547 Matching Annotations
  1. Dec 2022
  2. www.sciencedirect.com www.sciencedirect.com
    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
    1
    1. scibot 17 Dec 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2022.11.015

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    sciencedirect.com/science/article/pii/S1535610822005621
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    Expression of inducible factors reprograms CAR-T cells for enhanced function and safety
    1
    1. scibot 13 Dec 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2022.11.006

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    sciencedirect.com/science/article/pii/S1535610822005530
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    Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells
    1
    1. scibot 08 Dec 2022
      JAX:005557

      DOI: 10.1016/j.cmet.2022.11.003

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    sciencedirect.com/science/article/pii/S1550413122004946
  5. aacrjournals.org aacrjournals.org
    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
    1
    1. scibot 03 Dec 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-21-1491

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    aacrjournals.org/cancerdiscovery/article/12/12/2880/711164/BAF-Complex-Maintains-Glioma-Stem-Cells-in
  6. Nov 2022
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    Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis
    1
    1. scibot 18 Nov 2022
      JAX:005557

      DOI: 10.1016/j.molcel.2022.10.027

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    sciencedirect.com/science/article/pii/S1097276522010553
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    Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis
    1
    1. scibot 16 Nov 2022
      005557

      DOI: 10.1016/j.celrep.2022.111672

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    sciencedirect.com/science/article/pii/S2211124722015467
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    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
    1
    1. scibot 16 Nov 2022
      RRID:IMSR_JAX:005

      DOI: 10.1016/j.xcrm.2022.100815

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    sciencedirect.com/science/article/pii/S2666379122003743
  10. www.science.org www.science.org
    Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
    2
    1. scibot 12 Nov 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abm1463

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    2. scibot 12 Nov 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abm1463

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    science.org/doi/10.1126/scitranslmed.abm1463
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    Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma
    1
    1. scibot 11 Nov 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2022.10.009

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    sciencedirect.com/science/article/pii/S1535610822005001
  12. www.sciencedirect.com www.sciencedirect.com
    Protocol for evaluating antitumor activity of KIR3DL3 blockade in an NK cell-based xenogeneic lung tumor model
    1
    1. scibot 05 Nov 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xpro.2022.101818

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    sciencedirect.com/science/article/pii/S2666166722006980
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    Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy
    1
    1. scibot 03 Nov 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.111582

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    sciencedirect.com/science/article/pii/S2211124722014474
  14. Oct 2022
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier
    1
    1. scibot 27 Oct 2022
      JAX:005557

      DOI: 10.7554/eLife.80690

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    ncbi.nlm.nih.gov/pmc/articles/PMC9596162/
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    Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation
    1
    1. scibot 26 Oct 2022
      005557

      DOI: 10.1016/j.celrep.2022.111555

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    sciencedirect.com/science/article/pii/S2211124722014115
  17. www.sciencedirect.com www.sciencedirect.com
    PARP-inhibition reprograms macrophages toward an anti-tumor phenotype
    1
    1. scibot 13 Oct 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.111462

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    sciencedirect.com/science/article/pii/S2211124722013079
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    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
    1
    1. scibot 07 Oct 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.molcel.2022.09.007

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    sciencedirect.com/science/article/pii/S1097276522008966
  19. www.sciencedirect.com www.sciencedirect.com
    Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
    1
    1. scibot 07 Oct 2022
      JAX:005557

      DOI: 10.1016/j.chembiol.2022.09.002

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    sciencedirect.com/science/article/pii/S2451945622003506
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
    1
    1. scibot 04 Oct 2022
      RRID:IMSR_JAX

      DOI: 10.1016/j.medj.2022.09.002

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    sciencedirect.com/science/article/pii/S2666634022004032
  21. Sep 2022
  22. www.sciencedirect.com www.sciencedirect.com
    Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I−/− iPSCs for β cell replacement
    1
    1. scibot 29 Sep 2022
      JAX:005557

      DOI: 10.1016/j.celrep.2022.111423

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    sciencedirect.com/science/article/pii/S2211124722012645
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
    1
    1. scibot 29 Sep 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.111428

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    sciencedirect.com/science/article/pii/S2211124722012694
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    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
    1
    1. scibot 24 Sep 2022
      005557

