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www.nature.com www.nature.com

Epithelial tumor suppressor deletion promotes neuroendocrine differentiation in bladder cancer and reveals homoharringtonine as a candidate vulnerability

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1. scibot 24 Sep 2026
  
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  DOI: 10.1038/s41388-026-03975-7
  
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nature.com/articles/s41388-026-03975-7
Apr 2026
aacrjournals.org aacrjournals.org

P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy

1
1. scibot 23 Apr 2026
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1158/2159-8290.CD-25-1212
  
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aacrjournals.org/cancerdiscovery/article/16/3/571/774737/p21-Positive-Senescent-Stromal-Cells-Promote
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Serotonin modulates lineage plasticity in neuroendocrine prostate cancer via epigenetic reprogramming

1
1. scibot 03 Apr 2026
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1158/2159-8290.CD-25-0974
  
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aacrjournals.org/cancerdiscovery/article/16/4/760/775565/Serotonin-Modulates-Lineage-Plasticity-in
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury

1
1. scibot 03 Mar 2026
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.7554/eLife.87528
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12945389/
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Immunocompetent murine models recapitulate the heterogeneous tumor immune microenvironment of human liposarcoma

1
1. scibot 02 Dec 2025
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1158/1078-0432.CCR-25-1628
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12664306/
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models

1
1. scibot 01 Nov 2025
  
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  RRID: IMSR_JAX:006440
  
  DOI: 10.1158/2767-9764.CRC-25-0279
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12569591/
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Non-cell-autonomous tumor promotion in DICER1 cancer predisposition

1
1. scibot 01 Oct 2025
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.devcel.2025.09.001
  
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sciencedirect.com/science/article/pii/S1534580725005398
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Enhancing neural stem cell integration in the injured spinal cord through targeted PTEN modulation

1
1. scibot 07 Sep 2025
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.4103/NRR.NRR-D-24-00455
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12407558/
Jul 2025
onlinelibrary.wiley.com onlinelibrary.wiley.com

Synergistic Inhibition of Prostate Cancer Progression in Mice With a Combination of Curcumin and Ursolic Acid in the Diet

1
1. scibot 22 Jul 2025
  
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  006440
  
  DOI: 10.1002/mc.70000
  
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onlinelibrary.wiley.com/doi/full/10.1002/mc.70000
Jun 2025
elifesciences.org elifesciences.org

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

1
1. scibot 18 Jun 2025
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.7554/eLife.100604
  
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elifesciences.org/articles/100604
Apr 2025
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Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

1
1. scibot 19 Apr 2025
  
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  JAX:006440
  
  DOI: 10.1016/j.ccell.2025.03.027
  
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sciencedirect.com/science/article/pii/S153561082500128X
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pten Loss Triggers Progressive Photoreceptor Degeneration in an mTORC1-Independent Manner

1
1. scibot 27 Mar 2025
  
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  RRID:IMSR_JAX
  
  DOI: 10.1167/iovs.66.3.45
  
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  Curator: @evieth
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11935561/
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Somatostatin interneuron fate-mapping and structure in a Pten knockout model of epilepsy

1
1. scibot 07 Nov 2024
  
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  IMSR_JAX:006440
  
  DOI: 10.3389/fncel.2024.1474613
  
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  Curator: @AleksanderDrozdz
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532043/
Aug 2024
www.biorxiv.org www.biorxiv.org

Local glycolysis supports injury-induced axonal regeneration

1
1. scibot 15 Aug 2024
  
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  Ptenfl/fl
  
  DOI: 10.1101/2024.01.29.577706
  
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  Curator: @vtello
  
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biorxiv.org/content/10.1101/2024.01.29.577706v1
www.cell.com www.cell.com

Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior

1
1. scibot 02 Aug 2024
  
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  JAX: 006440
  
  DOI: 10.1016/j.celrep.2021.109249
  
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cell.com/cell-reports/fulltext/S2211-1247(21)00614-8
molecularbrain.biomedcentral.com molecularbrain.biomedcentral.com

Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes

1
1. scibot 02 Aug 2024
  
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  Stock #: 006440
  
  DOI: 10.1186/s13041-021-00731-8
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Missing
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molecularbrain.biomedcentral.com/article/10.1186/s13041-021-00731-8
Jul 2024
www.sciencedirect.com www.sciencedirect.com

