81 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
    1
    1. scibot 04 Apr 2024
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.devcel.2024.03.020

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    sciencedirect.com/science/article/pii/S1534580724001886
  3. Mar 2024
  4. www.sciencedirect.com www.sciencedirect.com
    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
    1
    1. scibot 22 Mar 2024
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.molcel.2024.02.037

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    sciencedirect.com/science/article/pii/S1097276524001801
  5. www.sciencedirect.com www.sciencedirect.com
    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
    2
    1. scibot 12 Mar 2024
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.xcrm.2024.101461

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    2. scibot 12 Mar 2024
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.xcrm.2024.101461

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    sciencedirect.com/science/article/pii/S2666379124001058
  6. Feb 2024
  7. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 27 Feb 2024
      RRID:IMSR_JAX:008462

      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  8. Jan 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
    1
    1. scibot 18 Jan 2024
      RRID:IMSR_JAX:008462

      DOI: 10.1158/0008-5472.CAN-22-3464

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524763/
  10. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 10 Jan 2024
      RRID:IMSR_JAX:008462

      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  11. www.sciencedirect.com www.sciencedirect.com
    Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
    2
    1. scibot 04 Jan 2024
      JAX:008462

      DOI: 10.1016/j.devcel.2023.07.025

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    2. scibot 04 Jan 2024
      JAX:008462

      DOI: 10.1016/j.devcel.2023.07.025

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    sciencedirect.com/science/article/pii/S1534580723003945
  12. Dec 2023
  13. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation
    1
    1. scibot 15 Dec 2023
      RRID:IMSR_JAX:008462

      DOI: 10.1111/cas.16037

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    onlinelibrary.wiley.com/doi/10.1111/cas.16037
  14. Oct 2023
  15. www.nature.com www.nature.com
    Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia
    1
    1. scibot 07 Oct 2023
      RRID:IMSR_JAX:008462

      DOI: 10.1038/s41467-023-41952-w

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    nature.com/articles/s41467-023-41952-w
  16. Aug 2023
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
    1
    1. scibot 12 Aug 2023
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.isci.2023.107368

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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  18. Jun 2023
  19. 52.53.155.43 52.53.155.43
    can-22-3464-html.html
    1
    1. scibot 30 Jun 2023
      RRID:IMSR_JAX:008462

      DOI: 10.1158/0008-5472.CAN-22-3464

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    52.53.155.43/8f4ba7cf674bbb2f5b6878f674808aab8499538e/can-22-3464-html.html
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
    1
    1. scibot 17 Jun 2023
      RRID:IMSR_JAX:008462

      DOI: 10.1158/0008-5472.CAN-22-3848

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    ncbi.nlm.nih.gov/pmc/articles/PMC10267679/
  21. May 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
    1
    1. scibot 04 May 2023
      JAX:008462

      DOI: 10.1158/0008-5472.CAN-22-3000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
  23. Apr 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development
    1
    1. scibot 13 Apr 2023
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.devcel.2023.03.016

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    sciencedirect.com/science/article/pii/S1534580723001326
  25. Mar 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease
    1
    1. scibot 04 Mar 2023
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.celrep.2023.112198

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    sciencedirect.com/science/article/pii/S2211124723002097
  27. Jan 2023
  28. www.sciencedirect.com www.sciencedirect.com
    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
    1
    1. scibot 28 Jan 2023
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.celrep.2022.111878

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    sciencedirect.com/science/article/pii/S2211124722017740
  29. Dec 2022
  30. www.sciencedirect.com www.sciencedirect.com
    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
    1
    1. scibot 17 Dec 2022
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.ccell.2022.11.015

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    sciencedirect.com/science/article/pii/S1535610822005621
  31. Nov 2022
  32. aacrjournals.org aacrjournals.org
    The cAMP/PKA/CREB and TGF-β/SMAD4 pathways regulate stemness and metastatic potential in colorectal cancer cells
    1
    1. scibot 22 Nov 2022
      RRID:IMSR_JAX:008462

      DOI: 10.1158/0008-5472.CAN-22-1369

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    aacrjournals.org/cancerres/article/82/22/4179/710134/The-cAMP-PKA-CREB-and-TGF-SMAD4-Pathways-Regulate
  33. www.sciencedirect.com www.sciencedirect.com
    NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma
    1
    1. scibot 09 Nov 2022
      008462