      DOI: 10.1016/j.ccell.2022.08.015

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    sciencedirect.com/science/article/pii/S1535610822003798
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acute Myeloid Leukemia Alters Group 1 Innate Lymphoid Cell Differentiation from a Common Precursor
    1
    1. scibot 21 Sep 2022
      RRID:IMSR_JAX:005557

      DOI: 10.4049/jimmunol.2100023

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    ncbi.nlm.nih.gov/pmc/articles/PMC8429221/
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    In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy
    1
    1. scibot 15 Sep 2022
      JAX:005557

      DOI: 10.1016/j.chembiol.2022.08.006

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    sciencedirect.com/science/article/pii/S2451945622003142
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    Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters
    1
    1. scibot 15 Sep 2022
      RRID:IMSR_JAC:005557

      DOI: 10.1016/j.isci.2022.105013

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    sciencedirect.com/science/article/pii/S2589004222012858
  28. www.sciencedirect.com www.sciencedirect.com
    ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes
    1
    1. scibot 08 Sep 2022
      Mouse: NSG NOD/ShiLtJ

      DOI: 10.1016/j.cmet.2022.08.007

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    sciencedirect.com/science/article/pii/S1550413122003503
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
    1
    1. scibot 02 Sep 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-21-1077

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904298/
  30. Aug 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Vitamin D receptor activation is a feasible therapeutic target to impair adrenocortical tumorigenesis
    2
    1. scibot 30 Aug 2022
      JAX_005557

      DOI: 10.1016/j.mce.2022.111757

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    2. scibot 30 Aug 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.mce.2022.111757

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    sciencedirect.com/science/article/pii/S0303720722002052
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors
    1
    1. scibot 28 Aug 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1172/jci.insight.155899

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    ncbi.nlm.nih.gov/pmc/articles/PMC9462490/
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    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
    1
    1. scibot 22 Aug 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2022.07.012

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    sciencedirect.com/science/article/pii/S1535610822003257
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    Off-The-Shelf Third-Party HSC-Engineered iNKT Cells for Ameliorating GvHD While Preserving GvL Effect in the Treatment of Blood Cancers
    1
    1. scibot 17 Aug 2022
      The Jackson LaboratoryStock #: 005557

      DOI: 10.1016/j.isci.2022.104859

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    sciencedirect.com/science/article/pii/S2589004222011312
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    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
    1
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      Jackson LaboratoryCat #005557

      DOI: 10.1016/j.isci.2022.104827

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    sciencedirect.com/science/article/pii/S2589004222010999
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL
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      RRID:IMSR_JAX

      DOI: 10.1158/2159-8290.CD-21-1566

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    ncbi.nlm.nih.gov/pmc/articles/PMC9357155/
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    EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity
    1
    1. scibot 06 Aug 2022
      Jackson LaboratoriesCat# 005557

      DOI: 10.1016/j.stem.2022.06.014

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    sciencedirect.com/science/article/pii/S1934590922002958
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-20-1848

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    ncbi.nlm.nih.gov/pmc/articles/PMC8831451/
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    Co-targeting of specific epigenetic regulators in combination with CDC7 potently inhibit melanoma growth
    1
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      Jackson LaboratoryStock No. 005557

      DOI: 10.1016/j.isci.2022.104752

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    sciencedirect.com/science/article/pii/S2589004222010240
  40. Jul 2022
  41. www.sciencedirect.com www.sciencedirect.com
    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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      The Jackson Laboratory005557

      DOI: 10.1016/j.celrep.2022.111095

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    sciencedirect.com/science/article/pii/S221112472200897X
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EGFR inhibition enhances the cellular uptake and antitumor-activity of the HER3 antibody drug conjugate HER3-DXd
    1
    1. scibot 06 Jul 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-21-2426

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    ncbi.nlm.nih.gov/pmc/articles/PMC8732289/
  43. Jun 2022
  44. 52.53.155.43 52.53.155.43
    cd-21-0680-html.html
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    1. scibot 30 Jun 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-21-0680

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    Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
    1
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      JAX:005557

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    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
    1
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      Jackson LaboratoryStock# 005557

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    Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas
    1
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      JacksonCat#005557

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    Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
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      The Jackson LaboratoryStock No: 005557

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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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      Jackson Laboratory005557

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  50. aacrjournals.org aacrjournals.org
    Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-22-0124

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    Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids
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      The Jackson LaboratoryStrain #005557

