152 Matching Annotations
  1. Oct 2026
  2. www.sciencedirect.com www.sciencedirect.com
    Chromatin accessibility trajectories reveal pre-cancerous epigenetic priming and an acid-driven immunotherapy-resistant gastric cancer subtype
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    sciencedirect.com/science/article/pii/S1535610826004010
  3. Sep 2026
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    Dietary α-ketoglutarate modulates lung adenocarcinoma growth and epigenetic remodeling in a sex-dependent fashion
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    sciencedirect.com/science/article/pii/S2211124726011307
  5. Aug 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancreatic carcinogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13453609/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13434761/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting CCR1 remodels the tumor microenvironment and relieves immune suppression in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13429029/
  9. Jul 2026
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    Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis
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    sciencedirect.com/science/article/pii/S1534580726002406
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATM Deficiency Induces TGFβ-Mediated Stromal Programming in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13370118/
  12. 54.241.53.176 54.241.53.176
    The central precocious puberty-associated gene MKRN3 is a tumor suppressor regulating CSDE1 ubiquitination in ovarian cancer
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  13. Jun 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant methylation limits antitumoral inflammation in lung adenocarcinoma by restricting RIPK3 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13249207/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas
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    pmc.ncbi.nlm.nih.gov/articles/PMC13227558/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of polarity by Cdc42 depletion and oncogenic Kras activation in the mouse intestinal epithelia leads to a necrotizing enterocolitis (NEC)-like disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC13223224/
  17. May 2026
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bcl-xL blockade targets neutrophils and synergizes with chemotherapy in lung squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13179379/
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    A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1535610826001753
  20. Apr 2026
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Myofibroblasts induce neuroplasticity to promote pancreatic inflammation and cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13102267/
  22. 54.241.53.176 54.241.53.176
    cd-25-1337-html.html
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    An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection
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  24. jpet.aspetjournals.org jpet.aspetjournals.org
    Corrigendum to “Histamine H1 receptor: a potential therapeutic target for pancreatic ductal adenocarcinoma”
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    jpet.aspetjournals.org/article/S0022-3565(26)00504-5/fulltext
  25. Mar 2026
  26. www.sciencedirect.com www.sciencedirect.com
    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    sciencedirect.com/science/article/pii/S2211124726002664
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RORγt Inhibition Reduces Pro-Tumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12288671/
  28. Feb 2026
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12885529/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immune Stromal Components Impede Biological Effectiveness of Carbon Ion Therapy in a Preclinical Model of Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12869159/
  31. Jan 2026
  32. www.science.org www.science.org
    Aberrant methylation limits antitumoral inflammation in lung adenocarcinoma by restricting RIPK3 expression
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    science.org/doi/10.1126/sciadv.adz9227
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrinsic resistance to RAS inhibitors is driven by dysregulation of KRAS degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12796258/
  34. www.sciencedirect.com www.sciencedirect.com
    MITA/STING-driven CD38 induction in Siglec-Flow macrophages promotes regulatory T cell survival and non-small cell lung cancer progression
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  35. Dec 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SMURF2 facilitates GAP17 Isoform 1 membrane displacement to promote mutant p53-KRAS oncogenic synergy
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  37. Nov 2025
  38. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Protein kinase Cι dictates tumor trajectory, cell plasticity, and immune surveillance in lung adenocarcinoma
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  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes
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  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EML4-ALK variant-specific genetic interactions shape lung tumorigenesis
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression
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    Injury and inflammation promote cancer progression at the anorectal junction
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    Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
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    sciencedirect.com/science/article/pii/S193459092500373X
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12569591/
  45. Oct 2025
  46. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas
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  48. Sep 2025
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma
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  51. www.sciencedirect.com www.sciencedirect.com
    Early adipose tissue wasting in a preclinical model of human lung cancer cachexia
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  52. Aug 2025
  53. www.biorxiv.org www.biorxiv.org
    L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma
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    biorxiv.org/content/10.1101/2025.08.22.671773v1
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12319406/
  55. Jul 2025
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11623500/
  57. Jun 2025
  58. www.sciencedirect.com www.sciencedirect.com
    Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice
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    sciencedirect.com/science/article/pii/S2666166725003132
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12169444/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11627241/
  61. May 2025
  62. www.sciencedirect.com www.sciencedirect.com
    Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression
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  63. www.sciencedirect.com www.sciencedirect.com
    Distinct Roles for the Thioredoxin and Glutathione Antioxidant Systems in Nrf2-Mediated Lung Tumor Initiation and Progression
