18 Mar 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1038/s44319-025-00374-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11894219/
Feb 2025
www.nature.com www.nature.com

Molecular mechanisms of CAND2 in regulating SCF ubiquitin ligases

1
1. scibot 27 Feb 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1038/s41467-025-57065-5
  
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nature.com/articles/s41467-025-57065-5
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase

1
1. scibot 30 Jan 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.molcel.2025.01.002
  
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sciencedirect.com/science/article/pii/S1097276525000024
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A microscopy-based screen identifies cellular kinases modulating mitochondrial translation

1
1. scibot 03 Jan 2025
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.celrep.2024.115143
  
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sciencedirect.com/science/article/pii/S2211124724014943
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SLP2 and MIC13 synergistically coordinate MICOS assembly and crista junction formation

1
1. scibot 14 Dec 2024
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.isci.2024.111467
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11667180/
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Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

1
1. scibot 12 Dec 2024
  
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  RRID:CVCL_U427
  
  DOI: 10.1016/j.molcel.2024.11.015
  
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sciencedirect.com/science/article/pii/S1097276524009201
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m6A sites in the coding region trigger translation-dependent mRNA decay

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1. scibot 02 Dec 2024
  
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  R78007
  
  DOI: 10.1016/j.molcel.2024.10.033
  
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sciencedirect.com/science/article/pii/S1097276524008736
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Nuclear Factor I family members are key transcription factors regulating gene expression

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Homozygous variant in translocase of outer mitochondrial membrane 7 leads to metabolic reprogramming and microcephalic osteodysplastic dwarfism with moyamoya disease

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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

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Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint

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Pervasive mislocalization of pathogenic coding variants underlying human disorders

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The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain

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C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes

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Multi-omics analysis using antibody-based in situ biotinylation technique suggests the mechanism of Cajal body formation

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Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ

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DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs

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Subtype-Specific Ligand Binding and Activation Gating in Homomeric and Heteromeric P2X Receptors

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  Flp-In-T-REx 293
  
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Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role

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The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress

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Assembly mechanism of Integrator’s RNA cleavage module

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circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA

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The molecular basis of tRNA selectivity by human pseudouridine synthase 3

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Functional implications of the interaction of the SARS-CoV-2 Nucleocapsid protein with factors involved in nonsense-mediated mRNA decay

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Bioisosteric analogs of MDMA: Improving the pharmacological profile?

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Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

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The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges

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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates

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CAND1 inhibits Cullin-2-RING ubiquitin ligases for enhanced substrate specificity

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Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies

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Mechanism of orphan subunit recognition during assembly quality control

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Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation

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Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV

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Coupled protein quality control during nonsense-mediated mRNA decay

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Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair

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Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism

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A central chaperone-like role for 14-3-3 proteins in human cells

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Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis

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Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome

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Human mitochondria require mtRF1 for translation termination at non-canonical stop codons

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Oct 2022
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ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins

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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

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Aug 2022
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N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

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Jun 2022
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Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillance

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  DOI: 10.1093/nar/gkac428
  
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The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

1
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Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine

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Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay

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diabetesjournals.org diabetesjournals.org

Sulfated Progesterone Metabolites That Enhance Insulin Secretion Via Trpm3 are Reduced in Serum From Women with Gestational Diabetes Mellitus

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Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

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Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36

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Promiscuous G-protein coupled receptor inhibition of transient receptor potential melastatin 3 ion channels by Gβγ subunits

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Untitled document

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Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression

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The Exon Junction Complex Undergoes a Compositional Switch that Alters mRNP Structure and Nonsense-Mediated mRNA Decay Activity

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System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection

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MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition

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Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity

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Lysozyme Counteracts β-Lactam Antibiotics by Promoting the Emergence of L-Form Bacteria

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Untitled document

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An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells

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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

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Endogenous p53 expression in human and mouse is not regulated by its 3′UTR

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The final step of 40S ribosomal subunit maturation is controlled by a dual key lock

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TopBP1 assembles nuclear condensates to switch on ATR signaling

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Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability

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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

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Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

1
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SON and SRRM2 are essential for nuclear speckle formation

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Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

1
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A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

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EDF1 coordinates cellular responses to ribosome collisions

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The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness

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Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

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Using TT chem -seq for profiling nascent transcription and measuring transcript elongation

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BPS Publications

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Multiplex Cell Fate Tracking by Flow Cytometry

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Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

1
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Combined proximity labeling and affinity purification−mass spectrometry workflow for mapping and visualizing protein interaction networks

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An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis

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sciencedirect.com/science/article/pii/S1097276519303922
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Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

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1. scibot 13 Jan 2020
  
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  RRID:CVCL_U427
  
  DOI: 10.7554/eLife.46740
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6541436/
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1. scibot 13 Jan 2020
  
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  RRID:CVCL_U427
  
  DOI: 10.1111/bph.14547
  
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Untitled document

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  RRID:CVCL_U427
  
  DOI: 10.7554/eLife.39180
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6345565/
Nov 2018
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Untitled document

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1. scibot 05 Nov 2018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6141234/
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ncbi.nlm.nih.gov/pmc/articles/PMC6087429/
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Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death

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1. scibot 05 Nov 2018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6070338/
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Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S0969212618301783
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Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

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sciencedirect.com/science/article/pii/S1097276517308808
Nov 2017
elifesciences.org elifesciences.org

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

1
1. scibot 08 Nov 2017
  
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  RRID:CVCL_U427
  
  Curator: @kaitlinsung
  
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elifesciences.org/articles/26138
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TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III

1
1. scibot 08 Nov 2017
  
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  Flp-In T-REx 293 Cell Line
  
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Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex

1
1. scibot 08 Nov 2017
  
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  CVCL_U427
  
  Curator: @chewbeccax
  
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EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus

1
1. scibot 08 Nov 2017
  
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  CVCL_U427
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5224922/
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Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

1
1. scibot 08 Nov 2017
  
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  CVCL_U427
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5016092/
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Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

1
1. scibot 08 Nov 2017
  
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  CVCL_U427
  
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sciencedirect.com/science/article/pii/S0092867416309734

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