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    A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs
    1
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      RRID:IMSR_JAX:005557

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  53. May 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Therapeutic development for Canavan disease using patient iPSCs introduced with the wild-type ASPA gene
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      Jackson Laboratory005557

      DOI: 10.1016/j.isci.2022.104391

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    Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors
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      The Jackson LaboratoryCat#005557

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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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      The Jackson Laboratory005557

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    c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity
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      Jackson Laboratory005557

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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
    1
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      JACKSON LABORATORYStock #: 005557

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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Matricellular protein WISP2 is an endogenous inhibitor of collagen linearization and cancer metastasis
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-20-3982

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    Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling
    1
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      RRID:IMSR_JAX:005557

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    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
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      Jackson Laboratories#005557

      DOI: 10.1016/j.cell.2022.04.019

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    Antigen presentation safeguards the integrity of the hematopoietic stem cell pool
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      JAX:005557

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    Patient-derived models of brain metastases recapitulate human disseminated disease
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      RRID:IMSR_JAX:005557

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  64. Apr 2022
  65. www.sciencedirect.com www.sciencedirect.com
    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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    1. scibot 29 Apr 2022
      The Jackson LaboratoryStrain: 005557

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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SynNotch CAR Circuits Enhance Solid Tumor Recognition and Promote Persistent Anti-tumor Activity in Mouse Models
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abd8836

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    The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma
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      Jackson Laboratoriesstrain 005557

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    Enhanced safety and efficacy of protease-regulated CAR-T cell receptors
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      Jackson Laboratory005557

      DOI: 10.1016/j.cell.2022.03.041

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  69. www.science.org www.science.org
    SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models
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      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abd8836

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    The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes
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      Jackson Laboratory005557

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    The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
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      Jackson LaboratoryJax: 005557

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    Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia
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    Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche
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      The Jackson LaboratoryStrain #:005557

      DOI: 10.1016/j.cell.2022.03.033

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    Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis
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    Modular design of synthetic receptors for programmed gene regulation in cell therapies
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    1. scibot 20 Apr 2022
      Jackson LaboratoriesCat#005557

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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
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    Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment
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    Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
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      Jackson#005557

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    Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma
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      Jackson LaboratoriesCat# 005557

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    Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors
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      The Jackson Laboratory; OCI colonyCat#005557

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  81. aacrjournals.org aacrjournals.org
    mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment
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      DOI: 10.1158/1541-7786.MCR-20-0799

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    Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
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      RRID:IMSR_JAX:005557

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      RRID:IMSR_JAX:005

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    Subversion of serotonin-receptor signaling in osteoblasts by kynurenine drives Acute Myeloid Leukemia
    1
    1. scibot 05 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-21-0692

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    aacrjournals.org/cancerdiscovery/article/12/4/1106/689604/Subversion-of-Serotonin-Receptor-Signaling-in
  84. Mar 2022
  85. www.nature.com www.nature.com
    ADARs act as potent regulators of circular transcriptome in cancer
    1
    1. scibot 26 Mar 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41467-022-29138-2

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    nature.com/articles/s41467-022-29138-2
  86. www.sciencedirect.com www.sciencedirect.com
    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
    1
    1. scibot 18 Mar 2022
      Jackson LaboratoryStock No: 005557

      DOI: 10.1016/j.cmet.2022.02.009

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    sciencedirect.com/science/article/pii/S1550413122000535
  87. www.sciencedirect.com www.sciencedirect.com
    Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function
    1
    1. scibot 18 Mar 2022
      Jackson labscat#: 005557

      DOI: 10.1016/j.stem.2022.02.010

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    sciencedirect.com/science/article/pii/S1934590922000613
  88. www.sciencedirect.com www.sciencedirect.com
    3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells
    1
    1. scibot 18 Mar 2022
      Jackson LaboratoryStrain #005557

      DOI: 10.1016/j.stem.2022.02.009

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    sciencedirect.com/science/article/pii/S1934590922000601
  89. www.sciencedirect.com www.sciencedirect.com
    Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML
    1
    1. scibot 09 Mar 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.110481

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    sciencedirect.com/science/article/pii/S2211124722002145
  90. www.sciencedirect.com www.sciencedirect.com
    Tumor-derived Jagged1 promotes cancer progression through immune evasion
    1
    1. scibot 09 Mar 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.110492