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    sciencedirect.com/science/article/pii/S2213231725001661
  64. Apr 2025
  65. www.sciencedirect.com www.sciencedirect.com
    Histamine 1 Receptor (HRH1): A potential therapeutic target for Pancreatic Ductal Adenocarcinoma
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    sciencedirect.com/science/article/pii/S0022356525397867
  66. 52.53.155.43 52.53.155.43
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  67. Mar 2025
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  69. Feb 2025
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combinatorial In Vivo Genome Editing Identifies Widespread Epistasis and an Accessible Fitness Landscape During Lung Tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11824425/
  71. www.sciencedirect.com www.sciencedirect.com
    KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31
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  72. aacrjournals.org aacrjournals.org
    Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
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    aacrjournals.org/cancerres/article/84/18/2968/747793/Scribble-Deficiency-Promotes-Pancreatic-Ductal
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    sciencedirect.com/science/article/pii/S2666379124006980
  74. Dec 2024
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography
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    pmc.ncbi.nlm.nih.gov/articles/PMC11652680/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC5517315/
  77. Nov 2024
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC9915899/
  79. www.sciencedirect.com www.sciencedirect.com
    A subset of neutrophils activates anti-tumor immunity and inhibits non-small-cell lung cancer progression
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  80. Sep 2024
  81. www.biorxiv.org www.biorxiv.org
    A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
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    biorxiv.org/content/10.1101/2024.09.14.613043v1
  82. Aug 2024
  83. www.biorxiv.org www.biorxiv.org
    Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes
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    biorxiv.org/content/10.1101/2024.08.19.607671v1
  84. www.sciencedirect.com www.sciencedirect.com
    FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia
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  85. www.researchsquare.com www.researchsquare.com
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  86. Jul 2024
  87. www.science.org www.science.org
    Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer
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    science.org/doi/10.1126/science.adh4567
  88. 52.53.155.43 52.53.155.43
    Cancer-associated endocrine cells participate in pancreatic carcinogenesis
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  89. Jun 2024
  90. www.biorxiv.org www.biorxiv.org
    Aging represses lung tumorigenesis and alters tumor suppression
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    biorxiv.org/content/10.1101/2024.05.28.596319v1
  91. May 2024
  92. www.sciencedirect.com www.sciencedirect.com
    CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724006144
  93. www.sciencedirect.com www.sciencedirect.com
    Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1074761324002267
  94. Apr 2024
  95. www.sciencedirect.com www.sciencedirect.com
    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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  96. Mar 2024
  97. www.biorxiv.org www.biorxiv.org
    Modeling the genomic complexity of human cancer using Cas12a mice
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    biorxiv.org/content/10.1101/2024.03.07.583774v1
  98. www.biorxiv.org www.biorxiv.org
    Combinatorial in vivo genome editing identifies widespread epistasis during lung tumorigenesis
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    biorxiv.org/content/10.1101/2024.03.07.583981v1
  99. Feb 2024
  100. aacrjournals.org aacrjournals.org
    Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma
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    aacrjournals.org/clincancerres/article/29/24/5183/731660/Nuclear-GRP78-Promotes-Metabolic-Reprogramming-and
  101. link.springer.com link.springer.com
    Exosomes define a local and systemic communication network in healthy pancreas and pancreatic ductal adenocarcinoma
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    link.springer.com/article/10.1038/s41467-024-45753-7
  102. Jan 2024
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810848/
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    Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
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    sciencedirect.com/science/article/pii/S1534580723003945
  105. Dec 2023
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    A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas
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  108. Oct 2023
  109. www.sciencedirect.com www.sciencedirect.com
    Novel tumor organoid-based mouse model to study image-guided radiation therapy of rectal cancer after non-invasive and precise endoscopic implantation
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    sciencedirect.com/science/article/pii/S0360301623080148
  110. www.nature.com www.nature.com
    Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia
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    nature.com/articles/s41467-023-41952-w
  111. Aug 2023
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10463307/
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  114. Jun 2023
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
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    Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion
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  117. www.cell.com www.cell.com
    Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer
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  118. May 2023
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gender-specific changes of the gut microbiome correlate with tumor development in murine models of pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10225934/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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  121. Mar 2023
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  130. Sep 2022
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  140. Mar 2022
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  142. Feb 2022
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  144. Jan 2022
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  147. Dec 2021
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  149. Nov 2021
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  161. Jul 2021
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  169. Jun 2021
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  173. May 2021
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  185. Mar 2021
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  187. Feb 2021
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