      DOI: 10.1016/j.celrep.2022.111623

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    sciencedirect.com/science/article/pii/S2211124722014942
  34. Oct 2022
  35. 52.53.155.43 52.53.155.43
    can-22-1369-html.html
    1
    1. scibot 27 Oct 2022
      RRID:IMSR_JAX:008462

      DOI: 10.1158/0008-5472.CAN-22-1369

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    52.53.155.43/73ac479c11a5b7254565d9c8982a4bd5bdf3415d/can-22-1369-html.html
  36. www.sciencedirect.com www.sciencedirect.com
    The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
    1
    1. scibot 09 Oct 2022
      008462

      DOI: 10.1016/j.cell.2022.09.020

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    sciencedirect.com/science/article/pii/S0092867422011928
  37. Aug 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma
    1
    1. scibot 31 Aug 2022
      JAX:008462

      DOI: 10.1016/j.celrep.2022.111253

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    sciencedirect.com/science/article/pii/S2211124722010713
  39. Jul 2022
  40. www.sciencedirect.com www.sciencedirect.com
    Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling
    1
    1. scibot 13 Jul 2022
      THE JACKSON LABORATORYCat # 008462

      DOI: 10.1016/j.celrep.2022.111072

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      Curator: @sophiastull

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    sciencedirect.com/science/article/pii/S2211124722008701
  41. Jun 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
    1
    1. scibot 22 Jun 2022
      Jackson LaboratoryStock# 008462

      DOI: 10.1016/j.celrep.2022.110991

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    sciencedirect.com/science/article/pii/S221112472200777X
  43. May 2022
  44. www.sciencedirect.com www.sciencedirect.com
    Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling
    1
    1. scibot 18 May 2022
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.cmet.2022.04.012

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    sciencedirect.com/science/article/pii/S1550413122001826
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer
    1
    1. scibot 04 May 2022
      JAX 008462

      DOI: 10.1158/0008-5472.CAN-20-4028

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    ncbi.nlm.nih.gov/pmc/articles/PMC8563406/
  46. Apr 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis
    1
    1. scibot 15 Apr 2022
      RRID:IMSR_JAX:008462

      DOI: 10.7554/eLife.74595

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    ncbi.nlm.nih.gov/pmc/articles/PMC9007587/
  48. Feb 2022
  49. www.sciencedirect.com www.sciencedirect.com
    Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
    1
    1. scibot 04 Feb 2022
      JAX:008462

      DOI: 10.1016/j.ccell.2022.01.003

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    sciencedirect.com/science/article/pii/S1535610822000058
  50. www.sciencedirect.com www.sciencedirect.com
    Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
    1
    1. scibot 04 Feb 2022
      JAX:008462

      DOI: 10.1016/j.ccell.2022.01.004

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    sciencedirect.com/science/article/pii/S153561082200006X
  51. Dec 2021
  52. www.sciencedirect.com www.sciencedirect.com
    Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
    1
    1. scibot 21 Dec 2021
      Jax stock 008462

      DOI: 10.1016/j.devcel.2021.11.020

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    sciencedirect.com/science/article/pii/S1534580721009448
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia
    1
    1. scibot 11 Dec 2021
      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.isci.2021.103440

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    ncbi.nlm.nih.gov/pmc/articles/PMC8633967/
  54. Nov 2021
  55. www.sciencedirect.com www.sciencedirect.com
    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
    1
    1. scibot 24 Nov 2021
      Stock# 008462

      DOI: 10.1016/j.celrep.2021.110054

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    sciencedirect.com/science/article/pii/S2211124721015400
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy
    2
    1. scibot 05 Nov 2021
      RRID:IMSR_JAX:008462

      DOI: 10.1158/0008-5472.CAN-20-2870

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    2. scibot 05 Nov 2021
      RRID:IMSR_JAX:008462

      DOI: 10.1158/0008-5472.CAN-20-2870

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    ncbi.nlm.nih.gov/pmc/articles/PMC8137580/
  57. Sep 2021
  58. www.sciencedirect.com www.sciencedirect.com
    Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors
    1
    1. scibot 24 Sep 2021
      Stock No: 008462