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    sciencedirect.com/science/article/pii/S221112472200225X
  91. www.sciencedirect.com www.sciencedirect.com
    CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
    1
    1. scibot 02 Mar 2022
      JAX:005557

      DOI: 10.1016/j.ccell.2022.02.003

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    sciencedirect.com/science/article/pii/S1535610822000368
  92. Feb 2022
  93. www.sciencedirect.com www.sciencedirect.com
    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
    1
    1. scibot 23 Feb 2022
      Jackson LaboratoryCat# 005557

      DOI: 10.1016/j.molcel.2022.01.022

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    sciencedirect.com/science/article/pii/S1097276522000879
  94. www.sciencedirect.com www.sciencedirect.com
    Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination
    1
    1. scibot 16 Feb 2022
      The Jackson Laboratory005557

      DOI: 10.1016/j.celrep.2022.110388

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    sciencedirect.com/science/article/pii/S2211124722001097
  95. www.sciencedirect.com www.sciencedirect.com
    Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth
    1
    1. scibot 13 Feb 2022
      RRID:IMSR_JAX

      DOI: 10.1016/j.medj.2021.12.008

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    sciencedirect.com/science/article/pii/S2666634021004098
  96. www.sciencedirect.com www.sciencedirect.com
    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
    2
    1. scibot 11 Feb 2022
      005557

      DOI: 10.1016/j.celrep.2022.110322

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    2. scibot 09 Feb 2022
      005557

      DOI: 10.1016/j.celrep.2022.110322

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    sciencedirect.com/science/article/pii/S221112472200033X
  97. link.springer.com link.springer.com
    When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer
    1
    1. scibot 08 Feb 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1186/s10020-022-00440-5

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    link.springer.com/article/10.1186/s10020-022-00440-5
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.
    1
    1. scibot 02 Feb 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-20-1200

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    ncbi.nlm.nih.gov/pmc/articles/PMC7854521/
  99. Jan 2022
  100. www.sciencedirect.com www.sciencedirect.com
    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
    1
    1. scibot 27 Jan 2022
      #005557

      DOI: 10.1016/j.devcel.2021.12.020

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    sciencedirect.com/science/article/pii/S1534580721010406
  101. www.sciencedirect.com www.sciencedirect.com
    Autologous humanized mouse models of iPSC-derived tumors enable characterization and modulation of cancer-immune cell interactions
    1
    1. scibot 16 Jan 2022
      The Jackson LaboratoryCat# 005557

      DOI: 10.1016/j.crmeth.2021.100153

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    sciencedirect.com/science/article/pii/S2667237521002307
  102. www.sciencedirect.com www.sciencedirect.com
    SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
    1
    1. scibot 12 Jan 2022
      The Jackson LaboratoryStock No: 005557

      DOI: 10.1016/j.celrep.2021.110233

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    sciencedirect.com/science/article/pii/S2211124721017423
  103. www.sciencedirect.com www.sciencedirect.com
    Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness
    1
    1. scibot 05 Jan 2022
      Cat#005557

      DOI: 10.1016/j.cmet.2021.12.001

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    sciencedirect.com/science/article/pii/S1550413121006203
  104. Dec 2021
  105. www.sciencedirect.com www.sciencedirect.com
    GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity
    1
    1. scibot 31 Dec 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2021.12.005

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    sciencedirect.com/science/article/pii/S1535610821006589
  106. www.sciencedirect.com www.sciencedirect.com
    EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion
    1
    1. scibot 28 Dec 2021
      Stock No. 005557

      DOI: 10.1016/j.cell.2021.12.005

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    sciencedirect.com/science/article/pii/S0092867421014276
  107. www.sciencedirect.com www.sciencedirect.com
    An NK-like CAR T cell transition in CAR T cell dysfunction
    1
    1. scibot 03 Dec 2021
      Cat# 5557

      DOI: 10.1016/j.cell.2021.11.016

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    sciencedirect.com/science/article/pii/S0092867421013313
  108. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
    1
    1. scibot 03 Dec 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s42003-021-02842-3

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    nature.com/articles/s42003-021-02842-3
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer
    1
    1. scibot 01 Dec 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abb3738

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    ncbi.nlm.nih.gov/pmc/articles/PMC8627689/
  110. Nov 2021
  111. www.sciencedirect.com www.sciencedirect.com
    Immuno-transcriptomic profiling of extracranial pediatric solid malignancies
    1
    1. scibot 30 Nov 2021
      Stock No: 005557

