140 Matching Annotations
  1. Last 7 days
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    An IL-34–IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression
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    biorxiv.org/content/10.64898/2026.07.14.738492v1
  3. Aug 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13434761/
  5. Jul 2026
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    Mouse model of Merkel cell carcinoma derived from the hair follicle
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    pmc.ncbi.nlm.nih.gov/articles/PMC13383575/
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    Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis
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    sciencedirect.com/science/article/pii/S1534580726002406
  8. Jun 2026
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    Interleukin-34–Induced Arg1+ Macrophages Play a Key Role in Breast Cancer Brain Metastasis
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    Aberrant methylation limits antitumoral inflammation in lung adenocarcinoma by restricting RIPK3 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13249207/
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    Plasma signals of lung tumor promotion for molecular cancer prevention
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    sciencedirect.com/science/article/pii/S0092867426005222
  12. May 2026
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    Bcl-xL blockade targets neutrophils and synergizes with chemotherapy in lung squamous cell carcinoma
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    A conserved re-epithelialization program underlies malignancy in pancreatic ductal adenocarcinoma
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  15. Apr 2026
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    Stem cell control in the lung by an autocrine injury-activated Igf complex
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    science.org/doi/10.1126/science.adt1310
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    Corrigendum to “Histamine H1 receptor: a potential therapeutic target for pancreatic ductal adenocarcinoma”
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    jpet.aspetjournals.org/article/S0022-3565(26)00504-5/fulltext
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    Serotonin modulates lineage plasticity in neuroendocrine prostate cancer via epigenetic reprogramming
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  19. Mar 2026
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies
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  22. Feb 2026
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    Nonsense-mediated mRNA decay orchestrates neuronal migration and cortical lamination while modulating Reelin and ciliary gene regulatory networks
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    Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer
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    Immune Stromal Components Impede Biological Effectiveness of Carbon Ion Therapy in a Preclinical Model of Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12869159/
  26. Jan 2026
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    Aberrant methylation limits antitumoral inflammation in lung adenocarcinoma by restricting RIPK3 expression
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    A Jagged1-regulated hybrid-EMT state identifies pancreatic cancer stem cells
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    MITA/STING-driven CD38 induction in Siglec-Flow macrophages promotes regulatory T cell survival and non-small cell lung cancer progression
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  30. Dec 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immunocompetent murine models recapitulate the heterogeneous tumor immune microenvironment of human liposarcoma
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    An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
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  33. Nov 2025
  34. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Protein kinase Cι dictates tumor trajectory, cell plasticity, and immune surveillance in lung adenocarcinoma
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    Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes
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    EML4-ALK variant-specific genetic interactions shape lung tumorigenesis
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  37. 54.241.53.176 54.241.53.176
    2025.11.16.688689v1.full-html.html
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    Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
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    Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models
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  40. Oct 2025
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    Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma
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    Deciphering Precursor Cell Dynamics in Esophageal Preneoplasia via Genetic Barcoding and Single-Cell Transcriptomics
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    pmc.ncbi.nlm.nih.gov/articles/PMC11888434/
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    Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas
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  44. Sep 2025
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    Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state
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  46. Aug 2025
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    Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy
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    L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma
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    biorxiv.org/content/10.1101/2025.08.22.671773v1
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    Activation of PI3K and deletion of p53 in keratin 15-expressing mouse mammary cells induces tumor heterogeneity and plasticity modeling metaplastic breast cancer
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    pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6463
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    A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma
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  51. Jul 2025
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    RIT1 Drives Oncogenic Transformation and is an Actionable Target in Lung Adenocarcinoma
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  53. Jun 2025
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    MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma
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  55. May 2025
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    KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy
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    sciencedirect.com/science/article/pii/S1535610825001394
  57. Apr 2025
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    Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation
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    Histamine 1 Receptor (HRH1): A potential therapeutic target for Pancreatic Ductal Adenocarcinoma
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    sciencedirect.com/science/article/pii/S0022356525397867
  60. Feb 2025
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    KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31
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    Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811823/
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    sciencedirect.com/science/article/pii/S2666379124006980
  64. Dec 2024
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography
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    Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence
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  67. Nov 2024
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    IL‐36γ and IL‐36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell–Matrix Adhesion Network and Wnt Signaling
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    A subset of neutrophils activates anti-tumor immunity and inhibits non-small-cell lung cancer progression
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  70. Sep 2024
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    Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes
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    biorxiv.org/content/10.1101/2024.08.19.607671v1
  72. Jul 2024
  73. www.science.org www.science.org
    Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer
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    science.org/doi/10.1126/science.adh4567
  74. Jun 2024
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    CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma
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    Aging represses lung tumorigenesis and alters tumor suppression
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    biorxiv.org/content/10.1101/2024.05.28.596319v1
  77. May 2024
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    CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma
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    An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
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    Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor
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    Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size
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    sciencedirect.com/science/article/pii/S0896627324002447
  82. Apr 2024
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    Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
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  84. Mar 2024
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
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  87. Feb 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  89. Jan 2024
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    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
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  93. Dec 2023
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    TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation
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    onlinelibrary.wiley.com/doi/10.1111/cas.16037
  95. Oct 2023
  96. www.nature.com www.nature.com
    Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia
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    nature.com/articles/s41467-023-41952-w
  97. Aug 2023
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  99. Jun 2023
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    Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10267679/
  102. May 2023
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
  104. Apr 2023
  105. www.cell.com www.cell.com
    Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development
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  106. Mar 2023
  107. www.sciencedirect.com www.sciencedirect.com
    Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease
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  108. Jan 2023
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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    sciencedirect.com/science/article/pii/S2211124722017740
  110. Dec 2022
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  112. Nov 2022
  113. aacrjournals.org aacrjournals.org
    The cAMP/PKA/CREB and TGF-β/SMAD4 pathways regulate stemness and metastatic potential in colorectal cancer cells
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    aacrjournals.org/cancerres/article/82/22/4179/710134/The-cAMP-PKA-CREB-and-TGF-SMAD4-Pathways-Regulate
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    NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma
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  115. Oct 2022
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    The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
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  118. Aug 2022
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    Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma
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  120. Jul 2022
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    Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling
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  122. Jun 2022
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    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
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  124. May 2022
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    Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8563406/
  127. Apr 2022
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis
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  129. Feb 2022
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