      DOI: 10.1016/j.cell.2021.08.020

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    sciencedirect.com/science/article/pii/S0092867421009946
  59. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
    1
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      JAX 008462

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    Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes
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    UV-induced reduction in Polycomb repression promotes epidermal pigmentation
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      008462

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  62. Aug 2021
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      JAX:008462

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  65. Jul 2021
  66. www.sciencedirect.com www.sciencedirect.com
    The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
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      JAX:008462

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    Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma
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      The Jackson Laboratory008462

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    Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer
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      B6.129P2-Trp53tm1Brn/J (Trp53L)

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    Multi-organ Mapping of Cancer Risk
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      IMSR_JAX:008462

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      IMSR_JAX:008462

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    Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype
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      008462

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    Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness
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  72. elifesciences.org elifesciences.org
    Signaling levels mold the RAS mutation tropism of urethane
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  73. Jun 2021
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    Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response
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      JAX:008462

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    Protocol for single-cell ATAC sequencing using combinatorial indexing in mouse lung adenocarcinoma
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      008462

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  76. May 2021
  77. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    Cell of Origin Influences Pancreatic Cancer Subtype
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    Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer
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  79. Apr 2021
  80. www.sciencedirect.com www.sciencedirect.com
    High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer
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      008462

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    Emergence of a High-Plasticity Cell State during Lung Cancer Evolution
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      008462

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    Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma
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      stock 008462

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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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      JAX 008462

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    PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis
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  85. Mar 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Skeletal Muscle Subpopulation Rearrangements upon Rhabdomyosarcoma Development through Single-Cell Mass Cytometry
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      RRID:IMSR_JAX:008462

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  87. Feb 2021
  88. elifesciences.org elifesciences.org
    Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth
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      RRID:IMSR_JAX:008462

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  89. Jan 2021
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    An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming
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      RRID:IMSR_JAX:008462

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  91. Dec 2020
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    Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation
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      JAX:008462

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  93. Sep 2020
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    Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma
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      RRID:IMSR_JAX:008462

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    Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer
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      RRID:IMSR_JAX:008462

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    High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down
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      JAX Stock No. 008462

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    Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation
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      The Jackson Laboratory008462

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    The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer
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      JaxLab, Stock number 008462

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    Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth
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      JAX#008462

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    Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma
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      The Jackson Laboratory008462

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  101. Jan 2020
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    IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development
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      RRID:IMSR_JAX:008462

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    Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch
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      RRID:IMSR_JAX:008462

      DOI: 10.1016/j.cell.2019.09.010

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      JAX:008462

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  105. Nov 2018
  106. www.sciencedirect.com www.sciencedirect.com
    The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment
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    Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells
    1
    1. scibot 05 Nov 2018
      RRID:IMSR_JAX:008462

      Curator: @Jmenke

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      RRID:IMSR_JAX:008462 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1934590918304375
  108. www.sciencedirect.com www.sciencedirect.com
    Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia
    1
    1. scibot 05 Nov 2018
      008462

      Curator: @Jmenke

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      RRID:IMSR_JAX:008462 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1534580718304192
  109. elifesciences.org elifesciences.org
    Untitled document
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    1. scibot 05 Nov 2018
      RRID:IMSR_JAX:008462

      Curator: @evieth

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    elifesciences.org/articles/36389
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation
    1
    1. scibot 05 Nov 2018
      RRID:IMSR_JAX:008462

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC5720590/
  111. www.sciencedirect.com www.sciencedirect.com
    Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors
    1
    1. scibot 05 Nov 2018
      JAX:008462

      Curator: @anp055

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      RRID:IMSR_JAX:008462 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761317305721
  112. Nov 2017
  113. www.sciencedirect.com www.sciencedirect.com
    A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
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    1. scibot 08 Nov 2017
      008462

      Curator: @Jmenke

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      RRID:IMSR_JAX:008462 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1535610817304117
  114. www.sciencedirect.com www.sciencedirect.com
    Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition
    1
    1. scibot 08 Nov 2017
      008462

      Curator: @Jmenke

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      RRID:IMSR_JAX:008462

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      RRID:IMSR_JAX:008462 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1934590916303599