      DOI: 10.1016/j.celrep.2021.110047

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    sciencedirect.com/science/article/pii/S2211124721015333
  112. www.sciencedirect.com www.sciencedirect.com
    Distinct contributions of partial and full EMT to breast cancer malignancy
    1
    1. scibot 30 Nov 2021
      JAX:005557

      DOI: 10.1016/j.devcel.2021.11.006

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    sciencedirect.com/science/article/pii/S1534580721008911
  113. www.sciencedirect.com www.sciencedirect.com
    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
    1
    1. scibot 24 Nov 2021
      Stock# 005557

      DOI: 10.1016/j.celrep.2021.110054

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    sciencedirect.com/science/article/pii/S2211124721015400
  114. www.sciencedirect.com www.sciencedirect.com
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    1
    1. scibot 24 Nov 2021
      005557

      DOI: 10.1016/j.celrep.2021.110056

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    sciencedirect.com/science/article/pii/S2211124721015424
  115. www.sciencedirect.com www.sciencedirect.com
    Effective chimeric antigen receptor T-cells (CAR-Ts) against SARS-CoV-2
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    1. scibot 18 Nov 2021
      005557

      DOI: 10.1016/j.isci.2021.103295

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    sciencedirect.com/science/article/pii/S2589004221012645
  116. www.sciencedirect.com www.sciencedirect.com
    Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy
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    1. scibot 17 Nov 2021
      Stock #: 005557

      DOI: 10.1016/j.xcrm.2021.100449

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    sciencedirect.com/science/article/pii/S2666379121003177
  117. www.sciencedirect.com www.sciencedirect.com
    A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors
    1
    1. scibot 09 Nov 2021
      005557

      DOI: 10.1016/j.celrep.2021.109953

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    sciencedirect.com/science/article/pii/S2211124721014303
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells
    1
    1. scibot 05 Nov 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ebiom.2021.103646

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    ncbi.nlm.nih.gov/pmc/articles/PMC8546421/
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies
    1
    1. scibot 05 Nov 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-20-1243

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    ncbi.nlm.nih.gov/pmc/articles/PMC8406797/
  120. Oct 2021
  121. www.sciencedirect.com www.sciencedirect.com
    Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections
    1
    1. scibot 30 Oct 2021
      005557

      DOI: 10.1016/j.cell.2021.10.004

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    sciencedirect.com/science/article/pii/S0092867421011788
  122. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
    1
    1. scibot 21 Oct 2021
      005557

      DOI: 10.1016/j.celrep.2021.109870

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    sciencedirect.com/science/article/pii/S2211124721013371
  123. www.sciencedirect.com www.sciencedirect.com
    Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer
    1
    1. scibot 21 Oct 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2021.109852

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    sciencedirect.com/science/article/pii/S221112472101319X
  124. www.sciencedirect.com www.sciencedirect.com
    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
    1
    1. scibot 21 Oct 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2021.109873

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    sciencedirect.com/science/article/pii/S2211124721013401
  125. www.science.org www.science.org
    Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels
    1
    1. scibot 18 Oct 2021
      005557

      DOI: 10.1126/sciadv.abi7511

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    science.org/doi/10.1126/sciadv.abi7511
  126. www.science.org www.science.org
    Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer
    1
    1. scibot 18 Oct 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abb3738

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    science.org/doi/abs/10.1126/scitranslmed.abb3738
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels
    1
    1. scibot 15 Oct 2021
      JAX stock #005557

      DOI: 10.1126/sciadv.abi7511

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    ncbi.nlm.nih.gov/pmc/articles/PMC8494442/
  128. www.sciencedirect.com www.sciencedirect.com
    Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells
    1
    1. scibot 13 Oct 2021
      005557

      DOI: 10.1016/j.celrep.2021.109812

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    sciencedirect.com/science/article/pii/S2211124721012766
  129. Sep 2021
  130. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
    1
    1. scibot 23 Sep 2021
      Strain# 005557

      DOI: 10.1016/j.molcel.2021.08.034

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    sciencedirect.com/science/article/pii/S1097276521007140
  131. www.sciencedirect.com www.sciencedirect.com
    Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
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    1. scibot 21 Sep 2021
      Stock# 005557

