Hypothesis

22 Matching Annotations

Last 7 days
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Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence

1
1. scibot 25 Sep 2025
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1016/j.celrep.2025.116339
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

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sciencedirect.com/science/article/pii/S2211124725011106
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Survivin promotes stem cell competence for skin cancer initiation

1
1. scibot 20 Sep 2025
  
  in Public
  
  JAX:005130
  
  DOI: 10.1158/2159-8290.CD-24-0263
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC7617290/
May 2025
www.sciencedirect.com www.sciencedirect.com

Epidermal growth factor receptor specific immunotherapy for SHH medulloblastoma tested in an in vitro blood-brain-barrier model

1
1. scibot 29 May 2025
  
  in Public
  
  JAX #005130
  
  DOI: 10.1016/j.ctarc.2025.100950
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

sciencedirect.com/science/article/pii/S2468294225000863
Jan 2025
www.sciencedirect.com www.sciencedirect.com

A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance

1
1. scibot 28 Jan 2025
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1016/j.devcel.2025.01.001
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

sciencedirect.com/science/article/pii/S1534580725000012
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma

1
1. scibot 25 Sep 2024
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1158/0008-5472.CAN-22-3784
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10948029/
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cell populations

1
1. scibot 15 Dec 2023
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1016/j.isci.2023.108443
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10716552/
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors

1
1. scibot 25 Jan 2023
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1158/2767-9764.crc-22-0124
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9853917/
Dec 2022
www.sciencedirect.com www.sciencedirect.com

Niche-mediated repair of airways is directed in an occupant-dependent manner

1
1. scibot 24 Dec 2022
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1016/j.celrep.2022.111863
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

sciencedirect.com/science/article/pii/S2211124722017594
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice

1
1. scibot 17 Aug 2022
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1016/j.devcel.2022.07.016
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

sciencedirect.com/science/article/pii/S1534580722005470
Jul 2022
www.jneurosci.org www.jneurosci.org

Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning

1
1. scibot 14 Jul 2022
  
  in Public
  
  The Jackson Laboratory, stock #005130
  
  DOI: 10.1523/JNEUROSCI.2073-21.2022
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

jneurosci.org/content/42/26/5130
Jun 2022
aacrjournals.org aacrjournals.org

Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors

1
1. scibot 15 Jun 2022
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1158/2767-9764.CRC-22-0124
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

aacrjournals.org/cancerrescommun/article/2/6/402/699311/Cancer-Stem-Cells-not-Bulk-Tumor-Cells-Determine
Sep 2021
www.nature.com www.nature.com

Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

1
1. scibot 28 Sep 2021
  
  in Public
  
  JAX # 005130
  
  DOI: 10.1038/s42003-021-02567-3
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  What is this?
  
  RRID:IMSR_JAX:005130 RRIDCUR:Missing
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RRID:IMSR_JAX:005130

RRIDCUR:Missing

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scibot

URL

nature.com/articles/s42003-021-02567-3
Jul 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Stage‐specific regulation of oligodendrocyte development by Hedgehog signaling in the spinal cord

1
1. scibot 31 Jul 2021
  
  in Public
  
  005130
  
  DOI: 10.1002/glia.23729
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  What is this?
  
  RRID:IMSR_JAX:005130 RRIDCUR:Missing
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RRID:IMSR_JAX:005130

RRIDCUR:Missing

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/glia.23729
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

1
1. scibot 27 Jul 2021
  
  in Public
  
  RRID:MGI:3576373
  
  DOI: 10.7554/eLife.42918
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  Curator comments: IMSR Cat# JAX:005130, STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J Mus musculus
  
  What is this?
  
  RRIDCUR:Unresolved RRID:IMSR_JAX:005130 RRIDCUR:Incorrect
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RRIDCUR:Incorrect

RRID:IMSR_JAX:005130

RRIDCUR:Unresolved

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6459675/
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia

1
1. scibot 21 Apr 2021
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.1016/j.stem.2021.03.019
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  What is this?
  
  RRID:IMSR_JAX:005130 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:005130

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scibot

URL

sciencedirect.com/science/article/pii/S1934590921001521
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

1
1. scibot 24 Feb 2021
  
  in Public
  
  MGI:3576373
  
  DOI: 10.7554/eLife.60234
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  What is this?
  
  RRID:IMSR_JAX:005130 RRIDCUR:Unresolved RRIDCUR:NotRRID
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RRID:IMSR_JAX:005130

RRIDCUR:Unresolved

RRIDCUR:NotRRID

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7655103/
Nov 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

1
1. scibot 18 Nov 2020
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  DOI: 10.7554/eLife.60234
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  What is this?
  
  RRID:IMSR_JAX:005130 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:IMSR_JAX:005130

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7655103/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog

1
1. scibot 03 Sep 2020
  
  in Public
  
  The Jackson LaboratoryStock No. 005130
  
  DOI: 10.1016/j.celrep.2020.03.027
  
  Resource: (IMSR Cat# JAX_005130,RRID:IMSR_JAX:005130)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
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  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720303417
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

1
1. scibot 05 Nov 2018
  
  in Public
  
  005130
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:005130
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:005130 RRIDCUR:Missing
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RRID:IMSR_JAX:005130

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1534580718301072
www.sciencedirect.com www.sciencedirect.com

mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

1
1. scibot 05 Nov 2018
  
  in Public
  
  005130
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:005130
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:005130 RRIDCUR:Missing
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RRID:IMSR_JAX:005130

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1534580717308249
www.sciencedirect.com www.sciencedirect.com

Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:005130
  
  Resource used:
  
  RRID:IMSR_JAX:005130
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:005130
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RRID:IMSR_JAX:005130

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scibot

URL

sciencedirect.com/science/article/pii/S153561081730524X
Nov 2017
www.sciencedirect.com www.sciencedirect.com

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme

1
1. scibot 08 Nov 2017
  
  in Public
  
  005130
  
  Curator: @Jmenke
  
  Resource used:
  
  RRID:IMSR_JAX:005130
  
  SciCrunch record: RRID:IMSR_JAX:005130
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:IMSR_JAX:005130 RRIDCUR:Missing
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RRID:IMSR_JAX:005130

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1534580717306792