42 Matching Annotations
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    The WEE1 inhibitor azenosertib broadly enhances efficacy of antibody-drug conjugates with topoisomerase I and microtubule inhibitor payloads
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    sciencedirect.com/science/article/pii/S2589004226017657
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis
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  5. May 2026
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    DNA hypomethylation-activated PRAME drives early-stage lung adenocarcinoma recurrence via ZNF740 and PI3K/AKT/mTOR signaling
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  7. Apr 2026
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    Prenatal bisphenol A exposure reprograms SF1-lactylation pathways to promote endometriosis susceptibility
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    Potency and safety of novel [225Ac]Ac-labeled pertuzumab-PEGylated emtansine drug conjugate against HER2-positive breast cancer
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    nature.com/articles/s41416-026-03393-2
  10. Mar 2026
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    Expanded applications of bioluminescence microscopy with phasor analysis
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells
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  14. Feb 2026
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    [225Ac]Ac-labeled matuzumab is an effective radioimmunotherapeutic against EGFR-positive triple negative breast cancer
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    Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis
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    Pharmacokinetic-pharmacodynamic-efficacy modeling of the MDM2 inhibitor brigimadlin in glioblastoma patient-derived xenografts
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  18. Jan 2026
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    A Jagged1-regulated hybrid-EMT state identifies pancreatic cancer stem cells
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  20. Dec 2025
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    Nε-Carboxymethyl-Lysine Drives Centrosome Amplification and Hepatocarcinogenesis via Pathological Dysregulation of the PLK1-CEP20-CCDC116 Axis
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  23. Oct 2025
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    Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3
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  25. Sep 2025
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    Pre-clinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-wildtype Glioblastoma
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  27. Jul 2025
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    Tumor-specific antigen delivery for T-cell therapy via a pH-sensitive peptide conjugate
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  29. Jun 2025
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    BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma
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    Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma
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  35. Feb 2025
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    SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer
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  37. Jan 2025
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  39. Dec 2024
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    Development and evaluation of a single domain antibody targeting folate receptor alpha for radioligand therapy
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  41. Nov 2024
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    Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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  46. May 2024
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    SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer
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  48. Mar 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
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  50. Feb 2024
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    Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors
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  53. Apr 2023
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    Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
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  55. Mar 2023
  56. www.thelancet.com www.thelancet.com
    Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence
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    Safety and efficacy of intraventricular immunovirotherapy with oncolytic HSV-1 for CNS cancers
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  58. Dec 2022
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  60. Sep 2022
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    A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling
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  62. May 2022
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    Secretion of interleukin-1 by dedifferentiated melanoma cells inhibits JAK1-STAT3-driven actomyosin contractility of lymph node fibroblastic reticular cells
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  64. Nov 2021
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    Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug
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  66. Jul 2021
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    ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors
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  68. Apr 2021
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    YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
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  70. Nov 2017
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    Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis
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    Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature
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