      DOI: 10.1016/j.celrep.2021.109689

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    sciencedirect.com/science/article/pii/S2211124721011360
  132. www.sciencedirect.com www.sciencedirect.com
    Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer
    1
    1. scibot 15 Sep 2021
      005,557

      DOI: 10.1016/j.chembiol.2021.08.011

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    sciencedirect.com/science/article/pii/S2451945621004001
  133. www.sciencedirect.com www.sciencedirect.com
    Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
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    1. scibot 15 Sep 2021
      JAX:005557

      DOI: 10.1016/j.stem.2021.08.013

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    sciencedirect.com/science/article/pii/S1934590921003507
  134. www.sciencedirect.com www.sciencedirect.com
    Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
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    1. scibot 14 Sep 2021
      005557

      DOI: 10.1016/j.ccell.2021.08.009

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    sciencedirect.com/science/article/pii/S1535610821004499
  135. Aug 2021
  136. www.sciencedirect.com www.sciencedirect.com
    Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
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    1. scibot 25 Aug 2021
      JAX:005557

      DOI: 10.1016/j.celrep.2021.109568

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    sciencedirect.com/science/article/pii/S2211124721010020
  137. www.sciencedirect.com www.sciencedirect.com
    Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection
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      Stock No: 005557

      DOI: 10.1016/j.celrep.2021.109538

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    sciencedirect.com/science/article/pii/S2211124721009724
  138. www.sciencedirect.com www.sciencedirect.com
    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
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    1. scibot 16 Aug 2021
      JAX:005557

      DOI: 10.1016/j.ccell.2021.07.006

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    sciencedirect.com/science/article/pii/S1535610821003834
  139. www.sciencedirect.com www.sciencedirect.com
    Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
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    1. scibot 16 Aug 2021
      JAX:005557

      DOI: 10.1016/j.cell.2021.07.020

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    sciencedirect.com/science/article/pii/S0092867421008795
  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
    1
    1. scibot 15 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-20-0331

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    ncbi.nlm.nih.gov/pmc/articles/PMC8110214/
  141. www.sciencedirect.com www.sciencedirect.com
    Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
    1
    1. scibot 14 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2019.06.003

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    sciencedirect.com/science/article/pii/S1535610819302946
  142. www.sciencedirect.com www.sciencedirect.com
    Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression
    1
    1. scibot 11 Aug 2021
      JAX:005557

      DOI: 10.1016/j.stem.2016.12.001

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    sciencedirect.com/science/article/pii/S193459091630457X
  143. www.sciencedirect.com www.sciencedirect.com
    ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
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    1. scibot 07 Aug 2021
      Stock No: 005557

      DOI: 10.1016/j.molcel.2021.07.018

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    sciencedirect.com/science/article/pii/S1097276521005876
  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer
    1
    1. scibot 06 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.7554/eLife.43024

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    ncbi.nlm.nih.gov/pmc/articles/PMC6597241/
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Studying immunotherapy resistance in a melanoma autologous humanized mouse xenograft.
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    1. scibot 05 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1541-7786.MCR-20-0686

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    ncbi.nlm.nih.gov/pmc/articles/PMC7864867/
  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
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    1. scibot 05 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.7554/eLife.70429

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    ncbi.nlm.nih.gov/pmc/articles/PMC8321552/
  147. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2018.11.006

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    sciencedirect.com/science/article/pii/S1535610818305270
  148. www.sciencedirect.com www.sciencedirect.com
    TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate
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    1. scibot 04 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2021.07.003

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    sciencedirect.com/science/article/pii/S1934590921002885
  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      JAX:005557

      DOI: 10.1016/j.stem.2016.12.001

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    ncbi.nlm.nih.gov/pmc/articles/PMC5822422/
  150. www.sciencedirect.com www.sciencedirect.com
    The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer
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    1. scibot 03 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.molcel.2017.11.025

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    sciencedirect.com/science/article/pii/S1097276517308845
  151. www.sciencedirect.com www.sciencedirect.com
    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2018.06.012

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    sciencedirect.com/science/article/pii/S1535610818302691
  152. www.sciencedirect.com www.sciencedirect.com
    The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma
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    1. scibot 01 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2019.05.069