PTEN acts as a crucial inflammatory checkpoint controlling TLR9/IL-6 axis in B cells

1
1. scibot 23 Jul 2024
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.isci.2024.110388
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
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sciencedirect.com/science/article/pii/S2589004224016134
www.biorxiv.org www.biorxiv.org

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

1
1. scibot 18 Jul 2024
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1101/2024.07.12.603298
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
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biorxiv.org/content/10.1101/2024.07.12.603298v1
www.cell.com www.cell.com

Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

1
1. scibot 12 Jul 2024
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2024.114431
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
May 2024
www.sciencedirect.com www.sciencedirect.com

Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity

1
1. scibot 23 May 2024
  
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  006440
  
  DOI: 10.1016/j.celrep.2024.114261
  
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sciencedirect.com/science/article/pii/S2211124724005898
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation

1
1. scibot 15 May 2024
  
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  JacksonJax 006440
  
  DOI: 10.1016/j.isci.2024.109747
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11089364/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α

3
1. scibot 09 Apr 2024
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2024.114056
  
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2. scibot 09 Apr 2024
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2024.114056
  
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3. scibot 09 Apr 2024
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2024.114056
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11112681/
Mar 2024
www.sciencedirect.com www.sciencedirect.com

Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina

1
1. scibot 29 Mar 2024
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2024.114005
  
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sciencedirect.com/science/article/pii/S2211124724003334
Jan 2024
link.springer.com link.springer.com

Distinct mesenchymal cell states mediate prostate cancer progression

1
1. scibot 11 Jan 2024
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1038/s41467-023-44210-1
  
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link.springer.com/article/10.1038/s41467-023-44210-1
Dec 2023
www.sciencedirect.com www.sciencedirect.com

De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function

1
1. scibot 21 Dec 2023
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2023.113518
  
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sciencedirect.com/science/article/pii/S2211124723015309
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neurovascular development in Pten and Tsc2 mouse mutants

1
1. scibot 02 Mar 2023
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1523/ENEURO.0340-22.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9953070/
Nov 2022
www.sciencedirect.com www.sciencedirect.com

Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting

1
1. scibot 10 Nov 2022
  
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  The Jackson Laboratory006440
  
  DOI: 10.1016/j.isci.2022.105383
  
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sciencedirect.com/science/article/pii/S2589004222016558
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Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss

1
1. scibot 03 Nov 2022
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2022.111574
  
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sciencedirect.com/science/article/pii/S2211124722014358
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

1
1. scibot 12 Aug 2022
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.neuron.2022.06.022
  
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sciencedirect.com/science/article/pii/S0896627322006018
Jul 2022
www.sciencedirect.com www.sciencedirect.com

PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis

1
1. scibot 27 Jul 2022
  
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  JAX# 006440
  
  DOI: 10.1016/j.celrep.2022.111125
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S2211124722009317
Jun 2022
www.sciencedirect.com www.sciencedirect.com

Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells

1
1. scibot 29 Jun 2022
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.neuron.2022.06.002
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
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sciencedirect.com/science/article/pii/S0896627322005402
www.sciencedirect.com www.sciencedirect.com

Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine

1
1. scibot 03 Jun 2022
  
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  The Jackson LaboratoryStock No: 006440
  
  DOI: 10.1016/j.celrep.2022.110884
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S2211124722006593
May 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

1
1. scibot 04 May 2022
  
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  JAX 006440
  
  DOI: 10.1158/0008-5472.CAN-20-4028
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8563406/
Jan 2022
www.eneuro.org www.eneuro.org

An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle

1
1. scibot 29 Jan 2022
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1523/ENEURO.0025-19.2019
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @scibot
  
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eneuro.org/content/6/2/ENEURO.0025-19.2019
Nov 2021
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Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities

1
1. scibot 24 Nov 2021
  
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  Stock# 006440
  
  DOI: 10.1016/j.celrep.2021.110054
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @Naa003
  
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  RRIDCUR:Missing RRID:IMSR_JAX:006440
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sciencedirect.com/science/article/pii/S2211124721015400
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 13 Aug 2021
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1523/ENEURO.0025-19.2019
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6464513/
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 29 Jul 2021
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2018.09.052
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6258034/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

