Hypothesis

30 Matching Annotations

Jun 2026
www.sciencedirect.com www.sciencedirect.com

Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis

1
1. scibot 27 Jun 2026
  
  in Public
  
  JAX:002650
  
  DOI: 10.1016/j.cell.2026.05.049
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

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sciencedirect.com/science/article/pii/S0092867426006495
www.biorxiv.org www.biorxiv.org

Transient protein phosphorylation promotes disease tolerance to sepsis

1
1. scibot 26 Jun 2026
  
  in Public
  
  Jackson Laboratories; stock 002650
  
  DOI: 10.64898/2026.06.09.731055
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

biorxiv.org/content/10.64898/2026.06.09.731055v1
Jan 2026
www.sciencedirect.com www.sciencedirect.com

Discovery, delineation, and therapeutic targeting of a hyper-translation pathway driving cytokine release syndrome

1
1. scibot 06 Jan 2026
  
  in Public
  
  JAX:002650
  
  DOI: 10.1016/j.xcrm.2025.102531
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S2666379125006044
Aug 2025
www.biorxiv.org www.biorxiv.org

Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Nerve Outgrowth and Tumor Progression

1
1. scibot 06 Aug 2025
  
  in Public
  
  Strain #002650
  
  DOI: 10.1101/2025.07.22.666151
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

biorxiv.org/content/10.1101/2025.07.22.666151v1
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis

1
1. scibot 11 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1158/2159-8290.CD-24-0093
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
www.sciencedirect.com www.sciencedirect.com

Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling

1
1. scibot 11 Jun 2025
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.cell.2025.05.012
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S0092867425005628
May 2025
52.53.155.43 52.53.155.43

1-s2.0-S221287782500078X-main-html.html

1
1. scibot 29 May 2025
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.molmet.2025.102171
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

52.53.155.43/ddf86bb28ecae9e94494761c9049b8a43fbeb69b/1-s2.0-S221287782500078X-main-html.html
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Meningeal lymphatics-microglia axis regulates synaptic physiology

2
1. scibot 01 Apr 2025
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.cell.2025.02.022
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
  What is this?
  
  RRID:IMSR_JAX:002650
2. scibot 01 Apr 2025
  
  in Public
  
  RRID:ISMR_JAX:002650
  
  DOI: 10.1016/j.cell.2025.02.022
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:002650
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RRIDCUR:Unresolved

RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S0092867425002107
Feb 2025
aacrjournals.org aacrjournals.org

Inflammation mediated by gut microbiome alterations promotes lung cancer development and an immunosuppressed tumor microenvironment

1
1. scibot 20 Feb 2025
  
  in Public
  
  JAX strain code: 002650
  
  DOI: 10.1158/2326-6066.CIR-24-0469
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

aacrjournals.org/cancerimmunolres/article/12/12/1736/750301/Inflammation-Mediated-by-Gut-Microbiome
Jul 2024
www.sciencedirect.com www.sciencedirect.com

PTEN acts as a crucial inflammatory checkpoint controlling TLR9/IL-6 axis in B cells

1
1. scibot 23 Jul 2024
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.isci.2024.110388
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S2589004224016134
Jul 2023
www.sciencedirect.com www.sciencedirect.com

LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer

1
1. scibot 13 Jul 2023
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.devcel.2023.06.006
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S1534580723003040
www.sciencedirect.com www.sciencedirect.com

TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation

1
1. scibot 01 Jul 2023
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.immuni.2023.06.007
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S1074761323002649
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Lymphatic vessels in bone support regeneration after injury

1
1. scibot 21 Jan 2023
  
  in Public
  
  RRID:IMSR_JAX:002
  
  DOI: 10.1016/j.cell.2022.12.031
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @MufeiL
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
  What is this?
  
  RRID:IMSR_JAX:002650 RRIDCUR:Unresolved
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RRIDCUR:Unresolved

RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S0092867422015744
Oct 2022
www.sciencedirect.com www.sciencedirect.com

Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output

1
1. scibot 05 Oct 2022
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.celrep.2022.111447
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722012888
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Decoding the activated stem cell phenotype of the neonatally maturing pituitary

1
1. scibot 31 Jul 2022
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.7554/eLife.75742
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9333987/
Jun 2022
www.sciencedirect.com www.sciencedirect.com

Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication

1
1. scibot 15 Jun 2022
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.immuni.2022.05.013
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S1074761322002333
Mar 2022
www.sciencedirect.com www.sciencedirect.com

A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise

1
1. scibot 11 Mar 2022
  
  in Public
  
  JAX:002650
  
  DOI: 10.1016/j.stem.2022.02.008
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S1934590922000595
Feb 2022
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein

1
1. scibot 16 Feb 2022
  
  in Public
  
  Jackson Labs002650
  
  DOI: 10.1016/j.celrep.2022.110358
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

pubmed.ncbi.nlm.nih.gov/35172141/
Nov 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy

1
1. scibot 05 Nov 2021
  
  in Public
  
  IMSR_JAX:002650
  
  DOI: 10.1038/s41467-021-26407-4
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8553783/
Oct 2021
www.sciencedirect.com www.sciencedirect.com

Interleukin-6 Promotes Microtubule Stability in Axons via Stat3 Protein-Protein Interactions

1
1. scibot 15 Oct 2021
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.isci.2021.103141
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S2589004221011093
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

1
1. scibot 25 Aug 2021
  
  in Public
  
  JAX:002650
  
  DOI: 10.1016/j.celrep.2021.109608
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721010469
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 12 Aug 2021
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.stemcr.2018.03.008
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5995693/
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

1
1. scibot 29 Jul 2021
  
  in Public
  
  Stock#2650
  
  DOI: 10.1016/j.stem.2019.06.007
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
  What is this?
  
  RRID:IMSR_JAX:002650 RRIDCUR:Unrecognized
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RRIDCUR:Unrecognized

RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S1934590919302711
www.sciencedirect.com www.sciencedirect.com

Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles

1
1. scibot 28 Jul 2021
  
  in Public
  
  002650
  
  DOI: 10.1016/j.immuni.2019.02.001
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
  What is this?
  
  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S1074761319300469
Feb 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Involvement of the Hsp70/TLR4/IL‐6 and TNF‐α pathways in delayed‐onset muscle soreness

1
1. scibot 25 Feb 2021
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1111/jnc.15006
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

onlinelibrary.wiley.com/doi/10.1111/jnc.15006
www.cell.com www.cell.com

Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons

1
1. scibot 25 Feb 2021
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  DOI: 10.1016/j.immuni.2020.12.016
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
  What is this?
  
  RRIDCUR:Validated RRID:IMSR_JAX:002650
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RRIDCUR:Validated

RRID:IMSR_JAX:002650

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scibot

URL

cell.com/immunity/abstract/S1074-7613(20)30544-6
Dec 2020
www.sciencedirect.com www.sciencedirect.com

The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells

1
1. scibot 31 Dec 2020
  
  in Public
  
  002650
  
  DOI: 10.1016/j.immuni.2020.12.001
  
  Resource: (IMSR Cat# JAX_002650,RRID:IMSR_JAX:002650)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S1074761320305082
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  Resource used:
  
  RRID:IMSR_JAX:002650
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:IMSR_JAX:002650
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RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S1931312818300428
www.sciencedirect.com www.sciencedirect.com

Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:002650
  
  Curator: @evieth
  
  Resource used:
  
  RRID:IMSR_JAX:002650
  
  SciCrunch record: RRID:IMSR_JAX:002650
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:002650 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:002650

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scibot

URL

sciencedirect.com/science/article/pii/S2213671118301358