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    sciencedirect.com/science/article/pii/S2211124719306989
  153. Jul 2021
  154. www.sciencedirect.com www.sciencedirect.com
    A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia
    1
    1. scibot 31 Jul 2021
      Mouse: NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG)

      DOI: 10.1016/j.ccell.2019.11.001

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    sciencedirect.com/science/article/pii/S1535610819305215
  155. www.sciencedirect.com www.sciencedirect.com
    TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
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    1. scibot 31 Jul 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2021.07.003

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    sciencedirect.com/science/article/pii/S1535610821003809
  156. www.sciencedirect.com www.sciencedirect.com
    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
    1
    1. scibot 31 Jul 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2019.01.006

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    sciencedirect.com/science/article/pii/S1535610819300406
  157. www.sciencedirect.com www.sciencedirect.com
    Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting
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    1. scibot 31 Jul 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2019.02.003

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    sciencedirect.com/science/article/pii/S1535610819300984
  158. www.sciencedirect.com www.sciencedirect.com
    Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body
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    1. scibot 30 Jul 2021
      Jackson Laboratory005557

      DOI: 10.1016/j.cell.2019.11.013

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    sciencedirect.com/science/article/pii/S0092867419312693
  159. www.sciencedirect.com www.sciencedirect.com
    N6-methyladenine DNA Modification in Glioblastoma
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    1. scibot 30 Jul 2021
      JAX:005557

      DOI: 10.1016/j.cell.2018.10.006

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    sciencedirect.com/science/article/pii/S009286741831314X
  160. www.sciencedirect.com www.sciencedirect.com
    Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
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    1. scibot 30 Jul 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cell.2018.09.051

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    sciencedirect.com/science/article/pii/S0092867418312637
  161. www.sciencedirect.com www.sciencedirect.com
    Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence
    1
    1. scibot 30 Jul 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.devcel.2018.10.001

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    sciencedirect.com/science/article/pii/S1534580718308220
  162. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity
    1
    1. scibot 30 Jul 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2018.08.018

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    sciencedirect.com/science/article/pii/S1934590918304363
  163. www.sciencedirect.com www.sciencedirect.com
    Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
    1
    1. scibot 29 Jul 2021
      Jackson LaboratoryStock No:#005557

      DOI: 10.1016/j.celrep.2019.11.007

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    sciencedirect.com/science/article/pii/S2211124719314780
  164. www.sciencedirect.com www.sciencedirect.com
    Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
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    1. scibot 29 Jul 2021
      The Jackson LaboratoryCat#005557

      DOI: 10.1016/j.stem.2019.10.005

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    sciencedirect.com/science/article/pii/S1934590919304266
  165. www.sciencedirect.com www.sciencedirect.com
    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
    1
    1. scibot 29 Jul 2021
      The Jackson LaboratoryStock# 005557

      DOI: 10.1016/j.celrep.2019.08.076

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    sciencedirect.com/science/article/pii/S2211124719311313
  166. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies
    1
    1. scibot 29 Jul 2021
      JAX : 005557

      DOI: 10.1016/j.ccell.2019.08.005

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    Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer
    1
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      The Jackson LaboratoryStock #: 005557

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    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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      The Jackson LaboratoryCat# 005557

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    Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs
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      005557

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    An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
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      Jackson laboratoryCat#5557

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    Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
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      RRID: IMSR_JAX:005557

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    Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function
    1
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      Mouse: NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG)

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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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      Mouse strain: NSG; NOD.Cg-PrkdcscidIL2rgtm1Wjl/ Szj

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  174. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
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      DOI: 10.1002/cpmo.38

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    Generation of an induced pluripotent stem cell line (TRNDi008-A) from a Hunter syndrome patient carrying hemizygous 208insC mutations in the IDS gene
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      JAX No. 005557

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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection
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      005557

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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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      005557

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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors
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      005557

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    IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation
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      005557

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    Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
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      005557

      DOI: 10.1016/j.celrep.2018.10.100

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    Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2
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      005557

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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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      005557

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    Untitled document
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2018.07.009

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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct skeletal stem cell types orchestrate long bone skeletogenesis
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      RRID:IMSR_JAX:005557

      DOI: 10.7554/eLife.66063

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    Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis
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      RRID:IMSR_JAX:005557

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    ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors
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      RRID:IMSR_JAX005557

      DOI: 10.1016/j.xcrm.2021.100350

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    Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
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      RRID:IMSR_JAX:005557