2
1. scibot 29 Jul 2021
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.7554/eLife.32021
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @evieth
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Duplicate RRIDCUR:Validated
2. scibot 29 Jul 2021
  
  in Public
  
  RRID:IMSR_JAX:006440
  
  DOI: 10.7554/eLife.32021
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @evieth
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC5839742/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cytokeratin 19 promoter directs the expression of Cre recombinase in various epithelia of transgenic mice

1
1. scibot 27 Jul 2021
  
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  B6.129S4-PTEN tm1Hwu/J
  
  DOI: 10.18632/oncotarget.15435
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @mpairish
  
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  RRIDCUR:Missing RRID:IMSR_JAX:006440
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ncbi.nlm.nih.gov/pmc/articles/PMC5392329/
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Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?

1
1. scibot 27 Jul 2021
  
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  RRID:IMSR_JAX
  
  DOI: 10.1016/j.expneurol.2019.113029
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @bandrow
  
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  RRIDCUR:Unresolved RRIDCUR:SyntaxError RRID:IMSR_JAX:006440
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sciencedirect.com/science/article/pii/S0014488619301785
Jun 2021
www.cell.com www.cell.com

Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior

1
1. scibot 16 Jun 2021
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.celrep.2021.109249
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @scibot
  
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cell.com/cell-reports/fulltext/S2211-1247(21)00614-8
May 2021
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mTOR-driven neural circuit changes initiate an epileptogenic cascade

1
1. scibot 07 May 2021
  
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  RRID:IMSR_JAX
  
  DOI: 10.1016/j.pneurobio.2020.101974
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
  Curator comments: B6.129S4-Ptentm1Hwu/J Mus musculus IMSR Cat# JAX:006440
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:006440 RRIDCUR:SyntaxError
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sciencedirect.com/science/article/pii/S030100822030229X
Sep 2020
www.sciencedirect.com www.sciencedirect.com

PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes

1
1. scibot 25 Sep 2020
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.nbd.2020.105026
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @Naa003
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0969996120303016
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1

1
1. scibot 10 Sep 2020
  
  in Public
  
  RRID:IMSR_JAX:006440
  
  DOI: 10.1038/s41598-020-69698-1
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7391766/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

1
1. scibot 13 Jan 2020
  
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  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.neuron.2019.05.044
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627319304970
www.sciencedirect.com www.sciencedirect.com

Activity-dependent dendritic elaboration requires Pten

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:IMSR_JAX:006440
  
  DOI: 10.1016/j.nbd.2019.104703
  
  Resource: (IMSR Cat# JAX_006440,RRID:IMSR_JAX:006440)
  
  Curator: @ethanbadger
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S096999611930378X
Nov 2018
www.sciencedirect.com www.sciencedirect.com

The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:006440
  
  Curator: @Jmenke
  
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  RRID:IMSR_JAX:006440
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1074761318304357
www.sciencedirect.com www.sciencedirect.com

Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID: IMSR_JAX STRAIN #006440
  
  Curator: @bandrow
  
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  RRID:IMSR_JAX:006440
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
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  RRID:IMSR_JAX:006440 RRIDCUR:SyntaxError
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sciencedirect.com/science/article/pii/S0014488618305259
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:006440
  
  Resource used:
  
  RRID:IMSR_JAX:006440
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
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sciencedirect.com/science/article/pii/S2211124718314979
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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:006440
  
  Curator: @anp055
  
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  RRID:IMSR_JAX:006440
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610818302290
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Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:IMSR_JAX:006440
  
  Curator: @evieth
  
  Resource used:
  
  RRID:IMSR_JAX:006440
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0960982218302549
Nov 2017
www.sciencedirect.com www.sciencedirect.com

PTEN deletion increases hippocampal granule cell excitability in male and female mice

1
1. scibot 08 Nov 2017
  
  in Public
  
  JAX:006440
  
  Curator: @Jmenke
  
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  RRID:IMSR_JAX:006440
  
  SciCrunch record: RRID:IMSR_JAX:006440
  
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  RRID:IMSR_JAX:006440 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0969996117302048