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    A universal gene correction approach for FKRP-associated dystroglycanopathies to enable autologous cell therapy
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      005557

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      RRID:IMSR_JAX:005557

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    Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides
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      Cat # 005557

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    Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction
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      RRID:IMSR_JAX:005557

      DOI: 10.7554/eLife.62927

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  193. Jun 2021
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    Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction
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      RRID:IMSR_JAX:005557

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    Metabolic imaging with hyperpolarized [1-13C] pyruvate in patient-derived preclinical mouse models of breast cancer
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    High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids - Nicholas Choo, Susanne Ramm, Jennii Luu, Jean M. Winter, Luke A. Selth, Amy R. Dwyer, Mark Frydenberg, Jeremy Grummet, Shahneen Sandhu, Theresa E. Hickey, Wayne D. Tilley, Renea A. Taylor, Gail P. Risbridger, Mitchell G. Lawrence, Kaylene J. Simpson, 2021
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      RRID:IMSR_JAX:005557

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    The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation
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    Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree
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      Stock 005557

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    STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
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  200. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Generation of an induced pluripotent stem cell line (TRNDi012-B) from Fibrodysplasia Ossificans Progressiva (FOP) patient carrying a heterozygous mutation c. 617G>A in the ACVR1 gene
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      JAX No. 005557

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  201. May 2021
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    N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
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    Charting human development using a multi-endodermal organ atlas and organoid models
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      strain no. 0005557

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    Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility
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    Dynamic BH3 profiling method for rapid identification of active therapy in BH3 mimetics resistant xenograft mouse models
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      005557

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  206. www.sciencedirect.com www.sciencedirect.com
    Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation
    1
    1. scibot 12 May 2021
      JAX 005557

      DOI: 10.1016/j.devcel.2021.02.025

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      Curator: @Naa003

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    sciencedirect.com/science/article/pii/S1534580721001659
  207. www.sciencedirect.com www.sciencedirect.com
    Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption
    1
    1. scibot 09 May 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2020.12.017

      Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)

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    sciencedirect.com/science/article/pii/S1934590920306019
  208. www.sciencedirect.com www.sciencedirect.com
    UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex
    1
    1. scibot 09 May 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2020.12.002

      Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)

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    sciencedirect.com/science/article/pii/S1934590920305865
  209. www.sciencedirect.com www.sciencedirect.com
    Generation of Functional Organs Using a Cell-Competitive Niche in Intra- and Inter-species Rodent Chimeras
    1
    1. scibot 09 May 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2020.11.019

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    sciencedirect.com/science/article/pii/S193459092030583X
  210. www.sciencedirect.com www.sciencedirect.com
    LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis
    1
    1. scibot 09 May 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2020.06.017

      Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)

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    sciencedirect.com/science/article/pii/S1934590920302848
  211. www.sciencedirect.com www.sciencedirect.com
    Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer
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    1. scibot 09 May 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2020.07.003

      Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)

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    sciencedirect.com/science/article/pii/S1934590920303416
  212. www.cell.com www.cell.com
    The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia
    1
    1. scibot 06 May 2021
      JAX:005557

      DOI: 10.1016/j.isci.2021.102435

      Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)

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    cell.com/iscience/abstract/S2589-0042(21)00403-X
  213. www.sciencedirect.com www.sciencedirect.com
    DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation
    1
    1. scibot 05 May 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.devcel.2020.09.021

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    sciencedirect.com/science/article/pii/S153458072030753X
  214. www.sciencedirect.com www.sciencedirect.com
    Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells
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    1. scibot 04 May 2021
      Jax Stock# 005557

      DOI: 10.1016/j.stem.2021.04.008

      Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)

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    sciencedirect.com/science/article/pii/S193459092100165X
  215. www.sciencedirect.com www.sciencedirect.com
    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
    1
    1. scibot 01 May 2021
      Cat# 005557

      DOI: 10.1016/j.cmet.2021.02.001

      Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)

      Curator: @Naa003

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    sciencedirect.com/science/article/pii/S1550413121000577
  216. www.sciencedirect.com www.sciencedirect.com
    Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis
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    1. scibot 01 May 2021
      JAX:005557

      DOI: 10.1016/j.cmet.2021.03.003

      Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)

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    sciencedirect.com/science/article/pii/S1550413121001108